cell injury and the pathogenesis of human disease (path 6266 )
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Cell Injury and the Pathogenesis of Human Disease (PATH 6266 ). April 30 and May 2 , 2012 Paul Boor M.D. “Cellular basis of disease” 200 years of observation : organ and microscopic. SUGGESTED READING (PATHOLOGIC BASIS OF DISEASE, 8 th EDITION) - PowerPoint PPT PresentationTRANSCRIPT
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Cell Injury and the Pathogenesis of Human
Disease(PATH 6266)
“Cellular basis of disease”200 years of observation: organ and
microscopic
April 30 and May 2, 2012 Paul Boor M.D.
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SUGGESTED READING(PATHOLOGIC BASIS OF DISEASE, 8th EDITION)
CHAPTER 1Cellular Response to Stress and Toxic Insult;
Adaptation, Injury, Death (pp 3-42)
CHAPTER 3Tissue Renewal, Repair, and Regeneration (pp
79-110)
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Rudolph Virchow (1821-1902)
Cell Theory“Social Medicine”
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Cell Injury – General Considerations
Numerous causes Biochemical events precede structural Duration and intensity of exposure important
(direct dose/response relationship) Injury may be TISSUE (or cell) specific Injury depends of ability of cells to respond,
resist, and repair injury
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Cell Injury – Causes Hypoxia / Ischemia Physical (mechanical, heat, radiation) Chemical Biologic Agents Immunologic (host) reaction Genetic derangement Nutritional imbalance, deficiency
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Cellular Degeneration
Sublethal, usually reversible forms of cellular injury unassociated with severe
cellular dysfunction.
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Oxidative Stress and Cell Injury
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Necrosis (or “Oncosis”) VS
Apoptosis
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Types of Necrosis Coagulation Liquefactive Caseous “Fat” necrosis
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Liquefactive Necrosis
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Caseous Necrosis
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“Fat” Necrosis
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Key Words(Week 1 BBSC 6266)
Anatomy of the hepatic lobule; Cell: Hepatocyte, Kupffer cell, bile ductules; Acetaminophen; Cytochrome p450s; imines; Reactive oxygen species; reactive nitrogen
species; peroxynitrite; Adducts
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Hepatic Injury: Regenerative Nodules
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How to look at a slide
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Recap
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