characteristics useful for the diagnosis and classification of non-lymphoid neoplasms gross...
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Characteristics Useful for the Diagnosis and Classification of Non-Lymphoid Neoplasms
Gross Pathology Counts and Cytology
Blood Bone Marrow
Lineage Assessment Flow Immunophenotyping Cyto- and
Immunohistochemistry Immune Receptor Gene
Rearrangements
Genetics Clonality Alterations in
Oncogenes/Tumor Suppressors
Gene Expression Patterns Biological
Characteristics Disease Course Transplantation
Gross Pathology Organ Size, Color, Appearance
Particularly Spleen, Liver, Lymph Nodes
Color of Bone Marrow Presence of Inflammatory Lesions Presence of Non-hematopoietic
Tumors
Counts and Cytology Peripheral Blood
Total White Blood Cell Count White Blood Cell Differential Count including
Presence of Young Forms (Blasts) Presence of Abnormal Leukocyte Morphology Hemoglobin
Bone Marrow Nucleated Cell Differential Count Percentage Young Forms (Blasts) Presence of Abnormal Megakaryocytes, Erythroid
Cells, or Granulocytes
Lineage Assessment of Young Forms and Accompanying Cells Immunophenotyping of Blood, Bone Marrow Cytochemical & Immunohistochemical Stains
Histopathology of Bone Marrow, Organs and Other Tissues
Amount, Appearance, and Location of Myeloid Cells
Disappearance of Normal Cell Types Disruption of Normal Architecture Spread into Adjacent Structures
Genetics Assessment of Clonality:
Karyotype, Proviral Integrations, Immune Receptor Gene Rearrangements
Alterations in Oncogenes/Tumor Suppressor Genes
Gene Expression Patterns
Biological Features-Disease Course Time from Detection of Illness by Observation
and Physical Examination Time from Detection of Illness by Peripheral
Blood Abnormalities
Biological Features-Transplantation Variables include
Number of cells injected Route of injection Character of disease in recipient
(localized vs. disseminated) Type of recipient
Immunodeficient, Nude Immunodeficient, Other Histocompatible, lethally irradiated Histocompatible, sub-lethally irradiated Histocompatible, unirradiated
Time from transplantation to illness