chemistry in industry - a guidance to bsc, msc graduates in chemistry
TRANSCRIPT
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CHEMISTRY IN INDUSTRY
A GUIDANCE TO BSC MSC GRADUATES IN
CHEMISTRY
Sudhir Sawant PhD (Chemistry)
DGM – Synthesis & Process Development
Enalteclabs Pharma, Ambernath
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WHY MAKE IN INDIA?
Increasing overhead costs in Europe due to various economic reasons
and
Less availability of trained manpower.
European companies looking at India as an opportunity towards
establishing manufacturing sites in India….Why India?
well educated and trained man power, youngest average age about 30
years
Good english speaking population,
good communication skills – verbal & written
Flexible, systematic approach, talent pool.
Professional integrity and reliable professional
Government is encouraging direct foreign investments in SEZs in all
over India
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PHARMACEUTICALS
Organic Chemistry
Named reactions:
Enantioselective synthesis [Chiral synthesis] Corey-Itsuno -
Dapoxetine.HCl
Wittig Reaction : Rosuvastatin
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HOW WE DO WHAT WE DO? – GENERICS APIS
Project allotment
Literature survey
Laboratory experiments
Optimisation experiments
Scale up – Kilo lab, Pilot plant, Manufacturing plant
Validation campaign
Filing for USFDA approval
Commercialisation
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DAPOXETINE.HCL
Retrosynthetic analysis
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ENANTIOSELECTIVE SYNTHESIS
Corey−Itsuno Reduction of Ketones
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MECHANISM – CHIRAL SYNTHESIS
Reference: Corey−Itsuno Reduction of Ketones: A Development of Safe and
Inexpensive Process for Synthesis of Some API Intermediates
Rajendra D. Mahale,* Sudhir P. Chaskar, Kiran E. Patil, Golak C. Maikap,* and
Mukund K. Gurjar, Organic Process Research & Development., 2012, 16,
710−713
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DAPOXETINE SYNTHESIS – NAMED REACTIONS
Knoevenagel condensationReductive alkylation
Fischer Esterfication
Michael Addition
Reduction
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ROSUVASTATIN – WITTIG REACTION
TEMPO OXIDATION
WITTIG REACTION
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TPAP/ TEMPO OXIDATION
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TEMPO OXIDATION MECHANISM
Proposed mechanism for the oxidation of primary alcohols under basic
conditions
M. Angelin, M. Hermansson, H. Dong, O. Ramström, Eur. J. Org. Chem., 2006,
4323-4326
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ANALYTICAL CHEMISTRY
Wet chemistry
HPLC method development
HPLC/MS analysis
GC, GC/MS
Ion chromatography
Spectroscopic instrumental analysis: NMR, IR, MS, PXRD,
Single Crystal, DSC, TGA, Reaction Calorimetry
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OPPORTUNITIES
Synthesis development
Analytical development*
Intellectual property management*
Quality assurance
Regulatory affairs*
Manufacturing: “Make in India” initiative
Industrial Safety & environment: Fire safety*
* post graduate courses offered
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Consumer Health care : FMCG : Colgate Palmolive, HLL, Godrej,Femicare
Forensic Science Laboratory
Foods and Beverages industry : Cadbury, Nestle.
Speciality chemicals Industry : Ciba Vision,
Flavours and fragnances industry : IFF
Inorganic Chemicals industry : Tata Chemicals,
Agrochemical industry : Gharda Chemicals,
Veterinary medicines : Pfizer,
Petrochemical Industry: Reliance,
Construction / Ceramic chemicals :
Effluent treatment chemicals / Water treatment /softening chemicals
Textile industry:
OPPORTUNITIES
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AN ADVICE
Prepare well for your final Exams!
All the best!
Do not forget your teachers after exams are
over.
Keep in touch with them for guidance and
career opportunities.