cell injury and cell death -...
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CELL INJURY and CELL DEATH: Part 1
Jhia Anjela D. RiveraDepartment of Biological SciencesSchool of Science and TechnologyCentro Escolar University
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CELL INJURY
A sequence of events that occur if the limits of adaptive capability are exceeded or no adaptive response is possible.
Causes:
• Ischemia
• Hypoxia
• Chemical injury and;
• Injury produced by infectious agents
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CELL INJURY: Ischemia
Deficient supply of blood to a body part that is due to obstruction of the inflow of arterial blood
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CELL INJURY: Hypoxia
Oxygen deficiency (reaching the tissues of the body)
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CELL INJURY: Chemical Injury
Exposure or intake of chemicals
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CELL INJURY: Infectious Agents
Bacteria, Virus etc.
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CELL INJURY OVERVIEW
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NORMAL CELL
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MECHANISMS OF CELL INJURY
1) Depletion of ATP2) Mitochondrial Damage3) Influx of Intracellular Calcium and Loss of Calcium
Homeostasis4) Accumulation of Oxygen-Derived free radical (Oxidative
stress)5) Defects in Membrane Permeability
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CELL INJURY• Reversible Injury• Cell swelling develops when cells are incapable of fluid
an ion homeostasis (↓ function of ATP dependent pumps).
• Irreversible injury (Necrosis)o Two basic processes underlie the morphologic changes of
necrosis1) Denaturation of protein2) Enzymatic digestion of cell components
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CELL INJURY AND CELL DEATH
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CELL INJURY AND CELL DEATH
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