classifications of thyroid tumours

7/29/2019 Classifications of Thyroid Tumours

1/15

CLASSIFICATION OF THYROID

TUMORS


2/15

THYROID TUMORS

BENIGN MALIGNANT

PRIMARY SECONDARY

IFFERNTIATED UNDIFFERENTIATED PARAFOLLICULAR LYMPHOID

FOLLICULAR

PAPILLARY

ANAPLASTIC MEDULLARY LYMPHOMA


3/15

THYROID TUMORS

BENIGN MALIGNANTFOLLICULAR ADENOMA

PRIMARY SECONDARY

DIFFERENTIATED METASTASIS

- FOLLICULAR

- PAPILLARY

UNDIFFERENTIATED

- ANAPLASTIC

PARAFOLLICULAR

- MEDULLARYLYMPHOID CELL

- LYMPHOMA


4/15

FOLLICULAR ADENOMA

- Presents as a solitary nodule

- Seen approx in 1% population

- It is characterised by 4 features

- Solitary nodule- Complete encapsulation

- Clearly distinct architecture

- Compression of the thyroid parenchyma


5/15

PAPILLARY CARCINOMA

- It is a most common type of thyroidcarcinoma

- Comprises of 70-80%

- Slow growing malignant tumor- It presents as a asymptomatic solidary nodule

- Involvement of regional lymph nodes

common.


6/15

PAPILLARY CARCINOMA


7/15

FOLLICULAR CARCINOMA

- It comprises of 10-12%- Common in females

- It can occur denovo or in a pre-existing multi

nodular goitre.- It presents either as a solitary nodule or

irregular firm & nodular thyroid enlargement.

- Blood borne metastasis is more common.


8/15

FOLLICULAR CARCINOMA


9/15

MEDULLARY CARCINOMA

- It is less frequent (5%)- It arises from the parafollicular cells

- There are 3 distinctive features

- Familial occurance

- Secretion of calcitonin

- Amyloid stroma

- Regional lymph node metastasis may occur.


10/15

MEDULLARY CARCINOMA


11/15

ANAPLASTIC CARCINOMA

- It comprises of


12/15

MALIGNANT LYMPHOMA

- It is NHL type.- Occurs in pre-existing Hashimotos

Thyroiditis.

- Chemotherapy is the main treatment.


13/15

PAPI LLARY FOLL ICULAR ANAPLASTIC MEDULLARY

AETIOLOGY Irradiation Endemic

goitre

Unknown Sporadic or

familiar

INCIDENCE 60% 17% 13% 6%

AGE 20-40yrs 30-50yrs >50yrs Middle age

DIAGNOSIS Thyroid

swelling with

lymph nodes

Swelling,meta

stasis

Swelling,local

invasion

Difficult to

diagnose

clinically


14/15

MICROSCOPY Orphan annie-

eyed

nuclei,psommo

ma bodies

Angio &

capsular

invasion

Poorly

differentiated

cells

Amyloid

stroma like

carcinoid

SPREAD Lymphatic blood Local

infiltration

Lymphatic,b

lood

INVESTIGATION

FNAC Frozensection

FNAC,biopsy FNAC,calcitonin

TREATMENT

OF PRIMARY

Near total

thyroidectomy

Near total

thyriodecto

my

Isthmusectom

y,external RT

Total

thyroidecto

my

TREATMENT

OF

METASTASIS

Functional

block

dissection

Radio-

iodine I131

or external

RT

Palliativa

external

radiotherapy

RBD


15/15

THANK YOU

classifications of thyroid tumours

Documents