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Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia

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Page 1: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Clinical Case Presentation

Hana Zoubeidi

Department of internal medicineRabta Hospital, Tunis, Tunisia

Page 2: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Mrs BH, 47 years old, was addressed from the ophtalmology department for

etiological investigation of a left anterior nodular scleritis.

The history taking:

Sicca syndrome with ocular and oral dryness

Inflammatory polyarthralgia of the metacarpophalangeal and the

proximal interphalangeal joints

Masses regarding proximal and distal interphalangeal joints of the indexes

and the right big toe

Dry cough

Nasal obstruction

Page 3: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Physical examination:

Afebrile

Urine Dipstick Analysis : No Hematuria, No Proteinuria

No palpated lymphadenopathy

Cardiopulmonary auscultation: Normal

Neurological examination: Normal

Dermatological Examination : No anomalies

Articular examination:

Painful active and passive mobilization of the proximal and the distal

interphalangeal joints of the two indexes and the two big toes.

Phalangeal nodules of the two indexes and the two big toes.

Ulcers and suppuration regarding the left index and the left big toe.

Page 4: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Figure 1: Ulcers of the left bigtoe

Figure 2: Ulcers and nodules of the indexes

Page 5: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Specialized ophthalmologic examination:

Left anterior nodular scleritis

Shirmer Test= Abnormal.

Lab Tests

Blood Count: Hb = 14.4 g / dl; lymphocytes: 870 elements / mm3

CRP = 10.7 mg / l ( <5 mg/L)

Creat = 8mg / L (9-13)

Serum electrophoresis: hypergammaglobulinaemia at a level of

18.32g /l (6-12 )

Blood and urinary calcium and phosphate: normal

Page 6: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

CHEST X RAY:

Bilateral interstitial

syndrome and

mediastinal widening

Chest computedtomography:

Granulomatous nodules inperilymphatic distribution

Mediastinal adenopathies

Parenchymal lungcongestion

Page 7: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Hand and feet X-rays:

Lytic bone lesions of the proximal and the second phalanx

giving a lacy appearance

Soft tissue swelling

Page 8: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

OTORHINOLARYNGOLOGICAL EXAMINATION AND ENDOSCOPIES:

Rhinitis

No masses

No tumors

HISTOLOGICAL STUDY:

Nasal biopsy: Granuloma without necrosis neither vasculitis.

Labial salivary gland biopsy exhibits: granulomatous

sialadenitis.

Bone biopsy: Granuloma without necrosis neither neoplastic

cells.

Page 9: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

To sum up:

Ocular

involvement

ORL

involvement

Oral dryness and labial granuloma

Osteolysis

Pulmonary

involvement

Biology:

Eye dryness and nodular scleritis

Nasal obstruction, epistaxis and nasal granuloma

Cough, dyspnea, interstitial syndrome and

mediastinal adenopathies

Lymphopenia,

Polyclonalhypergammaglobulinemia

Page 10: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Diagnosis ?

Page 11: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Infectious diseases

Tuberculousand non

tuberculousMycobacteria

Brucellosis Syphilis MycosisToxoplasmosis:

Intradermal tuberculin test: Negative

Quantiferon test: Negative

Chest X Ray and computed tomography: no

signs of tuberculosis

Negative serology Negative serology

No risk factors and no

immunodepression favoring

this type of infection

Negativeserology

Page 12: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Neoplasia

No impairment of the general condition

Normal blood count (no cytopenia, no

hyperleucocytosis)

Thoracoabdominopelviccomputed

tomography: No abnormalities, no masses.

Page 13: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Inflammatory diseases

Eosinophilic granulomatosis with polyangiitis(Churg-Strauss):

No history of asthma

No hypereosinophilia

No cutaneous signs of vasculitis ( Purpura, livedo…)

Histology: No eosinophilic infiltration neithervasculitis

Immunological tests: Antineutrophil cytoplasmicantibodies were negative

Granulomatosis with polyangiitis (Wegener'sgranulomatosis)

No radiologic signs

Antineutrophil cytoplasmic antibodies were negative

HISTIOCYTOSIS:

histological and immunophenotypic examination of lesional bone tissue:

Negative staining of the lesional cells with CD1a.

SARCOIDOSIS

Page 14: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

Clinical arguments:

No exposure to active pulmonary tuberculosis

The combination of intrathoracic and extra-thoracic

evocative locations such as nodular scleritis.

Radiological arguments:

Mediastinal adenopathies and interstitial

syndrome.

Biological and immunologicalarguments:

Tuberculin skin test anergy

Lymphopenia

Histological arguments:

Tuberculoid granuloma without necrosis in the

bone tissue, the labial tissue and the nasal

tissue

ARGUMENTS FOR SARCOIDOSIS

Page 15: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

We retained the diagnosis of sarcoidosis

She was treated with corticosteroids: 1mg/kg/day and Methotrexate:

15mg/week.

Corticotherapy was preceded of antibiotherapy

The evolution was favorable with:

Decrease swellings

Purulent flow disappearance

Disappearance of inflammatory signs

Wound healing but persistent strain

It is currently nine months of decline.

Page 16: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years
Page 17: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years

TAKE HOME MESSAGES:

Sarcoidosis bone involvement is rare and occurs in approximately 5% to 10%

of patients with sarcoidosis.

Phalanges of the hands and feet are the most common sites of involvement.

On radiographs, osseous sarcoid classically manifests as lacelike lytic bone

lesions in the phalanges of the hands or feet.

Sarcoid bone lesions are often multiple and lesions may have imaging features

that may be identical to osseous metastatic disease and biopsy may be

required for definitive differentiation.

The treatment of bone sarcoidosis is not coded and based on the

analgesics,steroidal and non-steroidal antiinflammatory and immunosuppressants if

necessary.

Page 18: Clinical Case Presentation Hana Zoubeidi Department of ... · Clinical Case Presentation Hana Zoubeidi Department of internal medicine Rabta Hospital, Tunis, Tunisia. Mrs BH, 47 years