central nervous system control of triglyceride metabolism-04

8/9/2019 Central Nervous System Control of Triglyceride Metabolism-04

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Cover Page

The handle http://hdl.handle.net/1887/22040 holds various files of this Leiden Universitydissertation.

Author : Geerling, Janine JanettaTitle : Central nervous system control of triglyceride metabolismIssue Date : 2013-10-23

http://hdl.handle.net/1887/22040http://hdl.handle.net/1887/22040http://hdl.handle.net/1887/22040https://openaccess.leidenuniv.nl/handle/1887/1http://hdl.handle.net/1887/22040https://openaccess.leidenuniv.nl/handle/1887/1


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GLP-1 RECEPTOR ACTIVATION INHIBITSVLDL PRODUCTION AND REVERSES

HEPATIC STEATOSIS BY DECREASINGHEPATIC LIPOGENESIS IN HIGH-FAT-FED

APOE*3-LEIDEN MICE

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GLP-1 RECEPTOR AGONISM REDUCES VLDL PRODUCTION

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ABSTRACT


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MATERIALS AND METHODS

Animals

Experiments


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Compounds

Plasma glucose and insulin analysis

Hepatic VLDL-TG and VLDL-apoB production


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Hepatic lipid content

Hepatic gene expression analysis

Statistical analysis


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RESULTS

GLP-1 receptor agonism reduces body weight and fasting plasma glucose andinsulin levels in high fat diet-fed E3L mice

GLP-1 receptor agonism reduces hepatic secretion of VLDL particles withoutaffecting particle composition


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GLP-1 receptor agonism reverses high fat diet-induced hepatic steatosis


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GLP-1 receptor agonism affects muscle expression of genes involved in fatty acidoxidation

DISCUSSION


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CHAPTER 4


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REFERENCES


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CHAPTER 4


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central nervous system control of triglyceride metabolism-04

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