cholestatic jaundice
TRANSCRIPT
![Page 1: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/1.jpg)
Prepared by 32-Ahmed Samir
36-Ahmed Khattab 49-Ahmed Abdel-Wane
60-Ahmed Shahen66-Ahmed Atwa
![Page 2: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/2.jpg)
![Page 3: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/3.jpg)
Cholestasis
Extrahepatic (obstructive)
Intrahepatic (hepatocellular)
![Page 4: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/4.jpg)
Extrahepatic (obstructive)
Lumen
Wall
Outside
![Page 5: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/5.jpg)
Intrahepatic (hepatocellular)
hereditary
acquired
![Page 6: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/6.jpg)
Causes :-lumen ....
![Page 7: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/7.jpg)
Wall ….
![Page 8: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/8.jpg)
![Page 9: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/9.jpg)
A) Hereditary Dublin –Johnson syndrome Rotor’s syndrome Progressive familial intrahepatic
cholestasis syndromes
![Page 10: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/10.jpg)
Autosomal recessive reduced ability to transport organic anions ….. liver biopsy dark pigment prognosis excellent
![Page 11: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/11.jpg)
same as Dubin-Johnson syndrome except
*it’s autosomal dominant *there is no hepatic
pigmentation
![Page 12: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/12.jpg)
heterogeneous group of conditions …. autosomal recessive the only cure Liver transplantation
![Page 13: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/13.jpg)
B) Acquired Acute hepatitis Liver cirrhosis Drugs
-unconjugated hyperbilirubinemia-conjugated hyperbilirubinemia
Benign recurrent intrahepatic cholestasis
![Page 14: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/14.jpg)
.Dark Urine
Pale Stool
Other symptoms
Pruritis
Yellowed Skin
Clinical Manifes-tations
![Page 15: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/15.jpg)
![Page 16: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/16.jpg)
![Page 17: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/17.jpg)
![Page 18: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/18.jpg)
![Page 19: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/19.jpg)
Nausea vomiting Fever Pain in the abdomen Loss of appetite Fatigue Confusion Headache
![Page 20: Cholestatic jaundice](https://reader038.vdocuments.us/reader038/viewer/2022102520/556db891d8b42aed2e8b48b8/html5/thumbnails/20.jpg)