2008

Thiophene derivativesR 0090 Studies on a Series of Milnacipran Analogues Containing a Heteroaromatic

Group as Potent Norepinephrine and Serotonin Transporter Inhibitors. — Many compounds show higher potency as monoamine transporter inhibitor than milnacipran at NET and NET/SERT with no significant change in the lipophilicity. For example, (Ic) appears to be about 10-fold more potent than milnacipran. — (CHEN*, C.; et al.; Bioorg. Med. Chem. Lett. 18 (2008) 11, 3230-3235; Dep. Med. Chem., Neurocrine Biosci., Inc., San Diego, CA 92121, USA; Eng.) — H. Toeppel

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