chairs: frédéric gottrand plenary session 1 - abstracts · programme subject to change. status as...
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Programme subject to change. Status as of March 2018
11 May 2018
08:45 – 10:15
Gastroenterology
Plenary Session 1 - AbstractsChairs: Frédéric Gottrand
08:45 – 08:55STAT6 variants interact with CYP2C19*17 to predict clinical outcome of
proton pump inhibitor therapy in children with eosinophilic oesophagitisJames Franciosci (United States)
08:55 – 09:05
Transmural healing evaluated by magnetic resonance enterography in
paediatric Crohn’s disease patients under maintenance treatment with
biologics
Ben Kang (Republic of Korea)
09:05- 09:15Viral infections as triggers of coeliac disease in a longitudinal birth
cohortChristian R. Kahrs (Norway)
09:15 – 09:25Mucosal healing and histological remission in pediatric ulcerative colitis:
does the target change the outcomes?Giulia D‘Arcangelo (Italy)
09:25 – 09:35Cystic fibrosis dyslipidemia revisited: a prospective, cross-sectional
studyJan Krzysztof Nowak (Poland)
09:35 – 09:45Development of the Pediatric Inflammatory Crohn´s MRE Index
(PICMI)- results from the ImageKids StudyGili Focht (Israel)
09:45 – 09:55 Profoundly increased mortality in patients with CF related cirrhosis Frederik H. Pals (Netherands)
09:55 – 10:05Retrospective analysis of pharmacokinetic Infliximab data in young IBD
patients at the age of 9 or younger
Maria Myrthe Elisabeth Jongsma
(Netherlands)
Programme subject to change. Status as of March 2018
11 May 2018
08:45 – 10:15
Nutrition
Plenary Session - AbstractsChairs: Iva Hojsak, Dominique Turck
08:45 – 08:45
Human milk oligosaccharides profiles from healthy European
mothers: New insights from Atlas of Human Milk Nutrients, a
multicenter observational cohort
Aristea Binia (Switzerland)
98:45 – 09:00
Utilization of human milk oligosaccharide 2’-fucosyllactose by various
probiotic strains and characterization of gene clusters involved in
HMO metabolism by Bifidobacterium longum ssp. infantis Bi-26
Johanna Hirvonen (Finland)
09:00 – 09:10
Iron fortification may reduce efficacy of oral antibiotics against
enteropathogens, whereas galacto-oligosaccharides (GOS) mitigate
the adverse effects of iron fortification on the gut microbiome in
Kenyan infants
Guus Kortman (Netherlands)
09:10 – 09:20Administration of iron as drops has significant effects on the gut
microflora of iron-sufficient infants: a randomized controlled studyTorbjörn Lind (Sweden)
09:20 – 09:30A single intake of a polysaccharides mix reduces postprandial
triglycerides, ghrelin and appetite in obese children: a clinical trialElena Fornari (Italy)
09:30 – 09:40 The Cow Milk Symptom Score (CoMiSSTM) in healthy infants Yvan Vandenplas (Belgium)
09:40 – 09:50Prolonged minimal enteral nutrition versus slowly advancing enteral
nutrition in very low birth weight infants: Randomized controlled trialOzlem Bozkurt (Turkey)
09:50 – 10:00Pre- and postnatal nutrient restriction has differential effects on
systemic immunity development in preterm pigletsOle Bæk (Denmark)
Programme subject to change. Status as of March 2018
11 May 2018
08:45 – 10:15
Hepatology
Plenary Session - Abstracts
Chairs: James Heubi, Dominique
Debray
08:45 – 09:00The liver regenerates ESPGHAN (50 years of ESPGHAN:
Hepatology)Deirde Kelly (United Kingdom)
09:00 – 09:15
The role of N-acetylcysteine in preventing hepatic injury associated
with systemic oxidative stress after extracorporeal shock wave
treatment
Sebahat Cam (Turkey)
09:15 – 09:25Portal infiltrate in protocol liver biopsies is associated with
histological phenotypes and donor specific antibodiesVladimir L Cousin (Switzerland)
09:25 – 09:35
The natural course of FIC1 deficiency and BSEP deficiency: initial
results from the NAPPED-consortium (NAtural course
andprognosis of PFIC and effect of biliary diversion)
Daan van Wessel (Netherlands)
09:35 – 09:45Alginate encapsulated hepatocytes for treatment of paediatric
failure in children: first clinical experienceAnil Dhawan (United Kingdoms)
09:45 – 09:55
Development and validation of a new diagnostic scoring system for
paediatric autoimmune hepatitis based on the ESPGHAN and
NASPGHAN 2009 proposal
José Vicente Arcos-Machancoses
(Spain)
09:55 – 10:05Chronic rejection after paediatric liver transplantation: impact of the
vanishing bile duct syndrome on long term graft survivalValeria Casotti (Italy)
10:05 – 11:15
The thrombogenic risk induced by intraportal infusion of Adult
Derived Human Liver Stem/Mesenchymal Cells in Wistar rats can
be controlled with a combination of anticoagulant drugs, heparin
and bivalirudin
Louise Coppin (Belgium)
Programme subject to change. Status as of March 2018
11 May 2018
10:15 – 10:45
Hepatology Keynote
Keynote Lecture (30 min)Chair: Henkjan Verkade
10:15 – 10:45 Low gamma-GT cholestasis Richard Thompson (United Kingdom)
Programme subject to change. Status as of March 2018
11 May 2018
11:15 – 12:15
Nutrition
Parallel Session 2 - Abstracts
Chairs: Christian Braegger,
Konstantinos Gerasimidis
11:15 – 11:25Nutrient fortification improves postnatal growth without effects on
neurodevelopment in preterm pigsAgnethe May Ahnfeldt (Denmark)
11:25 – 11:35Presence of 6’SL during lactation promotes attention,
learning/memory and reduces impulsivity in the adult offspring in miceJonas Hauser (Switzerland)
11:35 – 11:45Effects of early feeding patterns on Nrg4 expression in adipose tissue
and relationship with NAFLDFan Yan (China)
11:45 – 11:55
Maternal choline supplementation during the third trimester of
pregnancy improves infant information processing speed: a
randomized, double-blind, controlled feeding study
Richard L. Canfield (United States)
11:55 – 12:05 The Prevention of Obesity in Toddlers (PROBIT) trial Elena Fornari (Italy)
12:05 – 12:15Resting energy expenditure in children with cerebral palsy: accuracy
of prediction formulae and elaboration of a population specific formulaFrancesca Penagini (Itay)
Programme subject to change. Status as of March 2018
11 May 2018
11:15 – 12:15
Hepatology
Parallel Session 2 - Abstracts
Chairs: Emmanuel Gonzales, Deirdre
Kelly
11:15 – 11:25Next generation sequencing in the diagnostic approach to
neonatal/infantile cholestasisEmanuele Nicastro (Italy)
11:25 – 11:35MRI as a biomarker for Wilson’s disease in children: Early
observations from a larger trial into pediatric liver diseaseKamil Janowski (Poland)
11:35 – 11:45 Mutations in MYO5B in early onset cholestasis Iram Cockar (United Kingdom)
11:45 – 11:55
Capturing T-cell receptors. A potential new modality for targeting
hepatic tumours and Post-Transplantation Lymphoproliferative
Disease (PTLD)
Nicola Ruth (United Kingdoms)
11:55 – 12:05
Transient neonatal cholestasis of unknown cause is associated with
heterozygosity for pathogenic mutations in SERPINA1 or other
genes involved in cholestasis
Bert Holvast (Netherlands)
12:05 – 12:15BMP-2 restoration rescues liver fibrosis injuries by attenuating TGF-
β1 signalingYing-Hsien Huang (Taiwan)
Programme subject to change. Status as of March 2018
11 May 2018
11:15 – 12:15
Gastroenterology
Plenary Session 3 - Abstracts
Chairs: Andreas Nydegger, Gabor
Veres
11:15 – 11:25Evaluation of adalimumab effectiveness in paediatric patients with
ulcerative colitis in clinical practiceSteven Steiner (United States)
11:25 – 11:35Efficacy of Adalimumab as first-line “top-down” therapy in pediatric
Crohn’s Disease: 12 months of follow-upLetizia Zenzeri (Italy)
11:35 – 11:45Impact of changing treatment strategies on outcomes in paediatric
Ulcerative ColitisRishi Bolia (Australia)
11:45 – 11:55Manipulating the microbiome in pediatric Acute Severe Colitis with
antibiotics cocktail: a randomized controlled trialDan Turner (Israel)
11:55 – 12:05Cmorbidities in adolescents with inflammatory bowel disease: findings
from a population-based cohortAmit Assa (Israel)
12:05 – 12:15Improvements in medical treatment and surgical outcome of children
and adolescents with ulcerative colitis in the United KingdomMarcus Auth (United Kingdom)
Programme subject to change. Status as of March 2018
11 May 2018
11:15 – 12:15
Gastroenterology
Plenary Session 4 - Abstracts
Chairs: Jernej Dolinšek, Steffen
Husby
11:15 – 11:25The impact of genetic factors to familial predisposition of coeliac
disease in the TEDDY studyAnna Laitinen (Finland)
11:25 – 11:35Prevalence of type-1 diabetes autoimmunity in children at genetic risk
for coeliac diseaseKatharina Julia Werkstetter (Germany)
11:35 – 11:45Type 1 interferon pathway contributes to loss of tolerance to dietary
gluten in celiac diseaseValentina Discepolo (United States)
11:45 – 11:55
Exploring the gut-thyroid axis in paediatric cοeliac disease patients of
Hellenic origin reveals selected genomic variants in CTLA4, BACH2,
and IL23R genes that may account for overlapping susceptibility
between Graves’ disease and paediatric cοeliac disease
Theodora Katsila (Greece)
11:55 – 12:05Systemic antibiotics in the first year of life is associated with an
increased risk of diagnosed coeliac diseaseStine Dydensborg (Denmark)
12:05 – 12:15The large majority of coeliac children, adolescents and adults have a
high degree of perceived dietary competenceThomas Olsen Kipp (Denmark)
Programme subject to change. Status as of March 2018
11 May 2018
11:15 – 13:15
Gastroenterology
Clinical Practice in Gastroenterology
Chairs: Erasmo Miele, Ilse
Broeckhart
11:15 – 11:35 Proton Pump Inhibitors: use and misuse Rok Orel (Slovenia)
11:35 – 11:55 Dealing with Potential Coeliacs: to do or not to do? Renata Auricchio (Italy)
11:55 – 12:15 Managing massive acute GI bleeding Mike Thomson (United Kingdom)
12:15 – 12:35 Rumination Maartje Singendonk (The Netherlands)
12:35 – 12:55 Eosinophilic Esophagitis: the latest Jorge Amil Dias (Portugal)
12:55 – 13:15Gastro-oesophageal reflux disease in infants: should we test? should
we treat?Silvia Salvatore (Italy)
Programme subject to change. Status as of March 2018
11 May 2018
12:30 – 13:30
Gastroenterology
Plenary Session 5 - AbstractsChairs: Denise Herzog
12:30 – 12:40
Long-term outcomes of pediatric patients admitted with acute severe
colitis - a multi-center study from the pediatric IBD Porto group of
ESPGHAN
Dror Shouval (Israel)
12:40 – 12:50Looking the truth in the eye - benchmarking care and outcomes against
the world’s largest paediatric IBD registryKai O. Hensel (United Kingdom)
12:50 – 13:00Predicting relapse in new-onset Crohn disease - results of the
prospective GROWTH CD StudySéamus Hussey (Ireland)
13:00 – 13:10Investigating CD8+ T-cell gene expression signatures as potential
prognostic biomarkers in paediatric inflammatory bowel diseaseMarco Gasparetto (United Kingdom)
13:10 – 13:20A treat-to target strategy guided by Pan-enteric valuation in paediatric
Crohn’s disease improves outcomes at 2 yearsSalvatore Oliva (Italy)
13:20 – 13:30
Incidence and characteristics of rare and severe complications in
children with paediatric-onset IBD; the international PIBD SETQuality
Safety Registry by PIBDnet
Martine Aardoom (Netherlands)
Programme subject to change. Status as of March 2018
11 May 2018
12:30 – 13:30
Nutrition
Parallel Session 3 - Abstracts
Chairs: Robert Bandsma, Berthold
Koletzko
12:30 – 12:40Dairy lipids incorporation in the diet increased Omega-3 status in
post-weaning rats.Etienne Guillocheau (France)
12:40 – 12:50Maternal high-fat diet exposure leads to persistent inflammation and
altered metabolism of liver of male offspringSuchaorn Saengnipanthkul (Thailand)
12:50 – 13:00Glucocorticoids overexposure induced by neonatal overfeeding
enhanced hepatic LlipogenesisFan Yan (China)
13:00 – 13:10Newly developed infant gut simulator model for human milk
oligosaccharide fermentationKrista Salli (Finland)
13:10 – 13:20
Dietary treatment with extensively hydrolyzed casein formula with the
probiotic L.rhamnosus GG prevents the occurrence of functional
gastrointestinal disorders in children with cow’s milk allergy
Roberto Berni Canani (Italy)
13:20 – 13:30
Milk fat globule membrane alone and in combination with a prebiotic
moderates the impact of maternal separation on behavior and gut
microbiota
Sarmauli Manurung (Netherlands)
Programme subject to change. Status as of March 2018
11 May 2018
12:30 – 13:30
Hepatology
Parallel Session 3 - AbstractsChairs: Mohammad Ali Shagrani
12:30 – 12:40
MicroRNA-29a mitigation of endoplasmic reticulum and autophagy
aberrance counteracts in obstructive jaundice-induced fibrosis in
mice
Ying-Hsien Huang (Taiwan)
12:40 - 12:50Prospective evaluation of sclerosing cholangitis in children with
autoimmune liver diseaseNagendra Kumar (India)
12:50 – 13:00Validation of diagnostic scores including the new proposed
ESPGHAN score in Pediatric Autoimmune Liver diseaseVikrant Sood (India)
13:00 – 13:10
Sustained biochemical response to oral antibiotics in pediatric PSC
and ASC is correlated to changes in gut microbiota and serum bile
acids during therapy
Pauline Sambon (Belgium)
13:10 – 13:20The role of 2-Dimensional Ultrasound Shear Wave Elastography in
neonatal/infantile cholestatic jaundiceParaskevi Galina (Greece)
13:20 – 13:30Anticholestatic drugs as potential treatment for neonatal
hyperbilirubinemiaLori W.E. van der Schoor (Netherlands)
Programme subject to change. Status as of March 2018
11 May 2018
12:30 – 13:30
Gastroenterology
Plenary Session 6 – Abstracts
Chairs: Silvia Salvatore, Susanne
Schibli
12:30 – 12:40
Sensitisation to common food allergens and aeroallergens in relation to
functional gastrointestinal disorders in adolescents: results from the
GINIplus and LISA birth cohorts
Carla Harris (Germany)
12:40 – 12:50Long-term treatment with proton-pump inhibitors is effective in children
with eosinophilic esophagitisCarolina Gutiérrez-Junquera (Spain)
12:50 – 13:00A partly fermented infant milk formula with scGOS/lcFOS reduces
stress-induced gut permeability and gut hypersensitivity in ratsIngrid B. Renes (Netherlands)
13:00 – 13:10Predictive factors of histological complication in EA-TEF patients during
10 years’ prospective endoscopic follow-upLaetitia Marie Petit (Switzerland)
13:10 – 13:20 Automated detection of infant crying and fussing for clinical applications Thomas Ludwig (Singapore)
13:20 – 13:30Therapeutic efficacy of ginger on vomiting in children with acute
gastroenteritisRoberto Berni Canani (Italy)
Programme subject to change. Status as of March 2018
11 May 2018
15:15 – 17:15
Liver transplantation
Parallel Symposium
Chairs: Jörg Jahnel, Wendy van der
Woerd
15:15 – 15:48Donor specific antibodies and liver transplantation - current
concepts and future Suzanne McDiarmid (USA)
15:48 - 15:58Abstract: Subclinical biliary strictures revealed by mild ductular
proliferation in grafts of paediatric liver transplant recipientsNaire Sansotta (Italy)
15:48 – 16:31 Pharmacokinetics and pharmacogenetics in liver transplantation Vanessa Guy (Belgium)
16:31 - 16:41
Abstract: Comparison of outcome in post-transplant
lymphoproliferative disorder after paediatric small bowel versus
isolated liver transplantation in a single tertiary transplant centre
Fang Kuan Chiou (United Kingdom)
16:41 – 17:14 Nutrition – before and after liver transplantation Girish Gupte (UK)
Programme subject to change. Status as of March 2018
11 May 2018
15:15 – 17:15
Nutrition
Severe acute malnutrition (SAM); aetiology and management
Chairs: Christian Molgaard, André
Briend
15:15 – 15:40 The history of treatment of SAM: Where are we today? André Briend (Finland)
15:40 – 15:50
Abstract: Refeeding with lactose and milk minerals alters the gut
microbiota and expands plasma volume in a piglet model of moderate
malnutrition
Thomas Thymann (Denmark)
15:50 – 16:15Starved Guts: Morphologic and Functional Intestinal Changes in
MalnutritionPaul Kelly (United Kingdom)
16:15 – 16:25Abstract: Development of grip strength references in healthy children
and their usability in sick childrenSarah Williamson (United Kingdom)
16:25 – 16:50 Key nutrients in the treatment of acute malnutrition Robert Bandsma (Canada)
16:50 – 17:15 How should we treat SAM in practice? Tsinuel Girma (Ethiopia)
Programme subject to change. Status as of March 2018
11 May 2018
15:15 – 17:15
Gastroenterology
Updates in paediatric IBDChairs: Paolo Lionetti, Dan Turner
15:15 – 15:3350 years of IBD in ESPGHAN Part 1:
History of IBD in ESPGHAN Ian Sanderson (United Kingdom)
15:33 – 15:56 Classification of IBD into subtypes - beyond CD vs UC Richard Russell (United Kingdom)
15:56 – 16:06Abstract: Phenotypic variation in pediatric IBD by age: A multi-centre
inception cohort study of the Canadian Children IBD NetworkJasbir Dhaliwal (Canada)
16:06 – 16:29 It is not always IBD: eosinophilic diseases of the intestine Noam Zevit (Israel)
16:29 – 16:52 Cannabis for IBD and in children - what is the current evidence Lissy de Ridder (Netherlands)
16:52 – 17:15Thromboembolic prophylaxis in paediatric IBD - time to learn from the
adults?David Wilson (United Kingdom)
Programme subject to change. Status as of March 2018
11 May 2018
15:15 – 17:15
Gastroenterology
Pancreatitis in children: major challenges
Chairs: Michael Wilschanski,
Dominique Debray
15:15 – 15:23 50 years of the Pancreas in ESPGHAN John Dodge (United Kingdom)
15:23 -15:46Recurrent and chronic pancreatitis - what have we learned from
INSPPIRE?Aliye Uc (USA)
15:46 – 16:09 The genetics of recurrent pancreatitis: an update Heiko Witt (Germany)
16:09 – 16:32 New aspects of imaging in paediatric pancreatitis Grzegorz Oracz (Poland)
16:32 – 16:55 Autoimmune Pancreatitis in Children – A distinct Entity Isabelle Scheers (Belgium)
16:55 – 17:05Abstract: Butyrate has effects on intestinal smooth muscle adaptation
in rats with massive small bowel resectionLina Dai (China)
17:05 – 17:15
Abstract: Primary experience in safety and efficacy with
duodenojejunal bypass liner in morbidly obese adolescents implanted
for one year
Matjaz Homan (Slovenia)