chapter 2 immunology
DESCRIPTION
ImmunologyTRANSCRIPT
![Page 1: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/1.jpg)
The Immune System Fourth Edition
Chapter 2 Innate Immunity: The Immediate
Response to Infection
Copyright © Garland Science 2015
Peter Parham
![Page 2: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/2.jpg)
CHAPTER CONTENTS
2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens
2-2 Intracellular and extracellular pathogens require different types of immune response
2-3 Complement is a system of plasma proteins that mark pathogens for destruction
2-4 At the start of an infection, complement activation proceeds by the alternative pathway
2-5 Regulatory proteins determine the extent and site of C3b deposition
2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganismstes
![Page 3: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/3.jpg)
CHAPTER CONTENTS
2-7 The terminal complement proteins lyse pathogens by forming membrane pores
2-8 Small peptides released during complement activation induce local inflammation
2-9 Several classes of plasma protein limit the spread of infection
2-10 Antimicrobial peptides kill pathogens by perturbing their membranes
2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes
![Page 4: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/4.jpg)
Innate Immunity: the Immediate Response to Infection
2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens
![Page 5: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/5.jpg)
2-1 Physical barriers colonized by commensal microorganisms protect against infection by pathogens
![Page 6: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/6.jpg)
Innate Immunity: the Immediate Response to Infection
2-2 Intracellular and extracellular pathogens require different types of immune response
![Page 7: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/7.jpg)
2-2 Intracellular and extracellular pathogens require different types of immune response
![Page 8: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/8.jpg)
Innate Immunity: the Immediate Response to Infection
2-3 Complement is a system of plasma proteins that mark pathogens for destruction
![Page 9: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/9.jpg)
2-3 Complement is a system of plasma proteins that mark pathogens for destruction
![Page 10: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/10.jpg)
2-3 Complement is a system of plasma proteins that mark pathogens for destruction
![Page 11: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/11.jpg)
2-3 Complement is a system of plasma proteins that mark pathogens for destruction
![Page 12: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/12.jpg)
Innate Immunity: the Immediate Response to Infection
2-4 At the start of an infection, complement activation proceeds by the alternative pathway
![Page 13: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/13.jpg)
2-4 At the start of an infection, complement activation proceeds by the alternative pathway
![Page 14: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/14.jpg)
2-4 At the start of an infection, complement activation proceeds by the alternative pathway
![Page 15: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/15.jpg)
2-4 At the start of an infection, complement activation proceeds by the alternative pathway
![Page 16: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/16.jpg)
Innate Immunity: the Immediate Response to Infection
2-5 Regulatory proteins determine the extent and site of C3b deposition
![Page 17: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/17.jpg)
2-5 Regulatory proteins determine the extent and site of C3b deposition
![Page 18: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/18.jpg)
Innate Immunity: the Immediate Response to Infection
2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganisms
![Page 19: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/19.jpg)
2-6 Phagocytosis by macrophages provides a first line of cellular defense against invading microorganisms
![Page 20: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/20.jpg)
Innate Immunity: the Immediate Response to Infection
2-7 The terminal complement proteins lyse pathogens by forming membrane pores
![Page 21: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/21.jpg)
2-7 The terminal complement proteins lyse pathogens by forming membrane pores
![Page 22: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/22.jpg)
2-7 The terminal complement proteins lyse pathogens by forming membrane pores
![Page 23: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/23.jpg)
2-7 The terminal complement proteins lyse pathogens by forming membrane pores
![Page 24: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/24.jpg)
2-7 The terminal complement proteins lyse pathogens by forming membrane pores
![Page 25: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/25.jpg)
2-7 The terminal complement proteins lyse pathogens by forming membrane pores
![Page 26: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/26.jpg)
2-7 The terminal complement proteins lyse pathogens by forming membrane pores
![Page 27: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/27.jpg)
Innate Immunity: the Immediate Response to Infection
2-8 Small peptides released during complement activation induce local inflammation
![Page 28: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/28.jpg)
2-8 Small peptides released during complement activation induce local inflammation
![Page 29: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/29.jpg)
Innate Immunity: the Immediate Response to Infection
2-9 Several classes of plasma protein limit the spread of infection
![Page 30: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/30.jpg)
2-9 Several classes of plasma protein limit the spread of infection
![Page 31: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/31.jpg)
Innate Immunity: the Immediate Response to Infection
2-10 Antimicrobial peptides kill pathogens by perturbing their membranes
![Page 32: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/32.jpg)
2-10 Antimicrobial peptides kill pathogens by perturbing their membranes
![Page 33: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/33.jpg)
2-10 Antimicrobial peptides kill pathogens by perturbing their membranes
![Page 34: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/34.jpg)
2-10 Antimicrobial peptides kill pathogens by perturbing their membranes
![Page 35: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/35.jpg)
2-10 Antimicrobial peptides kill pathogens by perturbing their membranes
![Page 36: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/36.jpg)
2-10 Antimicrobial peptides kill pathogens by perturbing their membranes
![Page 37: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/37.jpg)
Innate Immunity: the Immediate Response to Infection
2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes
![Page 38: Chapter 2 Immunology](https://reader031.vdocuments.us/reader031/viewer/2022020506/56d6beb41a28ab301693411d/html5/thumbnails/38.jpg)
2-11 Pentraxins are plasma proteins of innate immunity that bind microorganisms and target them to phagocytes