ch 23 catalysis 1. list three ways a catalyst can speed up a reaction
TRANSCRIPT
Ch 23 Catalysis
1. List three ways a catalyst can speed up a reaction.
Ch 23 Catalysis2. Identify the type of catalysis in the following, and draw arrows to show the mechanism.
a.
b.
S
Cl
s lo w S+
Cl- O H -
S
OH
OH
O
H +
OH
O+
H
C H 3O HOH
O
H
O+
H
Ch 23 Catalysisc.
d.
e.
NH
OO
N+
OO- HH
OH
H 2O
OH
OH
OH
O
O+
OH
O-
H
OH
+
O
OH
OHOH
+
O
O
H 2O
Z n 2 +
O
OH
Ch 23 Catalysis3. Propose a mechanism for the following that involves a general acid catalyst
Ch 23 Catalysis4. Propose a mechanism for the following that involves a general base catalyst
Ch 23 Catalysis5. What are three factors that determine the rate of a reaction?
6. How does the rate of an intramolecular reaction compare to an intermolecular one?
Ch 23 Catalysis7. Which of the following will react more rapidly?
a.Elimination of HBr
O-
H
CH2Br
H
CH2Br
O-
Ch 23 Catalysisb. Lactone formation
c. Anhydride formation
H COOH
OH
H3C COOH
OH
O
O
O-
OBr
O
OBrO
O-
Ch 23 Catalysisd. Reaction with ethanol
ClSC6H5 E tO H
OEtSC6H5
+ HCl
cis or trans ?
Ch 23 Catalysis8. What role does imidazole play in catalyzing the following reaction?
Ch 23 Catalysis9. Explain the difference between the lock-and-key versus the induced fit model.
10. List three ways an enzyme can catalyze a reaction.
Ch 23 Catalysis11. Analyze the catalysis of carboxypeptidase
A:
Ch 23 Catalysis continued:
Ch 23 Catalysis12. Analyze the catalysis of chymotrypsin:
Ch 23 Catalysiscontinued:
Ch 23 Catalysiscontinued:
Ch 23 Catalysis13. Analyze the catalysis of lysozyme: