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CELL SOCIETY3RD ANNUAL CLINICAL MEETINGA COURSE IN REGENERATIVE MEDICINE

September 19-20, 2013

Cell Society International, in collaboration with the Society for Women’s Health Research, presents

CELL SOCIETY

COURSE DESCRIPTION:Cell Society’s Annual Clinical Conference was created to meet demand for evidence-based clinical information on regenerative stem cell therapies. This year’s meeting will bring together more than 35 international and national faculty. All are leading experts in fields including cardiology, neurology, sports medicine, tissue engineering, aging, plastic and reconstructive surgery, and regulatory issues. This will be a 2 day opportunity for them to share and discuss their most recent findings.

TARGET AUDIENCE:This conference is designed to meet the educational needs of physicians and other healthcare professionals involved in the care of patients who may benefit from cell therapy treatments. This conference is also for physicians and healthcare workers interested in keeping abreast of quickly evolving research in what many believe is the future of medicine – regenerative stem cell therapies.

NEEDS ASSESSMENT:The utility and usefulness of this conference is based on the fact that regenerative stem cell therapies have the potential to transform the care of patients who suffer a multitude of medical conditions. Clinical research and trials around the world are revealing important clinical benefits, yet physicians and patients have little access to the growing collection of clinical evidence in this burgeoning field. This conference highlights many leading clinical trials and evolving cell therapy applications. This is a unique and important opportunity for physicians to learn of the latest developments in regenerative medicine.

More cardiovascular, neurovascular, orthopedic, regulatory topics, and multi-disciplinary clinical panel discussions were requested in the evaluation summary of the Cell Society 2012 Conference. As a result, several changes have been made to the 2013 conference, which has been designed to share information across medical disciplines and multiple therapeutic specialty areas.

There is clearly a need for practicing physicians to understand the advances in stem cell clinical research and applications, as well as the clinical science behind the cell therapies. A growing number of these therapies are available today and more are coming.

LEARNING OBJECTIVES:As a result of participating in this activity, participants should be able to:

DESCRIBE the basic science and biology of stem cell therapies and their use for various medical applications.

EVALUATE the best practices and obstacles, currently available, for the application of cell therapies in reconstructive and aesthetic plastic surgery.

DETERMINE the best practices and obstacles, currently available, for cardiovascular applications of stem cell therapies.

ESTIMATE the best practices and obstacles, currently available, for orthopedic surgery and sports medicine applications of stem cell therapies.

CALCULATE the best practices and obstacles, currently available, for neurological applications of stem cell therapies.

ASSESS the best practices and obstacles, currently available, for using stem cell therapies in tissue engineering.

EXPLAIN the current regulatory environment regarding the use of cell therapies by practicing physicians.

ACCREDITATION:Physicians: USF Health is accredited by the Accreditation Council for Continuing Medical Education to provide continuing education for physicians.

USF Health designates this live activity for a maximum of 14.25 AMA PRA Category 1 Credits TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

3RD ANNUAL CLINICAL MEETING

19 -20SEPTEMBER2013

THURSDAY, SEPTEMBER 19, 2013Time Description Presenter

7:15 AM – 8:15 AM Registration, Breakfast, Exhibits8:15 AM – 8: 30 AM Welcome and Introductions James T. Willerson, MD, Program Chairman8:30 AM – 8:45 AM Stem Cell Therapies CURRENT CLINICAL APPLICATIONS AND TRIALS FOR CELL THERAPIES IN NEUROLOGY Sean Savitz, MD, Chairman8:45 AM – 9:05 AM Cell Therapies for Stroke Patients Sean Savitz, MD9:05 AM – 9:25 AM MSCs: An Investigational New Therapeutic Approach For MS Antonio Uccelli, MD 9:25 AM – 9:45 AM The Effect of Parkinson’s and Huntington’s Disease on Neural Transplants: Implications for Stem Cell Therapies Thomas Freeman, MD9:45 AM – 10:05 AM TBD10:05 AM – 10:20 AM Questions

10:20 AM – 10:45 AM Break

CURRENT CLINICAL APPLICATIONS AND TRIALS FOR CELL THERAPIES IN ORTHOPEDICS/SPORTS MEDICINE Mark Adickes, MD, Chairman10:45 AM – 11:05 AM Regenerative Medicine Based on Adult Stem Cells for Musculoskeletal Tissue Regeneration and Repair John Huard, PhD11:05 AM – 11:25 AM TBD11:25 AM – 11:45 AM Innovation in the Treatment of Hip Disorders in Athletes Marc Phillipon, MD11:45 AM – 12:00 PM Questions12:00 PM – 12:30 PM Panel: The Future of Cell Therapies In Treating Athletes12:30 PM – 12:45 PM Panel Questions

12:45 PM – 1:45 PM Lunch

CURRENT CLINICAL APPLICATIONS AND TRIALS FOR CELL THERAPIES IN TISSUE ENGINEERING Jason Wertheim, MD, PhD, Chairman1:45 PM – 2:05 PM A Biological Scaffold Approach for Functional Musculotendinous Tissue Reconstruction Stephen Badylak, DVM, PhD, MD2:05 PM – 2:25 PM Cell-Scaffold Interactions in Clinical Tissue Engineering Transplantation Paolo Macchiarini, MD, PhD2:25 PM – 2:45 PM Preclinical & Clinical Results of Tissue Engineered AV Graft Laura Niklason, MD, PhD2:45 PM – 3:00 PM Questions

3:00 PM – 3:30 PM Break

3:30 PM – 4:00 PM PANEL: REVAMPING PHASE II TRIAL DESIGN: HOW SHOULD IT END? Moderator: Doris Taylor, PhD Panelists: Arnold Caplan, MD / Robert Simari, MD / Robert Harrington, MD 4:00 PM – 4:15 PM Panel Questions

5:00 PM – 6:15 PM Reception

COURSE AGENDA19 -20SEPTEMBER2013

COURSE AGENDATime Description Presenter

CURRENT CLINICAL APPLICATIONS AND TRIALS FOR CELL THERAPIES IN CARDIOLOGY Emerson Perin, MD, PhD, Chairman8:15 AM – 8:35 AM Stem Cell Therapy for Refractory Angina Timothy Henry, MD8:35 AM – 8:55 AM The Path to Approval of Cell Therapy in Acute Myocardial Infarction Andreas Zeiher, MD8:55 AM – 9:15 AM Stem Cell Therapy for Heart Failure Emerson Perin, MD, PhD9:15 AM – 9:35 AM Building Cardiovascular Solutions for Transplantation Doris Taylor, PhD9:35 AM – 9 :55 AM Lessons and Perspectives from the Cardiovascular Cell Therapy Research Network Robert Simari, MD9:55 AM – 10:10 AM Questions10:10 AM – 10:30 AM Break CHAIRMAN’S CHOICE: REGENERATIVE MEDICINE AND HEALTHY AGING James T. Willerson, MD, Chairman10:30 AM – 11:00 AM VSELS in Tissue Organ Rejuvenation – A Novel View on Aging Mariusz Ratajczack, MD, PhD, D.Sci11:00 AM – 11:30 AM Myocardial Aging and Cardiac Stem Cell Therapy Piero Anversa, MD11:30 AM – 12:00 PM Delaying the Aging of Mesenchymal Stem Cells Ilaria Bellantuono, MD, PhD12:00 PM – 12:15 PM Questions12:15 PM – 1:15 PM Lunch CURRENT CLINICAL APPLICATIONS AND TRIALS IN IMMUNOLOGY 1:15 PM – 1:35 PM The Use of Adipocyte Derived Regenerative Cells (ADRCs) In the Treatment of Scleroderma of the Hands: A Prospective Trial Guy Magalon, MD1:35 PM – 1:55 PM Treating Inflammatory Bowel Disease with Adipose Derived Regenerative Cells Hiroshi Yoshimoto, MD, PhD1:55 PM – 2:15 PM Hematopoietic Stem Cells for Treating Multiple Sclerosis Richard Burt, MD2:15 PM – 2:30 PM Questions CURRENT CLINICAL APPLICATIONS AND TRIALS FOR CELL THERAPIES IN PLASTIC AND RECONSTRUCTIVE SURGERY Steven Cohen, MD, Chairman2:30 PM – 2:50 PM Adult Cell Therapy with Adipocyte Derived Regenerative Cells: Promising Cases and Preliminary Clinical Trial Results in Plastic Surgery and Wound Healing Steven Cohen, MD2:50 PM – 3:10 PM Tissue Engineering a Breast Mound Roger Khouri, MD3:10 PM – 3:30 PM Fat, Platelet-Rich Plasma (PRP) and Stromal Vascular Fraction (SVF) Harvesting and Processing: Safety, Differences, Cost and Efficacy Gordon Sasaki, MD3:30 PM – 3:50 PM Treating Lipoatrophy with Adipose Derived Regenerative Cells Sadanori Akita, MD, PhD3:50 PM – 4:00 PM Questions4:00 PM – 4:15 PM Break

4:15 PM – 4:45 PM Panel: An Update of the Practice of Medicine in the Current Regulatory Environment Moderator: Ken Kleinhenz Panelists: Alex Denoon, Esq / Joyce Frey-Vasconcells, PhD / Mitchell Fuerst, Esq4:45 PM – 5:00 PM Panel Questions 5:00 PM – 5:30 PM Panel: Are Any Regenerative Cell Therapies Ready for Clinical Use? Moderator: Doris Taylor, PhD Panelists: Paulo Macchiarini, MD, PhD / Richard Burt, MD / Guy Magalon, MD5:30 PM – 5:45 PM Panel Questions

5:45 PM Conclusion

FRIDAY, SEPTEMBER 20, 2013

Time Description Presenter

CURRENT CLINICAL APPLICATIONS AND TRIALS FOR CELL THERAPIES IN CARDIOLOGY Emerson Perin, MD, PhD, Chairman8:15 AM – 8:35 AM Stem Cell Therapy for Refractory Angina Timothy Henry, MD8:35 AM – 8:55 AM The Path to Approval of Cell Therapy in Acute Myocardial Infarction Andreas Zeiher, MD8:55 AM – 9:15 AM Stem Cell Therapy for Heart Failure Emerson Perin, MD, PhD9:15 AM – 9:35 AM Building Cardiovascular Solutions for Transplantation Doris Taylor, PhD9:35 AM – 9 :55 AM Lessons and Perspectives from the Cardiovascular Cell Therapy Research Network Robert Simari, MD9:55 AM – 10:10 AM Questions10:10 AM – 10:30 AM Break CHAIRMAN’S CHOICE: REGENERATIVE MEDICINE AND HEALTHY AGING James T. Willerson, MD, Chairman10:30 AM – 11:00 AM VSELS in Tissue Organ Rejuvenation – A Novel View on Aging Mariusz Ratajczack, MD, PhD, D.Sci11:00 AM – 11:30 AM Myocardial Aging and Cardiac Stem Cell Therapy Piero Anversa, MD11:30 AM – 12:00 PM Delaying the Aging of Mesenchymal Stem Cells Ilaria Bellantuono, MD, PhD12:00 PM – 12:15 PM Questions12:15 PM – 1:15 PM Lunch CURRENT CLINICAL APPLICATIONS AND TRIALS IN IMMUNOLOGY 1:15 PM – 1:35 PM The Use of Adipocyte Derived Regenerative Cells (ADRCs) In the Treatment of Scleroderma of the Hands: A Prospective Trial Guy Magalon, MD1:35 PM – 1:55 PM Treating Inflammatory Bowel Disease with Adipose Derived Regenerative Cells Hiroshi Yoshimoto, MD, PhD1:55 PM – 2:15 PM Hematopoietic Stem Cells for Treating Multiple Sclerosis Richard Burt, MD2:15 PM – 2:30 PM Questions CURRENT CLINICAL APPLICATIONS AND TRIALS FOR CELL THERAPIES IN PLASTIC AND RECONSTRUCTIVE SURGERY Steven Cohen, MD, Chairman2:30 PM – 2:50 PM Adult Cell Therapy with Adipocyte Derived Regenerative Cells: Promising Cases and Preliminary Clinical Trial Results in Plastic Surgery and Wound Healing Steven Cohen, MD2:50 PM – 3:10 PM Tissue Engineering a Breast Mound Roger Khouri, MD3:10 PM – 3:30 PM Fat, Platelet-Rich Plasma (PRP) and Stromal Vascular Fraction (SVF) Harvesting and Processing: Safety, Differences, Cost and Efficacy Gordon Sasaki, MD3:30 PM – 3:50 PM Treating Lipoatrophy with Adipose Derived Regenerative Cells Sadanori Akita, MD, PhD3:50 PM – 4:00 PM Questions4:00 PM – 4:15 PM Break

4:15 PM – 4:45 PM Panel: An Update of the Practice of Medicine in the Current Regulatory Environment Moderator: Ken Kleinhenz Panelists: Alex Denoon, Esq / Joyce Frey-Vasconcells, PhD / Mitchell Fuerst, Esq4:45 PM – 5:00 PM Panel Questions 5:00 PM – 5:30 PM Panel: Are Any Regenerative Cell Therapies Ready for Clinical Use? Moderator: Doris Taylor, PhD Panelists: Paulo Macchiarini, MD, PhD / Richard Burt, MD / Guy Magalon, MD5:30 PM – 5:45 PM Panel Questions

5:45 PM Conclusion

FACULTY PROGRAM CHAIRMANJAMES T. WILLERSON, MDPresident and Medical DirectorTexas Heart InstituteHouston, Texas

SESSION CHAIRMENPLASTIC AND RECONSTRUCTIVE SURGERY CHAIRSTEVEN R. COHEN, MDPrivate Practice, Plastic SurgeryFACES + Plastic Surgery, Skin and Laser CenterChief, Craniofacial Surgery, Rady Children’s Hospital San Diego, CAClinical Professor, Division of Plastic Surgery, University of California, San Diego, CACARDIOLOGY CHAIREMERSON C. PERIN, MD, PHDDirector of New Interventional Cardiovascular TechnologyMedical Director, Stem Cell Center, Texas Heart Institute Houston, TXNEUROLOGY CHAIRSEAN SAVITZ, MDProfessor of Neurology, Director of Stroke Program University of TexasDirector of Bidirectional Lab and Clinical Research Program in Stroke, Conducting Some of the First Clinical Trials Using Stem Cell Therapies in StrokeHouston,TXTISSUE ENGINEERING CHAIRJASON A. WERTHEIM, MD, PHDAssistant Professor of Surgery – Organ Transplant, Feinberg School of Medicine Institute for BioNanotechnology in Medicine Chemistry of Life Processes Institute Northwestern University.Co-Editor in Chief of OrganogenesisChicago, ILORTHOPEDICS/ SPORTS MEDICINE CHAIRMARK ADICKES, MDAssistant Professor, Dept. of Orthopedic SurgeryUniversity of Texas Medical SchoolCo-Medical Director, Ironman Sports Medical InstituteAt Memorial HermannHouston, TXMULTI-DISCIPLINARY PANEL /WORKSHOPS CHAIRDORIS TAYLOR, PHDDirector, Regenerative Medicine, Texas Heart Institute Houston, TXAdjunct Professor, Department of Integrative Biology and Physiology, University of MinnesotaMinneapolis, MNREGULATORY PANELKEN KLEINHENZVice President, Quality Control & Regulatory Affairs Cytori TherapeuticsSan Diego, CA

SADANORI AKITA, MD, PHD Division of Plastic Surgery Department of Developmental and Reconstructive Medicine Graduate School of Biomedical Sciences Nagasaki University Nagasaki, Japan

PIERO ANVERSA, MD Professor, Department of Anesthesia and Medicine Harvard Medical School Brigham & Women’s Hospital Boston, MA

STEPHEN BADYLAK, DVM, PHD, MD Professor, Dept of Surgery Deputy Director, McGowan Institute for Regenerative Medicine University of Pittsburgh Pittsburgh, PA

ILARIA BELLANTUONO, MD, PHD Head, Bone Analysis Laboratory, MCBR Director of Training, MRC-Arthritis Research University of Sheffield Sheffield, UK

RICHARD K. BURT, MD Chief, Division of Immunotherapy Department of Medicine Northwestern Memorial Hospital Chicago, IL

ARNOLD I. CAPLAN, PHD Professor, Department of Biology Director, Skeletal Research Center Case Western Reserve University Cleveland, OH

ALEX DENOON, ESQ. Partner, Lawford Davies Denoon London, UK

THOMAS FREEMAN, MD Professor, Department of Neurosurgery and Brain Repair USF Health Tampa, FL

MITCHELL FUERST, ESQ. Managing Partner Fuerst, Littleman, David & Joseph, PL Miami, FL

ROBERT A. HARRINGTON, MD Arthur L. Bloomfield Professor of Medicine Chairman, Department of Medicine Stanford University Stanford, CA

TIMOTHY HENRY, MD Professor of Medicine University of Minnesota Director of Research and Interventional Cardiologist Minnesota Heart Institute Foundation Minneapolis, MN

JOHN HUARD, PHD Henry J. Mankin Professor and Vice Chair, Department of Orthopaedic Surgery, Molecular Genetics & Biochemistry, Bioengineering and Pathology Director, Stem Cell Research Center University of Pittsburgh School of Medicine Pittsburgh, PA

ROGER KHOURI, MD Founder, Miami Breast Center Miami, FL

PAOLO MACCHIARINI, MD, PHD Professor of Regenerative Surgery Karolina Institutet Director, European Airway Institute & Advanced Center of Translational Regenerative Medicine Stockholm, Sweden

GUY MAGALON, MD Professor of Medicine Plastic and Reconstructive Surgery Marseilles, France

LAURA NIKLASON, MD, PHD Professor, Department of Anesthesia Professor, Department of Biomedical Engineering Yale School of Medicine New Haven, CT

MARC J. PHILIPPON, MD Assoc. Clinical Professor Department of Surgery McMaster University Hamilton, Ontario, Canada Managing Partner, Sports Medicine/ Hip Disorders The Steadman Clinic Vail, CO

MARIUSZ RETAJCZACK, MD, PHD, D. SCI Professor, Department of Medicine Director, Stem Cell Biology Program University of Louisville Louisville, KY

GORDON SASAKI, MD Clinical Professor of Plastic Surgery Loma Linda University Sasaki Advanced Aesthetic Medical Center Pasadena, CA

ROBERT D. SIMARI, MD Professor of Medicine Division of Cardiovascular Diseases Mayo Clinic Rochester, MN

ANTONIO UCCELLI, MD Asst. Professor of Neurosciences, Opthalmology andGenetics University of Genoa Genoa, Italy

JOYCE FREY-VASCONCELLS, PHD Regulatory Expert, Frey-Vasconcells Consulting LLC Princeton, NJ

HIROSHI YOSHIMOTO, MD, PHD Senior Assistant Professor of Plastic Surgery Nagasaki University Hospital Nagasaki, Japan

ANDREAS ZEIHER, MD Professor and Chairman, Department of Cardiology/Angiology Goethe University of Frankfurt Frankfurt, Germany

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REGISTRATION FEES:Registration Fees includes program materials, breakfasts, breaks, lunches and reception. A confirmation letter will be sent upon receipt and processing of your registration and payment. (No registration is confirmed without full payment).

PHYSICIANS (MD, RN/NP, PA): CELL SOCIETY FACULTY ALUMNI: OTHERS:On or before 0819/13 $800.00 On or before 08/19/13 $300.00 On or before 08/19/13 $800.0008/20/13 and afterwards: $1,000.00 08/20/13 and afterwards: $400.00 08/20/13 and afterwards: $1,000.00

GUEST fee for reception - $ 30.00

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Refund Policy: Registration fees will be refunded minus a $100.00 processing fee with written notice on or prior to August 19, 2013. No refunds will be made after this date. No registration is confirmed without FULL Payment.

PAYMENT METHOD: Check: Enclosed is my check made payable to: USF Health Professions Conferencing Corporation (USF HPCC)

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Program #: Ch2014309/1170

REGISTRATION FORM:

3 WAYS TO REGISTER:1 ONLINE at www.cme.hsc.usf.edu

Click on Course Catalog, and then click on September 2013.

MAIL registration form with payment to: USF HPCCAttn: Ch2014309/1170 PO Box 628263 Orlando, FL 32862-8263

For further information, call (813) 224-7860 or (800) 852-5362

CELL SOCIETY 19-20SEPTEMBER20133RD ANNUAL CLINICAL MEETING

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FAX registration form and payment information to 813-224-7864.

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ACCOMMODATIONS: Coronado Island Marriott 2000 Second StreetCoronado, CA 921181-619-435-3000

This Coronado Bay hotel features amenities including an intimate spa, three heated pools, tennis courts, and fantastic dining. Set on 16 acres of scenic waterfront, the best of Coronado Island is easily at hand, with Ferry Landing, beaches, and other activities just a short stroll away.

A block of rooms have been reserved for our conference at the special rate of $185 per night, plus tax. To reserve your room, please call the hotel and reference the Cell Society 2013 Conference, or register online at http://www.marriott.com/hotels/travel/sanci?groupCode=tcstcsa&app=resvlink&fromDate=9/19/13&toDate=9/22/13

CANCELLATION The Office of Continuing Professional Development (CPD) at USF Health reserves the right to cancel this activity due to unforeseen circumstances, in which the full registration fee will be refunded. USF Health is not responsible for travel expenses incurred by the participants in the unlikely event that the course is cancelled.

MAIL registration form with payment to: USF HPCCAttn: Ch2014309/1170 PO Box 628263 Orlando, FL 32862-8263

FACULTY DISCLOSUREUSF Health adheres to the ACCME Standards regarding commercial support of continuing medical education. It is the policy of USF Health that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflicts(s) of interest are resolved and also that speakers will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made at the conference.

ACCOMMODATIONS FOR DISABILITIESPlease notify the Office of Continuing Professional Development at (813) 224-7860 or CPDSupport@health.usf.edu a minimum of 10 working days in advance of the event if a reasonable accommodation for a disability is needed.

EQUAL OPPORTUNITYEvents, activities and facilities of the University of South Florida are available to all without regard to race, color, marital status, gender, sexual orientation, religion, national origin, disability, age, Vietnam or disabled veteran status as provided by law and in accordance with the University’s respect for personal dignity.

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