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CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 125387Orig1s000 PHARMACOLOGY REVIEW(S)

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Page 1: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and

CENTER FOR DRUG EVALUATION AND RESEARCH

APPLICATION NUMBER:

125387Orig1s000

PHARMACOLOGY REVIEW(S)

Page 2: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 3: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 4: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 5: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 6: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 7: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 8: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 9: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 10: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 11: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 12: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 13: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 14: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 15: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 16: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 17: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 18: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 19: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 20: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 21: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 22: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 23: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 24: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 25: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 26: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 27: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 28: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 29: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 30: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 31: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 32: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 33: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 34: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 35: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 36: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 37: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 38: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 39: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
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Page 41: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 42: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
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Page 51: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
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Page 58: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
Page 59: CENTER FOR DRUG EVALUATION AND RESEARCH · Determination of Equilibrium Binding Constants for the Interaction of Human VEGF-A165 and Human PIGF-2 with Aflibercept Conformance and
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