cheminform abstract: k2co3-mediated, one-pot, multicomponent synthesis of medicinally potent...

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ChemInform 2012, 43, issue 01 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Pyridine derivatives R 0380 DOI: 10.1002/chin.201243150 K 2 CO 3 -Mediated, One-Pot, Multicomponent Synthesis of Medicinally Potent Py- ridine and Chromeno[2,3-b]pyridine Scaffolds. — An efficient potassium carbon- ate-catalyzed three-component reaction of malononitrile (I) with a wide variety of al- dehydes (II), (V), (VII) and thiols (III), (VIII) is presented to afford dihydropyrimidine intermediates which are aromatized with potassium permanganate. Potassium carbon- ate also catalyzes the cyclization of salicylic aldehyde derivatives (X) and (XII) with malononitrile (I) and thiols (VIII). — (MISHRA, S.; GHOSH*, R.; Synth. Commun. 42 (2012) 15, 2229-2244, http://dx.doi.org/10.1080/00397911.2011.555284 ; Dep. Chem., Jadavpur Univ., Kolkata 700 032, India; Eng.) — M. Bohle 43- 150

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Page 1: ChemInform Abstract: K2CO3-Mediated, One-Pot, Multicomponent Synthesis of Medicinally Potent Pyridine and Chromeno[2,3-b]pyridine Scaffolds

Pyridine derivativesR 0380 DOI: 10.1002/chin.201243150

K2CO3-Mediated, One-Pot, Multicomponent Synthesis of Medicinally Potent Py-ridine and Chromeno[2,3-b]pyridine Scaffolds. — An efficient potassium carbon-ate-catalyzed three-component reaction of malononitrile (I) with a wide variety of al-dehydes (II), (V), (VII) and thiols (III), (VIII) is presented to afford dihydropyrimidine intermediates which are aromatized with potassium permanganate. Potassium carbon-ate also catalyzes the cyclization of salicylic aldehyde derivatives (X) and (XII) with malononitrile (I) and thiols (VIII). — (MISHRA, S.; GHOSH*, R.; Synth. Commun. 42 (2012) 15, 2229-2244, http://dx.doi.org/10.1080/00397911.2011.555284 ; Dep. Chem., Jadavpur Univ., Kolkata 700 032, India; Eng.) — M. Bohle

43- 150

ChemInform 2012, 43, issue 01 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Page 2: ChemInform Abstract: K2CO3-Mediated, One-Pot, Multicomponent Synthesis of Medicinally Potent Pyridine and Chromeno[2,3-b]pyridine Scaffolds

ChemInform 2012, 43, issue 01 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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