chapter 43 · chapter 43 the pathophysiology and differential diagnosis of acute respiratory...

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Chapter 43REFERENCES 1. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368. 2. Friedman G, De Backer D, Shahala M, Vincent JL. Oxygen dependency can characterize septic shock. Intensive Care Med. 1998;24:118-123. 3. Schumacker PT. Oxygen supply dependency in critical illness: an evolving understanding. Intensive Care Med. 1998;24:97-99. 4. Bakker J, Gris P, Coffernils M, Kahn R, Vincent J. Serial blood lactate levels can predict the development of multiple organ failure in septic shock. Am J Surg. 1995;171:221-226. 5. Powers SR, Mannal R, Neclerio, M, et al. Physiologic con- sequences of positive end expiratory pressure. Ann Surg. 1973;3:265-271. 6. Danek SJ, Lynch JP, Weg JG, et al. The dependence of oxygen uptake on oxygen delivery in the adult respiratory distress syn- drome. Am Rev Resp Dis. 1980;122;387-395. 7. Mohsenifar Z, Jasper AC, Koerner SK. Relationship between oxygen uptake and oxygen delivery in patients with pulmonary hypertension. Am Rev Resp Dis. 1988;138:69-73. 8. Archic JP Jr. Mathematical coupling of data: a commons source of error. Ann Surg. 1981;193:296-303. 9. Phang PT, Cunningham KF, Ronco JJ, Wiggs BR, Russel JA. Mathematical coupling explains dependence of oxygen con- sumption on oxygen delivery in ARDS. Am J Respir Critical Care Med. 1994;150:318-323. 10. Wood LDH. The respiratory system. In: Hall JB, Schmidt GA, Wood LDH, eds. Principles of Critical Care. New York: McGraw- Hill; 1992:3. 11. Hall JB, Wood LDH. Oxygen therapy in the critically ill patient. In: Hall JB, Schmidt GA, Wood LDH, eds. Principles of Critical Care. New York: McGraw-Hill; 1992:165. 12. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, ran- domized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999;340(6):409-417. 13. Koval KJ, Rosenberg AD, Zuckerman JD, et al. Does blood transfusion increase the risk of infection after hip fracture? J Orthopaedic Trauma. 1997;11:260. 14. Houbiers JG, van de Velde CJ, van de Watering LM, et al. Transfusion of red cells is associated with increased incidence of bacterial infection after colorectal surgery: a prospective study. Transfusion. 1997;37:126. 15. Manthous CA, Hall JB, Kushner R, et al. The effect of mechani- cal ventilation on oxygen consumption in critically ill patients. Am J Respir Crit Care Med. 1995;151:210. 16. Kress JP, Pohlman AS, Alverdy J, Hall JB. The impact of morbid obesity on oxygen cost of breathing at rest. Am J Respir Crit Care Med. 1999;160:883. 17. Manthous CA, Hall JB, Olson D, et al. Effect of cooling on oxygen consumption in febrile critically ill patients. Am J Respir Crit Care Med. 1995;151:10. 18. Schumacker PT, Rowland J, Saltz S, et al. Effects of hyperther- mia and hypothermia on oxygen extraction by tissues in hypo- volemia. J Appl Physiol. 1987;63:1246. 19. Walley KR. Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory. J Appl Physiol. 1996;81:885. 20. Schumacker PT, Samsel RW. Analysis of oxygen delivery and uptake relationships in the Krogh tissue model. J Appl Physiol. 1989;67:1234. 21. Vary TC. Increased pyruvate dehydrogenase kinase activity in response to sepsis. Am J Physiol. 1991;260:E669. 22. Curtis SE, Cain SM. Regional and systemic oxygen deliver/ uptake relations and lactate flux in hyperdynamic, endotoxin treated dogs. Am Rev Respir Dis. 1992;145:348. 23. Siegel JH, Cerra FB, Coleman B, et al. Physiologic and metabolic correlations in human sepsis. Surgery. 1979;86:163. 24. Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively down- regulating mitochondrial oxygen consumption. Cell Metab. 2006;3:187-197. 25. Crouser ED. Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion. 2004;4:729-741. 26. Ronco JJ, Fenwick JC, Wiggs JR, et al. Oxygen consumption is independent of increases in oxygen delivery by dobutamine in septic patients who have normal or increased plasma lactate. Am Rev Respir Dis. 1993;147:25. 27. Manthous CA, Schumacker PT, Pohlman A, et al. Absence of supply dependent of oxygen consumption in patients with septic shock. J Crit Care. 1993;8:203. 28. Gutierrez G, Bismar H, Dantzker DR, et al. Comparison of gastric intramucosal pH with measures of oxygen transport Section04-O-ref.indd 1 1/21/2015 11:23:12 AM

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Chapter 43The Pathophysiology and Differential Diagnosis of Acute Respiratory FailureEdward T. NaureckasLawrence D.H. Wood

REFERENCES

1. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368.

2. Friedman G, De Backer D, Shahala M, Vincent JL. Oxygen dependency can characterize septic shock. Intensive Care Med. 1998;24:118-123.

3. Schumacker PT. Oxygen supply dependency in critical illness: an evolving understanding. Intensive Care Med. 1998;24:97-99.

4. Bakker J, Gris P, Coffernils M, Kahn R, Vincent J. Serial blood lactate levels can predict the development of multiple organ failure in septic shock. Am J Surg. 1995;171:221-226.

5. Powers SR, Mannal R, Neclerio, M, et al. Physiologic con-sequences of positive end expiratory pressure. Ann Surg. 1973;3:265-271.

6. Danek SJ, Lynch JP, Weg JG, et al. The dependence of oxygen uptake on oxygen delivery in the adult respiratory distress syn-drome. Am Rev Resp Dis. 1980;122;387-395.

7. Mohsenifar Z, Jasper AC, Koerner SK. Relationship between oxygen uptake and oxygen delivery in patients with pulmonary hypertension. Am Rev Resp Dis. 1988;138:69-73.

8. Archic JP Jr. Mathematical coupling of data: a commons source of error. Ann Surg. 1981;193:296-303.

9. Phang PT, Cunningham KF, Ronco JJ, Wiggs BR, Russel JA. Mathematical coupling explains dependence of oxygen con-sumption on oxygen delivery in ARDS. Am J Respir Critical Care Med. 1994;150:318-323.

10. Wood LDH. The respiratory system. In: Hall JB, Schmidt GA, Wood LDH, eds. Principles of Critical Care. New York: McGraw-Hill; 1992:3.

11. Hall JB, Wood LDH. Oxygen therapy in the critically ill patient. In: Hall JB, Schmidt GA, Wood LDH, eds. Principles of Critical Care. New York: McGraw-Hill; 1992:165.

12. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, ran-domized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999;340(6):409-417.

13. Koval KJ, Rosenberg AD, Zuckerman JD, et al. Does blood transfusion increase the risk of infection after hip fracture? J Orthopaedic Trauma. 1997;11:260.

14. Houbiers JG, van de Velde CJ, van de Watering LM, et al. Transfusion of red cells is associated with increased incidence of

bacterial infection after colorectal surgery: a prospective study. Transfusion. 1997;37:126.

15. Manthous CA, Hall JB, Kushner R, et al. The effect of mechani-cal ventilation on oxygen consumption in critically ill patients. Am J Respir Crit Care Med. 1995;151:210.

16. Kress JP, Pohlman AS, Alverdy J, Hall JB. The impact of morbid obesity on oxygen cost of breathing at rest. Am J Respir Crit Care Med. 1999;160:883.

17. Manthous CA, Hall JB, Olson D, et al. Effect of cooling on oxygen consumption in febrile critically ill patients. Am J Respir Crit Care Med. 1995;151:10.

18. Schumacker PT, Rowland J, Saltz S, et al. Effects of hyperther-mia and hypothermia on oxygen extraction by tissues in hypo-volemia. J Appl Physiol. 1987;63:1246.

19. Walley KR. Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory. J Appl Physiol. 1996;81:885.

20. Schumacker PT, Samsel RW. Analysis of oxygen delivery and uptake relationships in the Krogh tissue model. J Appl Physiol. 1989;67:1234.

21. Vary TC. Increased pyruvate dehydrogenase kinase activity in response to sepsis. Am J Physiol. 1991;260:E669.

22. Curtis SE, Cain SM. Regional and systemic oxygen deliver/uptake relations and lactate flux in hyperdynamic, endotoxin treated dogs. Am Rev Respir Dis. 1992;145:348.

23. Siegel JH, Cerra FB, Coleman B, et al. Physiologic and metabolic correlations in human sepsis. Surgery. 1979;86:163.

24. Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively down-regulating mitochondrial oxygen consumption. Cell Metab. 2006;3:187-197.

25. Crouser ED. Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion. 2004;4:729-741.

26. Ronco JJ, Fenwick JC, Wiggs JR, et al. Oxygen consumption is independent of increases in oxygen delivery by dobutamine in septic patients who have normal or increased plasma lactate. Am Rev Respir Dis. 1993;147:25.

27. Manthous CA, Schumacker PT, Pohlman A, et al. Absence of supply dependent of oxygen consumption in patients with septic shock. J Crit Care. 1993;8:203.

28. Gutierrez G, Bismar H, Dantzker DR, et al. Comparison of gastric intramucosal pH with measures of oxygen transport

Section04-O-ref.indd 1 1/21/2015 11:23:12 AM

References2

and consumption in critically ill patients. Crit Care Med. 1992;20:451.

29. Dantzker RM. Gas exchange in the adult respiratory distress syndrome. Clin Chest Med. 1982;3:57.

30. Wagner P, Dantzker D, Dueck D, et al. Ventilation-perfusion inequality in chronic obstructive pulmonary disease. J Clin Invest. 1977;59:203.

31. Torres A, Reyes A, Roca J, et al. Ventilation-perfusion mis-matching in chronic obstructive pulmonary disease during ventilator weaning. Am Rev Respir Dis. 1989;140:1246.

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33. Agusti AGN, Roca J, Gea J, et al. Mechanisms of gas exchange impairment in idiopathic pulmonary fibrosis. Am Rev Respir Dis. 1991;143:219.

34. Gottfried SB, Rossi A, Higgs BD, et al. Noninvasive determi-nation of respiratory system mechanics during mechanical ventilation for acute respiratory failure. Am Rev Respir Dis. 1985;131:414.

35. Ranieri VM, Eissa NT, Corbeil C, et al. Effects of positive end-expiratory pressure on alveolar recruitment and gas exchange in patients with the adult respiratory distress syndrome. Am Rev Respir Dis. 1991;144:544.

36. Malo J, Ali J, How does PEEP reduce intrapulmonary shunt in canine pulmonary edema J Appl Physiol. 1984;57:1002.

37. Roussos C. Respiratory muscle fatigue and ventilatory failure. In: Hall JB, Schmidt GA, Wood LDH, eds. Principles of Critical Care. New York: McGraw-Hill;1992;1701.

38. Palm KH, Decker WW. Acute exacerbations of chronic obstruc-tive pulmonary disease. Emerg Med Clin North Am. 2003;21:331.

39. Rodrigo GJ, Rodrigo C, Hall JB. Acute asthma in adults: a review. Chest. 2004;125:1081.

40. Light RB, Mink SN, Wood LDH. The pathophysiology of gas exchange and pulmonary perfusion in pneumococcal lobar pneumonia in dogs. J Appl Physiol. 1981;50:524.

41. Rodriguez W, Hanania N, Guy E, Guntupalli J. Pulmonary-renal syndromes in the intensive care unit. Crit Care Clin. 2002;18:881.

42. The National Heart L, Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342(18):1301-1308.

43. Brower RG, Lanken PN, Macintyre N, et al. National Heart Lung and Blood Institute ARDS Clinical Trials Network. NEJM. 2004;351: 327-336.

44. Wiedemann HP, Wheeler AP, Bernard GR, et al. Comparison of two fluid-management strategies in acute lung injury. NEJM. 2006;354(24):2564-2575.

45. Raju P, Manthous CA. The pathogenesis of respiratory failure: an overview. Respir Care Clin North Am. 2000;6:195.

46. Ali J. Special considerations in the surgical patient. In: Hall JB, Schmidt GA, Wood LDH, eds. Principles of Critical Care. New York: McGraw-Hill; 1998:1289.

47. Alexander JL, Horton PW, Millar WT, et al. The effect of upper abdominal surgery on the relationship of airway closing point to end tidal position. Clin Sci. 1972;43:137.

48. Ali J, Weisel RD, Layug AB, et al. Consequences of postoperative alterations in respiratory mechanics. Am J Surg. 1974;128:376.

49. Ford GT, Whitelaw WA, Rosenal TW, et al. Diaphragm function after upper abdominal surgery in humans. Am Rev Respir Dis. 1983;127:431.

50. Craig DB, Wahba WM, Don HF, et al. “Closing volume” and its relationship to gas exchange in seated and supine positions. J Appl Physiol. 1971;31:717.

51. Hoeppner VH, Cooper DM, Zamel N, et al. Relationship between elastic recoil and closing volume in smokers and non-smokers. Am Rev Respir Dis. 1974;109:81.

52. Ali J, Yaffe C, Serrette C. The effect of transcutaneous electric nerve simulation on postoperative pain and pulmonary func-tion. Surgery. 1981;89:507.

53. Warner MA, Divertie MB, Tinker JH. Preoperative cessation of smoking and pulmonary complications in coronary artery bypass patients. Anesthesiology. 1984;60:380.

54. Gottfried SB, Rossi A, Higgs BD, et al. Noninvasive determina-tion of respiratory system mechanics during mechanical venti-lation for respiratory failure. Am Rev Respir Dis. 1985;131:414.

55. Ward ME, Magder SA, Hussain SNA. Oxygen delivery- independent effect of blood flow on diaphragm fatigue. Am Rev Respir Dis. 1992;145:1058.

56. Vassilakopoulos T, Petrof BJ. Ventilator-induced diaphragmatic dysfunction. Am J Respir Crit Care Med. 2004;169:336.

57. Respiratory Muscle Fatigue Workshop Group. NHLBI Workshop Summary: Respiratory muscle fatigue. Am Rev Respir Dis. 1990;142:474.

58. Mador MJ. Respiratory muscle fatigue and breathing pattern. Chest. 1991;100:1430.

59. Jabour ER, Rabil DM, Truwit JD, et al. Evaluation of a new weaning index based on ventilatory endurance and the effi-ciency of gas exchange. Am Rev Respir Dis. 1991;144:531.

60. Yang KL, Tobin MJ. A prospective study of indexes predicting the outcome of trials of weaning from mechanical ventilation. N Engl J Med. 1991;324:1445.

61. Viires N, Sillie G, Aubier A, et al. Regional blood flow distribu-tion in dogs during induced hypotension and low cardiac out-put: spontaneous breathing versus artificial ventilation. J Clin Invest. 1983;72:935.

62. Smith TC, Marini JJ. Impact of PEEP on lung mechanics and work of breathing in severe airflow obstruction. J Appl Physiol. 1988;65:1488.

63. Chao DC, Scheinhorn DJ, Stearn-Hassenpflug M. Patient-ventilator trigger asynchrony in prolonged mechanical ventila-tion. Chest. 1997;112:1592-1599.

64. MacIntyre NR, Cook DJ, Ely EW, et al. Evidence based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the American College of Chest Physicians, the American Association for Respiratory Care, and the American College of Critical Care Medicine. Chest. 2001;120:375S.

65. Hall JB, Wood LDH. Liberation of the patient from mechanical ventilation. JAMA. 1991;257:1621-1628.

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66. Talpers SS, Romberger DJ, Bunce SB, Pingleton SK. Nutritionally associated increased carbon dioxide production. Chest. 1992;102:551.

67. Aubier M, Murciano D, Lecocguic Y, et al. Hypophosphatemia-associated respiratory muscle weakness in a general inpatient population. Am J Med. 1988;84:870.

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70. Lacomis D, Campellone JV. Critical illness neuromyopathies. Adv Neurol. 2002;88:325.

71. Schweickert WD, Hall J. ICU-acquired weakness. Chest. 2007;131:1541-1549.

72. Schweickert WD, Pohlman MC, Pohlman AS, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomized controlled trial. Lancet. 2009;373(9678):1874-1882.

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Chapter 44Noninvasive VentilationLaurent BrochardEvangelia AkoumianakiRicardo Cordioli

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6. Nourdine K, Combes P, Carton MJ, Beuret P, Cannamela A, Ducreux JC. Does noninvasive ventilation reduce the ICU nos-ocomial infection risk? A prospective clinical survey. Intensive Care Med. 1999;25:567-573.

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8. Antonelli M, Conti G, Bufi M, et al. Noninvasive ventilation for treatment of acute respiratory failure in patients undergo-ing solid organ transplantation: a randomized trial. JAMA. 2000;283:235-2341.

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Chapter 45Airway ManagementMichael F. O’connorDavid B. Glick

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36. Martin SE, Ochsner MG, Jarman RH, et al. Use of the laryngeal mask airway in air transport when intubation fails. J Trauma. 1999;47:352.

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38. Patel RG. Percutaneous transtracheal jet ventilation: a safe, quick, and temporary way to provide oxygenation and ven-tilation when conventional methods are unsuccessful. Chest. 1999;116:1689.

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Chapter 46TracheostomyJeff DoyleDamon C. Scales

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41. Pracy JP, Watkinson JC. Surgical tracheostomy—how I do it. Ann R Coll Surg Engl. 2005;87(4):285-287.

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Chapter 47Upper Airway ObstructionBrian K. GehlbachJohn P. Kress

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34. Jaber S, Carlucci A, Boussarsar M, et al. Helium-oxygen in the postextubation period decreases inspiratory effort. Am J Respir Crit Care Med. 2001;164(4):633-637.

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Chapter 48Ventilator Waveforms: Clinical InterpretationGregory A. Schmidt

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1. Esteban A, Anzueto A, Alia I, et al. How is mechanical ventilation employed in the intensive care unit? An international utilization review. Am J Respir Crit Care Med. 2000;161:1450-1458.

2. Kress JP, O’Connor MF, Schmidt GA. Clinical examination reliably detects intrinsic positive end-expiratory pressure in critically ill, mechanically ventilated patients. Am J Respir Crit Care Med. 1999;159:290-294.

3. Barberis L, Manno E, Guerin C. Effect of end-inspiratory pause duration on plateau pressure in mechanically ventilated patients. Intensive Care Med. 2003;29:130-134.

4. Nassar BS, Collett ND, Schmidt GA. The flow-time waveform predicts respiratory system resistance and compliance. J Crit Care. 2012;27:418.e7-418.e14.

5. Tassaux D, Gainnier M, Battisti A, Jolliet P. Impact of expira-tory trigger setting on delayed cycling and inspiratory muscle workload. Am J Respir Crit Care Med. 2005;172:1283-1289.

6. Pepe PE, Marini JJ. Occult positive end-expiratory pressure in mechanically ventilated patients with airflow obstruction. Am Rev Respir Dis. 1982;126:166-170.

7. Rossi A, Gottfried SB, Zocchi L, et al. Measurement of static compliance of the total respiratory system in patients with acute respiratory failure during mechanical ventilation: the effect of intrinsic positive end-expiratory pressure. Am Rev Respir Dis. 1985;131:672-677.

8. Aldrich TK, Hendler JM, Vizioli LD, et al. Intrinsic positive end-expiratory pressure in ambulatory patients with airways obstruction. Am Rev Respir Dis. 1993;147:845-849.

9. Gay PC, Rodarte JR, Tayyab M, et al. Evaluation of bronchodila-tor responsiveness in mechanically ventilated patients. Am Rev Respir Dis. 1987;136:880-885.

10. MacIntyre N, Kuo-Chen G, McConnell R. Applied PEEP during pressure support reduces the inspiratory threshold load of intrinsic PEEP. Chest. 1997;111:188-193.

11. Coussa ML, Guérin C, Eissa NT, et al. Partitioning of work of breathing in mechanically ventilated COPD patients. J Appl Physiol. 1993;75:1711-1719.

12. Petrof BJ, Legaré M, Goldberg P, et al. Continuous posi-tive airway pressure reduces work of breathing and dyspnea during weaning from mechanical ventilation in severe chronic obstructive pulmonary disease. Am Rev Respir Dis. 1990;141:281.

13. de Lucas P, Tarancón C, Puente L, et al. Nasal continuous positive airway pressure in patients with COPD in acute respiratory failure: a study of the immediate effects. Chest. 1993;104:1694-1697.

14. Gay PC, Rodarte JR, Hubmayr RD. The effects of positive expi-ratory pressure on isovolume flow and dynamic hyperinflation in patients receiving mechanical ventilation. Am Rev Respir Dis. 1989;139:621-626.

15. Tuxen DV. Detrimental effects of positive end-expiratory pressure during controlled mechanical ventilation of patients with severe airflow obstruction. Am Rev Respir Dis. 1989;140:5-9.

16. Marini JJ, Capps JS, Culver BH. The inspiratory work of breath-ing during assisted mechanical ventilation. Chest. 1985;87: 612-618.

17. Pohlman MC, McCallister KE, Schweickert WD, et al. Excessive tidal volume from breath stacking during lung-protective ventilation for acute lung injury. Crit Care Med. 2008;36: 3019-3023.

18. Chanques G, Kress JP, Pohlman A, et al. Impact of ventilator adjustment and sedation-analgesia practices on severe asyn-chrony in patients ventilated in assist-control mode. Crit Care Med. 2013;41:2177-2187.

19. Jubran A, Van de Graff W, Tobin MJ. Variability of patient-ven-tilator interaction with pressure support ventilation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1995;152:129-136.

20. Leung P, Jubran A, Tobin MJ. Comparison of assisted ventilator modes on triggering, patient effort, and dyspnea. Am J Respir Crit Care Med. 1997;155:1940-1948.

21. Hubmayr RD. The importance of patient/ventilator interactions during non-invasive mechanical ventilation. Acta Anaesthesiol Scand. 1996;109:46-47.

22. Zakynthinos SG, Vassilakopoulos T, Zakynthinois E. Accurate measurement of intrinsic positive end-expiratory pressure: how to detect and correct for expiratory muscle activity. Eur Respir J. 1997;10:522-529.

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Chapter 49Management of the Ventilated PatientGregory A. SchmidtJesse B. Hall

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9. Neto AS, Cardoso SO, Manetta JA, et al. Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respira-tory distress syndrome: a meta-analysis. JAMA. 2012;308: 1651-1659.

10. Futier E, Constantin J-M, Paugam-Burtz C, et al. A trial of intra-operative low-tidal-volume ventilation in abdominal surgery. N Engl J Med. 2013;369:428-437.

11. Levine S, Nguyen T, Taylor N, et al. Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med. 2008;358:1327-1335.

12. Hussain SNA, Mofarrahi M, Sigala I, et al. Mechanical ventila-tion-induced diaphragm disuse in humans triggers autophage. Am J Respir Crit Care Med. 2010;182:1377-1386.

13. Demoule A, Jung B, Prodanovic H, et al. Diaphragm dysfunc-tion on admission to the intensive care unit: prevalence, risk factors, and prognostic impact—a prospective study. Am J Respir Crit Care Med. 2013;188:213-219.

14. Powers SK, Wiggs MP, Sollanek KJ, et al. Ventilator-induced diaphragm dysfunction: cause and effect. Am J Physiol Regul Integr Comp Physiol. 2013;305(5):R464-R477.

15. Repessé X, Charron C, Vieillard-Baron A. Right ventricular failure in acute lung injury and acute respiratory distress syn-drome. Minerva Anestesiol. 2012;78:941-948.

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17. Marini JJ, Capps JS, Culver BH. The inspiratory work of breathing during assisted mechanical ventilation. Chest. 1985;87:612-618.

18. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000;342:1301-1308.

19. Kallet RH, Campbell AR, Dicker RA, et al. Work of breathing during lung-protective ventilation in patients with acute lung injury and acute respiratory distress syndrome: a comparison between volume and pressure-regulated modes. Respir Care. 2005;50:1623-1631.

20. Nassar BS, Collett ND, Schmidt GA. The flow-time waveform predicts respiratory system resistance and compliance. J Crit Care. 2012;27:418.e7-418.e14.

21. Pohlman MC, McCallister KE, Schweickert WD, et al. Excessive tidal volume from breath stacking during lung-protective venti-lation for acute lung injury. Crit Care Med. 2008;36:3019-3023.

22. Marini JJ, Rodriguez RM, Lamb V. The inspiratory workload of patient-initiated mechanical ventilation. Am Rev Respir Dis. 1986;134:902-909.

23. Esteban A, Frutos F, Tobin MJ, et al. A comparison of four methods of weaning patients from mechanical ventilation. N Engl J Med. 1995;332:345-350.

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Chapter 50Novel Modes of Mechanical VentilationMashael Al-HegelanNeil R. MacIntyre

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24. Sassoon CSh.Triggering of the ventilator in patient-ventilator interactions. Resp Care. 2011;56:39-51.

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26. MacIntyre NR, McConnell R, Cheng KC, et al. Patient-ventilator flow dyssynchrony: flow-limited versus pressure-limited breaths. Crit Care Med. 1997;25:1671-1677.

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73. Dojat M, Harf A, Touchard D, et al. Evaluation of a knowledge-based system providing ventilatory management and decision for extubation. Am J Respir Crit Care Med. 1996;153:997-1004.

74. Dojat M, Harf A, Touchard D, et al. Clinical evaluation of a computer-controlled pressure support mode. Am J Respir Crit Care Med. 2000;161:1161-1166.

75. Lellouche F, Mancebo J, Jolliet P, et al. A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation. Am J Respir Crit Care Med. 2006;174:894-900.

76. Rose L, Presneill J, Johnston L, Cade JF. A randomised, con-trolled trial of conventional versus automated weaning from mechanical ventilation using SmartCare/PS. Int Care Med. 2008;34:1788.

77. Jaber S, Sebbane M, Verzilli D, et al. Adaptive support ventila-tion and pressure support ventilation behavior in response to increased ventilator demand. Anesthesiol. 2009;110:620-627.

78. Lellouche F, Brochard L. Advanced closed loops during mechan-ical ventilation. Best Pract Research Clin Anaesth. 2009;23:81-93.

79. Dongelmans DA, Veelo DP, Binnekade JM, et al. Adaptive sup-port ventilation with protocolized de-escalation and escalation does not accelerate tracheal extubation of patients after non fast track cardiothoracic surgery. Anesth Analg. 2010;111:961-967.

80. Linton DM, Potgieter PD, Davis S, et al. Automatic weaning from mechanical ventilation using an adaptive lung controller. Chest. 1994;106:1843-1850.

81. Sulzer CF, Chiolero R, Cassot PG, et al. Adaptive support ventilation for fast tracheal extubation after cardiac surgery: a randomized, controlled study. Anesthesiology. 2001;95:1339-1345.

82. Cassina T, Chiolero R, Mauri R, Revelly JP. Clinical experience with adaptive support ventilation for fast-track cardiac surgery. J Cardiother Vasc Anesth. 2003;17:571-575.

83. Petter AH, Chiolero RL, Cassina T, et al. Automatic “respirator/ weaning” with adaptive support ventilation: the effect on dura-tion of endotracheal intubation and patient management. Anesth Analg. 2003;97:1743-1750.

84. Younes M. Proportional assist ventilation, a new approach to ventilatory support. Theory. Am Rev Respir Dis. 1992; 145:114-120.

85. Grasso S, Ranieri VM. Proportional assist ventilation. Respir Care Clin N Am. 2001;7:465-473, ix-x.

86. Dreher M, Kabitz H, Burgardt V, Walterspacher S, Windisch W. Proportional assist ventilation improves exercise capacity in patients with obesity. Respiration. 2010;80(2):106-111.

87. Moderno EV, Yamaguti WPS, Schettino GPP, et al. Effects of proportional assisted ventilation on exercise perfor-mance in idiopathic pulmonary fibrosis patients. Respir Med. 2010;104(1):134-141.

88. Mitrouska J, Xirouchaki N, Patakas D, Siafakas N, Georgopoulos D. Effects of chemical feedback on respiratory motor and venti-latory output during different modes of assisted mechanical ventilation. Eur Respir J. 1999;13:873-882.

89. Sinderby C. Neurally adjusted ventilatory assist (NAVA). Minerva Anestes. 2002;68:378-380.

90. Sinderby C, Navalesi P, Beck J, et al. Neural control of mechanical ventilation in respiratory failure. Nat Med. 1999; 5:1433-1436.

91. Coisel Y, Chanques G, Jung B, et al. Title neurally adjusted ven-tilatory assist in critically ill postoperative patients: a crossover randomized study. Anesthesiology. 2010;113(4):925-935.

92. Terzi N, Pelieu I, Guittet L, et al. Neurally adjusted ventilatory assist in patients recovering spontaneous breathing after acute respiratory distress syndrome: physiological evaluation. Crit Care Med. 2010;38(9):1830-1837.

93. Bengtsson J, Edberg K. Neurally adjusted ventilatory assist in children: an observational study. Ped Crit Care Med. 2010;11(2):253-257.

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Chapter 51Ventilator-Induced Lung InjuryVito FanelliJohn T. GrantonArthur S. Slutsky

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Chapter 52Acute Lung Injury and the Acute Respiratory Distress SyndromeMark E. MikkelsenPaul N. LankenJason D. Christie

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Chapter 53Extracorporeal Lung SupportLena M. Napolitano

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Chapter 54Acute-on-Chronic Respiratory FailureIvor S. Douglas

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12. Rahman NM, Maskell NA, West A, et al. Intrapleural use of tissue plasminogen activator and DNase in pleural infection. N Engl J Med. Aug 11, 2011;365(6):518-526.

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25. Parulekar W, Di Primio G, Matzinger F, Dennie C, Bociek G. Use of small-bore vs large-bore chest tubes for treatment of malignant pleural effusions. Chest. Jul 2001;120(1):19-25.

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Chapter 57Massive HemoptysisAlexander B. BensonRichard K. Albert

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2. Shigemura N, Wan IY, Yu SC, et al. Multidisciplinary manage-ment of life-threatening massive hemoptysis: a 10-year experi-ence. Ann Thorac Surg. 2009;87:849-853.

3. Ibrahim WH. Massive haemoptysis: the definition should be revised. Eur Respir J. 2008;32:1131-1132.

4. Ong TH, Eng P. Massive hemoptysis requiring intensive care. Intensive Care Med. 2003;29:317-320.

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8. Revel MP, Fournier LS, Hennebicque AS, et al. Can CT replace bronchoscopy in the detection of the site and cause of bleed-ing in patients with large or massive hemoptysis? AJR Am J Roentgenol. 2002;179:1217-1224.

9. Jeudy J, Khan AR, Mohammed TL, et al. ACR appropriateness criteria hemoptysis. J Thorac Imaging. 2010;25:W67-W69.

10. Swanson KL, Johnson CM, Prakash UB, McKusick MA, Andrews JC, Stanson AW. Bronchial artery embolization: experience with 54 patients. Chest. 2002;121:789-795.

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Chapter 58Restrictive Disease of the Respiratory SystemBenjamin D. SingerThomas C. CorbridgeLawrence D.H. Wood

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105. Fernández-Pérez ER, Yilmaz M, Jenad H, et al. Ventilator settings and outcome of respiratory failure in chronic interstitial lung disease. Chest. 2008;133:1113.

106. Snyder JV, Froese A. Respirator lung. In: Snyder JV, Pinsky MR. eds. Oxygen Transport in the Critically Ill. Chicago, IL: Year Book Medical; 1987:358.

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Chapter 59Ventilator-Associated Pneumonia

Jean ChastreJean-Yves Fagon

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54. Rello J, Ollendorf DA, Oster G, et al. Epidemiology and out-comes of ventilator-associated pneumonia in a large US data-base. Chest. 2002;122:2115-2121.

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420. Tofil NM, Benner KW, Fuller MP, Winkler MK. Histamine 2 receptor antagonists vs intravenous proton pump inhibitors in a pediatric intensive care unit: a comparison of gastric pH. J Crit Care. 2008;23:416-421.

421. Lin PC, Chang CH, Hsu PI, Tseng PL, Huang YB. The efficacy and safety of proton pump inhibitors vs histamine-2 receptor antagonists for stress ulcer bleeding prophylaxis among critical care patients: a meta-analysis. Crit Care Med. 2010;38:1197-1205.

422. van Saene HK, Stoutenbeek CC, Stoller JK. Selective decontami-nation of the digestive tract in the intensive care unit: current status and future prospects. Crit Care Med. 1992;20:691-703.

423. Stoutenbeek CP, van Saene HK, Miranda DR, Zandstra DF. The effect of selective decontamination of the digestive tract on colonisation and infection rate in multiple trauma patients. Intensive Care Med. 1984;10:185-192.

424. Heyland DK, Cook DJ, Jaeschke R, Griffith L, Lee HN, Guyatt GH. Selective decontamination of the digestive tract. An over-view. Chest. 1994;105:1221-1229.

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425. Hurley JC. Prophylaxis with enteral antibiotics in ventilated patients: selective decontamination or selective cross-infection? Antimicrob Agents Chemother. 1995;39:941-947.

426. Nathens AB, Marshall JC. Selective decontamination of the digestive tract in surgical patients: a systematic review of the evidence [see comments]. Arch Surg. 1999;134:170-176.

427. Oostdijk EA, de Smet AM, Kesecioglu J, Bonten MJ. The role of intestinal colonization with gram-negative bacteria as a source for intensive care unit-acquired bacteremia. Crit Care Med. 2011;39:961-966.

428. Krueger WA, Lenhart FP, Neeser G, et al. Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical trial. Am J Respir Crit Care Med. 2002;166:1029-1037.

429. de Jonge E, Schultz MJ, Spanjaard L, et al. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet. 2003;362:1011-1016.

430. de Smet AM, Kluytmans JA, Cooper BS, et al. Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med. 2009;360:20-31.

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432. Ebner W, Kropec-Hubner A, Daschner FD. Bacterial resistance and overgrowth due to selective decontamination of the diges-tive tract. Eur J Clin Microbiol Infect Dis. 2000;19:243-247.

433. Humphreys H, Winter R, Pick A. The effect of selective decon-tamination of the digestive tract on gastrointestinal enterococcal colonization in ITU patients. Intensive Care Med. 1992;18:459-463.

434. Kaufhold A, Behrendt W, Krauss T, van Saene H. Selective decontamination of the digestive tract and methicillin-resistant Staphylococcus aureus. Lancet. 1992;339:1411-1412.

435. Oostdijk EA, de Smet AM, Blok HE, et al. Ecological effects of selective decontamination on resistant gram-negative bacterial colonization. Am J Respir Crit Care Med. 2010;181:452-457.

436. Bonten MJ. Prevention of infection in the intensive care unit. Curr Opin Crit Care. 2004;10:364-368.

437. de Smet AM, Kluytmans JA, Blok HE, et al. Selective digestive tract decontamination and selective oropharyngeal decon-tamination and antibiotic resistance in patients in intensive-care units: an open-label, clustered group-randomised, crossover study. Lancet Infect Dis. 2011;11:372-380.

438. Heininger A, Meyer E, Schwab F, Marschal M, Unertl K, Krueger WA. Effects of long-term routine use of selective diges-tive decontamination on antimicrobial resistance. Intensive Care Med. 2006;32:1569-1576.

439. van Essen EH, de Jonge E. Selective decontamination of the digestive tract (SDD): is the game worth the candle? Semin Respir Crit Care Med. 2011;32:236-242.

440. Rello J, Lorente C, Bodi M, Diaz E, Ricart M, Kollef MH. Why do physicians not follow evidence-based guidelines for prevent-ing ventilator-associated pneumonia?(*): a survey based on the opinions of an international panel of intensivists. Chest. 2002;122:656-661.

441. Ricart M, Lorente C, Diaz E, Kollef MH, Rello J. Nursing adher-ence with evidence-based guidelines for preventing ventilator-associated pneumonia. Crit Care Med. 2003;31:2693-2696.

442. Pronovost P, Needham D, Berenholtz S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006;355:2725-2732.

443. Apisarnthanarak A, Pinitchai U, Thongphubeth K, et al. Effectiveness of an educational program to reduce ventilator-associated pneumonia in a tertiary care center in Thailand: a 4-year study. Clin Infect Dis. 2007;45:704-711.

444. Babcock HM, Zack JE, Garrison T, et al. An educational intervention to reduce ventilator-associated pneumonia in an integrated health system: a comparison of effects. Chest. 2004;125:2224-2231.

445. Bouadma L, Mourvillier B, Deiler V, et al. Changes in knowl-edge, beliefs, and perceptions throughout a multifaceted behavioral program aimed at preventing ventilator-associated pneumonia. Intensive Care Med. 2010;36:1341-1347.

446. Bouadma L, Mourvillier B, Deiler V, et al. A multifaceted program to prevent ventilator-associated pneumonia: impact on compliance with preventive measures. Crit Care Med. 2010;38:789-796.

447. Salahuddin N, Zafar A, Sukhyani L, et al. Reducing ventilator-associated pneumonia rates through a staff education programme. J Hosp Infect. 2004;57:223-227.

448. Zack JE, Garrison T, Trovillion E, et al. Effect of an education program aimed at reducing the occurrence of ventilator-associ-ated pneumonia. Crit Care Med. 2002;30:2407-2412.

449. Al-Tawfiq JA, Abed MS. Decreasing ventilator-associated pneumonia in adult intensive care units using the Institute for Healthcare Improvement bundle. Am J Infect Control. 2010;38:552-556.

450. Blamoun J, Alfakir M, Rella ME, et al. Efficacy of an expanded ventilator bundle for the reduction of ventilator-associated pneumonia in the medical intensive care unit. Am J Infect Control. 2009;37:172-175.

451. Cocanour CS, Peninger M, Domonoske BD, et al. Decreasing ventilator-associated pneumonia in a trauma ICU. J Trauma. 2006;61:122-129; discussion 9-30.

452. Hawe CS, Ellis KS, Cairns CJ, Longmate A. Reduction of ven-tilator-associated pneumonia: active versus passive guideline implementation. Intensive Care Med. 2009.

453. Resar R, Pronovost P, Haraden C, Simmonds T, Rainey T, Nolan T. Using a bundle approach to improve ventilator care processes and reduce ventilator-associated pneumonia. Jt Comm J Qual Patient Saf. 2005;31:243-248.

454. Tolentino-DelosReyes AF, Ruppert SD, Shiao SY. Evidence-based practice: use of the ventilator bundle to prevent ventilator-associated pneumonia. Am J Crit Care. 2007;16:20-27.

455. Weiss CH, Moazed F, McEvoy CA, et al. Prompting physicians to address a daily checklist and process of care and clinical out-comes: a single-site study. Am J Respir Crit Care Med. 2011.

456. Kollef M. SMART approaches for reducing nosocomial infec-tions in the ICU. Chest. 2008;134:447-456.

457. Wip C, Napolitano L. Bundles to prevent ventilator-associated pneumonia: how valuable are they? Curr Opin Infect Dis. 2009;22:159-166.

458. Zilberberg MD, Shorr AF, Kollef MH. Implementing quality improvements in the intensive care unit: ventilator bundle as an example. Crit Care Med. 2009;37:305-309.

459. Edwards JR, Peterson KD, Andrus ML, et al. National Healthcare Safety Network (NHSN) Report, data summary for 2006, issued June 2007. Am J Infect Control. 2007;35:290-301.

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Chapter 60Liberation From Mechanical Ventilation

Constantine A. ManthousGregory A. SchmidtJesse B. Hall

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