Chronic Effects of Neurotrauma Consortium

• In response to President Obama’s call for a National Research Action Plan (NRAP) in 2013, the Departments of Defense and Veterans Affairs funded a nationwide research consortium to study the short- and long-term effects of concussions sustained during deployment on service members and Veterans.

• 30+ Universities, 12 VA’s, 3 DoD sites and 3 Institutes

• Five-year, $62.2 million award begun in October 2013.

• CENC also partners with NIH, NINDS, NCAA and NFL research groups to jointly study civilian, sports and combat concussions.

CENC.RTI.ORG

http://cenc.rti.org/

CENC Cores & Studies Timeline

Sept. 2014Sept. 2013 Sept. 2015 Sept. 2016 Sept. 2017 Sept. 2018

CENC PRP RFAs

Coordinating Center

Neuroimaging

Neuropathology

Biorepository

Data Management & Statistics

Longitudinal Cohort Study

ApprovalInitiation of ActivitiesFirst Human SubjectProjected InitiationProjected Completion

Tau Conformation

ADAPT

DTI Standardization

Vestibular Systems & Cognitive Adaptation

Otolith Dysfunction

Epidemiology

Novel White Matter Imaging Diagnosis

Visual Sensory Impairments and mTBI

Neurobiology of Veterans Exposed to Blast

Correlates of Neurodegeneration

Current Budget and Study Break Down

Structurally Study23%

White Matter (Jak)2%

Future Studies38.51%

VA Budget

Epidemiology Study4.4%

Tau Conformation 6.3%

Consortium Manage-

ment15.5%

Longitudinal Cohort Study14.5%

Tau Con-formation

Study9.8%

Epidemi-ology Study5.6%

ADAPT (MacDonald)2.7%

Biostatistics Core0.9%

Data Management Core

16.1%

Bioreposi-tory Core

6.6%

Vestibular (Klier)1.5%

Future Stud-ies

13.7%

DOD Budget

Structural & Functional (Taber)

6.1%Vestibular (Klier)

1.1%

DTI Standardization3.5%

Otolith Dysfunction

(Akin) 2.6%

NeuropathologyCore4.5%

Neuroimaging Core

8.6%

CENC: DoD and VA Budget Breakdown ($62.1M)

0

2

4

6

8

10

12

14

VA Funds DoD Funds

$M