chapter 23 - population genetics

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Chapter 23 (or 7): Population Genetics: The Evolution of Populations Oakton Community College - BIO 122 Dr. Paul Gulezian

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Page 1: Chapter 23 - Population Genetics

Chapter 23 (or 7): Population Genetics: The Evolution of Populations

Oakton Community College - BIO 122Dr. Paul Gulezian

Page 2: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Overview: The Smallest Unit of Evolution

• One misconception is that organisms evolve, in the Darwinian sense, during their lifetimes

• Natural selection acts on individuals, but only populations evolve

• Genetic variations in populations contribute to evolution

• Microevolution is a change in allele frequencies in a population over generations

Page 3: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Two processes, mutation and sexual reproduction, produce the variation in gene pools that contributes to differences among individuals

Concept 23.1: Mutation and sexual reproduction produce the genetic variation that makes evolution possible

Page 4: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Genetic Variation

• Variation in individual genotype leads to variation in individual phenotype

• Not all phenotypic variation is heritable

• Natural selection can only act on variation with a genetic component for evolution to proceed

Page 5: Chapter 23 - Population Genetics

Fig. 23-2

(a) (b)

Non-Heritable Variation

Page 6: Chapter 23 - Population Genetics

Fig. 23-2a

(a)

Page 7: Chapter 23 - Population Genetics

Fig. 23-2b

(b)

Page 8: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Variation Within a Population

• Both discrete and quantitative characters contribute to variation within a population

• Discrete characters can be classified on an either-or basis

• Quantitative characters vary along a continuum within a population

Page 9: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Population geneticists measure polymorphisms in a population by determining the amount of heterozygosity at the gene and molecular levels

• Average heterozygosity measures the average percent of loci that are heterozygous in a population

• Nucleotide variability is measured by comparing the DNA sequences of pairs of individuals

Page 10: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Variation Between Populations

• Most species exhibit geographic variation, differences between gene pools of separate populations or population subgroups

Page 11: Chapter 23 - Population Genetics

Fig. 23-3

13.17 19 XX10.169.128.11

1 2.4 3.14 5.18 6 7.15

9.10

1 2.19

11.12 13.17 15.18

3.8 4.16 5.14 6.7

XX

Page 12: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Some examples of geographic variation occur as a cline, which is a graded change in a trait along a geographic axis

Page 13: Chapter 23 - Population Genetics

Fig. 23-4

1.0

0.8

0.6

0.4

0.2

046 44 42 40 38 36 34 32 30

GeorgiaWarm (21°C)

Latitude (°N)

MaineCold (6°C)

Ldh

-B b

alle

le f

req

uen

cy

Page 14: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Mutation

• Mutations are changes in the nucleotide sequence of DNA

• Mutations cause new genes and alleles to arise

• Only mutations in cells that produce gametes can be passed to offspring.

Page 15: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Point Mutations

• A point mutation is a change in one base in a gene

Page 16: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• The effects of point mutations can vary:

– Mutations in noncoding regions of DNA are often harmless

– Mutations in a gene might not affect protein production because of redundancy in the genetic code

Page 17: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• The effects of point mutations can vary:

– Mutations that result in a change in protein production are often harmful

– Mutations that result in a change in protein production can sometimes increase the fit between organism and environment

Page 18: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Mutations That Alter Gene Number or Sequence

• Chromosomal mutations that delete, disrupt, or rearrange many loci are typically harmful

• Duplication of large chromosome segments is usually harmful

• Duplication of small pieces of DNA is sometimes less harmful and increases the genome size

• Duplicated genes can take on new functions by further mutation

Page 19: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Mutation Rates

• Mutation rates are low in animals and plants

• The average is about one mutation in every 100,000 genes per generation

• Mutations rates are often lower in prokaryotes and higher in viruses

Page 20: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Sexual Reproduction

• Sexual reproduction can shuffle existing alleles into new combinations

• In organisms that reproduce sexually, recombination of alleles is more important than mutation in producing the genetic differences that make adaptation possible

Page 21: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Concept 23.2: The Hardy-Weinberg equation can be used to test whether a population is evolving

• The first step in testing whether evolution is occurring in a population is to clarify what we mean by a population

Page 22: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Gene Pools and Allele Frequencies

• A population is a localized group of individuals capable of interbreeding and producing fertile offspring

• A gene pool consists of all the alleles for all loci in a population

• A locus is fixed if all individuals in a population are homozygous for the same allele

Page 23: Chapter 23 - Population Genetics

Fig. 23-5Porcupine herd

Porcupineherd range

Beaufort Sea NO

RTH

WEST

TERR

ITOR

IES

MAPAREA

AL

AS

KA

CA

NA

DA

Fortymileherd range

Fortymile herd

AL

AS

KA

YU

KO

N

Page 24: Chapter 23 - Population Genetics

Fig. 23-5a

Porcupineherd range

Beaufort Sea NO

RTH

WEST

TERR

ITOR

IES

MAPAREA

AL

AS

KA

CA

NA

DA

Fortymileherd range

AL

AS

KA

YU

KO

N

Page 25: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• The frequency of an allele in a population can be calculated

– For diploid organisms, the total number of alleles at a locus is the total number of individuals x 2

– The total number of dominant alleles at a locus is 2 alleles for each homozygous dominant individual plus 1 allele for each heterozygous individual; the same logic applies for recessive alleles

Page 26: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• By convention, if there are 2 alleles at a locus, p and q are used to represent their frequencies

• The frequency of all alleles in a population will add up to 1

– For example, p + q = 1

Page 27: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

The Hardy-Weinberg Principle

• The Hardy-Weinberg principle describes a population that is not evolving

• If a population does not meet the criteria of the Hardy-Weinberg principle, it can be concluded that the population is evolving

• Thus, the H-W principle is a null model.

Page 28: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Hardy-Weinberg Equilibrium

• The Hardy-Weinberg principle states that frequencies of alleles and genotypes in a population remain constant from generation to generation

• In a given population where gametes contribute to the next generation randomly, allele frequencies will not change

• Mendelian inheritance preserves genetic variation in a population

Page 29: Chapter 23 - Population Genetics

Fig. 23-6

Frequencies of alleles

Alleles in the population

Gametes produced

Each egg: Each sperm:

80%chance

80%chance

20%chance

20%chance

q = frequency of

p = frequency of

CR allele = 0.8

CW allele = 0.2

Page 30: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Hardy-Weinberg equilibrium describes the constant frequency of alleles in such a gene pool

• If p and q represent the relative frequencies of the only two possible alleles in a population at a particular locus, then

– p2 + 2pq + q2 = 1

– where p2 and q2 represent the frequencies of the homozygous genotypes and 2pq represents the frequency of the heterozygous genotype

Page 31: Chapter 23 - Population Genetics

Fig. 23-7-1

SpermCR

(80%)

CW

(20 %

)

80% CR ( p = 0.8)

CW (20%)

20% CW (q = 0.2)

16% ( pq) CRCW

4% (q2) CW CW

CR

(80%

)

64% ( p2) CRCR

16% (qp) CRCW

Eg

gs

Page 32: Chapter 23 - Population Genetics

Fig. 23-7-2

Gametes of this generation:

64% CRCR, 32% CRCW, and 4% CWCW

64% CR   +    16% CR    =   80% CR = 0.8 = p

4% CW     +    16% CW   =   20% CW = 0.2 = q

Page 33: Chapter 23 - Population Genetics

Fig. 23-7-3

Gametes of this generation:

64% CRCR, 32% CRCW, and 4% CWCW

64% CR   +    16% CR    =   80% CR = 0.8 = p

4% CW     +    16% CW   =   20% CW = 0.2 = q

64% CRCR, 32% CRCW, and 4% CWCW plants

Genotypes in the next generation:

Page 34: Chapter 23 - Population Genetics

Fig. 23-7-4

Gametes of this generation:

64% CR CR, 32% CR CW, and 4% CW CW

64% CR    +     16% CR    =   80% CR  = 0.8 = p

4% CW      +    16% CW    =  20% CW = 0.2 = q

64% CR CR, 32% CR CW, and 4% CW CW plants

Genotypes in the next generation:

SpermCR

(80%)

CW

( 20%

)

80% CR ( p = 0.8)

CW (20%)

20% CW (q = 0.2)

16% ( pq) CR CW

4% (q2) CW CW

CR

(80%

)

64% ( p2) CR CR

16% (qp) CR CW

Eg

gs

Page 35: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Conditions for Hardy-Weinberg Equilibrium

• The Hardy-Weinberg theorem describes a hypothetical population

• In real populations, allele and genotype frequencies do change over time

Page 36: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• The five conditions for nonevolving populations are rarely met in nature:

– No mutations

– Random mating

– No natural selection

– Extremely large population size

– No gene flow

Page 37: Chapter 23 - Population Genetics

• Natural populations can evolve at some loci, while being in Hardy-Weinberg equilibrium at other loci

Page 38: Chapter 23 - Population Genetics

Applying the Hardy-Weinberg Principle• We can assume the locus that causes

phenylketonuria (PKU) is in Hardy-Weinberg equilibrium given that:

– The PKU gene mutation rate is low

– Mate selection is random with respect to whether or not an individual is a carrier for the PKU allele

– Natural selection can only act on rare homozygous individuals who do not follow dietary restrictions

– The population is large

– Migration has no effect as many other populations have similar allele frequencies

Page 39: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• The occurrence of PKU is 1 per 10,000 births

– q2 = 0.0001

– q = 0.01

• The frequency of normal alleles is

– p = 1 – q = 1 – 0.01 = 0.99

• The frequency of carriers is

– 2pq = 2 x 0.99 x 0.01 = 0.0198

– or approximately 2% of the U.S. population

What is the frequency of carriers of the PKU allele?

Page 40: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Three major factors alter allele frequencies and bring about most evolutionary change:

– Natural selection

– Genetic drift

– Gene flow

Concept 23.3: Natural selection, genetic drift, and gene flow can alter allele frequencies in a population

Page 41: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Natural Selection

• Differential success in reproduction results in certain alleles being passed to the next generation in greater proportions

Page 42: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Genetic Drift

• The smaller a sample, the greater the chance of deviation from a predicted result

• Genetic drift describes how allele frequencies fluctuate unpredictably from one generation to the next

• Genetic drift tends to reduce genetic variation through losses of alleles

Page 43: Chapter 23 - Population Genetics

Fig. 23-8-1

Generation 1p (frequency of CR) = 0.7q (frequency of CW

) = 0.3

CW CW

CR CR

CR CW

CR CR

CR CR

CR CR

CR CR

CR CW

CR CW

CR CW

Page 44: Chapter 23 - Population Genetics

Fig. 23-8-2

Generation 1p (frequency of CR) = 0.7q (frequency of CW

) = 0.3

Generation 2p = 0.5q = 0.5

CW CW

CR CR

CR CW

CR CR

CR CR

CR CR

CR CR

CR CW

CR CW

CR CW

CR CWCR CW

CR CW

CR CW

CW CW

CW CW

CW CW

CR CR

CR CR

CR CR

Page 45: Chapter 23 - Population Genetics

Fig. 23-8-3

Generation 1

CW CW

CR CR

CR CW

CR CR

CR CR

CR CR

CR CR

CR CW

CR CW

CR CW

p (frequency of CR) = 0.7q (frequency of CW

) = 0.3

Generation 2

CR CWCR CW

CR CW

CR CW

CW CW

CW CW

CW CW

CR CR

CR CR

CR CR

p = 0.5q = 0.5

Generation 3p = 1.0q = 0.0

CR CR

CR CR

CR CR

CR CR

CR CR

CR CR CR CR

CR CR

CR CR CR CR

Page 46: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

The Founder Effect

• The founder effect occurs when a few individuals become isolated from a larger population

• Allele frequencies in the small founder population can be different from those in the larger parent population

Page 47: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

The Bottleneck Effect

• The bottleneck effect is a sudden reduction in population size due to a change in the environment

• The resulting gene pool may no longer be reflective of the original population’s gene pool

• If the population remains small, it may be further affected by genetic drift

Page 48: Chapter 23 - Population Genetics

Fig. 23-9

Originalpopulation

Bottleneckingevent

Survivingpopulation

Page 49: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Understanding the bottleneck effect can increase understanding of how human activity affects other species

Page 50: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Case Study: Impact of Genetic Drift on the Greater Prairie Chicken

• Loss of prairie habitat caused a severe reduction in the population of greater prairie chickens in Illinois

• The surviving birds had low levels of genetic variation, and only 50% of their eggs hatched

Page 51: Chapter 23 - Population Genetics

Fig. 23-10

Numberof allelesper locus

Rangeof greaterprairiechicken

Pre-bottleneck(Illinois, 1820)

Post-bottleneck(Illinois, 1993)

Minnesota, 1998    (no bottleneck)

Nebraska, 1998    (no bottleneck)

Kansas, 1998    (no bottleneck)

Illinois

1930–1960s

1993

Location Populationsize

Percentageof eggshatched

1,000–25,000

<50

750,000

75,000–200,000

4,000

5.2

3.7

93

<50

5.8

5.8

5.3 85

96

99

(a)

(b)

Page 52: Chapter 23 - Population Genetics

Fig. 23-10a

Rangeof greaterprairiechicken

Pre-bottleneck(Illinois, 1820)

Post-bottleneck(Illinois, 1993)

(a)

Page 53: Chapter 23 - Population Genetics

Fig. 23-10b

Numberof allelesper locus

Minnesota, 1998   (no bottleneck)

Nebraska, 1998   (no bottleneck)

Kansas, 1998   (no bottleneck)

Illinois

1930–1960s

1993

Location Populationsize

Percentageof eggshatched

1,000–25,000

<50

750,000

75,000–200,000

4,000

5.2

3.7

93

<50

5.8

5.8

5.3 85

96

99

(b)

Page 54: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Researchers used DNA from museum specimens to compare genetic variation in the population before and after the bottleneck

• The results showed a loss of alleles at several loci

• Researchers introduced greater prairie chickens from population in other states and were successful in introducing new alleles and increasing the egg hatch rate to 90%

Page 55: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Effects of Genetic Drift: A Summary

1. Genetic drift is significant in small populations

2. Genetic drift causes allele frequencies to change at random

3. Genetic drift can lead to a loss of genetic variation within populations

4. Genetic drift can cause harmful alleles to become fixed

Page 56: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Gene Flow

• Gene flow consists of the movement of alleles among populations

• Alleles can be transferred through the movement of fertile individuals or gametes (for example, pollen)

• Gene flow tends to reduce differences between populations over time

• Gene flow is more likely than mutation to alter allele frequencies directly

Page 57: Chapter 23 - Population Genetics

Fig. 23-11

Page 58: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Gene flow can decrease the fitness of a population, particularly if it is adapted to specific environmental conditions

• In bent grass, alleles for copper tolerance are beneficial in populations near copper mines, but harmful to populations in other soils

• Windblown pollen moves these alleles between populations

• The movement of unfavorable alleles into a population results in a decrease in fit between organism and environment

Page 59: Chapter 23 - Population Genetics

Fig. 23-12

NON-MINESOIL

MINESOIL

NON-MINESOIL

Prevailing wind direction

Ind

ex o

f co

pp

er t

ole

ran

ce

Distance from mine edge (meters)

70

60

50

40

30

20

10

020 0 20 0 20 40 60 80 100 120 140 160

Page 60: Chapter 23 - Population Genetics

Fig. 23-12a

NON-MINESOIL

MINESOIL

NON-MINESOIL

Prevailing wind direction

Ind

ex o

f co

pp

er t

ole

ran

ce

Distance from mine edge (meters)

70

60

50

40

30

20

10

020 0 20 0 20 40 60 80 100 120 140 160

Page 61: Chapter 23 - Population Genetics

Fig. 23-12b

Page 62: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Gene flow can also increase the fitness of a population

• Insecticides have been used to target mosquitoes that carry West Nile virus and malaria

• Alleles have evolved in some populations that confer insecticide resistance to these mosquitoes

• The flow of insecticide resistance alleles into a population can cause an increase in fitness

Page 63: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Only natural selection consistently results in adaptive evolution

Concept 23.4: Natural selection is the only mechanism that consistently causes adaptive evolution

Page 64: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

A Closer Look at Natural Selection

• Natural selection brings about adaptive evolution by acting on an organism’s phenotype

Page 65: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Relative Fitness

• The phrases “struggle for existence” and “survival of the fittest” are misleading as they imply direct competition among individuals

• Reproductive success is generally more subtle and depends on many factors

Page 66: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Relative fitness is the contribution an individual makes to the gene pool of the next generation, relative to the contributions of other individuals

• Selection favors certain genotypes by acting on the phenotypes of certain organisms

Page 67: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Directional, Disruptive, and Stabilizing Selection

• Three modes of selection:

– Directional selection favors individuals at one end of the phenotypic range

– Disruptive selection favors individuals at both extremes of the phenotypic range

– Stabilizing selection favors intermediate variants and acts against extreme phenotypes

Page 68: Chapter 23 - Population Genetics

Fig. 23-13

Original population

(c) Stabilizing selection(b) Disruptive selection(a) Directional selection

Phenotypes (fur color)F

req

uen

cy o

f in

div

idu

als

Originalpopulation

Evolvedpopulation

Page 69: Chapter 23 - Population Genetics

Fig. 23-13a

Original population

(a) Directional selection

Phenotypes (fur color)

Fre

qu

enc

y o

f in

div

idu

als

Original population

Evolved population

Page 70: Chapter 23 - Population Genetics

Fig. 23-13b

Original population

(b) Disruptive selection

Phenotypes (fur color)

Fre

qu

enc

y o

f in

div

idu

als

Evolved population

Page 71: Chapter 23 - Population Genetics

Fig. 23-13c

Original population

(c) Stabilizing selection

Phenotypes (fur color)

Fre

qu

enc

y o

f in

div

idu

als

Evolved population

Page 72: Chapter 23 - Population Genetics

What kind of selection does this situation describe?

Page 73: Chapter 23 - Population Genetics

What kind of selection does this situation describe?

Stabilizing selection….intermediates are favored.

Page 74: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

The Key Role of Natural Selection in Adaptive Evolution

• Natural selection increases the frequencies of alleles that enhance survival and reproduction

• Adaptive evolution occurs as the match between an organism and its environment increases

Page 75: Chapter 23 - Population Genetics

Fig. 23-14

(a) Color-changing ability in cuttlefish

(b) Movable jaw bones in snakes

Movable bones

Page 76: Chapter 23 - Population Genetics

Fig. 23-14a

(a) Color-changing ability in cuttlefish

Page 77: Chapter 23 - Population Genetics

Fig. 23-14b

(b) Movable jaw bones in snakes

Movable bones

Page 78: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Because the environment can change, adaptive evolution is a continuous process

• Genetic drift and gene flow do not consistently lead to adaptive evolution as they can increase or decrease the match between an organism and its environment

Page 79: Chapter 23 - Population Genetics

Sexual Selection

• Sexual selection is natural selection for mating success

• It can result in sexual dimorphism, marked differences between the sexes in secondary sexual characteristics

Page 80: Chapter 23 - Population Genetics

Fig. 23-15

Page 81: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Intrasexual selection is competition among individuals of one sex (often males) for mates of the opposite sex

• Intersexual selection, often called mate choice, occurs when individuals of one sex (usually females) are choosy in selecting their mates

• Male showiness due to mate choice can increase a male’s chances of attracting a female, while decreasing his chances of survival (an evolutionary tradeoff)

Page 82: Chapter 23 - Population Genetics

• How do female preferences evolve?

• The good genes hypothesis suggests that if a trait is related to male health, both the male trait and female preference for that trait should be selected for

Sexual Selection: Female Mate Choice

Page 83: Chapter 23 - Population Genetics

Fig. 23-16

SC male graytree frog

Female graytree frog

LC male graytree frog

EXPERIMENT

SC sperm Eggs LC sperm

Offspring ofLC father

Offspring ofSC father

Fitness of these half-sibling offspring compared

RESULTS

1995Fitness Measure 1996

Larval growth

Larval survival

Time to metamorphosis

LC better

NSD

LC better(shorter)

LC better(shorter)

NSD

LC better

NSD = no significant difference; LC better = offspring of LC malessuperior to offspring of SC males.

Page 84: Chapter 23 - Population Genetics

Fig. 23-16a

SC male graytree frog

Female graytree frog

LC male graytree frog

SC sperm Eggs LC sperm

Offspring ofLC father

Offspring ofSC father

Fitness of these half-sibling offspring compared

EXPERIMENT

Page 85: Chapter 23 - Population Genetics

Fig. 23-16b

RESULTS

1995Fitness Measure 1996

Larval growth

Larval survival

Time to metamorphosis

LC better

NSD

LC better(shorter)

LC better(shorter)

NSD

LC better

NSD = no significant difference; LC better = offspring of LC malessuperior to offspring of SC males.

Page 86: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

The Preservation of Genetic Variation

• Various mechanisms help to preserve genetic variation in a population

– Diploidy

– Balancing Selection

• Heterozygote Advantage

• Frequency-dependent Selection

Page 87: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Diploidy

• Diploidy maintains genetic variation in the form of hidden recessive alleles that selection does not act upon because they are not manifest in the phenotype.

Page 88: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Balancing Selection

• Balancing selection occurs when natural selection maintains stable frequencies of two or more phenotypic forms in a population

– Heterozygote Advantage

– Frequency-dependent selection

Page 89: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• Heterozygote advantage occurs when heterozygotes have a higher fitness than do both homozygotes

• Natural selection will tend to maintain two or more alleles at that locus

• Example: The sickle-cell allele causes mutations in hemoglobin (bad) but also confers malaria resistance (good)

Heterozygote Advantage

Page 90: Chapter 23 - Population Genetics

Fig. 23-17

0–2.5%

Distribution ofmalaria caused byPlasmodium falciparum(a parasitic unicellular eukaryote)

Frequencies of thesickle-cell allele

2.5–5.0%

7.5–10.0%

5.0–7.5%

>12.5%

10.0–12.5%

Page 91: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

• In frequency-dependent selection, the fitness of a phenotype declines if it becomes too common in the population

• Selection can favor whichever phenotype is less common in a population

• Example: prey-switching behavior in many predators leads to multiple forms of prey coexisting in populations

Frequency-Dependent Selection

Page 92: Chapter 23 - Population Genetics

Fig. 23-18

“Right-mouthed”

1981

“Left-mouthed”

Fre

qu

ency

of

“lef

t-m

ou

thed

” in

div

idu

als

Sample year

1.0

0.5

0’82 ’83 ’84 ’85 ’86 ’87 ’88 ’89 ’90

Page 93: Chapter 23 - Population Genetics

Fig. 23-18a

“Right-mouthed”

“Left-mouthed”

Page 94: Chapter 23 - Population Genetics

Fig. 23-18b

1981

Fre

qu

en

cy

of

“le

ft-m

ou

the

d”

ind

ivid

ua

ls

Sample year

1.0

0.5

0’82

’83

’84

’85

’86

’87

’88

’89

’90

Page 95: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Neutral Variation

• Neutral variation is genetic variation that appears to confer no selective advantage or disadvantage

• For example,

– Variation in noncoding regions of DNA (although many of these regions are now known to be “swtiches” that control the expression of other genes)

– Variation in proteins that have little effect on protein function or reproductive fitness

Page 96: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

Why Natural Selection Cannot Fashion Perfect Organisms

1. Selection can act only on existing variations, it is not the source of new alleles (mutations are)

2. Evolution is limited by historical constraints (developmental patterns, for example)

3. Adaptations are often compromises between different organismal needs (mate attraction, predator avoidance)

4. Chance events, natural selection, and the environment interact and conidtions constantly change so “perfection” is a moving target

Page 97: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

You should now be able to:

1. Explain why the majority of point mutations are harmless

2. Explain how sexual recombination generates genetic variability

3. Define the terms population, species, gene pool, relative fitness, and neutral variation

4. List the five conditions of Hardy-Weinberg equilibrium

Page 98: Chapter 23 - Population Genetics

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5. Apply the Hardy-Weinberg equation to a population genetics problem

6. Explain why natural selection is the only mechanism that consistently produces adaptive change

7. Explain the role of population size in genetic drift

Page 99: Chapter 23 - Population Genetics

Copyright © 2008 Pearson Education Inc., publishing as Pearson Benjamin Cummings

8. Distinguish among the following sets of terms: directional, disruptive, and stabilizing selection; intrasexual and intersexual selection

9. List four reasons why natural selection cannot produce perfect organisms