ch 17. systemic complications deep venous thrombosis
TRANSCRIPT
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Ch 17. Systemic complications
DEEP VENOUS THROMBOSIS
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DEEP VENOUS THROMBOSIS Geerts et al: ~60% trauma patient
deep venous thrombosis Diagnosis, prophylaxis, treatment
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silent thrombi symptomatic deep venous thrombosis pulmonary embolism death from pulmonary embolism
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2/3 patient: die of pulmonary embolism survive < 20 minutes from the onset of symptoms
prevent
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incidence of death from pulmonary embolism: 1% ~ 2%
effective treatment in reducing the rate of fatal pulmonary emboli ?? no randomized prospective studies
treatment / prophylaxis
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Virchow
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Clinical findings: pain, swelling, tenderness: not reliable for DVT diagnosis (70% false positive)
Impedance plethysmography (IPG)(電阻體積描記器 ) X
Fibrinogen leg scanning X
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Venography: invasive, difficult to perform, more accurate for calf thrombi and nonocclusive/asymptomatic DVT
Venous doppler/ultrasonography: more accurte, availableSpecificity: 95% for femoralSensitivity: 70% for calf veinsRepeat/routine exam: not cost-effective
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D/US: for lower extremity thrombi Pelvic thrombi: difficult to detect by
D/US, CT, MRI
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Pulmonary embolism Transient dyspnea Chest pain Hemoptysis Larger occlusive emboli Symptoms of right side heart failure /
syncope / hypotension D.D.: pulmonary infection,
musculoskeletal chest wall pain, pericarditis, esophageal spasm, anxiety
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Chest radiography Electrocardiogram Oxygenation (oximetry / gas) 70% of patient with PE: have evidence
of venous thrombosis ←→ < 50% patients have PE with lower extremity D/US studies positive
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Pulmonary angiography: gold standard normal pulmonary angiogram: excludes
the diagnosis normal perfusion scan: excludes PE more specific than ventilation-perfusion
scans of the lung
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~1995 CT pulmonary angiogram: most frequentlysensitivity and specificity: 90% for identifying
central PE (main, lobar, segmental arteries)
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venous thromboembolism, risk of recurrence: 5% to 10% per year
prevention of the first episode with prophylactic strategies
risk of recurrent: higher among men than women (20% vs. 6%)
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prophylaxis for preventing deep venous thrombosis
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Mechanical prophylaxis
Graduated compression stockings / Intermittent compression devices (IPC)low patient compliance lower extremity fractures
risk of pulmonary embolism or death: X As an adjutant to pharmacologic
anticoagulation / patients who have a high risk of bleeding
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inferior vena cava filters: prevention of fatal pulmonary embolism in trauma patients
Indication: contraindications to anticoagulation developed venous thrombosis despite anticoagulationhead injuries, multiple long bone fractures, pelvic and
acetabular fractures, patients that have evidence of deep venous thrombosis before a major surgical procedure
increased risk for recurrent deep venous thrombosis retrievable vena cava filters anticoagulation therapy
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use of systemic heparinization within the first week after THR: 50% wound complication rate from hematoma formation
Contraindications to the use of pharmacologic anticoagulation:associated intracranial bleeding, spinal cord
injuries, the observation of splenic injuries, any injury that has a high risk of developing recurrent bleeding
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intracranial injury: contraindication to the use of anticoagulation
using mechanical devices or repetitive screening to avoid worsening of the intracranial injury
vena caval filters (high risk for thromboembolism)
Removable vena caval filters: OK
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Pharmacologic anticoagulation mortality rate from pulmonary embolism
for patients with hip fractures: 1% to 2% after fixation of proximal femur fractures
pharmacologic prophylaxis: recommended
Fractures distal to the hip: 18% incidence of deep venous thrombosis
Factors associated with thrombi: age older than 40, a delay to surgery,
prolonged operative times
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ideal agent:low complication rate, easy administration,
low cost, and excellent bioavailability
Coumadin / LMWH: several prospective and randomized studies of deep venous thrombosis after total hip replacement: LMWH reduce the incidence of silent
thrombi
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differing forms of prophylaxis for venous thromboembolism ??patient's risk factorsinjuriessurgeryperiod of postoperative immobilization
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OUTCOME OF CRITICAL ILLNESS ASSOCIATED WITH ORTHOPEDIC TRAUMA short-term mortality (for example,
intensive care unit, 28 day, hospital mortality)
long-term outcomes, including delayed mortality, quality of life (QOL) in survivors, and the social effects on caregivers, including family members
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Pain common complaint after prolonged critical illness,
significantly impairing QOL 50 patients from a mixed intensive care unit (ICU)
with tracheotomy for prolonged critical illness 44% of patients: pain at the highest level of severity survive the acute phase prolonged chronic critical
illness having at least three components:
injury or illness and host characteristics leading to critical illness and ICU admission
ICU period of critical illness subsequent periods of post-ICU care, including hospital
ward, intermediate care and rehabilitation, and outpatient care
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ARDS common complication of trauma and sepsis
severe and prolonged critical illness improvement in mortality significant impairments in physical,
psychologic, and social functioning Sepsis with ARDS QOL < trauma with
ARDS pulmonary function: improves significantly
during the first 6 months illness
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Neuromuscular weakness more common 109 survivors identifying significant neuromuscular
weakness at 12 months after ARDS generalized weakness with global muscle wasting:
6-minute walk test, foot drop, large joint immobility, dyspnea
patients with critical illness–acquired neuromuscular weakness: 50% of ARDS survivors have not returned to work at 1 year after ICU discharge
weakness and fatigue increase in mortality, duration of hospital and rehabilitation care, and overall health care costs
neuromuscular weakness following critical significant and long-lasting impairments in QOL
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enhance neuromuscular function after severe critical illness
limiting use of neuromuscular blockade and corticosteroids
intensive insulin protocol with tight glucose control improved neurophysiologic testing
earlier involvement of physical and occupational therapy
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Survivors of ARDS: Significant impairments in psychologic and social domains
Depression more than 43% of ARDS survivors 6 to 41
months after lung injury
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Post-traumatic stress syndrome (PTSD) related to the frequency of patients' recall
of traumatic events in the ICU 9% incidence of PTSD if one or fewer
traumatic events are recalled compared to 41% if two or more traumatic events are recalled
presence of delusional memories with recall of factual events development of PTSD
delusional recall appears to be retained over time but factual recall declines over time.
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Cognitive impairment
common after prolonged critical illness impaired memory, attention,
concentration, or decreased mental processing speed
55 consecutive survivors of ARDS (mean ICU length of stay 29 days): 78% had cognitive impairment at 1 year after ARDS
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brain injury during critical illness neuropsychologic impairment ??
Reduction in cerebral blood flow, cerebral edema, and disruption in the blood–brain barrier septic encephalopathy
systemic inflammation endothelial and neuronal cell injury, (cellular hypoxia, and leukocyte-derived inflammatory mediator and free radical injury)
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Effective interventions early psychiatric consultation for
identification and treatment of depression, anxiety, and PTSD
easily miss formal neuropsychologic testing
Identification and treatment of sleep disturbance and delirium
daily interruption of sedation may reduce the development of PTSD