clinpath endocrine table
DESCRIPTION
Clinpath lectureTRANSCRIPT
GROWTH HORMONEGH EXCESSGH DEFICIENT
SERUM GH
SERUM OGTT, no change or slight decreaseNo response
SERUM IGF 1
RADIOLOGYSellar enlargement: pituitary tumor: arrowhead tufting of the hand(-)
THYROID FUNCTION TESTTSHFT4
PRIMARY HYPOTHYROIDISM
PRIMARY HYPERTHYROIDISM
T3 THYROTOXICOSIS FT3
HYPERTHYROIDISMTSHT4OTHERS
GRAVES DSETS Ig
TOXIC MULTINODULAR GOITERRadioactive iodine uptake and thyroid scan
TOXIC ADENOMARadioactive iodine uptake and thyroid scan
SUBACUTE THYROIDITIS ESR Radioactive iodine uptake
CHRONIC THYROIDITISN ESR radioactive Iodine uptake
HYPOTHYROIDISMTSHT4T3RT3OTHERS
HASHIMOTOS THYROIDITIS-NORMALAnti-thyroid peroxidase, anti-thyroglobulin
ABLATIVE THYROIDITISFollowed by ablation therapy
INFANTILESeen in newborn and infants
EUTHYROID SICK SYNDROMEMODATELY ILL
SEVERELY ILL
NORMAL
NORMAL
Abnormal hormone production, transport and metabolism
PARATHYROID GLAND FUNCTIONTEST1 HYPERPARA2 HYPERPARAHYOPARAHYPERCALCEMIA OF MALIGNANCY
SERUM PTH/UNDETECTABLE- NORMAL
SERUM/ IONIZED CA- NORMAL
SERUM 1,25(OH)D,NORMAL,- NORMAL
SERUM PHOSPHORUS- NORMAL
ALDOSTERONE1 HYPERALDO2 HYPERALDO1 HYPOALDO2 HYPOALDO
K
NA/ NORMAL
ALDOSTERONE
PLASMA RENIN ACTIVITY/ NORMAL
HYPERSECRETION OF CORTISOLTESTPITIUTARY CUSHINGS DSE ADRENAL CUSHINGS SYNDECTOPIC ACTH CUSHINGS SYND
24 HR URINE FREE/SALIVARY CORTISOL
LOW DOSE DEXAMETHASONE SUPPRESSION TESTNO ACTH SUPPRESSION
PLASMA ACTH- NORMAL
IMAGING STUDYPitiutary tumorAdrenal tumorExtra-adrenal tumor
ADDISONS DSE1 ADRENAL INSUFFICIENCY2 ADRENAL INSUFFICIENCY
ACTH STIMULATION TESTNO CORTISOL STIMULATION
SERUM CORTISOL
PLASMA ACTH
SERUM ALDOSTERONENORMAL
CRH STIMULATIONNOT USEFUL ACTH AND CORTISOL
ADRENAL AUTOANTIBODY TEST(+)NOT USEFUL
MALE REPRODUCTIVE DISEASESFSHLHTESTOSTERONE
HYPOGONADOTROPIC HYPOGONADISM (decreased gonadal stimulation)
HYPERGONADOTROPIC HYPOGONADISM (defective organ, aging process, injury)
TESTICULAR FEMINIZATION (androgen insensitivity syndrome, very severe inhibition of androgen action)/ occ NORMAL
FEMALE REPRODUCTIVE DISEASEDISORDERCONSIDERATION WITH LAB EVALUATION
1 AMMENORRHEA (totally zero)Turners syndrome: pure gonadal dysgenesisKaryotype analysisCongenital adrenal hyperplasia: adrenal hormone and enzyme activity measurementHypothyroidism: thyroid hormoneHypopituitarism: pituitary hormone
2 AMMENORRHEA (amenorrhea for 6 mos then returns to normal)Pregnancy: HCG testProlactinoma: Serum prolactinPCOS: Serum hormone test, radiologyCushings syndrome: adrenal hormone assayAdult onset congenital adrenal hyperplasia: adrenal hormone enzyme activityHypothyroidism, hypopituitarism: thyroid and pituitary hormone
ADHSERUM NA & OSMOLARITYURINE NA & OSMOLARITYSERUM ADH
NEUROGENICNORMAL-
NEPHROGENICNORMAL-NORMAL-
PSYCHOGENNIC POLYDIPSIANORMAL-
SIADHNORMAL-