ch 5 continued energy. what is energy? capacity to do work life depends on the fact that energy can...
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CH 5 continuedCH 5 continuedEnergy Energy
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What Is Energy?What Is Energy? Capacity to do workCapacity to do work
Life depends on the fact that energy can be Life depends on the fact that energy can be converted from one form to anotherconverted from one form to another
Forms of energyForms of energy Potential energyPotential energy – stored energy – stored energy (chemical & positional)(chemical & positional)
Kinetic energyKinetic energy – energy of motion – energy of motion (heat, light, electricity)(heat, light, electricity)
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Energy in Living OrganismsEnergy in Living Organisms
Examples of potential energy Examples of potential energy • Concentration gradientConcentration gradient• Energy stored in a chemical bondEnergy stored in a chemical bond
• the potential energy of moleculesthe potential energy of molecules
Examples of kinetic energy Examples of kinetic energy • Light, heat, electricityLight, heat, electricity
• Transport of substancesTransport of substances
• Muscle contractionsMuscle contractions
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Thermodynamics: study of energy transformationsThermodynamics: study of energy transformations
The First Law of ThermodynamicsThe First Law of Thermodynamics• Energy in the universe is constantEnergy in the universe is constant
Energy can be changed from one form to another but cannot Energy can be changed from one form to another but cannot be created or destroyedbe created or destroyed
• When one form of energy is converted to another the When one form of energy is converted to another the total energy present remains the sametotal energy present remains the same
Examples – firefly converts chemical/potential energy in food to Examples – firefly converts chemical/potential energy in food to kinetic energy (light and heat)kinetic energy (light and heat)
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Thermodynamics: study of energy transformationsThermodynamics: study of energy transformations
The Second Law of ThermodynamicsThe Second Law of Thermodynamics• Energy transformations increase the disorder of the Energy transformations increase the disorder of the
universe (entropy)universe (entropy)
• Each energy transformation releases some of the Each energy transformation releases some of the energyenergy as as heat heat
The increased movement of the particles due to the heat The increased movement of the particles due to the heat increases their disorderincreases their disorder
Say the energy become “less concentrated” – more spread outSay the energy become “less concentrated” – more spread out
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Fuel
Gasoline
Energy conversion in a cell
Energy for cellular work
Cellular respiration
Waste productsEnergy conversion
Combustion
Energy conversion in a carOxygen
Heat
Glucose
Oxygen Water
Carbon dioxide
Water
Kinetic energyof movement
Heatenergy
Carbon dioxide
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Energy and CellsEnergy and Cells
Each time a cell releases energy stored in Each time a cell releases energy stored in chemical bonds that energy is:chemical bonds that energy is: Captured in new, lower energy bonds, and/or Captured in new, lower energy bonds, and/or
used to do the work of the cell used to do the work of the cell andand
some is released as heat. some is released as heat. • Cells cannot use heat to do the work of the cellCells cannot use heat to do the work of the cell
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Chemical reactionsChemical reactions either either storestore or or release energyrelease energy
Endergonic reactions Endergonic reactions • Require an input of energy from the surroundingsRequire an input of energy from the surroundings• Yield products higher in potential energy than Yield products higher in potential energy than
reactantsreactants• Example: photosynthesisExample: photosynthesis
Exergonic reactions Exergonic reactions • Release energy Release energy • Yield products that contain less potential energy than Yield products that contain less potential energy than
their reactantstheir reactants• Examples: cellular respiration, burningExamples: cellular respiration, burning
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Reactants
Products
Amount ofenergy
required
Po
ten
tial
en
erg
y o
f m
ole
cule
s
Energy required
Endergonic reactionEndergonic reaction
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Examples of Endergonic ReactionsExamples of Endergonic Reactions
Reactions that Reactions that require an input require an input of energyof energy PhotosynthesisPhotosynthesis
• Multi-step process in which the sun’s energy is Multi-step process in which the sun’s energy is used to convert COused to convert CO22 and water into high energy and water into high energy
sugar molecules sugar molecules
Synthesis of ATPSynthesis of ATP• ADP + P + energy ADP + P + energy ATP ATP
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Energy released
Po
ten
tial
en
erg
y o
f m
ole
cule
s
Reactants
Products
Amount ofenergy
released
Exergonic reactionExergonic reaction
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Examples of Exergonic ReactionsExamples of Exergonic Reactions
Reactions that Reactions that releaserelease energy energy Cellular respirationCellular respiration
• Multi-step process by which energy stored in Multi-step process by which energy stored in glucose is releasedglucose is released
• Some of the energy released is used to make ATPSome of the energy released is used to make ATP• Some of the energy is released as heatSome of the energy is released as heat
Hydrolysis of ATPHydrolysis of ATP• ATP ATP ADP + P + energy ADP + P + energy
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Chemical reactions either release or store Chemical reactions either release or store energyenergy
A living organism produces thousands of A living organism produces thousands of endergonic and exergonic chemical reactionsendergonic and exergonic chemical reactions– All of these combined is called All of these combined is called metabolismmetabolism– A A metabolic pathwaymetabolic pathway is a series of chemical is a series of chemical
reactions that either break down a complex reactions that either break down a complex molecule or build up a complex moleculemolecule or build up a complex molecule
Copyright © 2009 Pearson Education, Inc.
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Energy CouplingEnergy Coupling
Coupled ReactionsCoupled Reactions Energy given off by the exergonic Energy given off by the exergonic
reaction is used to fuel/drive the reaction is used to fuel/drive the endergonic reactionendergonic reaction
Examples:Examples:• Active transportActive transport• First step of glycolysisFirst step of glycolysis
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ATPATP
ATP is the cell’s primary energy carrierATP is the cell’s primary energy carrier
ATP = adenosine triphosphateATP = adenosine triphosphate ATP = 1 adenine, 1 ribose, and 3 phosphates ATP = 1 adenine, 1 ribose, and 3 phosphates
(nucleotide)(nucleotide) The energy in an ATP molecule is in the The energy in an ATP molecule is in the
bonds between phosphatesbonds between phosphates
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The hydrolysis of ATP releases energy.The hydrolysis of ATP releases energy.
Adenosine Triphosphate
Phosphategroup
P P P
H2O
Hydrolysis
ATP ADPRibose
Adenine
Adenosine diphosphate
P P P Energy
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ATP shuttles chemical energy and drives ATP shuttles chemical energy and drives cellular workcellular work
Hydrolysis of ATP releases energy by Hydrolysis of ATP releases energy by transferring its third phosphate from ATP to transferring its third phosphate from ATP to some other moleculesome other molecule– The transfer is called phosphorylationThe transfer is called phosphorylation– In the process, ATP energizes moleculesIn the process, ATP energizes molecules
Copyright © 2009 Pearson Education, Inc.
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How Enzymes FunctionHow Enzymes Function
Even with an abundant source of ATP Even with an abundant source of ATP chemical reactions in cells would not occur chemical reactions in cells would not occur without the presence of catalysts called without the presence of catalysts called enzymes. enzymes.
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How Enzymes FunctionHow Enzymes Function
Chemical reactions require an input of Chemical reactions require an input of energy to get startedenergy to get started Called the activation energy (ECalled the activation energy (EAA))
Reactions with a large EReactions with a large EA A are relatively slow.are relatively slow.• Enzymes lower the activation energy Enzymes lower the activation energy
All reactions in the cell require the presence of All reactions in the cell require the presence of a specific enzymea specific enzyme
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Reactants
Netchangein energy
EA withoutenzyme
Products
Progress of the reaction
En
erg
y
EA withenzyme
Enzymes = proteins that function as biological catalystsEnzymes = proteins that function as biological catalysts• Increase the rate of a reaction without themselves being changedIncrease the rate of a reaction without themselves being changed• Decrease the energy of activation needed to begin a reactionDecrease the energy of activation needed to begin a reaction
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Enzymes and SubstratesEnzymes and Substrates
Enzymes are substrate specificEnzymes are substrate specific Each enzyme has a unique three-dimensional Each enzyme has a unique three-dimensional
shape that determines which chemical shape that determines which chemical reaction it catalyzesreaction it catalyzes
What determines the enzyme’s 3-D shape?What determines the enzyme’s 3-D shape?
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Enzymes and SubstratesEnzymes and Substrates
Terms:Terms: Substrate:Substrate: the reactant that fits into the active the reactant that fits into the active
site of an enzymesite of an enzyme
Active site:Active site: a pocket on the enzyme’s surface a pocket on the enzyme’s surface that the substrate attaches tothat the substrate attaches to
Each active site binds only specific substratesEach active site binds only specific substrates
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Induced Fit ModelInduced Fit Model
Binding of the substrate causes the enzyme to Binding of the substrate causes the enzyme to change shape and hold the substrates more change shape and hold the substrates more tightly.tightly. This creates conditions that are ideal for the reaction This creates conditions that are ideal for the reaction
by:by:• Holding reactants close togetherHolding reactants close together• Orienting reactants properlyOrienting reactants properly• Straining bondsStraining bonds• Shutting out / bringing in waterShutting out / bringing in water• Creating an acid or base environmentCreating an acid or base environment
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Enzyme availablewith empty activesite
Active site
Glucose
Fructose
Products arereleased
Enzyme(sucrase)
Substrate(sucrose)
H2O
Substrate isconverted toproducts
Substrate bindsto enzyme withinduced fit
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Enzyme SummaryEnzyme Summary
Most enzymes are proteins. Most enzymes are proteins. Speed up reactions by lowering the ESpeed up reactions by lowering the EA A
Enzymes are substrate specific Enzymes are substrate specific Enzymes are not permanently changed in the Enzymes are not permanently changed in the
reaction.reaction.• Enzymes can be used over and over again.Enzymes can be used over and over again.
A single enzyme may act on thousands or A single enzyme may act on thousands or millions of substrate molecules per second!millions of substrate molecules per second!
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Cellular Environment and EnzymesCellular Environment and Enzymes
Enzymes must be in their correct 3-D Enzymes must be in their correct 3-D shape to functionshape to function Each enzyme functions at its best under a Each enzyme functions at its best under a
specific set of conditions. specific set of conditions. • TemperatureTemperature• pHpH• SalinitySalinity
Why do these conditions matter?Why do these conditions matter?
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Temperature and Enzyme ActivityTemperature and Enzyme Activity
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Activity Data for 3 EnzymesActivity Data for 3 Enzymes
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Co-factorsCo-factors
Some enzymes require Some enzymes require cofactorscofactors to to functionfunction
• Metal ionsMetal ions Such as ions of iron, zinc, and calciumSuch as ions of iron, zinc, and calcium
• Organic molecules called coenzymesOrganic molecules called coenzymes The B vitamins are all coenzymesThe B vitamins are all coenzymes
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Enzyme InhibitorsEnzyme Inhibitors
Inhibitors are substances that interfere Inhibitors are substances that interfere with an enzyme’s ability to function with an enzyme’s ability to function Many toxins/poisons are enzyme inhibitorsMany toxins/poisons are enzyme inhibitors
• For example: Mercury binds to sulfur groups on For example: Mercury binds to sulfur groups on enzymes and cause the enzyme to change shape enzymes and cause the enzyme to change shape and lose functionand lose function
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Enzyme InhibitorsEnzyme Inhibitors
Inhibitors may bind to the enzyme with Inhibitors may bind to the enzyme with covalent bonds or H bondscovalent bonds or H bonds Covalent bonding inhibitors Covalent bonding inhibitors IrreversibleIrreversible
inhibitioninhibition
H bonding inhibitors H bonding inhibitors ReversibleReversible inhibition inhibition
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More on Enzyme InhibitorsMore on Enzyme Inhibitors
Irreversible enzyme inhibitorsIrreversible enzyme inhibitors have many have many uses.uses. Some inhibitors are deadlySome inhibitors are deadly
• Cyanide – inhibits an enzyme needed to make Cyanide – inhibits an enzyme needed to make ATPATP
• Sarin – inhibits an enzyme needed for nerve Sarin – inhibits an enzyme needed for nerve transmissiontransmission
• Pesticides and herbicides – bind to key enzymes in Pesticides and herbicides – bind to key enzymes in insects and plantsinsects and plants
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More on Enzyme InhibitorsMore on Enzyme Inhibitors
Some inhibitors are beneficialSome inhibitors are beneficial Antibiotics bind to essential enzymes found in Antibiotics bind to essential enzymes found in
bacteriabacteria• Enzymes not found in eukaryotic cellsEnzymes not found in eukaryotic cells
Protease inhibitors are HIV drugs that bind to Protease inhibitors are HIV drugs that bind to and inhibit an essential viral enzymeand inhibit an essential viral enzyme
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Types of InhibitorsTypes of Inhibitors
Competitive inhibitorsCompetitive inhibitors – compete with the – compete with the substrate for binding at the active sitesubstrate for binding at the active site Competitive inhibitors are similar in structure Competitive inhibitors are similar in structure
to the “real” substrateto the “real” substrate
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Types of InhibitorsTypes of Inhibitors
Noncompetitive inhibitorsNoncompetitive inhibitors – bind to the – bind to the enzyme at a location other than the active enzyme at a location other than the active sitesite Binding changes the shape of the active site Binding changes the shape of the active site
so that the substrate cannot bindso that the substrate cannot bind• Called Called allosteric controlallosteric control
Release of the inhibitor returns the active site Release of the inhibitor returns the active site to its proper shapeto its proper shape
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Substrate
Enzyme
Active site
Normal binding of substrate
Competitiveinhibitor
NoncompetitiveInhibitor -- also called an allostericinhibitor
Enzyme inhibition
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• A A competitive inhibitorcompetitive inhibitor takes the place of a takes the place of a substrate in the active sitesubstrate in the active site
• A A noncompetitive inhibitornoncompetitive inhibitor alters an alters an enzyme's function by binding at a location enzyme's function by binding at a location other than the active site and the binding other than the active site and the binding changes the shape of the active sitechanges the shape of the active site Also called - allosteric controlAlso called - allosteric control
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Feedback Inhibition of Tryptophan Feedback Inhibition of Tryptophan SynthesisSynthesis
enzyme 2 enzyme 3 enzyme 4 enzyme 5
enzyme 1
SUBSTRATE
END PRODUCT
(tryptophan)
enzyme activity of the first enzyme is enzyme activity of the first enzyme is blocked by the end-product of the pathwayblocked by the end-product of the pathway
Tryptophan builds up in the cell, binds to the first enzyme in the pathway, the active site changes shape so that it cannot bind the first substrate, and tryptophan synthesis stops
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Feedback InhibitionFeedback Inhibition
When the cell needs to make tryptophan When the cell needs to make tryptophan again:again: the tryptophan will detach from the enzymethe tryptophan will detach from the enzyme the enzyme will resume its original shape and the enzyme will resume its original shape and
bind substrate #1 againbind substrate #1 again
Many metabolic pathways in the cell are Many metabolic pathways in the cell are controlled by feedback inhibition.controlled by feedback inhibition.