cellular respiration part iii: krebs cycle - wikispaceskrebs+cycle.pdf · curriculum framework 4 3....
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Cellular Respiration Part III: Krebs Cycle
Figure 9.6-3
Electrons
carried
via NADH
Electrons carried
via NADH and
FADH2
Citric
acid
cycle
Pyruvate
oxidation
Acetyl CoA
Glycolysis
Glucose Pyruvate
Oxidative
phosphorylation:
electron transport
and
chemiosmosis
CYTOSOL MITOCHONDRION
ATP ATP ATP
Substrate-level
phosphorylation
Substrate-level
phosphorylation Oxidative
phosphorylation
Citric Acid Cycle
(Krebs Cycle)
Curriculum Framework
4
3. In the Krebs cycle, carbon dioxide is released from organic intermediates, ATP is synthesized from ADP and inorganic phosphate via substrate level phosphorylation, and electrons are captured by coenzymes. 4. Electrons that are extracted in the series of Krebs cycle reactions are carried by NADH and FADH2 to the electron transport chain.
Figure 9.11
Pyruvate
NAD
NADH
+ H Acetyl CoA
CO2
CoA
CoA
CoA
2 CO2
ADP + P i
FADH2
FAD
ATP
3 NADH
3 NAD
Citric
acid
cycle
+ 3 H
6
Krebs Cycle
• Occurs in the mitochondrial matrix
• Releases the remaining carbons from the remnant glucose
• Transfers the energy to NAD, FAD, and ADP
7
Coenzyme A
Carbon dioxide
Electron carrier (NADH)
Carbon dioxide
ATP
Electron carrier (FADH2)
Coenzyme A
Electron carrier (NADH)
Figure 9.12-1
1
Acetyl CoA
Citrate
Citric
acid
cycle
CoA-SH
Oxaloacetate
Figure 9.12-2
1
Acetyl CoA
Citrate Isocitrate
Citric
acid
cycle
H2O
2
CoA-SH
Oxaloacetate
Figure 9.12-3
1
Acetyl CoA
Citrate Isocitrate
-Ketoglutarate
Citric
acid
cycle
NADH
+ H
NAD
H2O
3
2
CoA-SH
CO2
Oxaloacetate
Figure 9.12-4
1
Acetyl CoA
Citrate Isocitrate
-Ketoglutarate
Succinyl
CoA
Citric
acid
cycle
NADH
NADH
+ H
+ H
NAD
NAD
H2O
3
2
4
CoA-SH
CO2
CoA-SH
CO2
Oxaloacetate
Figure 9.12-5
1
Acetyl CoA
Citrate Isocitrate
-Ketoglutarate
Succinyl
CoA
Succinate
Citric
acid
cycle
NADH
NADH
ATP
+ H
+ H
NAD
NAD
H2O
ADP
GTP GDP
P i
3
2
4
5
CoA-SH
CO2
CoA-SH
CoA-SH
CO2
Oxaloacetate
Figure 9.12-6
1
Acetyl CoA
Citrate Isocitrate
-Ketoglutarate
Succinyl
CoA
Succinate
Fumarate
Citric
acid
cycle
NADH
NADH
FADH2
ATP
+ H
+ H
NAD
NAD
H2O
ADP
GTP GDP
P i
FAD
3
2
4
5
6
CoA-SH
CO2
CoA-SH
CoA-SH
CO2
Oxaloacetate
Figure 9.12-7
1
Acetyl CoA
Citrate Isocitrate
-Ketoglutarate
Succinyl
CoA
Succinate
Fumarate
Malate
Citric
acid
cycle
NADH
NADH
FADH2
ATP
+ H
+ H
NAD
NAD
H2O
H2O
ADP
GTP GDP
P i
FAD
3
2
4
5
6
7
CoA-SH
CO2
CoA-SH
CoA-SH
CO2
Oxaloacetate
Figure 9.12-8
NADH
1
Acetyl CoA
Citrate Isocitrate
-Ketoglutarate
Succinyl
CoA
Succinate
Fumarate
Malate
Citric
acid
cycle
NAD
NADH
NADH
FADH2
ATP
+ H
+ H
+ H
NAD
NAD
H2O
H2O
ADP
GTP GDP
P i
FAD
3
2
4
5
6
7
8
CoA-SH
CO2
CoA-SH
CoA-SH
CO2
Oxaloacetate
Figure 9.12a
Acetyl CoA
Oxaloacetate
Citrate Isocitrate
H2O
CoA-SH
1
2
Figure 9.12b
Isocitrate
-Ketoglutarate
Succinyl
CoA
NADH
NADH
NAD
NAD
+ H
CoA-SH
CO2
CO2
3
4
+ H
Figure 9.12c
Fumarate
FADH2
CoA-SH 6
Succinate
Succinyl
CoA
FAD
ADP
GTP GDP
P i
ATP
5
Figure 9.12d
Oxaloacetate 8
Malate
Fumarate
H2O
NADH
NAD
+ H
7
Where does each atom end up?
C6H12O6
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So what did we get from Krebs?
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• Name the energy related end products of Krebs.
• By what process is ATP formed?
• Name the waste products.
• Where do the events of Krebs occur?
• Do cells in all kingdoms go through the Krebs cycle?
• Where are the electrons headed?
So, What Did We Get From Krebs?
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Figure 9.6-3
Electrons
carried
via NADH
Electrons carried
via NADH and
FADH2
Citric
acid
cycle
Pyruvate
oxidation
Acetyl CoA
Glycolysis
Glucose Pyruvate
Oxidative
phosphorylation:
electron transport
and
chemiosmosis
CYTOSOL MITOCHONDRION
ATP ATP ATP
Substrate-level
phosphorylation
Substrate-level
phosphorylation Oxidative
phosphorylation
Curriculum Framework
• f. Cellular respiration in eukaryotes involves a series of coordinated enzyme-catalyzed reactions that harvest free energy from simple carbohydrates.
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One Last Look & Listen!
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Created by: Debra Richards Coordinator of Secondary Science Programs Bryan ISD Bryan, TX