CHILDREN’S DIABETES FOUNDATION AT DENVER — WINTER 2004

16TH CAROUSEL OF HOPEPRESENTED BYMERCEDES-BENZ A “10”

he Carousel of Hope outdid itself once again by raising over $5 million on October 23rd at TheBeverly Hilton, in Beverly Hills,

California, when over 100 A-List stars joinedmusic Superstars Beyoncé, Faith Hill andJosh Groban who headlined theentertainment and acclaimed piano virtuosoWilliam Joseph who thrilled the guests withhis unique gift. Once again Jay Leno, theevening’s Master of Ceremonies, had the

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16TH CAROUSEL OF HOPEPRESENTED BYMERCEDES-BENZ A “10”

he Carousel of Hope outdid itself once again by raising over $5 million on October 23rd at TheBeverly Hilton, in Beverly Hills,

California, when over 100 A-List starsjoined music Superstars Beyoncé, Faith Hilland Josh Groban who headlined theentertainment and acclaimed piano virtuosoWilliam Joseph who thrilled the guests withhis unique gift. Once again Jay Leno, theevening’s Master of Ceremonies, had the

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1. Robert Graham, Anjelica Huston and Rebecca De Mornay

2. Blair and Désireé Underwood3. Jamie-Lynn DiScala & Amanda Bynes4. Faith Hill�

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1. LaTanya Richardson, Barbara Davis and Samuel L. Jackson

2. Annette Bening & Warren Beatty3. Alan Hamel & Suzanne Somers4. Courtney Peldon & Jason Davis5. Linda & David Foster6. Vivica A. Fox & Montel Williams7. Rob Lowe & Kenny G

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audience in stitches with hispolitical satire. Sir SidneyPoitier, longtime friend andsupporter of the Children’sDiabetes Foundation, introducedChairman Barbara Davis whospoke about the importance ofhelping children who suffer withdiabetes. Following Mrs. Davis’remarks, nine-year old TylerSmith joined her onstage to givethe evening’s invocation.

The evening also included atribute to the late Marvin Davis,introduced by Academy Award-winner and Davis family friendSir Michael Caine, whichincluded a montage of familyphotographs and lovingmemories of their father by thefive Davis children.

The highlight of this spectacularevent was Oprah Winfreypresenting Halle Berry, adiabetic herself, with the BrassRing Award. The Children’sDiabetes Foundation was proudto recognize Halle for herextraordinary contributions tothe cause of curing childhooddiabetes. We honor her as awoman of great courage,strength, talent and beauty. Herdetermination to fulfill herdreams despite having diabetesis an inspiration to all afflictedwith the disease. We thank herfor giving hope to children withdiabetes that one day they willgrasp their brass ring: the cure.The Brass Ring Award has beengiven only four times in the pastto: Sir Sidney Poitier, SenatorHillary Rodham Clinton, StevieWonder and Whitney Houston.Ms. Berry expressed herheartfelt appreciation for theaward and told the audiencehow she now feels as thoughhaving diabetes in her life is agift, a gift that has given her strength, taught her compassionand given her grace, every dayof her life.

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The evening’s program includedstellar musical performancesproduced by veteran televisionimpresario George Schlatterwith the help of our multipleGrammy-winner Music Director,David Foster. The MusicChairmen were recordingindustry legends Quincy Jonesand Clive Davis.

Major sponsors of this year’sevent were Mercedes-Benz USA,Toys “R” Us, Children’s FundInc., American Airlines, VanCleef & Arpels, GUESS?, Inc.,Reebok International Ltd.,Sotheby’s, The Beverly Hilton,Entertainment IndustryFoundation and Pfizer, whogenerously sponsored this year’sPfizer Carousel of HopeDiabetes Symposium.

Among the countless VIPs whojoined forces to help conquerdiabetes were Muhammad Ali,Tom Arnold, Patricia Arquette,Mischa Barton, Lance Bass,Warren Beatty & AnnetteBening, Lara Flynn Boyle, ChiefWilliam Bratton, Red Buttons,Amanda Bynes, James Caan, SirMichael Caine & Lady ShakiraCaine, Erika Christensen,Natalie Cole, Jackie Collins,Joan Collins, Tony Danza, GeenaDavis, Kristin Davis, Rebecca DeMornay, Neil Diamond, Jamie-Lynn DiScala, Haylie Duff,Carmen Electra, Rick Fox, VivicaA. Fox, Brendan Fraser, KennyG, Cuba Gooding, Jr., RobertGraham & Anjelica Huston,Harry Hamlin & Lisa Rinna,Marilu Henner, Dennis Hopper,Samuel L. Jackson, MelinaKanakaredes, Bai Ling, JaneKrakowski, Tara Lipinski, EvaLongoria, Rob Lowe, EdMcMahon, Dennis Miller, DonnaMills, Brittany Murphy, GaryOwens, Joe Pantoliano,Courtney Peldon, SuzannePleshette & Tom Poston, SirSidney Poitier & Lady JoannaPoitier, Holly Robinson Peete,

Keri Lynn Pratt, Mimi Rogers,Ray Romano, Jane Seymour,Nicollette Sheridan, HenrySimmons, Suzanne Somers,Randy Spelling, Tori Spelling,Rod Stewart & Penny Lancaster,Alan Thicke, Cheryl Tiegs,Michelle Trachtenberg, BlairUnderwood, Joan Van Ark, SelaWard, Forest Whitaker, VannaWhite, Montel Williams and RitaWilson.

Some 20,000 pink rosesspecially grown for The Carouselof Hope and flown in fromEcuador graced the mainballroom, where lavish goldcarousel centerpieces donatedby Fred Gibbons and Treefrogsdecorated each table covered inpink rose silk cloths custommade for the event by ultra-hipdesigner Roberto Cavalli. As aspecial gift, each guest wasinvited to take home theirnapkins which doubled as one-of-a-kind Roberto Cavalli scarves.During dinner, guests whothought they would have onlyone chance to bid on a fabulousall-new 2005 Mercedes-BenzSLK350 were surprised to hearthat Mercedes-Benz had verygenerously donated two of thesleek roadsters for the LiveAuction. The proud winners,Rod Stewart and Ivana Trump,could not have been moreexcited!

This year’s Silent Auction wasonce again chaired by Dana andNancy Davis and raised over$800,000. The Auction areawas a vision in yards and yardsof pink and white drapedchiffon. Over 650 items werefeatured, including donationsfrom Mercedes-Benz USA,American Airlines, Van Cleef &Arpels, Shaquille O’Neal, RickFox, Saks Fifth Avenue, NeimanMarcus, Tiffany & Co., GiorgioArmani, Gucci, Louis Vuitton,Ermenegildo Zegna, Luca Luca,Vera Wang, Oscar de la Renta,

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Hermés, Prada, Graff Diamonds,Cartier, Chanel, Brioni, Dolce &Gabbana, Escada, Polo/RalphLauren, Salvatore Ferragamo,Stella McCartney, Valentino,Yves Saint Laurent, Brioni, Mr.Chow, The Grill, The Ivy, SpagoBeverly Hills, Ducati NorthAmerica, Ritmo Mvndo, GEARYS,Bvlgari, Chopard, Christian Dior,Peace and Love Jewelry byNancy Davis, Kathrine Baumann,Los Angeles Lakers, LosAngeles Dodgers, NetJets,Northwest Airlines, Inc., BacaraResort & Spa, The CanyonRanch, Four Seasons, MGMMIRAGE, Hotel Bel-Air, The Ritz-Carlton, Segway, “AmericanIdol,” Karl Malone, Billy Crystal,Tony Danza, PlayboyEnterprises, Steven Cojocaru,Cindy Crawford, Tom Cruise,Dominick Dunne, Sir Elton John,Michael Jordan, B.B. King, DonRickles, Britney Spears, Mary-Kate & Ashley Olsen, SerenaWilliams and Sting.

Once again, the “CelebrityPlates” section drew attentionwith 50 hand-painted creationsdecorated by such celebrities asAlicia Keys, Bette Midler, Dr.Phil McGraw, George Clooney,Naomi Watts, Neil Diamond,Mandy Moore, Oprah Winfrey,Reese Witherspoon, RobinWilliams, Rod Stewart, SamuelL. Jackson, Queer Eye for theStraight Guy’s Ted Allen & ThomFilicia, Billy Bob Thornton,Heather Locklear and AnjelicaHuston. Color Me Mine donatedplates, brushes and paints forthis amazing project.

The Silent Auction also featuredover 75 pieces of art by suchworld-renowned artists andphotographers as CharlesArnoldi, John Baldessari, HarryBenson, Howard Bingham, RossBleckner, Fernando Botero,Louise Bourgeois, Andre deDienes, Patrick Demarchelier,Laddie John Dill, Amanda

Dunbar, Arthur Elgort, NancyEllison, Francesca Gabbiani,Robert Graham, Milton H.Greene, Jenny Holzer, MichaelKalish, Greg Lauren, AnnieLeibovitz, Roy Lichtenstein,Agnes Martin, Richard Meier,Christopher Makos, StevenMeisel, Ed Moses, AlexandraNechita, LeRoy Neiman, HelmutNewton, Nigel Parry, PiotrPowietrzynski, Ken Price,Robert Rauschenberg, EdRuscha, Kenny Scharf, AliceSprings, Donald Sultan, BruceWeber, William Wegman,Timothy White, Steve Wrubel,Russell Young and celebrityartists Tony Bennett, JeffBridges, Richard Gere, BrendanFraser, Dennis Hopper, DianeKeaton, John Mellencamp, ViggoMortenson, Jane Seymour andRingo Starr. In the week beforethe event, Sotheby’s hosted athree-day preview of selectedpieces at its gallery in BeverlyHills.

The evening was topped off bytwo fabulous gift bags for eachguest which contained itemsdonated by absolution workoutcomplex, Activision, Inc., BestBuy, Hollywood Movie Museum/Frans Billen, Christopher Radko,Jackie Collins, Dittie, NancyEllison, Equinox Fitness, Evian®Natural Spring Water, FerndaleConfectionery, Frederick’s ofHollywood, Grey Goose Vodka,GUESS?, Inc., Helen of Troy,

J Records, Los Angeles Lakers,MAC, Mag Instrument, Inc.,Mattel, Inc., Mercedes-BenzUSA, NetJets, O, The OprahMagazine, Reebok InternationalLtd., Ronna Schary Photography,ROOTS, Larry Thompson, Toys“R” Us Children’s Fund, Inc., TheWalt Disney Company andWarner Bros. Records.

A special VIP bag for thefeatured performers wascompiled by Julie Kenney ofJewels and Pinstripes andcontained items donated byHartmann, Mulholland, MarquisLos Cabos presented by Spa-quest.com, MEYERS SwissWatch, Tempur-pedic, T-mobile,Shari’s Berries, Dyson, CalistogaRanch, Corley FamilyWinery/Monticello Vineyards,Ho’oilo House, Frederick’s of

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suffer from diabetes in their lifetime. We owe it tothese children to teach them how to take care ofthemselves — how to balance their lives by testingtheir blood sugar four times a day, by exercising, bymaking sure they get proper nutrition, by taking theright amounts of insulin.”

— Barbara Davis, Chairman

“Dear God — Pleasebless us with thepeople and thetechnology to find acure for this terribledisease. Please helpus to stand stronguntil it happens. Iknow I will try.”

— Tyler Smith, Invocation child

Hollywood, Ike Behar, JackieChristie, Kookoon, Gerard Yoscafor Jennifer Kaufman, LondonSole, Altec Lansing, Nautilus,Procyte, RedEnvelope, RedHaute Couture handbag byBeverly Z, Rexford Holly,Electronic Arts, All-Clad, TeNoand Starbucks.

The Children’s DiabetesFoundation would like to thankall who made The Carousel ofHope a huge success including:A Video Affair, A.B. HirschfeldPress, Aardvark Clay & Supplies, Alta Dena Certified Dairy,

At Your Service, Bacardi U.S.A.,Berliner Studio, Canon U.S.A.,Color Me Mine, DeWitt SternGroup, The Elite Group Ltd.,Evian® Natural Spring Water,George Schlatter Productions,Good Fortunes, Grey GooseVodka, Index Stock Imagery,IZZE Beverage Company, JerrySolomon Picture Framing, MindyWeiss Party Consultants, ThePaper Bag Princess, PMK/HBH,Privilege Magazine, RutherfordRanch Vineyards, Solters &Digney Public Relations, TheStock Broker, Tilman & PaigeFertitta and Landry’sRestaurants, Inc., Fred Gibbonsand Treefrogs and Yahoo!.

Funds raised benefit theprograms of research andclinical care at the BDC whereover 5,000 children and youngadults receive the finestdiabetes care available in theworld. A portion of proceeds isalso given to the Los Angeleschapters of the AmericanDiabetes Association andJuvenile Diabetes ResearchFoundation International. Sinceits inception in 1978, theChildren’s Diabetes Foundationhas raised $70 million to helpchildren afflicted with diabetes.

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“I’m not sure if everyone knows thatHalle has diabetes. Like everythingin Halle’s life, she accepts it withgrace. She has never let it hinderher in any way.”

— Oprah Winfrey

“…my involvementwith this charity is soimportant because notonly do I suffer, but Ireally understand thelives of each andevery person whostruggles with thisdisease...every childwho wakes up andsays, ‘gosh, I hopeone day I’ll be able tolive a normal life likeeverybody else’.”

— Halle Berry, Brass Ring Award Honoree

“We are all sad thatMarvin cannot be herethis evening, but oursadness is overcomeby the joy we recall ofbeing with him on somany wonderfulevenings in so manywonderful places,shared with so manywonderful friends.”

— Sir Michael Caine

CHILDREN’SDIABETESFOUNDATIONAND BARBARADAVIS CENTERMOURN THELOSS OFFOUNDER,MARVIN DAVIS

arvin Davis, the former owner of 20th Century Fox, the Pebble Beach Company, the

Aspen Ski Company and theBeverly Hills Hotel, who wasknown in the oil and gasindustry as “Mr. Wildcatter,” diedpeacefully Saturday, September

25th in the presence of hisfamily. He was 79 years old.

Mr. Davis was a self-madeentrepreneur who earnedseveral fortunes — first as anoil and gas wildcatter and thenthrough savvy investments inindustries ranging fromentertainment to resorts to realestate. He was also a majorphilanthropist, who, along withhis wife Barbara, had beenactive for decades in raisingfunds for a variety of worthycauses, including the Children’sDiabetes Foundation and theBarbara Davis Center forChildhood Diabetes, whichcurrently cares for more than5,000 children from all over theworld and has made it possiblefor countless mothers withdiabetes to deliver healthy

babies (the Center is the largestfacility of its kind devoted tocare and research in pediatricdiabetes); the Cedars-SinaiMedical Center in Los Angeles;and the Nancy Davis Foundationfor Multiple Sclerosis.

In Denver, the Davis’ regularlyhosted what they called theCarousel Ball in support of thediabetes facility and it becameat the time the largest single-event fundraiser in the country.After relocating to Beverly Hills,the Davis’ hosted a glitteringbiennial fundraiser known asThe Carousel of Hope, whichattracted the entertainmentindustry’s top stars as well asthe business community’sprincipal leaders and became atop event on the city’s socialcalendar.

A disciplined dealmaker withimpeccable market timing, hedemonstrated an uncanny abilityto recognize both the top andbottom of market cycles and hewas credited with being able toidentify economic trends longbefore they became generallyapparent.

Until the end, Mr. Davisremained a major figure in boththe business and social sceneswho enjoyed a well-deservedreputation as a lively storyteller.

Marvin Davis was born onAugust 31, 1925, in Newark,New Jersey. After growing up inNew York City, he received aBachelor of Science degree fromNew York University in 1947,and married the former BarbaraLevine in 1951, the year shegraduated from AdelphiUniversity in Garden City, NewYork. Over the years, they hadfive children.

After graduating from NYU, Mr.Davis joined his father increating an oil and gas

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exploration business. Under hisleadership, Davis Oil Companybecame one of the premierwildcat drilling operations in thecountry, buying up low-priced oiland gas leases in the RockyMountain region, then ridingthem through the boom times ofthe 1970s. The company, whichis now known as DavisPetroleum Corp., also developedproducing leases in Louisiana,Oklahoma, Wyoming and Texas.During the 1970s, only threeother companies — multinationalgiants Shell, Amoco, and Exxon— drilled more exploratorywells in the United States. Thecompany is still one of the mostprolific exploration companies inthe oil and gas industry today.

In the 1980s, Mr. Davis and hisfamily relocated from Denver toBeverly Hills, where he turnedhis deal-making skills toentertainment and real estate.In 1981, he bought 20th Century-Fox with financier Marc Rich inone of the first successfulleveraged buyouts of the decade.Mr. Davis wound up buying outMr. Rich’s half of Fox in 1984and sold the movie studio andfilm library to Rupert Murdochin 1985.

In addition to the movie studioand film library, Fox’s assetsincluded a number of otherworld-class properties which Mr.Davis retained after the sale ofthe Fox studio to Mr. Murdoch.These properties included thePebble Beach Company, theNorthern California seasideresort with two luxury hotels,four world-class golf coursesand the world-famous 17-miledrive, the Aspen SkiingCompany, which owned 200miles of ski trails on threeColorado mountains(Breckenridge, SnowMass andButtermilk), as well as the LittleNell luxury hotel, in addition toproperty in Century City,

California, on which Mr. Davisbuilt and twice sold the 20th

Century Fox Plaza. An avidgolfer, Mr. Davis sold PebbleBeach to Japanese investors for$841 million at the top of themarket in 1990. Still, itremained one of his favoriteacquisitions. “Oh, I loved everyminute of it,” Mr. Davis said ofthe years he owned the resort.“I never fall in love with anyasset, but that one came theclosest to it.”

In addition to Pebble Beach, Mr.Davis bought, sold and/oroperated such high-profileproperties as the historicBeverly Hills Hotel; his othernotable commercial office andretail properties included 181West Madison, 515 North StateStreet and the Marriott Hotel inChicago; 75/101 Federal Streetin Boston; Regency and RegencyWest in the DenverTechnological Center; CityCenter in Denver; and RestonTown Center in Reston, Virginia.

Mr. Davis is survived by hisloving, devoted wife of morethan 53 years, Barbara, theirfive children, Patricia Ann DavisRaynes and her husband Marty,John Davis and his wife Jordan,Nancy Davis Rickel and herhusband Kenneth, Gregg Davisand his wife Elena and DanaDavis, as well as, Mr. Davis’sister, Joan Chorney. Despiteall his business accomplishments,Marvin Davis considered hisgreatest legacy to be his wife,his five children and 16grandchildren.

Photo: Silvia Mautner

Donations in Mr. Davis’memory may be made to theChildren’s DiabetesFoundation/Barbara DavisCenter at 777 Grant Street,Suite 302, Denver, CO80203.

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THE PFIZERCAROUSEL OFHOPEDIABETESSYMPOSIUM:“Inflammation: Causeand Consequence ofDiabetes and VascularComplications”

he Pfizer Carousel of Hope Diabetes Symposium focused on the

role of innate and adaptiveimmunity in development ofdiabetic complications, includingaccelerated atherosclerosis, aswell as development of novelmethods of inflammationimaging. The theme of theSymposium was “Inflammation:Cause and Consequence ofDiabetes and VascularComplications.” The Symposiumbrought together preeminentscientists and clinicians frommany different disciplines andcountries. Their interests rangefrom immunology to genetics,molecular biology and imaging.

Peter B. Corr, Ph.D., SeniorVice President for Scienceand Technology, Pfizer Inc,New York, NYDr. Peter B. Corr is responsiblefor aligning the company’sworldwide research anddevelopment organization withlicensing activities, science andmedical advocacy, globalmedical relations and sciencepolicy.

Prior to joining Pfizer in 2000,he held senior leadershippositions in research,development and discovery atboth Warner-Lambert Companyand Monsanto/Searle.

Dr. Corr, who received his Ph.D.from Georgetown UniversitySchool of Medicine andDentistry, spent more than 18years as a leading researcher inmolecular biology andpharmacology at WashingtonUniversity.

Robert H. Eckel, M.D.,Director of General ClinicalResearch Center; Professor ofMedicine in the Division ofEndocrinology, Metabolismand Diabetes, University ofColorado Health SciencesCenter, Denver, CODr. Eckel is an internationally-recognized expert in the area oflipid metabolism, diabetes andobesity. Dr. Eckel’s currentresearch interests includecauses of increased heartdisease risk in patients withtype 1 diabetes mellitus andproviding new and importantinsights into the physiology oflipoprotein lipase in muscle. Dr.Eckel is President-Elect of theAmerican Heart Association.

George S. Eisenbarth, M.D.,Ph.D., Executive Director ofthe Barbara Davis Center forChildhood Diabetes;Professor, Department ofPediatrics, Medicine andImmunology, University ofColorado Health SciencesCenter, Denver, CODr. Eisenbarth has pioneeredstudies of organ specificautoimmune disorders and, inparticular, prediction of type 1diabetes and trials for theprevention of type 1 diabetes.The main premise of his work isthat we are able to predict type1 diabetes in children andprevent in animal models, andwith immunologic therapies wewill eventually prevent childhooddiabetes.

Göran K. Hansson, M.D.,Ph.D., Professor ofCardiovascular Research atKarolinska Institutet,Stockholm, SwedenDr. Hansson works in theDepartment of Medicine andCenter for Molecular Medicineat Karolinska UniversityHospital. He is also thechairman of the NobelCommittee for Physiology orMedicine. His research focuseson the pathogenesis ofatherosclerosis. He hasdiscovered that immune cellsare activated in theatherosclerotic lesion. Hiscurrent research deals with therole of immune cells andinflammatory signalingmolecules in atherosclerosis andcoronary heart disease.

V. Michael Holers, M.D., Head,Division of Rheumatology;Professor of Immunology;Professor of Medicine,University of Colorado Schoolof Medicine, Denver, CODr. Holers’ research interestsare in the areas of complementbiology and innate immunity andthe roles that these systemsplay in the development oftissue injury and autoimmunity.He has played a central role inthe development of complementinhibitors that have been usedby his and other laboratories inpre-clinical models of humandiseases.

George L. King, M.D.,Research Director, JoslinDiabetes Center; Professor ofMedicine, Harvard MedicalSchool, Boston, MADr. King’s interests are in thebasic pathogenesis and clinicalpresentation of diabeticcomplications and insulinresistance. Dr. King’s laboratoryhas developed the idea that theelevation of glucose can altersignaling pathways in vascularcells, including an enzyme

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pathway called protein kinase C.This work has resulted in thedevelopment of various potentialtreatments for the complicationsof diabetes, which are nowundergoing clinical studies.

Wolfgang Koenig, M.D., FESC,FACC, Professor ofMedicine/Cardiology,University of Ulm; Director ofthe Cardiac CatheterizationLaboratories, Department ofInternal Medicine II –Cardiology, University of UlmMedical Center; Director ofthe Hypertension and HeartFailure Clinics and thePreventive CardiologyProgramme, GermanyDr. Koenig’s research interestsinvolve the molecular basis ofatherothrombogenesis withparticular interest in theinterrelations betweenhemostasis, inflammation,infection and atherothromboticcomplications / type 2 diabetes,the clinical pharmacology ofcardiovascular activecompounds and the clinicalepidemiology of cardiovasculardisorders.

Brian L. Kotzin, M.D., VicePresident of GlobalDevelopment and Head of theInflammation TherapeuticArea, Amgen, Inc., ThousandOaks, CA (Recent positionswere Professor of Medicineand Immunology and Head,Division of ClinicalImmunology at the Universityof Colorado Health SciencesCenter, Denver, CO). Dr. Kotzin’s research interestsinclude the genetic andimmunologic basis ofautoimmune diseases. Studiesfrom his laboratory have focusedparticularly on the genetic basisof systemic lupus erythematosusand the role of T cells in humanautoimmune and inflammatorydiseases.

Jerrold M. Olefsky, M.D.,Professor of Medicine;Medical and ScientificDirector, Whittier/UCSDDiabetes Program, La Jolla,CA; Research Scientist,Veterans Medical ResearchFoundation, San Diego, CA;Associate Dean for ScientificAffairs, University ofCalifornia, San Diego Schoolof Medicine. San Diego, CADr. Olefsky's studies focus onthe basic mechanisms of insulinaction and insulin resistanceusing cellular and moleculartechniques. Dr. Olefsky'sclinical research program isfocused on identification ofmolecular and physiologicmechanisms of insulinresistance in Type II diabetesmellitus, as well as otherclinical conditions.

Trevor J. Orchard, M.D.,Professor of Epidemiology,Graduate School of PublicHealth, University ofPittsburgh, Pittsburgh, PADr. Orchard heads theEpidemiology of DiabetesComplications study. This NIH-funded study has followed withbiennial exams a cohort of 658T1DM patients diagnosed beforethe age of 17 in 1950-1980. Ithas provided the most completeand current informationconcerning complications ofT1DM in the U.S. population andwill continue to advanceknowledge of the pathogenesisand prediction of diabetescomplications, hopefully leadingto appropriate preventivestrategies.

Marian J. Rewers, M.D.,Ph.D., Clinical Director of theBarbara Davis Center forChildhood Diabetes;Professor, Department ofPediatrics and PreventiveMedicine, University ofColorado Health SciencesCenter, Denver, CO

Dr. Rewers researchesprevention of diabetes and itscomplications through a seriesof large cohort studies. HisCoronary Artery Calcification intype 1 Diabetes has studied,since 1999, development andprogression of coronaryatherosclerosis in 656 T1Dpatients and 764 non-diabeticpersons aged 20-55.Participants have beenexamined twice, using theelectron beam tomography, forthe presence of coronarycalcification. The study isdiscovering novel cardiovascularrisk factors important forprevention of heart disease inpeople with type 1 diabetes.

Ann Marie Schmidt, M.D.,Gerald & Janet CarrusProfessor of Surgical Science,Department of Surgery; Chief,Division of Surgical Science,Department of Surgery; andDirector, Juvenile DiabetesResearch FoundationInternational Center forDiabetes Complications,Columbia University MedicalCenter, Columbia University,New York, NYDr. Schmidt’s research isdedicated to the study ofpathogenesis of macrovascularand microvascular complicationsof diabetes. Her laboratorygroup has identified centralroles for Receptor for AdvancedGlycation End products (RAGE)in the processes linked todiabetes-associated cellularperturbation. Her group’s workis focused on dissection of thebiology of RAGE and thetranslation of these findings intoclinical trials for subjects withdiabetes to prevent/treat itscomplications.

Jay S. Skyler, M.D., Directorof the Division ofEndocrinology, Diabetes &Metabolism, Department ofMedicine; Associate Director

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for Academic Programs,Diabetes Research Institute;Professor of Medicine,Pediatrics & Psychology,University of Miami, Miami, FLDr. Skyler’s research interestsare in clinical aspects ofdiabetes, particularly improvingthe care of type 1 diabetesthrough meticulous glycemiccontrol, psychosocial andbehavioral support and immuneintervention. He has long beeninterested in the complicationsof diabetes and in therelationship between bloodpressure and blood glucose. Heled the Diabetes Prevention Trial1 and is now leading themulticenter Type 1 DiabetesTrialNet effort.

Russell P. Tracy, Ph.D., SeniorAssociate Dean for Researchand Academic Affairs,Professor of Pathology andBiochemistry, Director of theLaboratory for ClinicalBiochemistry Research,University of Vermont MedicalCollege, Burlington, VTDr. Tracy is an internationally-renowned expert in the area ofinflammatory and hemostaticrisk factors in humanatherosclerosis. His laboratoryhas developed “gold standards”biochemical and genetic assaysfor biomarkers of inflammationand thrombosis and theirrelationship to heart disease,

diabetes and chronic diseases ofolder age. These services havebeen used by several seminalstudies, including, CHS, IRAS,MESA and GENCAC.

R. Paul Wadwa, M.D.,Assistant Professor ofPediatrics, Barbara DavisCenter for ChildhoodDiabetes, Denver, CODr. Wadwa is an attendingphysician in the Pediatric Clinicat the Barbara Davis Center forChildhood Diabetes. He providesclinical care to pediatricpatients with type 1 diabetesmellitus. His research interestsare in macrovascularcomplications of type 1 diabetesand early identification ofindividuals with type 1 diabeteswho are at increased risk forcardiovascular disease.

Samuel Wickline, M.D.,Professor of Medicine,Biomedical Engineering,Physics and Cell Biology andPhysiology, WashingtonUniversity School of Medicine,St. Louis, MODr. Wickline’s laboratory isengaged in a multidisciplinaryeffort (physics, engineering,chemistry, cell physiology,pharmacology and imaging) todevelop targeted nanoparticlesfor imaging the molecularcauses of cancer, cardiovasculardisease and other inflammatoryconditions. In particular, Dr.Wickline’s laboratory isinterested in sensitiveidentification of pathologicalangiogenesis and its inhibitionwith site-targeted therapies.

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2004 DAVIS AWARD WINNERichael Brownlee, M.D., Anita and Jack Saltz Professor of Diabetes Research, Departments ofMedicine and Pathology, Albert Einstein Collegeof Medicine, Bronx, NY

Dr. Brownlee is internationally recognized as a leader in diabeticcomplications research. Dr. Brownlee, who has type 1 diabetes,has received a number of honors for his work, most recently the2003 Claude Bernard Medal, the highest scientific award of theEuropean Association for the Study of Diabetes, and the 2004Banting Medal for Scientific Achievement, the highest scientifichonor given by the American Diabetes Association.

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Barbara Davis with the 2004 Pfizer Carousel of Hope Symposium participants

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MANAGEMENTOF DIABETES INYOUTHCONFERENCE

he 8th biennial educational meeting for diabetes healthcare

providers, with 400 attendeesfrom every state in the U.S., washeld July 18-21 at the KeystoneConference Center in Keystone,Colorado. This meeting wasplanned and coordinated underthe watchful eye of ConferenceDirector, Dr. H. Peter Chase.Guest speakers included Dr.William Tamborlane from YaleUniversity School of Medicine,Dr. Tim Wysocki from NemoursChildren’s Clinic and MayoMedical School, Richard Weil,M.Ed. from New York ObesityResearch Center and SusanAllen, M.S.N., R.N. fromCincinnati Children’s HospitalMedical Center.

The meeting was an intensethree and a half days of generalsessions and workshops.Members of the staff at theBarbara Davis Center and theguest speakers shared theirexpertise by presenting atgeneral sessions, leadingworkshops and facilitating paneldiscussions with patients, theirparents and athletes with type 1diabetes. Practical day-to-daymanagement was emphasizedwith special attention given tonew innovations in care,including new insulin analogues,continuous glucose monitoring,blood ketone checking, low doseglucagons and insulin pumptherapy. Education of the entirefamily, recent changes in dietaryrecommendations, suggestionsfor exercise and psychosocialimplications of diabetes werealso stressed.

The conference was once againsold-out. Comments afterwardswere “the best ever,” “the bestconference I have ever attended”and, “I’ll be back with othermembers of my team.” Thanksto Sue Palandri, LindaSchneider and Lisa Fisher fromthe Children’s DiabetesFoundation for their hard workin making this conferencepossible.

Plans are underway for the2006 conference and anadditional day has been added.

It will be held July 15-18, 2006at the Keystone ConferenceCenter in Keystone, Colorado.Many of the participantssuggested that some of themeetings begin in the afternoonso they can enjoy the beautifuland sunny Colorado mornings,so the schedule will be revisedto accommodate this request.Diabetes healthcareprofessionals — mark yourcalendars — it will be the one“must attend” meeting held in2006.

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Barbara D

avis CenterProgram speakers from top left: Dr. Bill Tamborlane, Dr. Ron Gill, Rita Temple-

Trujillo, Dr. Tim Wysocki, Rich Weil, M.Ed. and Susan Allen, M.S.N., R.N.

NIH HELPSCOMPLETENEW CENTER— Dr. George S. Eisenbarth M.D., Ph.D.

he Barbara Davis Center, withDr. Richard Krugman, Dean of the University of

Colorado Medical Center,recently received word that itwill receive a grant of almost $3million from the NationalInstitutes of Health (NationalCenter for Research Resources)to finish the remaining twofloors of the new Barbara DavisCenter on the medical schoolcampus at Fitzsimons. Thegrant followed a nationalcompetition. This is great newsas with matching funds,including the tremendoussupport from the Children’sDiabetes Foundation andmultiple gifts from the familieswho support the Center, as wellas the support of theUniversity/Medical School, willallow all four floors of theCenter to be finished. It isplanned that by April of 2005the first floor (Clinical andClinical Research) as well as thefourth floor (laboratories) willbe ready for occupancy. Thesecond floor (outpatient clinicalresearch) and the third floor(Islet Transplantation programand a Center for Autoimmunityincluding type 1 diabetes) willtake longer to finish, but arenow on track. We thank themany generous supporters ofthe Children’s DiabetesFoundation and the BarbaraDavis Center who have madethis possible.

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TThe Children’s Diabetes Foundation would like to thank our

many friends who have helped to contribute to the constructionof the new building. Without your help this wonderful buildingwould not be possible. Naming rights at the new Center are still available by calling 303-863-1200. Please help build the

new Center and have your family’s name be a lasting part of theefforts to conquer diabetes.

*We regret the omission of any name due to an early print deadline.

AndersonMasonDale Architects

Dr. & Mrs. Richard Abrams AndersonMasonDale ArchitectsFranklin Austin Sue Ann Baird Bradford & Suzanne Bennett Emanuel & Bea Bugelli Sharon Calkins John & Nancy Cowee Pem & JoAnn Dunn Mr. & Mrs. Philip Eckland Dr. & Mrs. George EisenbarthMr. & Mrs. Daniel Feiten Lee FlemingMr. Alan Folkestad

& Mrs. Marjorie T. Folkestad Mr. & Mrs. F.A. Foss Mr. & Mrs. Charles Foster Mr. & Mrs. Russ Frerichs The James J. & Joan A. Gardner

Family Foundation The Spencer Gardner Family Elizabeth Gregg The Guild of the Children's

Diabetes Foundation Dr. & Mrs. Richard Hamman Warren & Helen Hanks Dr. & Mrs. Lowell Hansen Dr. William Jackson Rick & Barb Jenkins Jeppesen Sanderson David Johnson Jill Kahkoska Lenny Kartus Mr. & Mrs. Steve KwasniakDarin Layman

“Triathlon for Tara” J. Leonard & Myra B. Levy

Family Fund Cynthia Losasso Mr. & Mrs. Gary Magness Mr. & Mrs. Charles McNeil Mr. & Mrs. Les Mendelson Camille Murphy Randy Peters Arnold & Connie Pohs Debra Price Mr. & Mrs. Clark Rheem Carrie Rodier Samantha RohwerFlorence Ruston Walter & Charlotte Soule

Family Foundation Wayne Sawden Mr. & Mrs. Bob SchenkenbergerEd & Barb Seifert Nancy SettleMr. & Mrs. Scott SmithStarz Encore The te Velda Family Toys “R” Us Children’s Fund, Inc.Mr. & Mrs. Robert WardenJoseph O. & Geraldine C.

Waymire Fund, a fund of the Central Indiana Community Foundation

Wells Fargo Kimberly Whitacre Dr. & Mrs. John Wilson Melvin & Elaine Wolf Mr. & Mrs. Lee Zastovinik

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FREESCREENINGFOR RELATIVESOF PEOPLEWITH TYPE 1DIABETES

he National Institutes of Health (NIH) has recently announced the

NIH-ADA-JDRF funded researchprogram to again start screeningrelatives of people with type 1diabetes. The program is nowcalled "TrialNet" (formerly theDiabetes Prevention Trial - DPT-1). First degree relatives(siblings, children or parents),ages 1-45 years, and second

degree relatives (cousins,uncles, aunts, nieces, nephews,grandchildren or half-siblings),ages 1-20 years, may bescreened to determine their riskof developing type 1 diabetes.(The relative with type 1diabetes must have beendiagnosed before age 40 andstarted on insulin in the firstyear after diagnosis.) Theadvantages of screening are:

1. The diagnosis can then bemade much earlier before theperson becomes seriously ill.

2. Interventions will soon beoffered to try to preventdiabetes.

If interested in the freescreening, please call 303-315-6397 (Denver area)or 800-572-3992 (outside ofDenver area) or 800-425-8361(outside of Colorado).

T

BOOK ORDER FORMName _____________________________________________________________________________________________

Address ____________________________________________________________________________________________

City/State/Zip ______________________________________________________________________________________

Phone (Day) _____________________ Phone (Eve) _____________________ Email _____________________

Understanding Diabetes $18 per copy Quantity ______

Managing and Preventing Diabetic Hypoglycemia (Video) $20 per copy Quantity ______

A First Book for Understanding Diabetes (English) $8 per copy Quantity ______

Un Primer Libro Para Entender La Diabetes (Spanish) $8 per copy Quantity ______

All orders must be paid in full before delivery. Costs include shipping and handling. Allow 1 to 3weeks for delivery.

Make checks payable to: The Guild – CDF at DenverVisa, MasterCard and Discover accepted.

Canadian and Foreign Purchasers: Please include sufficient funds to equal U.S. currency exchangerates and international postage.

For additional information call 303-863-1200 or 800-695-2873 or visit

www.ChildrensDiabetesFdn.org

Mailing address: The Guild of the Children’s Diabetes Foundation777 Grant Street, Suite 302Denver, CO 80203

Photo: kentmeireisphotography.com

22

QUESTIONSAND ANSWERS

— H. Peter Chase, M.D.

uestion:Which is better, an insulin pump or Multiple Daily Injections (MDI)

using Lantus®?

nswer:First let me say that both are far better than the peak-insulin

therapy using NPH, Lente orultralente insulins (particularlywhen one of the three is given atdinner or in the evening). Whenpumps or MDI’s with Lantus areused there is not a large peak ofinsulin acting during the night.Every good study has shown areduction in nighttime lowsusing either pumps or MDI incomparison to the twice-dailypeak insulins. Our studyregarding Lantus use (Chase etal, J. Pediatric 143:737, 2003)showed a reduction from 14 to 4seizures during the night in 114youth as they changed from NPHto Lantus insulin (both givenover nine month periods).

As far as glucose control isconcerned, Dr. Satish Garg,Director of the Young AdultClinic, analyzed the HbA1c datafrom 216 of his pump patients(mean A1c=7.5%) and 299 MDIpatients (mean A1c=7.7%).Thus, there was no difference,which has also been the case formost studies to date. However,for children who snack and whodo not take insulin injections, orwho do not tolerate multipleinjections, a pump may bebetter. The pump is moreexpensive and in Dr. Garg’sstudy, resulted in more cases ofketoacidosis or DKA (due topump insertions coming out).We have also found that some

youth do not attain optimal A1clevels because they forget tobolus with food intake(Pediatrics 113:3, e221, March2004). Research is currently inprogress to determine if alarmswill help to remedy thisproblem. In the meantime, Iwould say that the superiority ofone method of giving insulinover the other is probably “inthe eye of the beholder”(including the patient, familyand care-provider).

uestion:I was reading about the glycemic index in an online article

(www.Glycemicindex.com) andam both astounded andconfounded by what I foundthere. I know you’vepublished a mini-index in theBDC newsletter before, butI’ve always understood juice,little candies, etc. to be thebest things to eat (aside fromglucose and honey) when I amlow. Now it seems like whiterice or Rice Chex or ShreddedWheat would raise my bloodglucose even faster than, say,fruit juice. Is this true? I

feel like my whole center ofgravity has shifted if so!

nswer: I was very interested in the glycemic index 20 years ago. The

problem with it is that itmeasures glucose levels when afood is eaten alone. This rarelyhappens in real life, and theaccompanying food changesthings considerably (e.g. fatdelays stomach emptying andkeeps blood glucose levels uplonger no matter what theglycemic index of thecarbohydrate). Thus, thepracticality of the glycemicindex is limited when someoneeats a meal.

In regards to treatinghypoglycemia, our research fromdiabetes camp showed thatliquids passed through thestomach quicker than solids.The sugar is absorbed in thesmall intestine (not in thestomach). Thus, juice or asugar source that dissolvesquickly is still the best fortreating low blood sugars.

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JOIN THE BDC FOR AN UPDATEON DIABETES

Saturday, January 8, 2005

9:00 a.m. – Noon

CU Dennison Auditorium

SPEAKERS:

Dr. H. Peter Chase – Recent Advances

Dr. Ron Gill - Islet Transplants

Gail Spiegel M.S., R.D. – Dietary Dilemmas

Family Screening Will Be Available

Call 303-315-0566 if interested(Seating is limited)

SAMANTHAHEITSCH OFCHEYENNE, WYHORSEBACKRIDER

— Samantha Heitsch, patient at the BDC

i my name is Sammy Heitsch. Iwas diagnosed with type 1 diabetes when I

was 4 years old. I started ridinghorses when I was 7 years old.In the beginning, I thought Iwould do horrible because I haddiabetes. I thought that when Iwas riding I would have to stopand go test my blood sugar allthe time, but I was wrong.

Whenever I ride in horse shows,each event only takes about 10minutes. As long as I make sureI am in control before I ride, I dojust fine. Once, I did have a lowblood sugar when I was riding. Iknew the man that was in thearena with the judge. He sawthat I was having trouble and letme start over once I felt better.After that for each event, hewould ask me before the event if Iwas okay. Usually I would sayyes, I was okay with my diabetes,but no because I had butterfliesin my stomach.

I love to ride and it also justturned out that the horse that isin the picture is mine now. Iwas leasing him because theowner was a member of ourchurch. I would ride him everyday but I never got to say thathe was my horse. Now, theowner signed him over to me andhe is mine. The horse that Iride is a Palomino horse and isabout 16 years old. His name isRocky. He takes classes withme out at the communitycollege, LCCC. He does reallywell out there and likes to ridewith me. He has taken off oncewith me on him but he is areally good horse and loveswhen I ride him. I have neverhad a bad accident with himwhile I was riding that wascaused by diabetes. There hadbeen times where I went low onhim but never to make me faintor fall off.

I have one really good friend thatlikes to watch me ride. Her nameis Lauren. She is always therefor me and has also gotten to

ride Rocky a lot. I call her“nurse Lauren” because she hasknown me since I was 6 yearsold and knows a lot about meand my diabetes. Every year atmy County Fair, Lauren comes.

I have only gone to fair 3 timesbut still we are out there for atleast 5 hours, sometimes evenlonger. I really have to knowhow to take care of my diabetesand be on a horse for that long.I did so well one year at fairthat I got to go to State Fair inDouglas. I also got second upthere. That year was my bestyear. I had won at least 2 firstplaces and 3 second places. Iam planning on riding my wholelife but we will see how it worksout. But one thing for sure Iknow that diabetes will NEVERkeep me down.

One more thing. My mom hasalways told me that one day whenthey find the cure we are going tohave a big party and have mejump out of the cake!!!!!!

23

H

Winner’s C

ircle

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The Zavala family from Chile visitedthe Center on August 2nd and August

3rd. From left to right are: Dr. Chase,Joaquin, Diego, Senora Cecilia de

Zavala, Susie Owen, R.N., Fernando,and Senor Fernando, Sr. All three

boys have type 1 diabetes. Theypreviously visited the Center in 2001.

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3

EXPERIENCETHE WORLD— Elisa Rohlwing, patient at the BDC

traveled to China to study business and economics for a 21-day study

abroad program through AzusaPacific University with eightstudents and one professor. Ourexperience consisted of studyingat Zhejiang University and thencontinued travel to Shanghaiand Beijing. Although I probablycould write pages and pages ofthe cultural experience, I amgoing to share with you some ofmy experience in dealing withmy blood sugars, the pump andbeing a global diabetic.

Throughout the whole three-week trip one of my biggestconcerns was weather issues,humidity and temperature. Myblood sugars were surprisinglystable, probably because ourdiet consisted of mainly porkand lots of RICE!!! I did take theinitiative of decreasing myinsulin dosage by about 30%. I

did not change my basal ratebut my bolus amount shiftedbetween 1-6 units, whereas inthe U.S., my bolus amountsometimes goes as high as 10units. While I was there, I hadonly one “kind of” low because itwas after a day of intense hikingat the YinLin Temple. I wasamply prepared and brought lotsand lots of Gatorade® andNutrigrain bars from the U.S. forthat exact situation.

My biggest problem with thepump and international travelswas actually in the airports. Itwas sometimes humorousbecause when we flew intoSouth Korea I had my pumpstrapped to my ankle and thesecurity guard searched me andcompletely skipped the areawhere my pump was attached.We concluded that they had veryloose security in their airport.

I did have a minor situation withthe airport security in Shanghai.Of course, this had to happenwhen we were already late forour flight to Beijing and runningto get to the terminal. We wentthrough the metal detectors and

then they had to searcheveryone again. They cameacross my pump, which was stillstrapped to my ankle, and theguard looked up at me and saidsomething to me in Chinese, ofwhich I had no idea what theguard was telling me. I speakno Chinese, so I lifted my pantleg and told her “it’s medicine.”Why I thought she understoodEnglish is still beyond me. Shewent and brought two otherguards back, by this point I wassitting down on a chair showingthem the pump was strapped tomy leg and the tubing leads tothe incision point, whichhappened to be on my hip. Inaddition, I kept repeating thewords “medicine” and “diabetic”(like that was really going tohelp the situation). The guardthen motioned me to follow herto a closed room where shetried to see where the tubingwent. She tugged at my pantsand shirt, needless to say, sheeventually let me go figuringthat this crazy American wasprobably not dangerous. Webarely made it to the flight andthankfully made it safely. Forfellow diabetics and for myfuture traveling experience, Ithink I am going to have a cardthat says “I am a diabetic, it’s aninsulin pump” in the languagewhich they will be speaking orbetter yet, just detach the pumpand stick it in my bag for thesecurity portion of the airport.

Overall, this experience to Chinahas been one of the biggesthighlights of my entire life and Iencourage all diabetics to neverbe hindered by diabetes butexperience the world, don’t losehope and never stop beinginspired.

Win

ners

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Elisa at the Great Wall of China

25

The following letter was sent in byone of our BDC families.

he Insuflon®

device works extremely well for our five-year old son Brady who

was diagnosed with type 1diabetes in March 2004. He isstill in the “honeymoon” periodand only requires about fiveunits of insulin per day. All ofhis injections are given throughthe insuflon and he nevercomplains of pain during theinjections. We are able to mixdifferent kinds of insulin

together in the Insuflon with noapparent problem. He currentlytakes Lantus®, NPH andHumalog®.

Technically speaking, theinsuflon is an indwellingsubcutaneous catheter. Wewere introduced to this idea byDr. Peter Chase and his teamduring our first visit to the BDC.The Insuflon has a very lowprofile and Brady usually doesnot even remember which sideof his buttocks to expose whenwe ask him to take an injection.He can shower, bathe and evenswim with it in. Occasionally,the sticky tape has frayed at theedges and we have reinforced itwith Tegaderm® with goodsuccess. We usually change theinsuflon once a week and applyEMLA® topical anesthetic creamfor one hour, under a band-aid,before insertion. Most of thetime, he does not feel thecatheter going in at all.

Our local pharmacy gets theinsuflon from Amerisource (800-523-4020) and the item numberis 450-9725. The cost is $5-$6each. More information can befound at insuflon.com.

While not for everyone, theinsuflon has been wonderful forour son. If he wants to eat alittle extra snack, we can simply“cover it” with short actinginsulin to keep him in tightcontrol. Brady’s othercaregivers (babysitters andgrandparents) are especiallythankful since they no longerfeel intimidated when faced withgiving him an injection. Also,the insuflon may be a low costalternative for those people whocannot afford to start the pump.The insuflon has helped to makeour preschooler’s life as close tonormal as possible.

Best wishes, Bruce and Shelly Evans Rapid City, SD

rT

SOME DRIVE.SOME FLY!

r. Chase and Benita Lopez-Baca, R.N., met with Lucas Vogel and Chuck

Peterson. Chuck is a pilot andhas a Piper Cherokee 180.Chuck and Lucas got up early tofly from Stewart, Nebraska forLucas’ 8 a.m. clinic appointment.Lucas has been followed at theBDC since his diagnosis inAugust of 1997. He is now asophomore at Chadron StateCollege in Nebraska.

D

Brady Evans

GOODWILLAMBASSADOR!

ne of our patients recently learned how insulin infusion sets are

manufactured. Matthew Cooperwas invited to Unomedical’smanufacturing facility in Mexico.The company makes insulin pumpinfusion sets and the visit was inrecognition of the launch of theirnew device, the Inset®.Matthew has worn an insulinpump for five years and reallyenjoyed learning by working “onthe line” side by side with theworkers in the factory. Themanagers at the factory told usthat the employees found itrewarding to hear from apatient that uses their productsto stay healthy.

26

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LOW CARBCONES!

ince our five year-old son was diagnosed with type 1 diabetes last March,

making the proper food choiceshas been an ongoing challenge.Typically, our family tries to eathealthy food, but with threeyoung boys, we want to makeeating fun. Here are two low-carb treats that we havediscovered.

We buy plain ice cream conesand have the boys fill them withthe whipped cream that comesout of the can. Although thiscan be messy, the kids lovemaking their own "whippedcream cones." The whippedcream comes in both vanilla andchocolate flavors. This treat isusually 5-10 carbs depending onthe amount of whipped creamused.

Another special treat that thekids enjoy is making snow conesusing Kool-aid®’s new sugar-freeJammers. We bring a Jammeralong with us everywhere we goand if the opportunity arises andwe see a snow cone stand weask for a snow cone with justice. We then top it with thesugar-free Jammer and we havemade our own sugar-free snowcone. This treat is only 2 totalcarbs. Our boys love thesetreats and we feel good aboutletting them enjoy them.

Happy eating! Bruce and Shelly Evans

S▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼▼

Here’s an idea from one of our families!

Win

ners

Circ

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27

EDUCATIONAND PUBLICAWARENESS

he Education and Public Awareness Committee has recently sent out

diabetes packets to all Coloradopublic and private schools,grades K-12. It is our wish toshare information we feel isappropriate to the school nurseand faculty.

Bookmarks with diabetessymptoms have been placed inthe school packets with thesymptoms being listed in bothEnglish and Spanish. Thesebookmarks are free of charge toanyone who requests them.

Lastly, we would again like toencourage you to check out ourwebsite atChildrensDiabetesFdn.org(under "Education" and "Tips forCollege Students") to seeinformation for young peoplewith diabetes going off tocollege or living on their own.

Should you need diabetesinformation, please do nothesitate to contact Regina Reeceat 303-863-1200 or 800-695-2873.

membership reception was held for The Guild of the Children’s Diabetes

Foundation on Wednesday,October 6th at the L’OperaRistorante Italiano. GuildChairmen, Christy Hanson andKindall Pope welcomed ourcurrent Guild members and theirguests.

The Guild’s primary mission is tosupport clinical and researchprograms while helping improvethe lives of children and youngadults served at the BarbaraDavis Center for ChildhoodDiabetes. If you are interestedin becoming a Guild memberplease call the Children’sDiabetes Foundation office.

T

2005 GUILD EXECUTIVECOMMITTEE

President - Margy Epke President-Elect - Chris Foster

Treasurer - Lyn Schaffer Treasurer-Elect - Lisa Corley

Corresponding Secretary - Adrienne Fitzgibbons Recording Secretary - Gina Abou-Jaoude

A

GUILD MISSION STATEMENT

The Guild of the Children’s DiabetesFoundation at Denver raises funds forclinical and research programs for the

Barbara Davis Center for Childhood Diabetes.The Guild promotes diabetes awareness andeducation; assists families in need; provides

continuing education scholarships andsponsors social activities for children and

their families.

MEMBERSHIP EVENT FOR THE GUILD

Guild Membership Co-Chairs Kindall Pope and Christy Hanson

Guild G

uide

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any of you have been taught to use carbohydrate counting as a method of meal

planning. What you are usuallytaught by the dietitian is thatwhether you eat a foodcontaining sugar or a foodcontaining starch, they both willbe converted into blood sugar.And, if the food contains thesame amount of totalcarbohydrate, whether it’s twocookies or one slice of bread, itwill cause about the same risein blood sugar. We teachpatients and families to counttotal carbohydrate grams infoods because it is the totalamount of carbohydrate that youeat that is the most importantfactor affecting blood sugarsand not the source ofcarbohydrate. Theserecommendations are based onthe current nutrition guidelinesput forth by the AmericanDietetic Association and theAmerican Diabetes Association.

But, why is it that you’venoticed, for example, thatpotatoes cause a higher rise inblood sugars than beans do?That’s because there arevariations in how differentcarbohydrates affect bloodsugars. In fact, there have beenmany studies conducted onindividual foods and how theyaffect blood sugars. From thesestudies, a glycemic index hasbeen developed. Some of youmay be asking why you’ve neverheard about the glycemic index.That’s because the glycemicindex is not widely accepted asa method of diabetes mealplanning for a number ofreasons. It is complicated and ifa patient tries to eat only lowglycemic index foods, they may

be severely limiting the types offoods that they can eat and lackthe variety they need forbalanced nutrition. Manyexperts also feel that thedifference between carbohydratefoods is not significant.Although we do not regularlydiscuss the glycemic index indetail with patients, some of youmay find it helpful.

So, what is the glycemic index?The glycemic index is a rankingof foods based on how muchthey raise a person’s bloodsugar level compared to areference food. The referencefood is either white bread orglucose. To determine theglycemic index, test foods arefed to people with and withoutdiabetes and the blood sugarresponse is measured over threehours and compared to thevolunteers’ response to thereference food. Each food isgiven a number or glycemicindex using these results, and intheory, the higher the number,the higher the blood glucosewould be expected to rise aftereating that food.

Various other factors also affectthe blood sugar rise after eatinga carbohydrate food. Thesefactors include the protein andfat content of the meal, themethod of preparation andwhether a food is pureed orwhole. For example, a high fatand protein meal would slowdown the rise in blood sugar ascompared to a low fat andprotein meal. And foods thatare pureed and cooked will beabsorbed more quickly thanwhole, uncooked foods. Also,each person may reactdifferently to the samecarbohydrate food.

Since each person reactsdifferently to carbohydrate-containing foods, it is best touse blood sugar testing to findout how various carbohydratesaffect you or your child’s bloodsugars. It is important toremember, though, thatvariations in blood sugars canbe caused by factors other thanthe food that was eaten. If thereis a pattern over a few days witha certain food or meal, you canuse the blood sugar values tomake adjustments in insulindose.

How can you use the glycemicindex? First, I want toemphasize that you should notuse the glycemic index as thesole meal planning tool. We stillrecommend that when planningmeals, the most importantconsideration is the totalamount of carbohydrate and notthe source of carbohydrate.Then, if you are still notsatisfied with blood sugarcontrol you can try using somelower glycemic index foods tosee if they make a difference.You may want to include morefoods from the lower end of theglycemic index, such as lentilsand beans. However, there is noneed to omit a food just becauseit is at the higher end of thescale. When eaten with othertypes of foods, it may notproduce the higher responsesthat occur when it is eatenalone. Eating more fruits,vegetables and whole grains andreducing the amounts ofprocessed white flour productsyou eat can also be helpful andhealthful for many reasons. Seethe table on the next page for alisting of commonly eatencarbohydrate containing foodsand their glycemic index.

MCARBOHYDRATES AND THE GLYCEMIC INDEX

— Gail Spiegel, M.S., R.D., C.D.E

29

MEAN GLYCEMIC INDEX (GI) FOR SOME COMMONLY EATEN FOODS.

Low Glycemic Index foods 55 or lessIntermediate Glycemic Index foods 56-69High Glycemic Index foods ≥70

Food GI BREADSbagel, white 72 white bread 70 whole meal rye bread 56 100% stoneground whole wheat bread 53 whole grain pumpernickel rye 50

BREAKFAST CEREALSKellogg®’s Corn Flakes® 84 Cheerios® 74 Post® Grape-Nuts® 67 Cream of Wheat® 66 old fashioned oatmeal 42 All Bran® 42

GRAINS AND STARCHY VEGETABLES rice, white (instant) 87 potatoes, baked 85 potatoes, instant 83 corn, sweet 55 rice, brown 55 spaghetti, white 41

LEGUMES baked beans 48 chickpeas 33 lentils 29kidney beans 27

FRUITS banana 53 grapes 43 orange 43 apple 36 grapefruit 25 cherries 22

DAIRY ice cream 61 milk, skim 32 milk, whole 27 yogurt, low fat, artificial sweetener 14

SNACK FOODScorn chips 73 angel food cake 67 blueberry muffin 59 popcorn 55 chocolate 49

(Foster-Powell, Miller, JB. International Tables ofGlycemic Index. Am J Clin Nutr 1995:62:871S-890S)

GLYCEMIC INDEX RESOURCES: BOOKSThe New Glucose Revolution Pocket Guide toChildhood Diabetes by Jennie Brand-MillerMarlowe & Company 2003 The New Glucose Revolution by Jennie Brand-Miller Marlowe & Company 2004

WEBSITES www.glycemicindex.com www.mendosa.com

Photo: © Martin Crabb

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Coo

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r CHRISTMAS PUNCHINGREDIENTS:1 48 ounce bottle Light Cran-Raspberry® Cranberry Raspberry

Juice Drink

2 12 ounce cans of Fresca®

1 lemon, thinly sliced

2 strawberries, thinly sliced

DIRECTIONS:Combine juice drink, soda and fruit slices in a large punch bowl.Add ice. Float mint leaves if desired.

NUTRITIONAL INFORMATION: 4-6 ounce serving with ice is FREE!!!

HOLIDAY PARTY CAKE INGREDIENTS: 2 baked eight or nine inch white cake layers, cooled

2 boxes (four serving size) sugar-free gelatin, one red, one green

2 cups boiling water

31/2 cups (8 ounces) “lite” whipped topping

DIRECTIONS: • Prepare cake layers per package instructions.Remove from pans and cool on wire racks.

• Place baked cake layers, top side up, in twoclean eight or nine inch cake pans. Prick eachcake at 1/2 inch intervals.

• Dissolve red and green gelatin in separatemixing bowls using 1 cup boiling water in eachbowl.

• Carefully spoon dissolved red gelatin over onecake layer and the green gelatin over the othercake layer. Chill three to four hours.

• To unmold gelatin cake, dip bottom of one cakepan in hot water for 10 seconds. Unmold ontoserving plate. Top with 1 cup whipped topping

• Unmold second cake layer and carefully placeatop first “frosted” layer.

• Frost top and sides of cake with remainingwhipped topping. Chill. Garnish as desired.

NUTRITIONAL INFORMATION: Number of Servings: 20 Serving Size: 1/20 of cake Calories: 185 Carbohydrate: 27 Grams Protein: 2 grams Fat: 8 grams

◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆◆

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STRAWBERRY BAVARIAN INGREDIENTS:2 packages (four serving size) or 1 package(eight serving size) sugar-free strawberryflavored gelatin

2 cups boiling water

1 cup cold water

1 pint fresh strawberries

1 package (four serving size) sugar-free instantvanilla pudding

11/2 cups skim milk

1 cup “lite” whipped topping

18 low-fat graham cracker squares (9 fulllength crackers)

DIRECTIONS:• Dissolve gelatin in boiling water, then add coldwater. Chill until slightly thickened.

• Clean and slice berries, saving a few wholeberries for garnish.

• Prepare pudding per instructions, using ONLY11/2 cups skim milk.

• Fold whipped topping into pudding. Foldgelatin mixture into pudding mixture.

• Add sliced berries.

• Line bottom of 9 inch square pan with 9graham cracker squares. Spread half of mixtureover crackers. Repeat.

• Chill until firm, approximately three hours.Garnish with whole berries.

NUTRITIONAL INFORMATION: Number of Servings: 9Serving Size: 1/9 of dessert Calories: 120 Carbohydrate: 23 grams Protein: 3 grams Fat: 2 grams

HAPPY HEALTHY HOLIDAY EATING FROM YOUR BDC DIETITIANS!

TTT

Cooks C

orner

Photo: kentmeireisphotogrphy.com

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A HAUNTINGLYFUN TIME BY ALL

ids dressed up as princesses, cheerleaders, action figures, doctors,

dinosaurs and cowboys at thisyear’s Guild Halloween Party atthe Colorado School of MinesGreen Center hosted by PhiGamma Delta Fraternity. Thefraternity has hosted the Guild’sAnnual Halloween party since1983, offering an alternative tothe large quantity of sweetsoffered on this holiday.

The children enjoyed plentifulamounts of pizza donated byDominos and diet soda donatedby Pepsi Cola Bottling Company.They also had a “spooktacular”time decorating pumpkinssupplied by our Guild membersRobert and Judy Villano, whilealso having the opportunity toplay games and place theirprizes from games in theiroverflowing goody bags. Someof the game prizes were donatedby: BD Medical, Deltec,Medtronic MiniMed, RocheDiagnostics Corporation andTheraSense.

Special appreciation isexpressed to Event Chairmen,Debbie Gradishar and IngridWarden and the HalloweenCommittee who worked so hardto assure a memorable event.

KC

arousel Days

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© Cindy Barton

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FUNDINGOPPORTUNITIES:

LEVEL 1 $50,000 and above LEVEL 2 $30,000 to

$49,999 LEVEL 3 $10,000 to

$29,999 LEVEL 4 $1,000 to $9,999 LEVEL 5 $100 to $999

DONOR WALL FORM

Name ___________________________________________________________

Address _________________________________________________________

City ______________________________ State ____ Zip__________________

Home Phone ____________________ Work Phone _____________________

Cell Phone __________________ Email _____________________________

Amount $_______________

________________________________________________________________

(Name as you wish it to appear on donor wall)

Make check payable to Children’s Diabetes Foundation or❑ Visa ❑ MasterCard ❑ American Express

Name on Card ____________________________________________________

Card # ________________________________________ Exp. Date ________

Mail payment to:Children’s Diabetes Foundation — Donor Wall 777 Grant St, Ste. 302 • Denver, CO 80203

I s your child a patient at the Barbara Davis Center? Are you a patient at the Barbara Davis Center? Do you

have a special interest in diabetes?

This is an opportunity for you, yourfamily and your friends to have apresence at the new facility bypurchasing a place on the donor wall— a lasting symbol of your support.Help us catch the brass ring — a curefor diabetes.

I

BARBARA DAVIS CENTER AT FITZSIMONS DONOR WALL

34

A child reaching for the brassring on a carousel is symbolicof the most important goal ofthe Children’s DiabetesFoundation — a cure. Your con-tribution on behalf of a loved onewill make a difference. It willsupport treatment programs toassist children with diabetes inleading healthier lives and it willfund research to help CDF “catchthe brass ring” by finding a cure.

Mark an anniversary, birthday,special occasion; express appreci-ation or make a memorial tributein honor of someone special witha contribution — for any amount— to the Children’s DiabetesFoundation at Denver. We nowaccept gifts on-line.Donations are tax deductible. Tax ID #84-0745008

Enclosed is my Contribution of $ ___________________

In memory of ______________________________________Or in honor of _____________________________________Occasion _________________________________________

Please send acknowledgements to:(Amount of gift will not be mentioned)

Name ____________________________________________Address __________________________________________City __________________ State ________ Zip ___________

FromName ____________________________________________Address __________________________________________City __________________ State ________ Zip ___________

NEWSNOTES is published twice ayear by the Children’s DiabetesFoundation at Denver. We wel-come your comments. If you would like to submit an article or a letter to NEWSNOTESsend information to:

Children’s Diabetes Foundation at Denver777 Grant Street, Suite 302Denver, CO 80203

Hilary Talocco Christine LernerEditors

Cindy BartonGraphic Designer

Dorothy HarringtonAssociate Editor

Know the symptoms ofChildhood Diabetes:• Loss of weight• Extreme thirst• Excessive irritability• Frequent

Children’s Diabetes Foundation at Denver777 Grant Street, Suite 302, Denver, CO 80203

303-863-1200, 800-695-2873, www.ChildrensDiabetesFdn.org

Printed on Recycled Paper

The BrassRing FundRemember a loved one ––Help CDF “Catch the Brass Ring”

EXECUTIVE BOARD:Mrs. Marvin Davis, ChairmanRichard S. Abrams, M.D.Jules Amer, M.D.Ms. Dana Davis Mrs. Nancy Davis-RickelSteven Farber, Esq.Mr. Gerald S. GrayRichard F. Hamman, M.D., DrPHDepartment Chair, Preventive Medicine and Biometrics University of Colorado Health Sciences CenterMrs. A. Barry HirschfeldM. Douglas Jones, Jr., M.D.Richard D. Krugman, M.D. Dean, School of Medicine, University of Colorado HealthSciences CenterMr. Matthew J. LynettMr. Arnold C. Pohs

EX-OFFICIO MEMBER:George S. Eisenbarth, M.D., Ph.DExecutive Director, Barbara Davis Center for ChildhoodDiabetes, University of Colorado Health Sciences Center;Professor of Pediatrics and Medicine, University of ColoradoSchool of Medicine

SCIENTIFIC ADVISORY BOARD:Richard S. Abrams, M.D.Associate Clinical Professor of Medicine, University of ColoradoSchool of Medicine; Rose Medical Center, DenverJules Amer, M.D.Clinical Professor of Pediatrics, University of Colorado School ofMedicine; Partner, Children’s Medical Center, DenverM. Douglas Jones, Jr., M.D.Professor and Chairman, Department of Pediatrics, Universityof Colorado School of Medicine; Pediatrician-in-Chief, TheChildren’s Hospital, DenverBrian Kotzin, M.D.Professor of Immunology, University of Colorado School ofMedicine; National Jewish Center for Immunology andRespiratory Medicine, Denver

Aké Lernmark, M.D., Ph.D.Robert H. William Professor, Department of Medicine,University of Washington School of Medicine, SeattleAli Naji, M.D., Ph.D.J. William White Professor of Surgery, Hospital of University ofPennsylvania, PhiladelphiaGerald Nepom, M.D., Ph.D.Scientific Director and Director of Immunology and DiabetesResearch Programs, Virginia Mason Research Center, SeattleWilliam V. Tamborlane, M.D.Professor of Pediatrics, Yale University School of Medicine, NewHaven, Connecticut

ADVISORY BOARD:Mrs. Alan AngelichMr. and Mrs. Rand V. AraskogMrs. John AylsworthMr. Michael BoltonMrs. Joseph BroughtonMrs. Franklin L. BurnsSir Michael CaineDr. Bonita Carson Ms. Natalie Cole Mr. Phil CollinsMr. Lodwrick M. CookMrs. John CoweeMr. and Mrs. Robert A. DalyMrs. Thomas P. D’AmicoMr. Tony DanzaThe Honorable Diana DeGette,

U.S. House of Representatives, ColoradoMr. Neil DiamondMr. Placido DomingoMiss Donna DouglasPresident and Mrs. Gerald R. FordMr. David FosterMrs. Joseph FranzgroteMrs. Sally FrerichsMr. Kenny GMr. David GeffenMr. Merv GriffinMrs. Warren HanksMs. Whitney HoustonMrs. Walter ImhoffMrs. Olé T. Jensen

Mr. and Mrs. John H. JohnsonMr. Quincy JonesMrs. Michael JultakDr. Henry A. KissingerMrs. Robert KniselyMs. Sherry LansingMr. Jay LenoMrs. Suzy LoveMr. Paul MarcianoMiss Dina MerrillMr. Myron M. MillerSir Roger MooreEvelyn and Mo OstinThe Honorable and Mrs. Bill Owens,

Governor and First Lady of ColoradoSir Sidney PoitierMrs. Calvin PopeMrs. Ronald ReaganMr. Lionel RichieMrs. Sheldon RogerMr. Kenny RogersMiss Diana RossMrs. Florence RustonMrs. Adrienne Ruston FitzgibbonsMr. George SchlatterThe Honorable Arnold Schwarzenegger and Ms. Maria Shriver, Governor

and First Lady of CaliforniaAlan and Sandra SilvestriMr. Steven Spielberg and Ms. Kate CapshawMrs. Robert J. StewartMrs. Diane SweatMrs. Robert TuckerMrs. Thomas N. TuckerMiss Joan van ArkMrs. Peter WeingartenMrs. Luanne WellsMs. Barbera Thornhill

and Mr. Gary L. WilsonMr. Henry WinklerMr. Stevie Wonder

FOUNDATION:Christine Lerner, Executive DirectorSue Palandri, Program Director������������

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The Carousel of H

ope1 2

5

7

6

3

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1. Berry Gordy & Clive Davis2. James & Linda Caan3. Tom & Shelby Arnold4. Ed McMahon5. Barbara Davis & Invocation Child,

Tyler Smith6. Jane Krakowski7. Tony Danza & Vanna White �

CAROUSEL OF HOPE 2004 MEMORIESCAROUSEL OF HOPE 2004 MEMORIES

Nonprofit Org.

U.S. POSTAGE

PAIDDenver, CO

Permit No. 1752

Children’s DiabetesFoundation at Denver, CO

777 Grant Street, Suite 302Denver, CO 80203

Address Service Requested

Holly Robinson-Peete, Beyoncé Knowles, Halle Berry, Oprah Winfrey and Barbara Davis