chapter 3: non-associative learning and memory
DESCRIPTION
Chapter 3: Non-Associative Learning and Memory. From Mechanisms of Memory , second edition By J. David Sweatt, Ph.D. Cytoskeletal Rearrangement in Synaptic Plasticity. Hypothetical Graph of 32 P-PO 4. 32 P Incorporation into protein or adenine nucleotides. Steady State. 32 P added. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/1.jpg)
Chapter 3:Non-Associative
Learning and Memory
From Mechanisms of Memory, second editionBy J. David Sweatt, Ph.D.
![Page 2: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/2.jpg)
Cytoskeletal Rearrangement in Synaptic Plasticity
![Page 3: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/3.jpg)
32P
Inco
rpo
rati
on
into
pro
tein
o
r ad
enin
e n
ucl
eoti
des
Time (hrs)
32P added Steady State
Figure 1
Hypothetical Graph of 32P-PO4
![Page 4: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/4.jpg)
C
B
A
Figure 2
AMPA Receptors
![Page 5: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/5.jpg)
Figure 3
Isoelectic Point3 10
Mol
ecul
ar W
eigh
t
High(approx 200 kDa)
Low(approx 5 kDa)
Protein Turnover
![Page 6: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/6.jpg)
Figure 4
Actin Turnover
![Page 7: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/7.jpg)
Figure 5
Aplysia californica
![Page 8: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/8.jpg)
Figure 6
Siphon-gill and tail-siphon
withdrawal reflexes of Aplysia
![Page 9: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/9.jpg)
Figure 7:
C
Short-term Sensitization of the
gill-withdrawal reflex in Aplysia
![Page 10: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/10.jpg)
Figure 8
Circuit Diagrams of the Siphon-gill
![Page 11: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/11.jpg)
Figure 9
Heterosynaptic Facilitation of the Sensorimotor
![Page 12: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/12.jpg)
Figure 10
Molecular events in Aplysia
![Page 13: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/13.jpg)
Figure 11
Mechanisms of long-term memory formation
![Page 14: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/14.jpg)
Substrates
PO4 Substrates
Ubiquitin-mediatedproteolysis
Facilitation ofNeurotransmitter release
PDE
cAMP AMP
cAMP
Shorter Term
Longer Term
Reg. Cat.
Reg. Cat.
Reg. Cat.
Reg. Cat.Reg. Cat.
Reg.Cat.
Cat.
Cat.
Figure 12
PKA
Altered Gene Expression and
![Page 15: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/15.jpg)
Figure 13
Aplysia
![Page 16: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/16.jpg)
Figure 14
Cellular basis of behavior
![Page 17: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/17.jpg)
Figure 15
The Eskin/ Byrne model in Aplysia long-term facilitation
![Page 18: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/18.jpg)
Figure 16
Behavioral SensitizationSpinal Sensitization
Before After
Wit
hd
raw
al
Th
resh
old
pawstimulation
pawstimulation
A.
B. D.
C.Before After
Before After
Before After
Wit
hd
raw
al
Th
resh
old
pawstimulation
pawstimulation
Injury-induced Spinal and Behavioral Sensitization
![Page 19: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/19.jpg)
Figure 17
Anatomical Pain Pathways
Cortex
Spinal cord
Midbrain
Amygdala
Medulla
DRG
Aδ-fiber
C-fiber
Pons
Hypot
hala
mus
PAG
Thalamus
Ascending Pathways
Descending Pathways
Withdrawal Reflex
End-organtissue
no
cicepto
r
termin
als
RVM
![Page 20: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/20.jpg)
Blue Box 1
AdenylylCyclase
αγ
β
GTP GDPATP
cAMP
Substrate
PO4
Reg
Reg
Cat.
Cat.Ion Channels
“Gs” ProteinReceptor
cAMP-DependentProtein Kinase (PKA)
The cAMP System
Receptor
αγ
β
GTP GDP
“Go” Protein
PLC
IP3
DAGCa++
PKC
Substrate
PO4
PIP2
The PLC System
Coupling of Receptors to Intracellular Messengers
![Page 21: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/21.jpg)
Blue Box 2
Potential Signal Transduction routes leading to MAPK Activation in Neurons
GFR
Grb2Rap1
MEK
p42mapk
Raf-1 B-Raf
PKAPKC
PKA
AC
Effectors
SosRas
![Page 22: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/22.jpg)
PO4
ras rasGDP GTP
GTP
GTP Hydrolysis
GAPsGTPase Activating Proteins
e.g. NF1, SynGAP
GEFsGuanine Nucleotide
Exchange Factor Proteins
e.g. SOS, cAMP GEF,
Ca2+/DAG GEF, ras GRF
Inactive Active
++
Blue Box 3
Regulation of RAS
![Page 23: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/23.jpg)
Blue Box 4
Habituation and Synaptic Inhibition
![Page 24: Chapter 3: Non-Associative Learning and Memory](https://reader033.vdocuments.us/reader033/viewer/2022061612/56815861550346895dc5bcc7/html5/thumbnails/24.jpg)
Blue Box 6
Swimming
Contact WithdrawalPreparation for swimming
A
B
C
Escape Swimming in Tritonia