clinical observation on treatment of hyperinsulinemia and hyperandrogenism anovulatory patient with...

1
CJIM199713(1):2-5 5 sive deterioration of nephrons at the late stage of kidney damaage. After CRF patients with dysimmunity were treated by MP, the progress of disease was not significantly differ- ent from that in those patients with normal immune function, which illustrated that MP was markedly effective in modulating the dysimmunity of the patients. REFERENCES 1. ~, ~TjCJ3, ~{~L~. ~q~~l~l~'~XJJ~ ~~l~I~g~:~'~. :[~;~'q~ I~ep~;}:~ 1993;16(1) :51. 2. ~ ~, ~5. ~ ' ~ l ~ ~ J ~ ~1I=~. [~#b]~] ~. ~ffAr~j~9/'J~ 1990;17(1):16. 3. Oldirzzi L~ Rugiu C, Valva B, et al. Progression of renal failure in patients with renal diseases of diverse etiology on protein-restricted diet. Kidney Int 1985; 97:553. 4. Moorehead JF, Weeler DC, Fernaiado R. Injury to rat mesengial cell in culture by low density lipoproteins. Kidney Int 1989 ; 35 : 433. 5. Coritsidis G. The effects of oxidized lipoproteins on cultured mesengial cells (abstract). Kidney Int 1990 ;37: 502. 6. Sehollmeyer P, Bozkurt F. The immune status of the ure- mic patient; hemodialysis vs CAPD. Clin Nephrol 1988 ; 30 : 37. Clinical Observation on Treatment of Hyperinsulinemia and Hyperandrogenism Anovulatory Patient with Replenishing Kidney-Yin Drugs ZHOU Li-rong ( J ~ ) and YU jin (~" •) The Obstetrics and Gynecology Hospital, Shanghai Medical University, Shanghai (200011) Objective: In order to investigate the ef- fect of Chinese herbal medicine for replenishing Kidney-Yin in treating hyperinsulinemia and hyperandrogenism anovulatory syndrome. Methods: 35 patients were treated with re- plenishing Kidney-Yin drugs for 3 months, ba- sic body temperature, ultrasonic examination and blood levels of sex hormones were taken for monitoring the ovulation, and changes of serum insulin, blood sugar as well as oral glu- cose tolerence test were observed before and af- ter treatment. Results:Twenty in 24 patients who completed the regular treatment showed ovulation in the 43 menstrual cycles (59.72%). Seven of 17 (41. 2%)infertile cases became pregnant within 6 months. After 3 months of treatment, blood sugar and insulin level significantly decreased but the latter was still slightly higher than normal level. Serum testosterone level decreased significantly and reached normal. Conclusion : Replenishing Kidney-Yin Drugs could provide a good micro- circumstance for ovarian follicular growth, and resulted in ovulation and pregnancy. The mechnism is remained to be further explored. Original article on CJIM(Chin ) 1996; 16(9) : 515

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CJIM199713(1) :2-5 �9 5 �9

sive deterioration of nephrons at the late stage of kidney damaage. After CRF patients with dysimmunity were treated by MP, the progress of disease was not significantly differ- ent from that in those patients with normal immune function, which illustrated that MP was markedly effective in modulating the dysimmunity of the patients.

REFERENCES

1. ~ , ~TjCJ3, ~{~L~. ~ q ~ ~ l ~ l ~ ' ~ X J J ~ ~ ~ l ~ I ~ g ~ : ~ ' ~ . :[~;~'q~ I~ep~;}:~ 1993;16(1)

:51. 2. ~ ~, ~ 5 . ~ ' ~ l ~ ~ J ~

~1I=~. [~#b]~] ~. ~ffAr~j~9/'J~ 1990;17(1):16. 3. Oldirzzi L~ Rugiu C, Valva B, et al. Progression of renal

failure in patients with renal diseases of diverse etiology on protein-restricted diet. Kidney Int 1985; 97:553.

4. Moorehead JF, Weeler DC, Fernaiado R. Injury to rat mesengial cell in culture by low density lipoproteins. Kidney Int 1989 ; 35 : 433.

5. Coritsidis G. The effects of oxidized lipoproteins on cultured mesengial cells (abstract). Kidney Int 1990 ;37: 502.

6. Sehollmeyer P, Bozkurt F. The immu n e status of the ure-

mic patient; hemodialysis vs CAPD. Clin Nephrol 1988 ; 30 : 37.

Clinical Observation on Treatment of Hyperinsulinemia and Hyperandrogenism Anovulatory Patient

with Replenishing Kidney-Yin Drugs

ZHOU Li-rong ( J ~ ) and YU jin (~" •)

The Obstetrics and Gynecology Hospital, Shanghai Medical University, Shanghai (200011)

Objective: In order to investigate the ef- fect of Chinese herbal medicine for replenishing Kidney-Yin in treating hyperinsulinemia and hyperandrogenism anovulatory syndrome. Methods: 35 patients were treated with re- plenishing Kidney-Yin drugs for 3 months, ba- sic body temperature, ultrasonic examination and blood levels of sex hormones were taken for monitoring the ovulation, and changes of serum insulin, blood sugar as well as oral glu- cose tolerence test were observed before and af- ter treatment. Results:Twenty in 24 patients who completed the regular treatment showed

ovulation in the 43 menstrual cycles (59 .72%) . Seven of 17 (41. 2%)infert i le cases became pregnant within 6 months. After 3 months of treatment, blood sugar and insulin level significantly decreased but the latter was still slightly higher than normal level. Serum testosterone level decreased significantly and reached normal. Conclusion : Replenishing Kidney-Yin Drugs could provide a good micro- circumstance for ovarian follicular growth, and resulted in ovulation and pregnancy. The mechnism is remained to be further explored.

Original article on CJIM(Chin ) 1996; 16(9) : 515