chagas disease - university of california, los...
TRANSCRIPT
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Ancient, Exotic, Endemic, Deadly
Chagas Disease
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My Experience with Chagas
Disease
Simon Bolivar Visiting Professor, National University, Caracas, Venezuela
1970
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Progress in
Cardiovascular Diseases 1970
Uncommon Causes of Heart Failure (With a Section on Chagas Disease)
Joseph K. Perloff, Keith M. Lindgren
and Bertron M. Groves
Additional Experience
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Another Great Imitator:
South American Trypanasomiasis, (Trypanosoma Cruzi).
Osler called syphilis the great imitator because the signs and symptoms were similar to so many
other diseases.
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Chagas disease began millions of years ago as an enzootic (non-human) disease
of wild animals.
How Ancient is Ancient ?
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DNA evidence of Trypanosoma Cruzi has been found in 4000 year old South American
mummies.
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Caused by a hemoflagelate that enters the bloodstream after a bite of the reduvid sandfly.
Exotic
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Chagas disease is endemic In Mexico, Central and South America. Annual death
toll is 50,000. 18 million are already infected, and 100 million--25% of the population--are at risk of acquiring the
infection.
Endemic & Deadly
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African Trypanosomiasis Sleeping Sickness American Trypanasomiasis Chagas Disease
Types of Trypanosomiasis:
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African Trypanosomiasis Caused by the parasite Trypanosoma brucei that enters the bloodstream after a bite by the Tsetse fly.
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Animal-to-human and
human-to human transmission by a blood sucking reduvid bug---the phlebotomine
sandfly.
American Trypanasomiasis Chagas Disease
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Upper left--circulating flagellates. Upper right--pseudocysts light blue Lower left--myocardial fibrosis. Lower right--dilated cardiomyopathy.
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Who Was Chagas?
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Was 29 years old when he described the parasite in the blood stream, the cycle of the vector in the digestive tract, cultivation in agar-blood, and transmission to vertebrates by the bite of the infected reduvid sandfly.
In 1911, Oswaldo Cruz announced Chagas’ discovery at the National Academy of Medicine in Rio de Janeiro. In 1922, Chagas was awarded the Pasteur Prize.
Carlos Justiniano Rubiero Chagas
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Chagas was born on a Brazilian coffee farm in July 1879. His father died when the boy was four years old. An uncle urged young Carlos to study medicine. In 1908, while investigating malaria in the Amazon, Carlos learned of the existence of “kissing bugs,” so-called because of their habit of biting (kissing) sleeping human beings on the face. In 1909, Chagas described the case of a nine month old infant with the kissing bug disease.
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Who Was Cruz ?
The mentor of Carlos Chagas
Oswaldo Goncalves Cruz’s great work was the
eradication of malaria and yellow fever in Rio de Janeiro.
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At age 15, Cruz began his studies at the Rio de Janeiro Faculty of Medicine, and in 1892 he graduated. Inspired by Louis Pasteur, Cruz
wrote a thesis on water as a vehicle for the propagation of microbes.
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A Paradigm of Scientific Deduction Chagas proposed that the kissing bug---a
sandfly---transmitted a parasite to human beings and to other vertebrates. He recovered flagellates in the hindgut of the bug and in the bloodstream of domestic animals, and soon announced “a new species different from any other species of the same genus.”
The parasite was first named Schyzotrypanum Cruzi in honor of Oswaldo Cruz, and was later renamed Trypanasoma Cruzi.
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The Parasite The Vector
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Transmission of Chagas Disease
The insect is found in palm fronds of roofs and in cracks of the
mud or adobe walls of thatched houses of the poor.
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An infected mother passes the disease onto her baby either by placental transmission (chronic placentitis) or at delivery or from breast milk.
Congenital Chagas Disease
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Chagasic Fetal Hydrops
Intrauterine Heart Failure Detected by Ultrasound.
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Additional Forms of Transmission
Blood transfusion Organ transplantation
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Chagas Disease is an opportunistic infection among patients
with HIV and other types of immunosuppression.
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The Kissing Bug Kissing
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Bed Net Simple, effective, cheap, but not cheap enough for
the poor.
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During the nocturnal bite, the infected bug deposits feces laden with parasites. Transmission is
enhanced when the skin is scratched at the bite site.
A Good Night Kiss
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Charles Darwin is believed to have contracted Chagas disease during his
1833 South American expedition.
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Genetics Within the clinical spectrum of Chagas Disease, the role of parasitic genetic variability is emerging. T Cruzi is now divided into two divergent subgroups isolated from human beings, from insect vectors, and from sylvatic (wild) mammals. The two lineages diverged 37 to 88 million years ago. It has been hypothesized that lineage two is indigenous to South America, while lineage one was introduced more recently with North American placental mammals.
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Symptomatic Chagas in Newborns and Young Children
Chagoma—reddish area at bite site. Rash Romana’s sign---Unilateral periorbital edema. High fever Inappropriate (disproportionate) tachycardia. Myocarditis/pericarditis Meningoencephalitis Hepatomegaly Lymphadenopathy
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Bite Site
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Chagasic Rash
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Romana’s Sign
Painless unilateral periorbial edema
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Laboratory Tests Complement fixation —1913
Xenodiagnosis (1914) exposure of an infected individual or tissue to a clean vector
(laboratory -bred mosquito or tick). Sero-diagnosis---1970. Detection of
antibodies against the parasite. Of limited value in diagnosing the acute phase.
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Life Cycle
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When host cells rupture, flagellated parasites
are released into the lymphatics and bloodstream through which they spread to distant sites and invade new host cells.
The process continues for the life of the host.
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Acute to Chronic Disease Acute Phase -- Most acute cases escape medical attention because symptoms are non-specific (fever, malaise, vague signs of infection). Flagelates vanish from the blood stream as symtoms disappear. Latent Period ---As long as 20 years. Cardiac Involvement ---Conduction defects (RBBB/left anterior hemiblock, sudden death (complete heart block, ventricular tachyarrhythmias), cardiomyopathy, heart failure, unique LV apical aneurysm, mural thrombus. Involvement of Hollow Viscera---Esophagus, stomach, colon.
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Despite a century of research, the pathogenesis of chronic Chagas
cardiomyopathy remains incompletely understood.
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Pathogenetic Mechanisms of Chagas Heart Disease
1) Cardiac dysautonomia 2) Microvascular involvement 3) Parasite-dependent myocardial damage 4) Immune mediated myocardial injury
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Dysautonomia Disease or malfunction
of the autonomic nervous system
In 1922, Carlos Chagas and Eurico Vilella reported a blunted chronotropic response
to atropine. Cardiac neuronal damage was described in 1949.
Oria and Ramos. Arq Bras Cardiol.
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The Autonomic Nervous System.
Parasympathetic Denervation
Major neuronal damage of the heart with parasympathetic denervation confirmed
morphologically. Abnormal cardiac reflexes (Valsalva maneuver). Denervation of the sinus node with lack of parasympathetic inhibitory
action, and lack of vagally mediated response to changes in blood pressure and venous return.
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Neuronal Depopulation With Degenerative Changes
Atrial Ganglia
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Parasympathetic Denervation
Heart---Abnormal cardiac reflexes. Sinus node denervation. Neuronal damage at necropsy. Urethra/Bladder—Abnormal function Iris—Exaggerated pupillary responses
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Parasympathetic Denervation of the
Iris
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Microvascular Involvement
Clinical, pathological and experimental evidence of microvascular abnormalities in Chagas heart disease. Striking myocardial perfusion defects in the presence of normal coronary arteries. Intimal proliferation in intramyocardial arterioles, capillary basement membrane thickening, and occlusive platelet thrombi in intramural coronary arteries.
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Is There Parasite-dependent Myocardial Damage?
Myocardial lesions are usually devoid of parasites. Poor correlation between the level of parasitemia and disease severity. Seropositivity for T cruzi antigens is far more frequent than the incidence of cardiac involvement.
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Immune Mediated Myocardial Injury
Chronic Chagas heart disease has the hallmarks of delayed hypersensitivity reaction, namely, mononuclear inflammatory infiltrates
with immunoglobulin and complement deposition in myocardial tissue.
Eosinophilia
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Acute Chagasic Myocarditis
Tissue parasitism elicits a strong cellular and humeral immune response against T cruzi but does not
eliminate the parasite.
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Chronic Chagasic Cardiomyopathy
Left ventricular Apical Aneurysm.
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Left Ventricular Apical Aneurysm Twenty year old Argentine male with
asymptomatic bifascicular block.
<
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Color Doppler M-mode velocity propagation of LV inflow tract (vertical arrow). Diminished slope of color
edge in early diastole (white line) represents lower blood flow velocity toward the aneurysmal apex.
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Thromboembolism
Thrombus
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Electrocardiocardiographic Abnormalities
Sinus bradycardia Atrioventricular block Right bundle branch block Left anterior fascicular block Bifascicular block Complete heart block Multiform PVC’s Abnormal ST-T segments Abnormal T waves Abnormal Q waves
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Sudden Cardiac Death
Third degree heart block Ventricular tachycardia/fibrillation
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SAECG With Late Potentials
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AV Conduction Defects
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Right Bundle Branch Block
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Bifascicular Block Apical Aneurysm
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Hollow Organ Involvement
Gastrointestinal symptoms with chronic T.cruzi infection result from denervation of hollow viscera, especially esophagus and colon, rarely stomach, bladder and ureter.
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Megacolon
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Mega Esophagus
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Acute Chagasic pancreatitis results from local parasitism. Necrosis is caused by release of pancreatic enzymes from ruptured
parasitized cells and pseudocysts.
Chagasic Pancreatitis
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Treatment of American Trypanosomiasis
There is no preventive vaccine. , Anti-trypanosomal medications achieve only a 50% rate of parasitologic cure even in the early acute stage, and are accompanied by signifcant toxitity. Chronic stage--- No effective treatment .
.
Bed Net
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Heart Transplantation
Transplantation is problematic for chronic Chagas heart disease.
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Heart transplantation in patients with with Chagas' cardiomyopathy is accompanied by high rates of acute reactivation. A new acute phase is experienced, with fever, skin lesions, and myocarditis. Trypanosoma cruzi can be recovered in myocardial biopsies and in skin lesions.
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Marta Del Carmen Sandoval (391-28-13) The pathology report (read by Dr. Fishbein) from 2/7/2009 (labeled "MEDIASTINAL HEM") is the explanted heart which shows intracellular parasites and amastigotes. There is also diffuse myocarditis with eosinophils
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Chagas Disease Heart Transplantation
UCLA
In December 2005, a 64 year old man with idiopathic cardiomyopathy underwent heart transplantion. In January 2006, he was treated with enhanced immunosuppression for organ rejection. In February, he was admitted to hospital with anorexia and fever. A peripheral blood smear revealed T Cruzi. Blood cultures were positive, and endomyocardial biopsy contained the parasite.
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National Reference Centers for the Chagas Disease
The Chagas Disease Laboratory of Argentina serves as a National Reference Center.
Health Ministry initiatives have been established in Brazil, Bolivia, Chile, Paragray and Uruguay.
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Summary Ancient, Exotic,
Endemic, Deadly Chagas disease began
millions of years ago as an disease of wild animals.
DNA evidence of Trypanosoma cruzi has been found in 4000 year old South American mummies. In 1909, Carlos Chagas of Brazil
described the clinical picture of a new disease and identified the causative agent
as a blood-sucking triatomine reduvid parasite.
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Chagas disease is the commonest cause of heart failure and sudden cardiac
death in Mexico, Central and South America.
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What Next? Where Next ?
Never make predictions, especially
about the future, BUT
Latin American immigration to the United States is likely to spread this ancient, exotic
and deadly disease. .
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Increasing Chagas seroprevalence among
blood donors in Los Angeles County.
,
Emergence of Chagas disease in the United States and Canada
Transfusion-Associated Chagas' Disease in the United States.