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ChemInform 2012, 43, issue 08 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Metathesis reactions O 0286 DOI: 10.1002/chin.201208050 A New General Approach for the Stereocontrolled Synthesis of Functionalized γ- and δ-Lactams. — A general stereoselective synthesis of functionalized γ- and δ-lactams using the Overman rearrangement to install the key C—N bond and a ring closing metathesis reaction to form the ring is developed. The application of this ap- proach for the synthesis of the Boc-derivative of (-)-coniine (XI) is described. — (DALY, M.; GILL, K.; SIME, M.; SIMPSON, G. L.; SUTHERLAND*, A.; Org. Biomol. Chem. 9 (2011) 19, 6761-6770, http://dx.doi.org/10.1039/c1ob05833a ; WestCHEM, Sch. Chem., Univ. Glasgow, Glasgow G12 8QQ, UK; Eng.) — Bartels 08- 050

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Page 1: ChemInform Abstract: A New General Approach for the Stereocontrolled Synthesis of Functionalized γ- and δ-Lactams

Metathesis reactionsO 0286 DOI: 10.1002/chin.201208050

A New General Approach for the Stereocontrolled Synthesis of Functionalizedγ- and δ-Lactams. — A general stereoselective synthesis of functionalized γ- and δ-lactams using the Overman rearrangement to install the key C—N bond and a ring closing metathesis reaction to form the ring is developed. The application of this ap-proach for the synthesis of the Boc-derivative of (-)-coniine (XI) is described. — (DALY, M.; GILL, K.; SIME, M.; SIMPSON, G. L.; SUTHERLAND*, A.; Org. Biomol. Chem. 9 (2011) 19, 6761-6770, http://dx.doi.org/10.1039/c1ob05833a ; WestCHEM, Sch. Chem., Univ. Glasgow, Glasgow G12 8QQ, UK; Eng.) — Bartels

08- 050

ChemInform 2012, 43, issue 08 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Stereocontrolled Total Synthesis of (-)

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Announcements · pts 7 RCTs b-lactams vs. glycopeptides SSI 30 days post-op RR 1.14 (95% CI 0.91-1.42) Chambers et al Clean & clean-contaminated procedures 14 RCTs b-lactams vs. glycopeptides

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RESEARCHARTICLE Assessingtheinformationcontent ......Rodríguez‑Pérezet al. J Cheminform Page6of14 whichyieldedmedianMCCvaluesof0.67(IFP_85) and0.63(EFCP_folded).us,inhibitorswithbinding

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