clinical science accepted manuscript
TRANSCRIPT
![Page 1: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/1.jpg)
ACCEPTED MANUSCRIPT
Copyright 2016 The Author(s). Use of open access articles is permitted based on the terms of the specific Creative Commons Licence under which the article is published. Archiving of non-open access articles is permitted in accordance with the Archiving Policy of Portland Press (http://www.portlandpresspublishing.com/content/open-access-policy#Archiving).
Cite as Clinical Science (2016) DOI: 10.1042/CS20160530
Clinical Science
![Page 2: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/2.jpg)
![Page 3: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/3.jpg)
![Page 4: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/4.jpg)
![Page 5: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/5.jpg)
in vivo
![Page 6: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/6.jpg)
![Page 7: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/7.jpg)
β,
![Page 8: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/8.jpg)
![Page 9: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/9.jpg)
P
![Page 10: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/10.jpg)
![Page 11: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/11.jpg)
ca
ca
![Page 12: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/12.jpg)
β
ca
![Page 13: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/13.jpg)
β
![Page 14: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/14.jpg)
de novo
![Page 15: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/15.jpg)
![Page 16: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/16.jpg)
et
al
![Page 17: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/17.jpg)
β
![Page 18: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/18.jpg)
β
![Page 19: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/19.jpg)
![Page 20: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/20.jpg)
β
![Page 21: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/21.jpg)
![Page 22: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/22.jpg)
![Page 23: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/23.jpg)
![Page 24: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/24.jpg)
![Page 25: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/25.jpg)
![Page 26: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/26.jpg)
![Page 27: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/27.jpg)
![Page 28: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/28.jpg)
![Page 29: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/29.jpg)
![Page 30: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/30.jpg)
![Page 31: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/31.jpg)
![Page 32: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/32.jpg)
![Page 33: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/33.jpg)
![Page 34: Clinical Science ACCEPTED MANUSCRIPT](https://reader030.vdocuments.us/reader030/viewer/2022012711/61ab13724e060735213d41e6/html5/thumbnails/34.jpg)