cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with...

4
Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors by M. John Chapman, Wilfried Le Goff, Maryse Guerin, and Anatol Kontush EHJ Volume 31(2):149-164 January 14, 2010 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected]

Upload: clare-walters

Post on 05-Jan-2016

213 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin,

and cholesteryl ester transfer protein inhibitors

by M. John Chapman, Wilfried Le Goff, Maryse Guerin, and Anatol Kontush

EHJVolume 31(2):149-164

January 14, 2010

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected]

Page 2: Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer

Pathways of reverse cholesterol transport in man.

M. John Chapman et al. Eur Heart J 2010;31:149-164

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected]

Page 3: Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer

Comparison of pathways of cholesteryl ester transfer protein-mediated heterotransfer of neutral core lipids between lipoprotein particles in normotriglyceridaemia vs. mixed dyslipidaemia involving moderate to marked hypertriglyceridaemia and subnormal levels of triglyceride-

enriched high-density lipoprotein.

M. John Chapman et al. Eur Heart J 2010;31:149-164

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected]

Page 4: Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer

Cardiovascular risk remains high despite aggressive statin therapy.

M. John Chapman et al. Eur Heart J 2010;31:149-164

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: [email protected]