cheminform abstract: one-step synthesis of heteroaromatic-fused pyrrolidines via cyclopropane...

2008 Fused pyrrole derivatives R 0160 One-Step Synthesis of Heteroaromatic-Fused Pyrrolidines via Cyclopropane Ring-Opening Reaction: Application to the PKCβ Inhibitor JTT-010. — The cyclopropane ring-opening reaction with five-membered aromatics affords fused heteroaromatic products in one step and moderate yield. The method is successfully applied to the synthesis of the protein kinase inhibitor (XIV). — (TANAKA, M.; UBUKATA, M.; MATSUO, T.; YASUE, K.; MATSUMOTO, K.; KAJIMOTO, Y.; OGO, T.; INABA*, T.; Org. Lett. 9 (2007) 17, 3331-3334; Cent. Pharm. Res. Inst., Japan Tobacco Inc., Takatsuki, Osaka 569, Japan; Eng.) — R. Steudel 01- 111

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Page 1: ChemInform Abstract: One-Step Synthesis of Heteroaromatic-Fused Pyrrolidines via Cyclopropane Ring-Opening Reaction: Application to the PKCβ Inhibitor JTT-010

2008

Fused pyrrole derivativesR 0160 One-Step Synthesis of Heteroaromatic-Fused Pyrrolidines via Cyclopropane

Ring-Opening Reaction: Application to the PKCβ Inhibitor JTT-010. — The cyclopropane ring-opening reaction with five-membered aromatics affords fused heteroaromatic products in one step and moderate yield. The method is successfully applied to the synthesis of the protein kinase inhibitor (XIV). — (TANAKA, M.; UBUKATA, M.; MATSUO, T.; YASUE, K.; MATSUMOTO, K.; KAJIMOTO, Y.; OGO, T.; INABA*, T.; Org. Lett. 9 (2007) 17, 3331-3334; Cent. Pharm. Res. Inst., Japan Tobacco Inc., Takatsuki, Osaka 569, Japan; Eng.) — R. Steudel

01- 111

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