cheminform abstract: chemical and enzymatic synthesis of glycoconjugates. part 5. one-pot...

1999 carbohydrates carbohydrates U 0500 19 - 229 Chemical and Enzymatic Synthesis of Glycoconjugates. Part 5. One- Pot Regioselective Synthesis of Bioactive Galactobiosides Using a Clonezyme10s Thermophilic Glycosidase Library. — An eﬃcient enzymatic one-pot procedure to prepare disaccharides is developed. The enzymatic self-transglycosylation occurs in good yield, whereas tandem-transglycosylation aﬀords the desired products in only low yield [cf. (VIII)]. Gly001-06 prefers β1 → 4 linkage, while α1 → 3 linkage can be achieved by using Gly001-10. — (LI, JUN; ROBERTSON, DAN E.; SHORT, JAY M.; WANG, PENG GEORGE; Bioorg. Med. Chem. Lett. 9 (1999) 1, 35-38; Dep. Chem., Wayne State Univ., Detroit, MI 48202, USA; EN) 1

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Page 1: ChemInform Abstract: Chemical and Enzymatic Synthesis of Glycoconjugates. Part 5. One-Pot Regioselective Synthesis of Bioactive Galactobiosides Using a Clonezyme10s Thermophilic Glycosidase

1999 carbohydrates

carbohydratesU 0500

19 - 229Chemical and Enzymatic Synthesis of Glycoconjugates. Part 5. One-Pot Regioselective Synthesis of Bioactive Galactobiosides Using aClonezyme10s Thermophilic Glycosidase Library. — An efficient en-zymatic one-pot procedure to prepare disaccharides is developed. The enzymaticself-transglycosylation occurs in good yield, whereas tandem-transglycosylationaffords the desired products in only low yield [cf. (VIII)]. Gly001-06 prefers β1→ 4 linkage, while α1→ 3 linkage can be achieved by using Gly001-10. — (LI,JUN; ROBERTSON, DAN E.; SHORT, JAY M.; WANG, PENG GEORGE;Bioorg. Med. Chem. Lett. 9 (1999) 1, 35-38; Dep. Chem., Wayne State Univ.,Detroit, MI 48202, USA; EN)

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