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Wolfson Institute, Centre for Psychiatry qmul.ac.uk/wolfson/centres/cfp/

Summer 19 - Issue 16

Barts and The London

p

2 www.qmul.ac.uk/wolfson/centres/cfp/ Summer 2019 Newsletter

3 Editorial Isabelle Foote

4 Prizes and awards Samuel Gershon Junior Investigator Award

19th Annual Health Research Conference

Teaching and Learning Conference

Education Awards

6 Postgraduate taught courses

8 Interview with Psychiatry Consultant on BBC’s ‘Killing Eve’

10 Donato Favale’s report

11 NewstaffandstudentsattheCentre for Psychiatry

12 Publications

16 State of the Art Conference 2019 summary

Contents

3 www.qmul.ac.uk/wolfson/centres/cfp/

This year has seen the largest genome-wide association study of depression to date, identifying 102 common genetic risk variants. As it becomes possible to genotype large population samples, new findings relating to pathogenic mechanisms for multiple psychiatric disorders have been made possible. Alongside the expanding field of psychiatric genetics, the field of psychoimmunology has gained momentum in recent years as increasing evidence implicates chronic inflammation in playing a crucial role in the onset of depression and multiple physical diseases. These key areas of psychiatry promise to provide deeper understanding of the biological processes that lead to mental health disorders thus opening up the possibility of new therapeutics and prevention strategies.

In response to this, the first half of the year has seen the Centre for Psychiatry adopt a deeper research focus on the integration of biological and social aspects of psychiatric disease. In March, to showcase this change to the wider research community, the Centre hosted the 2019 State of the Art Annual Congress on ‘Psychological Medicine: Bio-Social Advances in Psychiatric Research.’ Chaired by Professors Kamaldeep Bhui and Frank Röhricht, the event included talks on the biology of ethnicity, music and the microbiome in mental health.

Within the Centre, Dr Georgina Hosang received a Barts Charity grant to conduct a study focusing on the epigenetics of childhood maltreatment in bipolar disorder. Simone Jayakumar and I have begun PhD studentships focusing on inflammation and depression in chronic kidney disease, and the mechanisms underlying the link between depression and dementia, respectively. For this, we are working in close collaboration with the Renal Department at Barts Health NHS Trust, the Department of Clinical Pharmacology at the William Harvey Institute and the Preventive Neurology Unit at the Wolfson Institute of Preventive Medicine to undertake large observational studies in the local population.

Editorial

Isabelle Foote George Henry Woolf PhD Candidate

With the era of genomics and big data it is more important than ever for ethical and societal impacts to be considered. I believe that the Centre is particularly well-suited for these topics to be explored due to the varied backgrounds of its researchers, ranging from anthropology to neuroscience, and its international expertise in issues surrounding ethnicity and cultural psychiatry. Being located in multi-cultural East London is an incredible asset for us and our planned studies are expected to recruit a diverse population that many other institutions do not have easy access to. Taken together, this puts us in good stead to tackle the bio-social interface of psychiatry in a holistic way to ensure that future findings can be applied to the wider population.

Thank you to everyone at the Centre for your hard work and support to make such a vibrant and inspiring atmosphere for all levels of staff and students. I hope you enjoy this newsletter covering our many successes this year, including an interview with Dr Mark Freestone on his experience in providing expert consultancy on psychopathy for the award-winning ‘Killing Eve’ series, which is now broadcasting its second season.

As always, if you have anything that you would like to contribute to the newsletter, please email Renata Samulnik ([email protected]).

Isabelle Foote George Henry Woolf PhD Candidate [email protected]

Summer 2019 Newsletter

Samuel Gershon Junior Investigator Award by the International Society for Bipolar DisordersGeorgina Hosang In March 2019 despite being 6 months pregnant, Georgina Hosang travelled across the globe to Sydney, Australia to receive the prestigious Samuel Gershon Junior Investigator Award from the International Society for Bipolar Disorders [ISBD] for her work on ADHD and hypomania. This award recognises the outstanding work of future leaders in the field of bipolar disorder and is offered annually with stiff international competition. As part of the award Georgina delivered a presentation at the congress entitled: ‘Do symptoms of ADHD and hypomania share genetic and environmental influences in young people? A longitudinal twin study’. Georgina said “I am absolutely thrilled to be honoured in this way for my research especially by ISBD who do tremendous work to support research and development of guidelines for clinical practice for bipolar disorder”. The results of this work have been recently accepted for publication in JAMA Psychiatry, so watch this space for more details.

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Prizes and awardsat the Centre of Psychiatry

Barts Charity GrantIn February 2019, Georgina Hosang received a small grant from Barts Charity to explore the epigenetic signature of childhood maltreatment in bipolar disorder taking into account the impact of social support. Childhood maltreatment (abuse and neglect) has been consistently associated with bipolar disorder however mechanisms which underpin this association are unclear. Research suggests that exposure to childhood maltreatment can lead to biological changes, such as, the extent to which genes are turned ‘on’ or ‘off’ or expressed. Epigenetics is one of the processes that is involved in the expression of genes and may occur through DNA methylation. Epigenetic changes are dynamic and reversible, and are thought to be governed by exposure to positive and negative environmental influences. For instance, individuals who have experienced childhood maltreatment have been found to exhibit differing DNA methylation patterns in adulthood compared to those without such experiences. But these results have not been found in all studies. There are various reasons for the differing results. Firstly, the samples used may have impacted the findings since many included maltreated individuals who have not developed mental illnesses and maybe classed as ‘resilient’. There are no published studies that have explored the DNA methylation patterns in people with BD who have experienced childhood maltreatment. Second, DNA methylation changes are influenced by both positive and negative environmental factors. The current literature concerned with childhood maltreatment has not accounted for positive experiences in adulthood such as supportive and positive relationships with friends and family (good social support). Georgina’s preliminary study will address these gaps in the literature using existing data from the BADGE (Gene-Environment interplay in Bipolar Affective Disorder) study.


I am absolutely thrilled to be honoured in this way for my research especially by ISBD who do tremendous work to support research and development of guidelines for clinical practice for bipolar disorder Georgina Hosang

19th Annual Health Research in East London half-day conferenceWednesday 2nd October 2019, 2-5pm Robin Brook Centre, Barts, West Smithfield

Sania Shakoor, Landon Kuester and Amy Ronaldson, of the Centre for Psychiatry, have been accepted to present at the 19th Annual Heath Research in East London half-day conference. A large number of applications were submitted to present, almost three for every available time slot, so it is considered a great achievement to be accepted.

Sania Shakoor: A twin study exploring the association between childhood emotional and behaviour problems and specific psychotic experiences in a community sample of adolescents

Landon Kuester: Personality Disorder in Custody: Delivering Support and Enabling Change

Amy Ronaldson: Using routine data to model associations between depression and A&E use in patient with Type 2 diabetes mellitus

Teaching and Learning Conference and Drapers’ Lecture 2019Our colleagues from the Centre attended and presented at the 20th February Teaching and Learning Conference and Drapers’ Lecture.

There were three presentations that formed a panel on ‘Promoting Wellbeing’. The talks included:

• ‘WellMed 18’ by Professor Ania Korszun;

• ‘Promoting wellbeing and resilience in the medical curriculum’ by Aiva Aksentyte; and

• ‘World Café - an approach to exploring student diversity and wellbeing’ by Heidrun Bien, Maria Turri, Rida Zahra and Gulce Sakallioglu.

Prizes and awardsat the Centre of Psychiatry


Education Awards for the Teacher of the Year award

Drs Maria Turri and Bridget Escolme one of four runners up

for the Education Awards for the Teacher of the Year award. Dr Turri

(middle) received a certificate of this prestigious award.

More details about the 19th Annual Heath Research in East London half-day conference, including a map and directions, are available at: https://www.elft.nhs.uk/Research/ELFT-Research-Conference-2019

The hashtag is #ELFTResearch

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MSc Creative Arts and Mental Health This programme offers an interdisciplinary approach to knowledge and research in mental health, with emphasis on both science and theatre and performance in the creative arts. This innovative and unique MSc is designed for education professionals, artists, scholars or mental health practitioners, and is jointly run by the Centre for Psychiatry and the Department of Drama.

Students on the course learn about the application of the creative arts to research, practice, education, advocacy and activism in the field of mental health. They study the ways in which mental health experiences are represented in the arts and in popular culture, and consider how arts practice can critique and expand both clinical and popular understanding of mental health and the mental healthcare system.

This programme is joint led by Dr Maria Turri (Psychiatry) and Professor Bridget Escolme (Drama)

The Centre for Psychiatry is responsible for the Mental Health Postgraduate Teaching Programme in the Wolfson Institute. We run four Master’s level pathways that are intended to provide those seeking to work, or already working in, mental healthcare settings with expert knowledge of evidence-based practice and latest developments of the field. The Centre’s postgraduate teaching is closely informed by our research, and adopts a holistic, biopsychosocial approach to training mental health expertise.

MSc Forensic Psychology and Mental Health

This MSc gives students a state-of-the art summary of forensic psychology and mental healthcare with a focus on psychosocial perspectives and the policy context of forensic mental health service delivery. Teaching on the course is co-delivered by staff and Experts by Experience at East London NHS Foundation Trust (ELFT), a recognised centre of excellence providing forensic care to a complex and diverse population. Students complete a placement within a forensic setting allowing them the opportunity to apply in-class teaching to ‘real world’ contexts.

The programme is seeking accreditation with the British Psychological Society for the Stage 1 qualification in Forensic Psychology and is ideal for psychology graduates seeking to train as forensic psychologists, or for other professionals working in forensic mental health services looking to gain more knowledge of risk assessment and research evidence.

This programme is led by Dr Hannah Jones (Psychiatry)

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Postgraduate taught courses in the centre


1 2New name from 2020


MSc Mental Health: Psychological Therapies

This popular programme teaches students how to assess mental health problems, understand their origins and help patients to recover. It provides a unique combination of clinical skills and analysis of psychological therapies, using a culturally informed biopsychosocial model to teach students how to think critically about the application of specific therapies. It is ideal for students who are keen in pursuing a career in counselling or clinical psychology, or becoming a psychological wellbeing practitioner.

As part of the programme, students learn which psychological therapies are effective and for whom in which circumstances; undertake a supervised placement in a clinical setting; and gain a comprehensive training in research methods and writing, whilst learning from leading experts in the field of psychological medicine.

This programme is led by Dr Heidrun Bien (Psychiatry).

MSc Mental Health: Cultural and Global Perspectives in Mental Healthcare

Students on this MSc explore how mental health, mental illness and treatment are affected by socio-cultural contexts. They examine how cultural factors such as belief systems, values, practices and traditions can affect an individual’s mental health risk, and their resilience to poor outcomes. Students also look at how migration and other cultural phenomena create mental health challenges and how these can be addressed.

All students complete a supervised placement with a mental health service or organisation that provides support to a diverse range of people (for example, asylum seekers or a global mental health and development agency). This programme is ideal for students who work in mental health care with culturally diverse populations and/or want to increase their therapeutic impact or the cultural competency of mental health care services.

This programme is joint led by Andrea Palinski and Professor Simon Dein (Psychiatry).

For more information about studying any of these courses, or if you would be interested in taking a placement student to assist you in your practice, please send us an email at: [email protected]

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Postgraduate taught courses in the centre (continued)

Also available

as distance learning

Also available

as distance learning


Interview with Psychiatry Consultant on BBC’s ‘Killing Eve’

Dr Mark Freestone, Senior Lecturer at the Centre for Psychiatry and Director of Postgraduate Programmes for Queen Mary’s Wolfson Institute, was the Psychiatry Consultant for the hit BBC show ‘Killing Eve’. In this interview, Dr Freestone talks about how he helped shape the character of Villanelle, the psychopathic assassin and also the antagonist of Luke Jennings’ original novellas.

Dr Mark Freestone, Senior Lecturer. Photo credit: Madeline Neeson

Reflectingreality“Of course television requires some suspension of belief,” he said, “but it’s most impactful when you see characters that might have an echo of peoples’ real experiences of a narcissist or a psychopath to them.

“So it’s ok for Villanelle to appear oddly naïve and emotionally confused, as she does in the show’s opening scene, but not for her to suddenly start reflecting on her situation and develop doubts or reservations about her treatment of other people.

“That is just not something a psychopath would plausibly do and their neuropsychological traits effectively prevent it, so the idea of a ‘psychopath with a heart of gold’ would just be nonsense.”


Dr Freestone said one of the challenges he faced as Psychiatry Consultant on the programme was being caught between wanting to shape and encourage the writers’ most exciting ideas but also sticking to the brief of ensuring the character’s arc and decisions were based on research evidence and clinical reality.

Dr Freestone’s work is shaped by previous roles he has held working in two of Britain’s three high-secure hospitals and a maximum security prison. He said: “Having worked in prisons and secure hospitals for over 10 years, I have a pretty deep well of disturbing, instructive or darkly comedic anecdotes about working in forensics to tell, echoes of some of which made it into the production.”

The character of Villanelle is described as a psychopath. Generally there are a checklist of traits that a psychologist or psychiatrist will apply against a criminal to reach a judgement about whether they would meet enough criteria to be a ‘clinical psychopath’.


Interview with Psychiatry Consultant on BBC’s ‘Killing Eve’ (continued)


“If you’ve watched the season all the way through to the end and think you understand the nature of the dynamic between Eve and Villanelle completely, then you are a better psychologist than me.”Dr Freestone

What makes a psychopath?Dr Freestone argues that there is an energetic debate in forensic psychology about how far a true psychopath should have what are called the ‘secondary’ more behavioural traits, such as juvenile delinquency, committing a range of crimes or promiscuous sexual behaviour.

He said: “This is why it’s plausible that Villanelle is so chameleonic: that she can come across as a nurse, Italian socialite or charming Home Counties girl when she needs to, in service of a particular end.

“Underneath that, however, is someone who is unaffected by gruesomely killing a room full of people so she can fund her lavish lifestyle. Or just because she enjoys it. Underlying all this is someone whose reality is quite fundamentally different to yours or mine.”

Dr Freestone relished the challenge of writing a genuinely psychopathic character, with all the difficulties that posed. He said: “If you’ve watched the season all the way through to the end and think you understand the nature of the dynamic between Eve and Villanelle completely, then you are a better psychologist than me.”

‘Killing Eve’ won critical acclaim when it first aired in 2018 and is centred on a cat and mouse chase between an MI5 agent and an assassin.

Donato Favale’s report


My name is Donato Favale and I am a specialty registrar in psychiatry from Italy. I will finish my specialization in Psychiatry in October and will take a course in Psychoanalytic Psychotherapy. For the last two months, I have completed a period of research as a Research Fellow in the Centre for Psychiatry, during which I have been writing a book chapter on terrorism and mental health. It has been a wonderful experience for me and I am thankful to the Centre staff for their hospitality and for giving me the opportunity to improve my research education.

Every Tuesday I participated in the research meetings with colleagues under the supervision of Professor Kamaldeep Bhui, the Centre Lead, to discuss our research projects together. Furthermore, I attended some very interesting conferences and lectures. For example, Dr Hannah Jones gave a lecture about ‘Personality in Maltreating Parents’ which helped me to understand the effects that personality disorders in parents have on their children. I also attended the Barts Academic Afternoon focusing on ‘Global Mental Health - Lessons for the East End’ chaired by Dr Graham Fawcett. This event covered very key topics that face immigrants and refugees. At the end of my period here I had the opportunity to attend a very interesting lecture titled ‘Individual differences in environmental sensitivity-risk and resilience, brain function and their implication for treatment’ by Professor Michael Pluess, Head of the Psychology Department at QMUL. This was very useful for me because I am working on a research project in Italy focusing on the role of resilience in patients with mental illness.

In my time with the Centre I have learnt about different research methods that I can apply to my future work. I’d like to keep a link with the Centre and thank everyone for this experience.

It has been a wonderful experience for me and I am thankful to the Centre staff for their hospitality and for giving me the opportunity to improve my research educationDonato Favale

Newstaffandstudentsat the Centre of Psychiatry


Simone JayakumarSimone completed her BSc in Psychology and an MSc in Applied Psychological Research Methods (Psychopathology endorsement) at the University of Roehampton, London. Simone is currently undertaking her PhD at the Centre for Psychiatry and her work focuses on the recognition and treatment of depression in renal dialysis patients: The role of inflammation.

Stacey JenningsStacey completed a BSc in Psychology at the University of Edinburgh followed by an MSc in Mental Health Services at King’s College London. At the Institute of Psychiatry she worked across multiple projects including: assessing the effectiveness of psychiatric services for acute postnatal disorders, an evaluation of Assertive Outreach Treatment for frequent hospital attenders with alcohol dependency, and a qualitative exploration of codeine misuse. She has also conducted evaluations of interventions for psychiatric ward staff.Stacey joined QMUL in 2019 to commence a PhD exploring alcohol use and ethnicity.

Roisin Mooney Roisin Mooney graduated from Brunel in 2012, with a first class honours degree in psychology with professional development. After which she worked in both research and teaching at the University of Hertfordshire, in various capacities. With a long standing history of being employed in East and North Herts NHS Trust, much of the research she has worked on has entailed NHS collaboration. Her teaching specialisms relate to undergraduate research skills, conducting research in the NHS and health psychology, with research experience in multicentre NHS research, systematic reviews and qualitative research. In 2019 she completed a PhD relating to the experience and screening of depression in South Asian Haemodialysis patients and has presented research at various professional conferences. She is currently employed as a trial manager the Synergi Collaborative Centre at Queen Mary University and project

manager for FEasibility and Acceptability Of Transcranial Stimulation in Obsessive Compulsive Symptoms (FEATSOCS) at the University of Hertfordshire. At present Roisin’s research interests relate to identifying and measuring depression in people with Chronic Kidney Disease, the lived experiences of depression in people from ethnic minorities and exploring the relationship between illness perceptions and depression.

Dr Shamea MiaDr Shamea Mia is a Research Assistant in the Centre for Psychiatry, who has recently taken up a place on a five-year Lankelly Chase commissioned project on ethnic inequalities in severe mental illness.

Prior to this position, Shamea worked on a research project that understood migrant children’s voices and engagement in classroom settings and was based at the University of Suffolk. She was a Dissertation Supervisor to third year undergraduate students and taught on a first year undergraduate module there as well.

She has also taught on an undergraduate Sociology module at the University of Greenwich.

Shamea obtained her PhD in Sociology from Goldsmiths’ College, University of London in 2015. Her thesis explored the identities of second generation British Bengali Muslim women living in London


Dr Shamea Mia

Stacey Jennings

Roisin Mooney

Publications


K Bhui Moschopoulou E, Hutchison I, Bhui K, Korszun A. Response to the letter to the editor: Post-traumatic stress in head and neck cancer survivors and their partners. Support Care Cancer. 2019.

Bhui K. Remembering, commemorating and mood matters for 2019. Br J Psychiatry. 2019;214(1):58.

Bhui K. Scotoma in psychiatric practice and research. Br J Psychiatry. 2019;214(3):180.

Misiak B, Samochowiec J, Bhui K, Schouler-Ocak M, Demunter H, Kuey L, Raballo A, Gorwood P, Frydecka D, Dom G. A systematic review on the relationship between mental health, radicalization and mass violence. Eur Psychiatry. 2019;56:51-9.

Eylem O, Dalgar I, Ince BU, Tok F, van Straten A, de Wit L, Kerkhof, Ajfm, Bhui, K. Acculturation and suicidal ideation among Turkish migrants in the Netherlands. Psychiatry Res. 2019;275:71-7.

Barnett P, Mackay E, Matthews H, Gate R, Greenwood H, Ariyo K, Bhui K, Halvorsrud K, Pilling S, Smith S. Ethnic variations in compulsory detention under the Mental Health Act: a systematic review and meta-analysis of international data. Lancet Psychiatry. 2019;6(4):305-17.

Bhui K. Depression and dementia in old age: improving effective care and prevention. Br J Psychiatry. 2019;214(4):244.

Bhui K, Otis M, Silva MJ, Halvorsrud K, Freestone M, Jones E. Extremism and common mental illness: cross-sectional community survey of White British and Pakistani men and women living in

England. Br J Psychiatry. 2019:1-8.

Curtis D, Adlington K, Bhui KS. Pursuing parity: genetic tests for psychiatric conditions in the UK National Health Service. Br J Psychiatry. 2019:1-3.

Engelbrecht A, Burdett H, Silva MJ, Bhui K, Jones E. The symptomatology of psychological trauma in the aftermath of war (1945-1980): UK army veterans, civilians and emergency responders. Psychol Med. 2019;49(5):811-8.

Staniszewska S, Mockford C, Chadburn G, Fenton SJ, Bhui K, Larkin M, Newton E, Crepaz-Keay D, Griffiths, F. Weich S. Experiences of in-patient mental health services: systematic review. Br J Psychiatry. 2019:1-10.

Giebel CM, Worden A, Challis D, Jolley D, Bhui KS, Lambat A, Kampanellou E, Purandare N. Age, memory loss and perceptions of dementia in South Asian ethnic minorities. Aging Ment Health. 2019;23(2):173-82.

Jones E, Bhui K, Engelbrecht A. The return of the traumatized army veteran: a qualitative study of UK ex-servicemen in the aftermath of war, 1945 to 2000. Int Rev Psychiatry. 2019:1-11.

Ullmann E, Perry SW, Licinio J, Wong ML, Dremencov E, Zavjalov EL, Shevelev OB, Khotskin N V, Koncevaya GV, Khotshkina AS, Moshkin MP, Lapshin MS, Komelkova, MV, Feklicheva, IV, Tseilikman, OB, Cherkasova OP, Bhui KS, Jones E, Kirschbaum C, Bornstein SR, Tseilikman V. From Allostatic Load to Allostatic State-An Endogenous Sympathetic Strategy to Deal With Chronic Anxiety and Stress? Front Behav Neurosci. 2019;13:47.

Bhui KS, Lee W, Kaufman KR, Lawrie SM. Ensuring research integrity: setting standards for robust and ethical conduct and reporting of research. The British Journal of Psychiatry. Cambridge University Press; :1–2

Bhui KS, Byrne P, Goslar D, Sinclair J. Addiction care in crisis: evidence should drive progressive policy and practice. The British Journal of Psychiatry. Cambridge University Press; :1–2

Bhui KS, Lee W, Kaufman KR, Lawrie SM. Ensuring research integrity: setting standards for robust and ethical conduct and reporting of research. Br J Psychiatry. 2019;215(1):381-2.

J Coid Yu H, Meng YJ, Li XJ, Zhang C, Liang S, Li ML, Li Z, Guo W, Wang Q, Deng W, Ma x, Coud J, Li T. Common and distinct patterns of grey matter alterations in borderline personality disorder and bipolar disorder: voxel-based meta-analysis. Br J Psychiatry. 2019:1-9.

A Korszun Moschopoulou E, Hutchison I, Bhui K, Korszun A. Response to the letter to the editor: Post-traumatic stress in head and neck cancer survivors and their partners. Support Care Cancer. 2019.

Skinner HK, Rahtz E, Korszun A. Interviews following physical trauma: A thematic analysis. Int Emerg Nurs. 2019;42:19-24.

Dimitrov L, Moschopoulou E, Korszun A. Interventions for the Treatment of Cancer-Related Traumatic Stress Symptoms: A Systematic Review of the Literature. Psychooncology. 2019.

Smeeth DM, Dima D, Jones L, Jones I, Craddock N, Owen MJ, Rietschel M, Maier W, Korszun A, Rice JP, Mors O, Preisig M, Uher R, Lewis CM, Thuret S, Powell TR, Polygenic risk for circulating reproductive hormone levels and their influence on hippocampal volume and depression susceptibility. Psychoneuroendocrinology. 2019;106:284-92.

S A Stansfeld Stafford M, Lacey R, Murray E, Carr E, Fleischmann M, Stansfeld S, Kuh D, Head J. Work-family life course patterns and work participation in later life. Eur J Ageing. 2019;16(1):83-94.

Browne P, Carr E, Fleischmann M, Xue B, Stansfeld SA. The relationship between workplace psychosocial environment and retirement intentions and actual retirement: a systematic review. Eur J Ageing. 2019;16(1):73-82.

Murray ET, Zaninotto P, Fleischmann M, Stafford M, Carr E, Shelton N, Stansfeld S, Kuh D, Head J. Linking local labour market conditions across the life course to retirement age: Pathways of health, employment status, occupational class and educational achievement, using 60 years of the 1946 British Birth Cohort. Soc Sci Med. 2019;226:113-22.

Guski R, Schreckenberg D, Schuemer R, Brink M, Stansfeld SA. Comment on Gjestland, T. A Systematic Review of the Basis for WHO’s New Recommendation for Limiting Aircraft Noise Annoyance. Int. J. Env. Res. Pub. Health 2018, 15, 2717. Int J Environ Res Public Health. 2019;16(7).


Publications (continued)


P D White Martin KR, Bachmair EM, Aucott L, Dures E, Emsley R, Gray SR, et al. Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT). BMJ Open. 2019;9(1):e026793.

Carr MJ, Ashcroft DM, White PD, Kapur N, Webb RT. Prevalence of comorbid mental and physical illnesses and risks for self-harm and premature death among primary care patients diagnosed with fatigue syndromes. Psychol Med. 2019:1-8.

Research/SeniorstaffA Ajaz Chow WS, Ajaz A, Priebe S. What drives changes in institutionalised mental health care? A qualitative study of the perspectives of professional experts. Soc Psychiatry Psychiatr Epidemiol. 2019;54(6):737-44.

R Bhattacharya Butt MF, Walls D, Bhattacharya R. Do patients get better? A review of outcomes from a crisis house and home treatment team partnership. BJPsych Bulletin. Cambridge University Press; 2019:1–6.

D Curtis Curtis D. A weighted burden test using logistic regression for integrated analysis of sequence variants, copy number variants and polygenic risk score. Eur J Hum Genet. 2019;27(1):114-24.

Tsavou A, Curtis D. In-silico investigation of coding variants potentially affecting the functioning of the

glutamatergic N-methyl-D-aspartate receptor in schizophrenia. Psychiatr Genet. 2019.

Al Eissa MM, Sharp SI, O’Brien NL, Fiorentino A, Bass NJ, Curtis D, McQuillin A.Genetic association and functional characterization of MCPH1 gene variation in bipolar disorder and schizophrenia Amercian Journal of Medical Genetics Part B Neuropsychiatric Genetics; 2019

Curtis D. Clinical relevance of genome wide polygenic score may be less than claimed. Annals of human genetics.0(0).

Curtis D, Adlington K, Bhui KS. Pursuing parity: genetic tests for psychiatric conditions in the UK National Health Service. Br J Psychiatry. 2019:1-3.

Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. Harold D, Connolly S, Riley BP, Kendler KS, McCarthy SE, McCombie WR, Richards A, Owen MJ, O’Donovan MC, Walters J; Wellcome Trust Case Control Consortium 2; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Donohoe G, Gill M, Corvin A, Morris DW. Am J Med Genet B Neuropsychiatr Genet. 2019

Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Drange OK, Smeland OB, Shadrin AA, Finseth PI, Witoelar A, Frei O; Psychiatric Genomics Consortium Bipolar Disorder Working Group, Wang Y, Hassani S, Djurovic S, Dale AM, Andreassen OA. Front Neurosci 2019.

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, T Nguyen H, Girdhar K, Boocock J, Roussos P, Fromer M, Kramer R, Domenici E, Gamazon ER, Purcell S; CommonMind Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium; iPSYCH-GEMS Schizophrenia Working Group, Demontis D, Børglum AD, Walters JTR, O’Donovan MC, Sullivan P, Owen MJ, Devlin B, Sieberts SK, Cox NJ, Im HK, Sklar P, Stahl EA. Nat Genet 2019.

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia. Gorman KM, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss KJ, Bryant E, Reich A, Schneider AL, Pressler RM, Simpson MA, Debelle GD, Wassmer E, Morton J, Sieciechowicz D, Jan-Kamsteeg E, Paciorkowski AR, King MD, Cross JH, Poduri A, Mefford HC, Scheffer IE, Haack TB, McCullagh G; Deciphering Developmental Disorders Study; UK10K Consortium; NIHR BioResource, Millichap JJ, Carvill GL, Clayton-Smith J, Maher ER, Raymond FL, Kurian MA. Collaborators (747) Am J Hum Genet. 2019 May 2;104(5):948-956. doi: 10.1016/j.ajhg.2019.03.005. Epub 2019 Apr 11.

Genome-wide association study identifies 30 loci associated with bipolar disorder. Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman JR, Gaspar HA, de Leeuw CA, Steinberg S,

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Barts and the London Psychiatry: State of the Art Annual Congress 2019 Summary

16 qmul.ac.uk

Our annual Mental Health Research Congress brought together the best psychiatric research from leading experts in their field for another lively day of presentations to an enthusiastic audience of over 200 consisting of psychiatrists, psychologists, social workers, nurses of various ranks, but certainly, the majority of consultants were from East London and Luton and Beds. This is our fourth year and is embedded as a must go-to diary event in the calendar. Dr Daisy Fancourt, Senior Research Fellow / Wellcome Research Fellow, Research Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London was the first speaker of the morning entrancing the audience on the subject of Psychobiological effects of music: stress, inflammation, depression and cognition.

Followed by our own Prof Kam Bhui presented on Ethnic inequalities and severe mental illness: could biomarkers help us resolve disputed evidence which certainly raised some controversial points that got the audience talking.

Prof Ted Dinan, Professor of Psychiatry and a Principal Investigator in the Alimentary Pharmabiotic Centre at University College Cork entertained us with his talk on Gut microbe to brain communication: implications for psychiatry.

And finally, Dr Livia A. Carvalho, Lecturer in Translational Pharmacology, Translational Pharmacology and Therapeutic Innovation, William Harvey Research Institute, Queen Mary University of London presented on Inflammation and depression in kidney disease that links with the collaboration with the Centre for Psychiatry and the WHRI on a recent grant awarded by Barts Charity on depression in renal dialysis patients.

After a hearty lunch, we were treated to an inspired afternoon of presentations from promising junior researchers who will become our future leaders. The judging panel, comprised of Dr Georgina Hosang, Dr Mark Freestone and Dr Kristoffer Halvorsrud of the Centre for Psychiatry and after a difficult task awarded prizes to the following.

First prize - Dr Jolene John Literature Review: Is the Prevalence of Autism Spectrum Disorder Decreased in Black and Minority Ethnic Children and Adolescents?

Joint Second Prize - Dr Georgia Templeton Evaluation of Care Planning in Community Mental Health Services: A Mixed-Methods Evaluation of a New Recovery Focused Care Planning Process

Dr Athanasios Tsoumpris and Dr Josephine Neale Abnormal Bodily Phenomena in First Episode Psychosis – A Longitudinal Cohort Study

Third Prize - Dr Mutahira Qureshi An Open-label Long-term Extension Safety Study of Intranasal Esketamine in Treatment-resistant Depression

All of the presentations were of a high standard and we were all extremely impressed. We know that the future is safe.


Sharmin Khonij (L) and Lisa Kass (R)

17 qmul.ac.uk

Professor Frank Röhricht, Medical Director for Research, Innovation and Medical Education at the East London Foundation Trust and Professor Kamaldeep Bhui, Head, Centre for Psychiatry. Professor of Cultural Psychiatry and Epidemiology at Queen Mary University of London Barts and The London School of Medicine and Dentistry were excellent Chairs and the feedback of the day was very positive. We received comments like ‘Fascinating’, ‘Learnt a lot’ , ‘Tricky topic but challenged the audience’ and ‘Very interesting cutting edge research’. One comment was ‘I would like a job with this presenter’.

Within the feedback we asked what topics participants would like featured in the future Bart’s Programmes which was most helpful and we will certainly consider the excellent suggestions provided.

Finally, thanks must also go to Lisa Kass and Sharmin Khonij for their excellent organisation skills and, of course, all the volunteers who helped on the day.

Please ensure that the 2020 date - Wednesday 4th March 2020 - is in your diary now for an even more exciting event. More details will follow but rest assured, as it was for this year, we guarantee it will be a full day of inspired talks and presentations.

Kam Bhui Centre Lead

Barts and the London Psychiatry: State of the Art Annual Congress 2019 Summary (continued)

Professor Ted Dinan


Barts and the London, Centre for Psychiatry: State of the Art Annual Congress 2020

Save

the date


Morris Lecture Theatre, Robin Brook Centre, West Smithfield EC1A 7BE

Wednesday 4 March 2020

This exciting all day mental health research congress brings together the best psychiatric research from expertsinthefieldwithcuttingedgeresearchpresentations by international experts and from promising junior researchers who will become future leaders.

More details and the theme for 2020 will be announced shortly. In the meantime, please make sure the date is in your diary.

Barts and The London

www.qmul.ac.uk/wolfson/centres/cfp/

For further information:Renata Samulnik, Centre for PsychiatryBarts and The London School of Medicine and DentistryOld Anatomy Building, Charterhouse Square, London EC1M 6BQTel: +44 (0)20 7882 2020 Email: [email protected] Twitter: @QMULPsychiatry

If you require this publication in a different accessible format we will endeavour to provide this, where possible. For further information

and assistance, please contact: [email protected]

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