Highlights of This Issue 2239

SPECIAL FEATURES

CCR Translations

2241 Vitamin D Status: Ready for Guiding ProstateCancer Diagnosis and Treatment?William B. GrantSee related article, p. 2289

CCR New Strategies

2244 New Strategies in Lung Cancer: EpigeneticTherapy for Non–Small Cell Lung CancerPatrickM. Forde, Julie R. Brahmer, and Ronan J. Kelly

Molecular Pathways

2249 Molecular Pathways: Resistance to KinaseInhibitors and Implications for TherapeuticStrategies

Christine M. Lovly and Alice T. Shaw

2257 Molecular Pathways: BRAF InducesBioenergetic Adaptation by AttenuatingOxidative PhosphorylationRizwan Haq, David E. Fisher, and Hans R. Widlund

Review

2264 Beyond Histology: Translating TumorGenotypes into Clinically Effective TargetedTherapiesCatherine B. Meador, Christine M. Micheel,Mia A. Levy, Christine M. Lovly, Leora Horn,Jeremy L. Warner, Douglas B. Johnson,Zhongming Zhao, Ingrid A. Anderson,Jeffrey A. Sosman, Cindy L. Vnencak-Jones,Kimberly B. Dahlman, and William Pao

HUMAN CANCER BIOLOGY

2276 Interleukin-32 Increases Human GastricCancer Cell Invasion Associated with TumorProgression and MetastasisChung-Ying Tsai, Chia-Siu Wang, Ming-Ming Tsai,Hsiang-Cheng Chi, Wan-Li Cheng, Yi-Hsin Tseng,Cheng-Yi Chen, Crystal D. Lin, Jun-I. Wu,Lu-Hai Wang, and Kwang-Huei Lin

2289 Vitamin D Deficiency Predicts Prostate BiopsyOutcomesAdam B. Murphy, Yaw Nyame, Iman K. Martin,William J. Catalona, Courtney M.P. Hollowell,Robert B. Nadler, JamesM. Kozlowski, Kent T. Perry,Andre Kajdacsy-Balla, and Rick KittlesSee related article, p. 2241

2300 Reverse-Phase Protein Array Profiling ofOropharyngeal Cancer and Significance ofPIK3CA Mutations in HPV-Associated Headand Neck CancerAndrew Sewell, Brandee Brown, Asel Biktasova,Gordon B. Mills, Yiling Lu, Darren R. Tyson,Natalia Issaeva, and Wendell G. Yarbrough

2312 Identification of miR-133b and RB1CC1 asIndependent Predictors for BiochemicalRecurrence and Potential Therapeutic Targetsfor Prostate CancerXia Li, Xuechao Wan, Hongbing Chen, Shu Yang,Yiyang Liu, Wenjuan Mo, Delong Meng,Wenting Du, Yan Huang, Hai Wu, Jingqiang Wang,Tao Li, and Yao Li

2326 PI3K Pathway Activation in High-Grade DuctalCarcinoma In Situ—Implications forProgression to Invasive Breast CarcinomaRita A. Sakr, Britta Weigelt, Sarat Chandarlapaty,Victor P. Andrade, Elena Guerini-Rocco, Dilip Giri,Charlotte K.Y. Ng, Catherine F. Cowell, Neal Rosen,Jorge S. Reis-Filho, and Tari A. King

2338 Prevalence and Clinical Implications ofEpstein–Barr Virus Infection in De NovoDiffuse Large B-Cell Lymphoma in WesternCountriesChi Young Ok, Ling Li, Zijun Y. Xu-Monette,Carlo Visco, Alexander Tzankov,Ganiraju C. Manyam, Santiago Montes-Moreno,Karen Dybaer, April Chiu, Attilio Orazi, Youli Zu,Govind Bhagat, Jiayu Chen, Kristy L. Richards,Eric D. Hsi, William W. L. Choi, J. Han van Krieken,Jooryung Huh, Weiyun Ai, Maurilio Ponzoni,Andr�es J.M. Ferreri, John P. Farnen,Michael B. Møller, Carlo E. Bueso-Ramos,Roberto N. Miranda, Jane N.Winter, Miguel A. Piris,L. Jeffrey Medeiros, and Ken H. Young

May 1, 2014 � Volume 20 � Number 9

Clinical Cancer Research

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CANCER THERAPY: PRECLINICAL

2350 Increased KIT Inhibition EnhancesTherapeutic Efficacy in GastrointestinalStromal TumorTeresa S. Kim, Michael J. Cavnar, Noah A. Cohen,Eric C. Sorenson, Jonathan B. Greer,Adrian M. Seifert, Megan H. Crawley,Benjamin L. Green, Rachel Popow,Nagavarakishore Pillarsetty, Darren R. Veach,Anson T. Ku, Ferdinand Rossi, Peter Besmer,Cristina R. Antonescu, Shan Zeng, andRonald P. DeMatteo

2363 Reversal of Acquired Drug Resistance in FLT3-Mutated Acute Myeloid Leukemia Cells viaDistinct Drug Combination StrategiesWeiguo Zhang, Chen Gao, Marina Konopleva,Ye Chen, Rodrigo O. Jacamo, Gautam Borthakur,Jorge E. Cortes, Farhad Ravandi,Abhijit Ramachandran, and Michael Andreeff

2375 Mesenchymal Stem Cells from HumanFat Engineered to Secrete BMP4 AreNononcogenic, Suppress Brain Cancer,and Prolong SurvivalQian Li, Olindi Wijesekera, Sussan J. Salas,Joanna Y. Wang, Mingxin Zhu, Colette Aprhys,Kaisorn L. Chaichana, David A. Chesler,Hao Zhang, Christopher L. Smith,Hugo Guerrero-Cazares, Andre Levchenko, andAlfredo Quinones-Hinojosa

2388 CD133þ Tumor Initiating Cells in a SyngenicMurine Model of Pancreatic Cancer Respondto MinnelideSulagna Banerjee, Alice Nomura, Veena Sangwan,Rohit Chugh, Vikas Dudeja, SelwynM. Vickers, andAshok Saluja

2400 Autophagy Is a Survival Mechanism of AcuteMyelogenous Leukemia Precursors duringDual mTORC2/mTORC1 TargetingJessica K. Altman, Amy Szilard, Dennis J. Goussetis,Antonella Sassano, Marco Colamonici,Elias Gounaris, Olga Frankfurt, Francis J. Giles,Elizabeth A. Eklund, Elspeth M. Beauchamp, andLeonidas C. Platanias

2410 BRaf and MEK Inhibitors DifferentiallyRegulate Cell Fate and Microenvironment inHuman Hepatocellular CarcinomaChristian Breunig, Bernadett J. Mueller,Ludmila Umansky, KristinWahl, Katrin Hoffmann,Frank Lehner, Michael P. Manns, Heike Bantel, andChristine S. Falk

CANCER THERAPY: CLINICAL

2424 CTLA4 Blockade Broadens the PeripheralT-Cell Receptor RepertoireLidia Robert, Jennifer Tsoi, Xiaoyan Wang,Ryan Emerson, Blanca Homet, Thinle Chodon,Stephen Mok, Rong Rong Huang,Alistair J. Cochran, Bego~na Comin-Anduix,Richard C. Koya, Thomas G. Graeber,Harlan Robins, and Antoni Ribas

2433 Phase I Dendritic Cell p53 Peptide Vaccinefor Head and Neck CancerPatrick J. Schuler, Malgorzata Harasymczuk,Carmen Visus, Albert DeLeo, Sumita Trivedi,Yu Lei, Athanassios Argiris, William Gooding,Lisa H. Butterfield, Theresa L. Whiteside, andRobert L. Ferris

2445 Phase I Safety, Pharmacokinetic, andPharmacodynamic Study of SAR245409(XL765), a Novel, Orally Administered PI3K/mTOR Inhibitor in Patients with AdvancedSolid TumorsKyriakos P. Papadopoulos, Josep Tabernero,BenMarkman, Amita Patnaik, AnthonyW. Tolcher,Jos�e Baselga, Weiliang Shi, Coumaran Egile,Rodrigo Ruiz-Soto, A. Douglas Laird, Dale Miles,and Patricia M. LoRusso

2457 Adoptive Transfer of MART-1 T-Cell ReceptorTransgenic Lymphocytes and Dendritic CellVaccination in Patients with MetastaticMelanomaThinle Chodon, Bego~na Comin-Anduix,Bartosz Chmielowski, Richard C. Koya,Zhongqi Wu, Martin Auerbach, Charles Ng,Earl Avramis, Elizabeth Seja, Arturo Villanueva,Tara A. McCannel, Akira Ishiyama,Johannes Czernin, Caius G. Radu, Xiaoyan Wang,David W. Gjertson, Alistair J. Cochran,Kenneth Cornetta, Deborah J.L. Wong,Paula Kaplan-Lefko, Omid Hamid,Wolfram Samlowski, Peter A. Cohen,Gregory A. Daniels, Bijay Mukherji, Lili Yang,Jerome A. Zack, Donald B. Kohn, James R. Heath,John A. Glaspy, Owen N. Witte, David Baltimore,James S. Economou, and Antoni Ribas

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PREDICTIVE BIOMARKERS ANDPERSONALIZED MEDICINE

2466 Replication of Genetic PolymorphismsReported to Be Associated with Taxane-Related Sensory Neuropathy in Patients withEarly Breast Cancer Treated with PaclitaxelJean E. Abraham, Qi Guo, Leila Dorling,Jonathan Tyrer, Susan Ingle, Richard Hardy,Anne-Laure Vallier, Louise Hiller, Russell Burns,Linda Jones, Sarah J. Bowden, Janet A. Dunn,Christopher J. Poole, Carlos Caldas,Paul P.D. Pharoah, and Helena M. Earl

2476 Integrated Next-Generation Sequencing andAvatar MouseModels for Personalized CancerTreatmentElena Garralda, Keren Paz, Pedro P. L�opez-Casas,Sian Jones, Amanda Katz, Lisa M. Kann,Fernando L�opez-Rios, Francesca Sarno,F�atima Al-Shahrour, David Vasquez,Elizabeth Bruckheimer, Samuel V. Angiuoli,Antonio Calles, Luis A. Diaz, Victor E. Velculescu,Alfonso Valencia, David Sidransky, andManuel Hidalgo

2485 Effect of Aromatase Inhibition on FunctionalGene Modules in Estrogen Receptor–PositiveBreast Cancer and Their Relationship withAntiproliferative ResponseQiong Gao, Neill Patani, Anita K. Dunbier,Zara Ghazoui, Marketa Zvelebil,Lesley-Ann Martin, and Mitch Dowsett

LETTERS TO THE EDITOR

2495 TGR Analysis in Phase I Clinical Trials—LetterRodrigo Dienstmann and Josep Tabernero

2497 TGR Analysis in Phase I Clinical Trials—ResponseCharles Fert�e, Serge Koscielny, andJean-Charles Soria

2498 Efficacy of Vemurafenib in a Trametinib-Resistant Stage IV Melanoma Patient—LetterMathias Bernhardt, Elias Orouji, Lionel Larribere,Christoffer Gebhardt, and Jochen Utikal

CORRECTIONS

2500 Correction: Genomic Estimates of AneuploidContent in Glioblastoma Multiforme andImproved Classification

2501 Correction: hERG1 Channels Regulate VEGF-A Secretion in Human Gastric Cancer:Clinicopathological Correlations andTherapeutical Implications

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ABOUT THE COVER

The cover shows a section of an orthotopic xenograft of a human primary glioblastoma.Immunohistochemical staining shows strong human nestin expression within the tumor bulk.For details, see the article by Li and colleagues on page 2375 of this issue.

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