chemistry 22.2-protein-synthesis-–-part-2
TRANSCRIPT
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Chapter 22 (Part 2)
Protein Synthesis
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Ribosomes
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Prokaryotic Ribosome Structure
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Eukaryotic Ribosome Structure
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Ribosome Assembly
• Assembly is coupled w/ transcription and pre-rRNA processing
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Ribosome Structure
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Identification of Initiator Codon in Prokaryotes
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Prokaryotic Translational Initiation
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Eukaryotic Initiation of Translation
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Recycling of EF-
Tu
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Peptide Bond formationN
NN
N
NH2
O
OHO
HHHH
O
5' tRNA
N
CH
C
H
O
N
NN
N
NH2
O
OHO
HHHH
O
5' tRNA
NH3+
CH
C
H
O
H
H
HBASE
H+
P-Site A-Site
N
NN
N
NH2
O
OHO
HHHH
O
5' tRNA
N
CH
C
H
O
N
NN
N
NH2
O
OHOH
HHHH
O
5' tRNA
NH3+
CH
C
H
O
HH
P-Site A-Site
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Formation of Peptide Bond
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More on elongation
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Regulation of Gene Expression
AAAAAA5’CAPmRNA
RNA Processing
RNA Degradation
Protein DegradationPost-translational modification
Activeenzyme
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Regulation of Globin gene
translation by heme
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