chronic pain management
TRANSCRIPT
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Dr.P.NARASIMHA REDDY M.D D.AProfessor And H.O.D Dept.Of AnesthesiologyNarayana medical college hospitalNellore.
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Good Evening
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Pain is defined by international association for study of pain as “An unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage”.
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Pain is always a subjective experience Everyone learns the meaning of “pain” through
experiences usually related to injuries in early life As an unpleasant sensation it becomes an
emotional experience Pain is a significant stress physically, emotionally
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Somatic pain:caused by the activation of pain receptors in either the cutaneous (the body surface) or deeper tissues (musculoskeletal tissues).
Visceral pain: pain that is caused by activation of pain receptors from infiltration, compression, extension or stretching of the thoracic, abdominal or pelvic viscera (chest, stomach and pelvic areas).
Neuropathic pain: caused by injury to the nervous system either as a result of a tumor compressing nerves or the spinal cord, or cancer actually infiltrating into the nerves or spinal cord.
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Mild: ?? Moderate: ?? Severe: ??
Although descriptive, does not provide correct information, perhaps these should be used to modify acute and chronic pain indications to allow patients to understand, but how do you measure what is mild, moderate, severe: ultimately it is the bias of the agency, investigators, sponsors to suggest which is which.
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Acute pain: short-lasting and manifesting in objective ways that can be easily described and observed. It may be clinically associated with diaphoresis and tachycardia. It can last for several days, increasing in intensity over time (subacute pain), or it can occur intermittently (episodic or intermittent pain). Usually related to a discreet event for onset: post op, post truama, fracture, etc
Chronic pain: Long-term and typically defined if it lasts for > three months. It is more subjective and not as easily clinically characterized as acute pain and is more psychological. This kind of pain usually affects a person's life, changing personality, their ability to function, and their overall lifestyle.
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Chronic pain has a psycho-social component that must be dealt with before depression becomes a part of the clinical picture. Chronic pain should be recognized as a multi-factorial disease state requiring intervention at many levels.
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1. Normal or Nociceptive pain – includes acute,subacute & inflammatory pain.
2. Abnormal or pathophysiologic pain – Neuropathic and central pain.
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Nociceptors : are free nerve endings, innervated by A-delta and C nerve fibers, that respond to intense ,potentially damaging stimuli that exist throughout the body.
Found in skin in form of - High threshold mechanoreceptors- Polymodal receptors- Silent receptors.
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Chemical mediators:
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Local release of prostaglandins potentiate the action of bradykinin and acts as sensitiser to nociceptors.
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First order neurons:Nociceptive afferent fibers terminate in spinal dorsal horn on the same side as the dorsal root ganglion where primary sensory neural cells are located.
Rexed laminae:
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Second order neurons:1. Wide dynamic range neurons.(WDR)2. Nociceptive specific neurons. WDR neurons are located in laminae V
of dorsal horn.
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Occurs at Nociceptor, spinal cord or in supra spinal structures.
It can either facilitate or inhibit pain. At the spinal level modulation is via
“GATE CONTROL THEORY” by MELZACK & WALL.
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Described physiological mechanism by which psychological factors can affect the experience of pain.
Neural gate can open and close thereby modulating pain.
Gate is located in the spinal cord.
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Physical conditions Extent of injury Inappropriate activity level
Emotional conditions Anxiety or worry Tension Depression
Mental Conditions Focusing on pain Boredom
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Physical conditions Medications Counter stimulation (e.g., heat, message)
Emotional conditions Positive emotions Relaxation, Rest
Mental conditions Intense concentration or distraction Involvement and interest in life activities
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A-delta fibers – small, myelinated fibers that transmit sharp pain
C-fibers – small unmyelinated nerve fibers that transmit dull or aching pain.
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Hypothalamus, pons and somatosensory cortex : stimulation of these areas causes analgesia
Three endogenous systems involved in the inhibitory pathways for pain: (1) the opioid system, (2) the noradrenergic system, and (3) the serotonergic system
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Increased catabolic demands: poor wound healing, weakness, muscle breakdown.
Decreased limb movement: increased risk of DVT/PE Respiratory effects: shallow breathing, tachypnea,
cough suppression increasing risk of pneumonia and atelectasis.
Increased sodium and water retention (renal) Decreased gastrointestinal mobility.
Tachycardia and elevated blood pressure
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Negative emotions: anxiety, depression Sleep deprivation Existential suffering: may lead to
patients seeking active end of life.
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Decrease natural killer cell counts Effects on other lymphocytes not yet
defined.
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Chronic pain is pain that: continues a month or more
beyond the usual recovery period for an injury or illness or
goes on for months or years due to a chronic condition.
The pain may not be constant but disrupts daily life.
It also can interfere with sleep, keeping you awake a night.
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Loneliness
HostilitySocial Factors
Anxiety Depression
Psychological Factors
Pathological Process
Physical Factors
TIM
E
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Nociceptive,Neuropathic or both. Psychological mechanisms play a major
role. Attenuated neuroendocrine stress
response and have prominent sleep and affective disturbances.
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Neuropathic pain: Paroxysmal and lancinating,has a burning quality and is associated with hyperpathia.
Deafferentation pain: neuropathic pain associated with loss of sensory input into the CNS.
Sympathetically mediated pain:sympathetic system plays a major role.
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Psychologic factors – depression, anxiety, somatization Socioeconomic factors – cultural differences, urban poor, gender Spiritual factors – spiritual suffering, meaning of pain
Physical factors – VERY complex neuroanatomy creating the pain sensation, from pain receptors to afferent nerves to spinothalamic tract, to thalamus to cortex with modulators all along the way
Therefore best approach is multi-disciplinary
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Episodic pain syndromes: Headaches – migraine, tension, cluster… Ischemic episodes – claudication, angina, sickle
cell disease Visceral pain – biliary colic, irritable bowel, pre-
menstrual syndrome, renal colic Somatic pain - gout
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Chronic pain syndromes: Somatic – low back pain ,degenerative and inflammatory
arthitis, lumbosacral radiculopathy,Failed back surgery, vertebral compression fractures, bony metastases, Myofascial pain syndrome.
Visceral – abdominal cancers, chronic pancreatitis.
Neuropathic – CRPS,Post herpetic neuralgia,Trigeminal neuralgia,diabetic neuropathy, phantom limb pain, spinal stenosis/sciatica, spinal mets,
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Neuralgia – an extremely painful condition consisting of recurrent episodes of intense shooting or stabbing pain along the course of the nerve.
Causalgia – recurrent episodes of severe burning pain.
Phantom limb pain – feelings of pain in a limb that is no longer there and has no functioning nerves.
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MEDICAL EVALUATION: Location,onset. Quality,radiation. Response to previous treatments. h/o
past,personal,social,economic,psychological and emotional status.
Plain radiographs,CT,MRI, bone scans.
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PSYCHOLOGICAL EVALUATION:1. Clinical interview.2. A structured pain inventorya. Mc Gill pain questionnaire.b. Psychosocial pain inventory.c. Westhaven - Yale multidimensional
pain inventory.d. Pain profile.
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3. Psychometric testing:a. Minnesota multiphasic pain
inventory(MMPI)b. Symptom check list-90.c. Million behavioural pain inventory.d. The beck depression inventory.e. The spielberger state-trait anxiety
scale.
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Electromyography and Nerve conduction studies:
Useful for confirming diagnosis of entrapment syndromes,neural trauma and polyneuropathies,radicular syndromes.
Can distinguish b/n neurogenic and myogenic disorders.
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Reliable quantitation of pain severity helps determine therapeutic interventions and evaluate the efficacy of treatments.
PAIN SCALES:- Numerical rating scale.- Faces rating scale- Visual analog scale.- McGill pain questionnaire.
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VISUAL ANALOGUE SCALE
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McGill Pain questionnaire: It is a checklist of words describing
symptoms. Attempts to define the pain in 3 major
dimensions.1. Sensory – discriminative.2. Motivational – affective.3. Cognitive – evaluative.
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Contains 20 sets of words that are divided into 4 groups.
1. 10 sensory.2. 5 affective.3. 1 evaluative.4. 4 miscellaneous.
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Low back pain:
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Treatment: Bed rest widely recommended but
shown to impede recovery. Current consensus – maintenance of
activity and work status. If beyond 4-wks – refer to
multidisciplinary pain centre.
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General term for congenital and acquired disorders of spine.
Narrowing of the bony frame surrounding the neural structures .
Can affect central spinal canal or lateral intervertebral foramen.
Narrowing can be caused by spondylolisthesis,osteoarthritis of spine,degenerative disk disease.
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Also called as post laminectomy syndrome.
One of the most difficult groups of chronic pain patients.
Exhibits strong nociceptive and neuropathic characteristics.
Pain may be sharp and shooting ,burning,dydesthic.
Iatrogenic and due to development of fibrous scarring.
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Soft tissue disorder that creates pain in tender areas within muscle groups.
Diagnosis made on clinical trigger points . Trigger points are painful regions in a taut
band of muscle that produces referenced pain with application of pressure.
Painful area usually feels like a “rope”. Created by events like trauma or
prolonged tension from poor posture.
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Local prolonged ischemia may trigger the formation of subsequent fibrosis.
Therapeutic modalities – passive stretching,cold spray,compression massage,injection of 0.5% lidocaine at the trigger point,botulinum toxin injection.
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Common complaint.
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Neuropathic pain that involves upper and lower extremities.
Reflex sympathetic dystrophy and causalgia are replaced by CRPS I ,CRPS II.
CRPS type I: follows minor trauma. Preceeding events are
trauma,surgery,sprain,fracture,dislocation.
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3 phases.
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CRPS type II: also called as causalgia. Burning pain,follows high velocity
injuries to large nerves. Pain immediate in onset. Associated with
allodynia,hyperpathia,vasomotor and sudomotor dysfunction.
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Treatment: Sympathetic blocks. Physical therapy plays major role. Cure rate is high if Rx initiated within
1month of symptoms and appears to decrease with time.
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Intractable pain that develops as a sequel of acute herpes zoster infection.(AHZ)
Pain from AHZ resolves usually within 3-4 weeks and if pain lasts longer than 4-6wks PHN should be suspected.
In AHZ large myelinated fibers are destroyed whereas in PHN pain processing by small fibers is compromised.
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Typically presents with unilateral pain in dermatomal distribution.
Treatment: Sympathetic blockade during attack Antidepressants,anticonvulsants,opioid
s. TENS.
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TIC DOULOUREUX classically presents as a painful, unilateral affliction
of the face, characterized by brief electric-shock-like pain, limited to the distribution of one or more divisions of the trigeminal nerve.
Pain is commonly evoked by trivial stimuli, including washing, shaving, smoking, talking and brushing the teeth, but may also occur spontaneously. The pain is abrupt in onset and termination may remit for varying periods.
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Treatment: Carbamazepine. Invasive treatment- Glycerol
injection,Radiofrequency ablation of gasserian ganglion
Microsurgical decompression of trigeminal nerve.
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Improvements in nociception, not curing.
Decrease pain and suffering Increase daily activity. Instill hope
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1. PHARMACOLOGICAL.2. PHYSICAL MEASURES/NON
PHARMACOLOGICAL.3. PSYCHOLOGICAL MEASURES.4. INVASIVE TECHNIQUES.
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About half of hospitalized patients who have pain are under-medicated.
Children are at particular risk of poor pain control methods.
Medications are given as: PRN – “as needed” As a prescribed schedule
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NSAIDS, COX INHIBITORS. OPIOIDS ANTI DEPRESSANTS ANTI CONVULSANTS CORTICOSTEROIDS LOCAL ANAESTHETICS – systemic
administration.
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Traditional NSAIDs are effective in the treatment of mild to moderate pain, but their use is limited by potentially serious adverse effects
ketorolac : indicated only in the management of moderately severe acute pain that requires opioid level analgesics ; no more than 5 days
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COX-2 selective inhibitors [celecoxib (Celebrex), rofecoxib (Vioxx) and valdecoxib (Bextra)]
200-fold to 300-fold selectivity for inhibition of COX-2 over COX-1
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Codeine Fentanyl Hydrocodone Hydormorphone
MethadoneMorphineOxycodoneOxymorphone
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Individualize route, dosage, and schedule Administer analgesics regularly (not PRN) if
pain is present most of day Become familiar with dose / time course of
several strong opioids Give infants / children adequate opioid
dose Follow patients closely, particularly when
beginning or changing analgesic regimens
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When changing to a new opioid or different route Use equianalgesic dosing table to estimate new dose Modify estimate based on clinical situation
Recognize and treat side effects
Be aware of potential hazards of meperidine / mixed agonist-antagonists - particularly pentazocine
Do not use placebos to assess nature of pain
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Watch for development of: Tolerance - treat appropriately Physical dependence – prevent withdrawal
Do not label a patient psychologically dependent, “addicted”, if you mean physically dependent on / tolerant to opioids
Be alert to psychological side of patient .
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Constipation , no tolerance develops to constipation, use stimulants (Senokot, Bisocodyl, Pericolace)
Nausea/vomiting – tolerance can occur in 2-5 days. Sedation – tolerance can occur in 2-3 days. Clonic jerks – usually high doses, can change drug or
diazepam can help Respiratory suppression in toxic doses, never see it if
have pain or use the drugs the right way. Can produce Hyperalgesia in certain individuals.
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PHYSICAL DEPENDENCE: Tolerance (20-40%) – up-regulate opioid receptors to need higher
dose for sustained effect Withdrawal (20-40%) – after 2 wks, withdrawing drug leads to
adrenaline response (sweating, tachycardia, tachypnea, cramps, diarrhea, hypertension); avoid by decreasing drug 25% a day.
PSYCHOLOGIC DEPENDENCE: Addiction (0.1% in CA pain) – a need to get “high” where drug
controls your life, compulsive uncontrolled behavior to get the drug; lie, cheat, steal.
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PSEUDO-ADDICTION: Physical dependence confused with
psychologic dependence Pain-relief seeking, not drug-seeking When right dose used, patient functions
better in life, whereas opposite true with the true addict
To help diffentiate: one MD controls the drug under a specific contract with pt., one pharmacy, frequent visits, pill counts
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Definition Agents which enhance analgesic efficacy,
have independent analgesic activity for specific types of pain, and / or relieve concurrent symptoms which exacerbate pain
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Antidepressants Anticonvulsants Corticosteroids Neuroleptics Antihistamines
Analeptics Benzodiazepines Antispasmodics Muscle relaxants Systemic local
anesthetics
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Antidepressants are effective agents in the treatment of neuropathic pain.
Action due to blockade of presynaptic reuptake of serotonin,norepinephrine or both.
serious side effects , include anticholinergic effects including dry mouth, confusion, and urinary retention .
Ex. Amitryptiline,Clomipramine,Doxepine,Fluoxetine,Imipramine.
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Antiepileptic drugs have been used for many years in the treatment of neuropathic pain particularly trigeminal neuralgia and diabetic neuropathy.
Blocks voltage gated sodium channels and can suppress spontaneous neuronal discharges.
phenytoin, carbamazepine, and valproic acid The newer agents, gabapentin appears to be the
most effective and well tolerated
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Useful in patients with marked agitation or psychotic symptoms.
Fluphenazine,Haloperidol,Chlorpromazine and perphenazine are commonly used.
Action due to blockade of dopaminergic receptors.
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Glucocorticoids are extensively used in pain management for their anti inflammatory and possibly analgesic actions.
Can be given topically,orally,parenterally.
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Lidocaine Infusion More effective in neuropathic pain but can be
used for all pain syndromes. Starting dose 0.5mg-2 mg/kg per hr IV or SC. Some studies demonstrate long-lasting pain relief even after drug has been stopped. Need to decrease opioids when starting.
Lidocaine Patch (Lidoderm®) On 12hrs off 12 hours (but can leave on 24) Expensive (great indigent program however)
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Alpha adrenergic agonist. Action – activation of descending
inhibitory pathways. Can be given
epidurally,intrathecally,parenterally.
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N-methyl-D-aspartate receptor antagonist (NMDA)
Used as an anesthetic for years Case reports show effectiveness when
traditional and invasive techniques fail Starting IV dose 150mg qd (0.1-0.2mg/kg)
with reduction of opioid achieved or 10-15 mg q6 increasing by 10 mg dose each day
Appears to have a synergistic effect with opioids
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Pamidronate (Aredia) Zoledronic acid (Zometa) Strontium-89 (Metastron) Calcitonin (Calcimar) Not in cancer ? arthritis Capsaicin (Zostrix) scheduled in neuropathic
pain Cannabinoid (Marinol)
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Pain
Step 1Nonopioid Adjuvant
Pain persisting or increasing
Step 2Opioid for mild to moderate pain
Nonopioid Adjuvant
Pain persisting or increasing
Pain persisting or increasing
Step 3Opioid for moderate to severe pain
Nonopioid Adjuvant
Invasive treatments
Opioid Delivery
Quality of Life
Proposed 4th Step
The WHOLadder
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Exercises :Graded exercise program prevents joint stiffness,muscle atrophy and contractures.
Superficial heating modalities:- Conductive – hot packs,paraffin
baths,fluido therapy.- Convective- Radiant.
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ULTRASOUND: for deep pain.
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ACCUPUNCTURE: Useful adjunct for patients with chronic
musculoskeletal disorders and headaches.
Technique – insertion of needles in discrete anatomically defined points called “MERIDIANS”.
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Used widely in chronic pain All available trials used TENS as an
adjuvant to medication, and it’s possible the effects of TENS was masked by the analgesic effect of medication
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Ice packs Chiropractic/osteopathic
manipulations Massage Yoga Topical agents (Ben
Gay/Icy Hot – with menthol, salcylates, Capcaicin)
Local injections (steroids, lidocaine)
Glucosamine shown to help with osteoarthritis
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Herbals/supplements – glucosamine shown to be useful in osteoarthritis, certain herbs like chamomile useful for colicky pain
Homeopathies/flower essences – for relaxation, visceral pain Healing touch/Reiki – using energy techniques, useful with
emotional components Neuro Emotional Technique – A chiropractic technique also useful
with emotional components Mind – focusing therapies:
• Meditation, yoga, guided-imagery, hypnosis, biofeedback• Art/music/humor therapy, pet therapy• By distraction, found to lower HR/RR and decrease pain up to 10-20%
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Integral part of multidisciplinary approach to pain management.
1. Self management techniques – cognitive methods,relaxation,biofeedback.
2. Operant techniques.3. Group therapy.
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Cognitive methods: Based on assumptions that a patients
attitude towards pain can influence the perception of pain.
Maladaptive attitudes contribute to suffering and disability.
Patient is taught skills for coping with pain either individually or in group therapy.
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Biofeedback – provides biophysiological feedback to patient about some bodily process the patient is unaware of (e.g., forehead muscle tension).
Relaxation – systematic relaxation of the large muscle groups.
Hypnosis – relaxation + suggestion + distraction + altering the meaning of pain.
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OPERANT / BEHAVIOUR THERAPY: Based on premise that behaviour in
patients with chronic pain is determined by consequences of behaviour.
Positive reinforcers aggravate the pain,negative reinforcers reduce pain behaviour.
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Intractable pain* Intractable side effects*
*Symptoms that persists despite carefully individualized patient management
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SELECTION OF BLOCK: Depends on - Location of pain- Its presumed mechanism- Skills of treating physician. L.A ‘s can be applied locally,at peripheral
nerve,somatic plexus,sympathetic ganglia or nerve root, centrally in neuraxis.
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Somatic nerve blocks:- Trigeminal nerve blocks- Cervical,thoracic,lumbar paravertebral
blocks- Facet blocks- Trans sacral nerve blocks etc.
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Sympathetic blocks:- Stellate ganlion block- Celiac plexus block- Thoracic,lumbar sympathetic chain
block etc.
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CELIAC PLEXUS BLOCK
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EPIDURAL INJECTIONS:- Lumbar interlaminar epidural injections- Fluoroscopic injections- Transforaminal injections- Radiofrequency rhizotomy
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SPINAL INJECTIONS: Therapeutic effects of spinal injections
are a combination of primary physiologic changes that result from the procedure and the secondary results arising from the enhanced pain control that allow other treatments.
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Also called dorsal coloumn stimulation. Produces analgesia by directly
stimulating large A beta fibers in dorsal coloumns of the spinal cord.
Mechanism – activation of descending modulating systems and inhibition of sympathetic outflow.
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Indications:- Sympathetically mediated pain- Spinal cord lesions- Phantom limb pain- Failed back surgery syndrome. Technique: electrodes placed epidurally
and connected to an external generator. Complications: infection,lead
migration,lead breakage.
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Deep brain stimulation may be used for intractable cancer pain and rarely for intractable neuropathic pain of nonmalignant origin.
- Electrodes are implanted stereotactically into periaqueductal and periventricular gray areas for nociceptive pain.
- Complications: intracranial hemorrhage and infection.
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Pain is unnecessary. Effective tools are available to help doctors evaluate pain in
their patients. Unrelieved pain should be treated just like any other vital sign: with aggressive measures.
Effective therapies are available to treat pain. Use guidelines to develop a rational plan to relieve pain.
Side effects are manageable. Anticipate side effects and treat aggressively.
Addiction rarely occurs. Trust your patient when they report pain. Tolerance and physical dependence can occur.
Plan and you will succeed. Take the initiative and focus on relieving pain at your hospital. Your patients depend on it.
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John C.Rowlingson – Chronic Pain.Miller’s Anaesthesia.
Raj PP:Practical Management Of Pain . Wall PD,Melzack OC:Text book of pain. ISA Journal On pain. Gowri devi M;Chronic pain Management-
Psychological aspectsin current conceptsin pain management.CMEabstract 1998.
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