childhood headaches §dr adi aran §neuropediatric unit §szmc
TRANSCRIPT
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Childhood headaches
Dr Adi AranNeuropediatric UnitSZMC
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Childhood Headaches -Occur in approx. 35% of
children by 7 years of age and 50% of children by 15.
Frequent headache occure in approx. 2.5 % of children by 7 years of age and 15% of children by 15.
-Parents are looking for reassurance that the headache is not due to a serious cause
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Where the pain coming from?
Not - the brain, most of the meninges overlying the brain and the bony skull
Pain referred to the head can arise from: Extra/Intra-cranial arteries and veins Cranial or spinal nerves Basal meninges Cranial or cervical muscles Extracranial structures (sinuses, teeth, etc.)
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Pathogenesis of pain- cont.
Cranial circ. & supratentorial structures exhibit pain via the trigeminal nerve
Posterior fossa structures exhibit pain via the first three cranial nerves, the vagus nerve and the glossopharyngeal nerve
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Categorize the Headache Acute
Acute recurrent
Chronic non-progressive
Chronic progressive
Mixed
time
severity
time
severity
time
severity
time
severity
time
severity
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An Isolated, Acute Headache
Causes: Viral illness Sinusitis Migraine Dental abscess Intracranial hemorrhage w/ or w/o
trauma Hypertension Meningitis
All of the children with serious underline condition had one or more objective finding on neurological examination
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Other common Headaches
Migraine Headache (Acute recurrent)
Stress-Related (Tension) Headache (Chronic non progressive)
Headache Due to Increased ICP (Chronic progressive)
Cluster Headache (Acute recurrent)
Migraine superimposed on Stress-Related (Tension) Headache (mixed)
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As Usual-Take a Good History
Characteristics of a typical episode Location Intensity of pain Duration Frequency Preceding aura? Associated symptoms (GI, visual, neuro)
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Other Good Questions
What makes the headache better or worse?When do the headaches occur?Any known triggers or stressors?
School, lack of sleep, problems in the family
Any medications?Any pertinent family history?
Allergies, migraines
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A Focused Physical Exam Growth Parameters Blood Pressure Head Circumference Head and neck palpation Fundoscopic Exam Complete Neurologic
Examination Skin More than 98% of
children with brain tumors have objective neurologic findings
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Neuroimaging – pros and cons Pros – some times it is the only thing that will assist the parents (and the doctor) to sleep at night.
Cons – it is not cost- effective - the vast majority of children in Israel will undergo CT scan.
- The estimates of lifetime attributable risk for fatal cancer from
one current generation CT scan range from 1 per 2000 scans for
young infants to 1 per 5000for those 10 years old. - Low doses of inoising radiation in infancy may adversely affect cognitive abilities
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Indications For A Scan
Any neurologic abnormalitySigns of increased intracranial pressure
Papilledema HA’s or vomiting at night or awakening. Pain is worsened with sneezing, coughing, etc. Chronic progressive pattern
Worst headache of life Presence of neurocutaneus syndrome Presence of V-P shunt Age younger than three years Unvarying location of headaches
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Is an LP indiciated?
After brain imaging Herniation is bad!
If pseudotumor cerebri is suspected
Elevated opening pressure
Partial relief in HA
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Migraines in Childhood
Most common cause of intermittent HA’s in childhood
The prevalence in children under 7 years old is higher in boys and after 11 years is higher in girls.
Diagnosis is based on classical symptoms
0%
1%
2%
3%
4%
5%
6%
Migraineincidence
Age 7Age 15
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Criteria for Diagnosis of pediatric migraine without aura (ICHD, IHS – 2004)
A. Five or more attacks fulfilling features B-D.B. Headache attack lasting 1 to 72 hours.C. Episodes are accompanied by at least one of the following:
Photophobia and phonophobia Abdominal pain, nausea or vomiting
D. Episodes characterized by at least two of the following: Bilateral or unilateral ( frontal / temporal) location pulsatile pain Moderate to severe intensity Aggravated by routine physical activitiesNot a criteria: Complete relief after rest Family history of migraines
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Potential Migraine Triggers
Emotional or Physiological Stress Missing a meal, lack of sleep
Environmental FactorsFoods and Chemicals
Caffeine, chocolate, cheese, aspartame, etc.
Drugs Histamine-2 blockers, OCP’s, Ritalin.....
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Migraine with Aura (Classic)
Precedes the HA onset and lasts 5-20 minutes
What’s an aura? Flashing or colored
lights, dots, zigzags Scotomas Distortions of size
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Complicated Migraine
Migraine associated with a transient neurologic abnormality Hemiparesis, visual field defects, CN palsy
• Most common cause of CN-III palsy in children “Basilar” migraine
• Vertigo, ataxia, tinnitus, etc.
• More common in adolescent females
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Migraine Equivalent Episodes
Episodes that do not necessarily include headache, but believed to be of a migrainous etiology Confusional migraine Benign paroxysmal vertigo Alice in Wonderland Syndrome Abdominal migraine
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Stress-Related Headache
Also known as a tension headachePain is characteristically:
A “band-like” distribution Generally, a constant ache w/ some throbbing Usually constant
More common in older girls
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Similar to Common Migraine
Stress-Related More related to fatigue,
but do not readily respond to sleep
Minimal nausea Usually involve the
whole head
Common Migraine Respond to sleeping Nausea and vomiting
are characteristic Usually unilateral
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Increased Intracranial Pressure
Expanding lesion may cause progressive worsening of headaches Direct expansion Obstruction of CSF flow
Headache is worse at night or immediately after waking
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Other Cues That ICP is Elevated
Headache is worsened by maneuvers which raise venous pressure Bending over, coughing, straining
Transient obscurations of vision
Vomiting may provide temporary relief
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Look for Papilledema
It may not be seen in every instance of elevated ICP.
If seen, a Head CT or MRI is indicated prior to attempting an LP
Fig 19-105 from Zitelli: Atlas of Pediatric Physical Diagnosis, St. Louis, 1997, Mosby-Wolfe
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Causes of increased ICP
Neoplasm Mass-effect Resulting in obstructive hydrocephalus
Hydrocephalus Independent of or resulting from neoplasm
Pseudotumor cerebriSubdural hemorrhage
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Brain Tumors in Children
Etiology of headacheHeadaches occur in
60-65% of patients w/ brain tumors
Symptoms are: Worse on waking May improve with
vomiting
Contemporary Pediatrics, 16:11 November 1999, p86.
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Cluster Headaches
0
20
40
60
80
100
Male Female
Occurs rarely during adolescence
Recurrent, extreme, non-throbbing pain
Usually around an eye Eye watering Facial Flushing
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Other Headaches to Consider
Refractive errors Related to reading or working at a computer Providing eye rest improves symptom
Ictal or postictal phenomenon Poorly-controlled seizure d/o Head-grabbing in a developmentally delayed
patient?
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Management and Therapy for Recurrent Headaches
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Patient and Family Education
Reassurance that the etiology is benign
Explain the diagnosis and underlying cause
Help the patient recognize situations that precipitate and exacerbate headaches
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Acute Migraine Management
Sleep-effective in most attacks Sedatives may be helpful
Simple analgesics Less efficacious once an attack is established Neurophen is more effective than Acamol / Optalgin
Sumatriptan (Imitrex)Cafergot / Temigran (DHE)Migralev
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Sumatriptan (Imitrex)
A selective 5-HT agonist
(Relert, Naramig, Rizalt)Effective, but expensive
Dosage recommendations in children have not been fully established
Comes in a variety of preparations PO, Intranasal
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Prophylaxis Against Migraines
Identification of precipitating factors and subsequently avoiding them Food diary, family dynamics, school problems
Pharmacologic TherapyBehavioral therapy
Biofeedback Relaxation therapy Hypnosis
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One Form of Relaxation Therapy
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Another Form of Relaxation Therapy
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When to Use Pharmacotherapy
When the frequency of headaches interferes with the child’s daily functioning Missing school Nutritional concerns
Most regimens are based on adult practice or anecdotal reports
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Prophylactic Agents
Propranolol (deralin)– 1-4 mg/kg divided TID
Clonirit– 25 mcg x 2/d
Amitryptiline (Elavil)– Can be used for children 6 or older
Topamax
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Tension Headache Treatment
Acute attacks Simple analgesia, rest, and removal of stressors
is very effective
Chronic occurrence Identification of stressful situations Relaxation techniques, massage therapy and
acupuncture
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“Analgesic” Abuse Headache
AKA “Drug-induced Refractory” headacheA consequence of frequent analgesic use
Do not occur only with opiates Ergotamine, NSAIDS and acetaminophen have
also been cited as being causative
Treatment- Educating the patient and family on how to alter pattern of analgesic use
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A Little Review on Headaches
Take a thorough historyCategorize the headache Perform a physical exam
Any neurological abnormality or papilledema?
Head Imaging? LP?Acute TreatmentProphylaxis/Avoidance