challenging opt frm india

7/30/2019 Challenging Opt Frm India

1/4

1

Challenging Opportunity to do Global Research from India

At TCGA we have created a culture that nurtures creative thinking and provides opportunitiesfor individuals to excel in a collaborative, team-based environment. Our entrepreneurialmindset fosters diverse perspectives and drives our passion for innovative research.

What is unique about being a scientist @TCGA?

The research projects at TCGA are endeavors towards translational research. TCGA combinesacademic freedom with high-end sophisticated instrumentation and facilities with the objectiveto take away the primary burden of operation and maintenance of equipments from thediscovery group. We have developed an ambience where each member respects thecomplementary skills and responsibility of the other and works towards surrpetition rather thancompetition.

In terms of output we look forward to discoveries and designs of high IPR value, high qualitypublications in the chosen areas and direct revenue generation designs either singularly or in

collaboration with complementing groups within or outside The Chaterjee Group (TCG).Scientists at the group leader level will be adjunct faculty of IGIB. Scientists @TCGA willclosely interact with scientists of Institute for Genomics and Integrative Biology (IGIB) and allthe facilities available at IGIB will be accessible to TCGA scientists.

Compensations for scientists are well benchmarked with the industry standards. We haveevolved a compensation system that is closer to the corporate system than a governmentalstructure, considering the high pressure that will be shouldered by the group leaders and thescientists.

There are separate units and personnel @TCGA to handle the accounts, marketing andbusiness management. Scientists are strictly kept out of these activities. However scientists areexpected to discuss and provide guidance for technical trouble shooting and innovation of costeffective methods for experimental protocols for the service section involving the variousfacilities.

Structure of TCGATechnicalDirector/Research Fellow

Associate Director/Principal Research ScientistGroup Leader

Team LeaderSenior Research ScientistResearch ScientistResearch AssociateSenior Research BiologistResearch BiologistProject Fellows


2/4

2

Broad areas of research @TCGABiomedical sciencesFunctional genomicsBioinformatics

Specific areas of focus

Disease genomics.Bioinformatics for Functional Genomics.Disease proteomics and expression analysis.Model systems for human diseases.Identification of biomarkers.

Translational research is the backbone for all projects

Central facilities accessible to all scientistsTCGA is a DSIR registered non-profit-making organization therefore the unique strength ofTCGA services is available to scientists @TCGA at very a special cost. The TCGA services arebased on three fundamental aspects of people, process and technology. The services ensure thatcutting edge technologies are brought to the door step of every scientist not only at TCGA butalso the laboratories in India at a very competitive price.

The scientists @TCGA work closely with the scientists of Institute for Genomics andIntegrative Biology (IGIB) and all the facilities available at IGIB are accessible to TCGAscientists.

Computing Facilities:Bioinformatics being a backbone of genomics research scientists @TCGA have access to high-end computing facilities of IGIB(CSIR) in addition to the high-band width internetfacilities@TCGA.

The CSIR High Performance Computing Facility (HPC) @IGIB is a 288-node Cluster Platform 3000 based on HPIntel Xeon-based ProLiant systems running the Linuxoperating system. The high-speed InfiniBand 10Gbpscluster interconnect is used and HP's XC System Softwareprovides cluster management capability. In addition, this

center will also have a 24-node, high-performance HPProLiant cluster running Linux, a powerful IntegritySuperdome server that can be used for experimentalprojects by the students/developer community. Thesystems are supported by 12 terabytes of HP Storage Works Enterprise Virtual Array 5000(EVA5000) storage and a MSL6060 tape library.To help customers manage and visualize the large volumes of data created by computationalanalysis, HP's Unified Cluster Portfolio, which includes entry-level HP Integrity and ProLiant


3/4

3

servers and an enhanced HP Storage Works Scalable File Share, provide a commonimplementation across multiple operating systems- HP-UX, Microsoft Windows and Linux andservers based on industry-standard processors (Intel Xeon , Itanium and AMD Opteron).

Experimental Facilities:

Genotyping by Sequenome Mass ArrayTo meet the demands of high-throughput SNP analysis in the post genomic era, TCGA uses areal time system that enables rapid SNP genotyping on a MALDI-TOF mass spectrometer.

With this, the accuracy, analytical process and the reliability ofmass spectroscopy has been brought to bear genotypingapplications on an industrial scale. Its advantages include;Rapid sample analysis in less then 5 seconds/sample , UtilizesSpectroCHIP bioarray for proven, high capacity sampleslaunching pad, analysis of up to 10 SpectroCHIPs without anyuser intervention., fully automated analysis of genotypereactions in MALDI system with automated identification ofall samples and controls, accompanied by Assay DesignSoftware, Liquid Handler and nano dispenser.

Microarray facility.Microarray Facility consists of a robotic spotter, parallel slide processing unit and confocal and

non-confocal dual laser scanners allowing us to carry out geneexpression profiling and development of novel nucleic acidattachment chemistry using the spotted microarray platform

and a complete Affymetrix Genechip system for the Highdensity oligonucleotide platform used for both genotyping andgene expression profiling. This system includes the GeneChipScanner, Fluidics Station, Hybridization Oven, and a powerfulcomputer workstation with dual Xeon processors loaded withGeneChip Operating Software. Dedicated workstations for

advanced data analysis with microarray analysis software complete the setup.

Proteomics facility.2D gel electrophoresis system, MALDI ToF/ToF (BrukerUltraflex) and Nano LC-MS(Agilent).


4/4

4

High-throughput sequencing & fragment analysis.ABI 3730ABI 377BiomekMultimekHydra

Nucleic acid synthesis.Oligo Synthesizers are flexible to fit a wide variety of applicationssuch as gene building, PCR, RNAi, dual labeled probes, microarray, sequencing, antisense, and others. 192 20mer PCR primerscan be synthesized in less than 6 hours. It is equipped tosynthesize up to 192 oligos (two 96 well plates) in a single run in acolumn or plate format, it has Run Logging facilities and 10

Amidite Ports.

Funding for research.A start-up fund will be provided depending on the project and its immediate relevance to on-going projects @TCGA. But a reasonable start-up fund will be provided to scientists at alllevels.

The scientists are encouraged and required to procure competitive funding from National andInternational organizations. Project proposals have to be cleared by a Monitoring Committee

and the Ethical Committee before submission to the funding agency.

CollaborationsCollaborations with well specified goals and outcomes especially aimed at translational research

with National and International Institutions/scientists are encouraged. The terms ofcollaboration should follow the guidelines of Department of Biotechnology, Indian Council forMedical Research especially in areas of disease genomics.

Personnel for research

A limited number of highly skilled technical personnel from the services section of TCGA willbe identified with specific projects. Additional personnel may be recruited under sanctionedproject positions by individual scientists. A limited number of students working towards Ph.D.degree may be involved in joint projects under faculty from IGIB or otherInstitutes/Universities.

challenging opt frm india

Documents