Citow Review Pathology

Citow ReviewPathology8/2/13High levels of alpha-fetoprotein are associated withEndodermal sinus tumorsChoriocarcinomasGerminomasPineoblastomasTeratomasHigh levels of alpha-fetoprotein are associated withEndodermal sinus tumorsChoriocarcinomasGerminomasPineoblastomasTeratomasHigh levels of human chorionic gonadotropin are seen inChoriocarcinomaEmbyronal carcinomaEndodermal sinus tumorGerminomaTeratomaHigh levels of human chorionic gonadotropin are seen inChoriocarcinomaEmbyronal carcinomaEndodermal sinus tumorGerminomaTeratomaTumorAlpha FetoproteinBeta HCGPlacental Alk PhosGerminoma--+Embryonal Carcinoma+/-+/-+/-Yolk Sac (Endodermal sinus tumor)++/-+/-Choriocarcinoma+/-++/-Teratoma+/---Viral inclusions seen in herpes encephalitis areBasophilicCalled Cowdry B bodiesFound in neurons onlyIntranuclearOnly evident several weeks after infectionViral inclusions seen in herpes encephalitis areBasophilicCalled Cowdry B bodiesFound in neurons onlyIntranuclearOnly evident several weeks after infectionInclusion BodiesIntracytoplasmicIntranuclearNF tangles

Pick bodies

Lewy bodies

Negri bodies

Lafora bodies

Bunina bodiesCowdry ACowdry BMarinesco bodies(ALS)(myoclonic epilepsy)(rabies)(Parkinsons, Lewy body dis)(Picks disease)(Alzheimers)(CMV, Herpes, SSPE)(Polio)Cowdry A Inclusions

Each of the following is characteristic of Wilsons disease exceptAlzheimers type II astrocytesAtrophy & brownish discoloration of globus pallidus & putamenAutosomal dominantDecreased serum ceruloplasminDecreased serum copperEach of the following is characteristic of Wilsons disease exceptAlzheimers type II astrocytesAtrophy & brownish discoloration of globus pallidus & putamenAutosomal dominantDecreased serum ceruloplasminDecreased serum copper

Wilsons DiseaseMutation in ATP7B gene (ch. 13)ATPase transporter that incorporates copper into ceruloplasminLow ceruloplasmin, low copperAlzheimer type II astrocytesAbnormal LFTsMRI: hyperintense BG on T2Keiser Fleischer rings Renal tubular acidosisCardiomyopathy