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Chronic Lymphocytic

Leukemia

SANCHEZ, Kenneth Xavier, O.

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Lymphoproliferative disorder involving CD5-positive B cells,considered as neoplasm

Cell of origin: B-lymphocyte

Abnormal groth in number of leukemic cells, crodinghealthy hite blood cells

!ay complicate into more aggressive form "#ichter$ssyndrome%

Chronic LymphocyticLeukemia

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Comparison&ealthy vs' Leukemic (issue

Figure A' A normal blood smear itherythrocytes "RBCs%, a lymphocyte "A%

and a neutrophil "B%'

Figure AFigure B

RBCs

A

B

Figure B' (his smear shos thepresence of small neoplastic

lymphocytes "A% and smudge cells "B%'(he neoplastic lymphocytes are

relatively small but slightly larger thannormal small lymphocytes and shonegligible cytoplasm and clumped

chromatin'

A

B

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)rgan !orphology

Figure C' Bone marro aspirate slide ofCLL, shoing cells ith thin cytoplasm' Figure D' Bone Anatomy shoing theorigin of hite blood cells from blood

stem cell' Blood stem cell oflymphocytes are lymphoid blasts'#eferences:

http:**hematologyinprogress'net*+p5.5 http:**'dana-farber'org*images*pd/*CD#0000.5512.'3pg http:**leukemia-melanoma-lung-breast-cancer-brain-tumor-chemotherapy'com*leukemia*chronic-lymphocytic-le

ukemia-cll-cancer*

http://www.dana-farber.org/images/pdq/CDR0000755927.jpghttp://www.dana-farber.org/images/pdq/CDR0000755927.jpghttp://leukemia-melanoma-lung-breast-cancer-brain-tumor-chemotherapy.com/leukemia/chronic-lymphocytic-leukemia-cll-cancer/http://leukemia-melanoma-lung-breast-cancer-brain-tumor-chemotherapy.com/leukemia/chronic-lymphocytic-leukemia-cll-cancer/http://leukemia-melanoma-lung-breast-cancer-brain-tumor-chemotherapy.com/leukemia/chronic-lymphocytic-leukemia-cll-cancer/http://leukemia-melanoma-lung-breast-cancer-brain-tumor-chemotherapy.com/leukemia/chronic-lymphocytic-leukemia-cll-cancer/http://leukemia-melanoma-lung-breast-cancer-brain-tumor-chemotherapy.com/leukemia/chronic-lymphocytic-leukemia-cll-cancer/http://leukemia-melanoma-lung-breast-cancer-brain-tumor-chemotherapy.com/leukemia/chronic-lymphocytic-leukemia-cll-cancer/http://www.dana-farber.org/images/pdq/CDR0000755927.jpghttp://www.dana-farber.org/images/pdq/CDR0000755927.jpg