Sterisonic GxP Series Cell Culture Incubators

Features:• The industry’s most complete cell culture

solution for highly regulated applications or conventional incubation.

• Safe, effective and documented 3 hour in situ H2O2

decontamination for the fastest cycle turn-around.

MCO-19AIC/UV/UVH MCO-19M/UV/UVH

Cell Culture CO2 and CO2/O2 Incubators

www.panasonic.com/biomedical

Panasonic… the new name for SANYO

2 Sterisonic GxP Series Cell Culture Incubators

Product ApplicationsThe combination of Sterisonic GxP incubator performance functions permit use with confidence in high-value cell protocols among hard-to-grow cell lines, cells highly sensitive to contamination and vibration, ultra-sensitive media and reagents, or protocols that require a strict isolation and decontamination between processes. These include but are not limited to:

• Stem cell research• Autologous tissue regeneration

and regenerative medicine• In vitro fertilization• Genomic and proteomic expression• Esoteric plant and amphibian

cell culture• Hypersensitive and transgenic

cell culture• Low media volume microplate work

Sterisonic GxP Selection CO2 Incubators CO2/O2 Incubators

FeatureMCO-

19AIC(UVH)MCO-

19AIC(UV)MCO- 19AIC

MCO-19M(UVH)

MCO- 19M(UV)

MCO- 19M

H2O2 Vapor Decontamination Standard Optional Optional Standard Optional Optional

SafeCell UV Decontamination Standard Standard Optional Standard Standard Optional

Single Beam, Dual Detector IR CO2 Sensor Standard Standard Standard Standard Standard Standard

Solid Zirconia O2 Control N/A N/A N/A Standard Standard Standard

Designed for use with a variety of standard cell culture vessels and protocols.

• Interior components and adjustable shelves are configured for easy access, in situ decontamination and flexible ar-rangement for a variety of applications.

• Four adjustable shelves are included standard; maximum shelf capacity is 15 shelves.

MCO-19AIC(UVH)

The industry’s most complete cell culture solution for highly regulated applications or conventional incubation. Now with safe, effective and documented 3 hour in situ H2O2 decontamination for the fastest turn-around and maximum availability.

Sterisonic GxP Series Cell Culture CO2 and CO2/O2 Incubators

MCO-19AIC MCO-19AIC(UV)MCO-19AIC(UVH)

MCO-19M MCO-19M(UV)MCO-19M(UVH)

Multi-Gas Incubator, Oxygen and CO2 Control

Ideal for in vitro fertilization (IVF), genetic research, regenerative medicine and other protocols that require CO2 and sub-ambient (hypoxic) or above-ambient oxygen control.

MCO-19M

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Decontamination System• The unique Sterisonic GxP H2O2 de-

contamination system limits down-time to less than three hours when total chamber decontamination with verification is desired.

• All interior components and CO2 sampling loop are decontaminated in situ; no need for removal and autoclaving.

• Active Background Contamination Control fights contamination while cell culture protocols are in process.

The patented SafeCell UV system scrubs interior airflow

to destroy airborne and humidity pan contaminants.

Exclusive inCu-saFe® copper-enriched stainless steel interior

surfaces assure constant germicidal protection.

Sterisonic GxP Features and Benefits

The Panasonic Sterisonic GxP is designed for a wide array of demanding and highly regulated applications in the biomedical, pharmaceutical, medical research and clinical laboratory. Representing years of research, development and component testing, the Sterisonic GxP incorporates a collective of mutually functional systems and design attributes to offer a holistic solution to cell culture protocols, from the most sophisticated to more familiar and conventional processes.

Control and Monitoring• The Sterisonic GxP control and infor-

mation center includes an intuitive pop-up menu, high resolution LCD for inputs, outputs and performance at-a-glance.

• Multi-point data logging offers push-button graphical display. An optional PC interface permits remote transmission for GMP/GLP protocols as required.

• Precise PID logic controls and adjusts to all temperature, CO2 set-points and alarm parameters.

CO2 ControlPanasonic proprietary single-

beam, dual detector infrared (IR2) CO2 sensor delivers precise CO2 control, quick recovery following door openings, and auto sampling with no moving parts.

• Continuous zero calibration is standard.

• An optional semi-automatic, one-point calibration system is available. Catalog No. MCO-SG; see accessories.

Zirconia O2 Control System, MCO-19M Series

A zirconia oxygen sensor maintains sub-ambient O2 levels from 1% to 18%. Ad-ditionally, enriched O2 levels from 22% to 80% are enabled with proper safety precautions.

• Concurrently the MCO-19M permits a CO2 range 0% to 20% via infrared sensor.

• Nitrogen gas bubbler accelerates recovery of chamber humidity levels following door openings.

• An electronic P.I.D. control maintains accurate temperature and gas set-points over the entire system range.

• The MCO-19M includes an automatic gas switchover system that changes from the primary to a secondary gas cylinder for either oxygen or nitrogen; an optional second gas switchover system is available for CO2.

• Cabinet based on MCO-19 platform with inCu-saFe® copper-enriched stainless steel chamber, continuous contamination control, patented D.H.A. multi-point, air-jacketed temperature control system, elevated relative hum- idity with integral water-level sensor.

Shelf brackets are formed with an exaggerated angle to minimize surface contact with flat shelves*.

MCO-19M shown with four separate inner doors with gaskets.

MCO-19M

4 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

3 Hours 14 Hours

Panasonic Sterisonic

Brand X

H2O2 decontamination vs. high heat decontamination = Uptime (Hours) = Downtime (Hours)

Temperature and Humidity Control• The patented Direct Heat and Air Jack-

et heating system manages setpoint temperature through multiple, variable warming points under microprocessor control.

• The humidity pan is easy to fill, easy to clean; the automatic optical sensor advises of low water level.

H2O2 DecontaminationThe use of H2O2 decontamination

in biological safety cabinets and barrier isolators is a popular alternative to ethylene oxide (EtO) as a safer, more efficient decontamination method. H2O2 has long been widely used in the pharmaceutical industry. In aerospace research, H2O2 is used to decontaminate satellites and cleanrooms.

Sterisonc GxP Features and Benefits

• Orientation of interior sample ports of the single beam, dual detector IR CO2 sensor creates a slight Venturi flow through the sample chamber, per-mitting total decontamination of the CO2 system at the same time.

• Shape and location of interior components such as shelves, shelf brackets, plenum covers and the humidity pan permit the components to remain in the chamber during the decontamination process, conveniently bypassing the need for a separate autoclave cycle.

• Once the cycle is complete, the door locking system is released; the inner door can be opened, interior compo-nents repositioned and the incubator is returned to service.

Ergonomic Cabinet DesignWith reversible inner and outer doors, a single Panasonic incubator offers the industry's most flexible installation options available.

• Low profile cabinet with door-mounted control panel permits easy access and viewing.

• The outer door latch and door heater cable is easily switched if a reverse opening is required.

Unlike conventional incubators, unique features of the Panasonic Sterisonic GxP incubator permit use of the H2O2 process in situ with complete safety, zero impact on adjacent equipment or the environment, and speed to return the incubator to service.

• The H2O2 decontamination process functions with the patented Pana-sonic SafeCell UV system. Following a seven-minute H2O2 vaporization, circulation and dwell cycle, vaporization is stopped and the SafeCell UV lamp turned ON for up to ninety minutes.

• When exposed to UV light, the H2O2 vapor breaks down into water and oxygen, leaving only traces of water droplets. These droplets automatically condense onto a cooler section of the interior floor for easy wipe-up.

• Throughout the entire cycle the Sterisonic GxP airflow system con-tinues to gently circulate interior air assuring 100% vapor contact with all interior surfaces, ultimately creating a serial dilution of H2O2 as it passes over the UV lamp.

The documented a 3 hour in situ H2O2 sequence puts the fully decontaminated Sterisonic GxP available and ready for use quicker than any other incubator worldwide.

Sterisonic GxP Series H2O2 Decontamination Performance Value

5

Sterisonc GxP Features and Benefits

• Cabinet knock-outs are pre-drilled and tapped to eliminate drilling and to simplify re-mounting of door hardware.

• The heated outer door closes against a soft, easily cleaned magnetic gasket designed to eliminate ambient air shear across the glass inner door, minimizing condensation.

• A door ajar alarm provides an audible and visual warning if the outer door is left open.

• A center-mounted key lock is located beneath the door for added security. (Model MCO-19AIC(UVH) only)

Shelves and Inventory ManagementConvenient space efficient inventory management is simplified through a sys-tem of adjustable, extendable shelves.

• Inventory shelves and brackets are formed from polished copper-enriched stainless steel, removable without tools, and can remain inside the incubator during the H2O2 decontamination cycle or autoclaved separately if desired.

• Shelves are perforated to permit natu-ral vertical air convection through and around labware.

• Shelf brackets are formed with an exaggerated angle to minimize surface contact with flat shelves. Brackets slip easily into vertical supports that attach to interior chamber walls with clear-ance sufficient to permit proper air circulation.

Inner Door and GasketThe inner design is critical to successful contamination control technique.

• The inner gasket body forms an effective thermal transition between the ambient air and warm, humidified incubator atmosphere, minimizing condensation and eliminating moisture traps which can harbor contaminants.

• The inner door gasket is a dual durometer extrusion (two levels of softness) from closed-cell silicone to inhibit contamination.

• The gasket feather-edge allows the inner glass door to close gently against the chamber opening for a tight peripheral seal.

• The entire inner door gasket is remov-able for cleaning and/or replacement if required.

• Radiant heat from the outer door, apportioned by the microprocessor control as a function of the patented Direct Heat and Air Jacket heating cycle, automatically warms the inner door glass in proportion to total heat demand and condensation control.

Field Reversible DoorThe field-reversible door allows universal installation using the left-hand hinge (standard) or a right-hand hinge modification

• The outer door includes a universal finger grip at each side.

• Mounting holes for hinge hardware are pre-drilled and capped with easily removable trim plugs.

Elevated Humidity, Low Water Level WarningTo avoid cell culture desiccation, the Panasonic Sterisonic GxP CO2 incubator maintains ~95% RH at 37°C.

• Humidification is achieved by a com-bined forced-air and natural evapora-tion method enhanced by the Direct Heat and Air Jacket heating system base heater, and protected by an opti-cal water level indicator to warn of low water in the removable humidity pan.

• The humidity pan removes easily for regular cleaning and refill.

• When filled, the pan slides into place. The optical sensor returns to position and the SafeCell UV lamp destroys contaminants introduced during the process.

• For the H2O2 in situ decontamination cycle the humidity pan is repositioned against the chamber wall to eliminate the need for separate autoclaving.

Stacking Doubles Capacity in Same Footprint.

• The Sterisonic GxP cabinet is designed for stacking, allowing one unit to be positioned on top of another, doubling interior volume without additional floor space.

• The combination of stacking and reversible doors offers the most installation options possible.

• An optional roller base is recom- mended for stacked installations to permit mobility if required; see accessories.

MCO-38AIC(UVH)

6 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Sterisonic GxP Control System

Sterisonic GxP H202 Decontamination Cycle

(3 Hours, total)

Elapsed Time: 15 min. 30 min. 45 min. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24

Conventional High Heat

Decontamination (24 Hours, total)

PREP: 15 min. Reposition shelves, humidity pan and plenum inside Panasonic chamber. Interior surfaces are exposed.

PREP: 15 min. Remove interior components sensitive to high heat.

Start Cycle: 30 min. Press H2O2 start button. Chamber warms to 45˚C.

Start Cycle: 90 min. Interior chamber elevates to high heat.

Decontaminate: 14 hours Interior chamber remains at high heat.

Decontaminate: 10 min. Panasonic H2O2 atomizer creates vapor which is circulated throughout chamber by interior blower.

Resolve: 90 min. UV lamp glows for 90 minutes, reducing H2O2 to harmless water droplets.

Finish. Shelves, humidity pan and plenum are returned to operating position.

Control Features• The Sterisonic GxP control and informa-

tion center includes an intuitive pop-up menu, high resolution LCD for inputs, outputs and performance at-a-glance.

• Multi-point data logging offers push-button graphical display. An optional PC interface permits remote transmission for GMP/GLP protocols as required.

• Selected performance histories can be acquired in graphical format for easy interpretation.

• Precise PID logic controls and adjusts to all temperature and CO2 setpoints and alarm parameters.

• A range of setpoint, alarm and program-mable inputs are established through pop-up menus and function keys.

• Standard parameters are factory-set for quick start-up, and all parameters can be changed as required.

• Logged parameters can be exported to remote databases, off-site alarm or data capture systems through optional communications board for compliance monitoring; see accessories.

• A remote alarm terminal mounted at the rear of the cabinet can be connected to an external alarm system.

• Tactile feedback, touch pad data shift and entry keys simplify operation.

• The control panel is center mounted in the outer door for easy access and viewing.

Decontamination CycleThe H2O2 decontamination cycle is monitored for safety and cycle status. A physical interlock and neutralization sequence assures total decontamination and operator safety.

Start Cycle: When the H2O2 button is pressed a confirming message prompts the user to proceed with the decontamination cycle or cancel.

H2O2 Vapor Cycle: Once the door locks auto-matically, the cycle starts. The flashing H2O2 display confirms the process and counts down remaining H2O2 vaporization time.

UV Resolution: The H2O2 atomizer automatically completes after a 10 minute cycle. UV lamp comes ON. The flashing UV Resolve display counts down remaining time in the UV cycle as H2O2 is reduced to water and trace oxygen.

Cycle Complete: When the cycle is complete the door lock releases automatically. The H2O2 atomizer and cable can be disconnected and removed and all interior components restored to their normal position.

1

2

3

4

Intelligent interface through integrated LCD control with graphical display — The Sterisonic GxP incubator is managed by an integrated micro-processor controller with LCD graphical display to simplify all incubator functions. Stable temperature and humidity conditions are achieved through a combination of performance systems supervised by the controller complete with alarm, programming, calibration and diagnostic protocols.

7

Sterisonic GxP Control System

Sterisonic GxP H202 Decontamination Cycle

(3 Hours, total)

Elapsed Time: 15 min. 30 min. 45 min. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24

Conventional High Heat

Decontamination (24 Hours, total)

Decontaminate: 14 hours Interior chamber remains at high heat.

Finish. Incubator must cool from high heat temperatures to near ambient.

• Digital alphanumeric LCD display. • Message display• Pop-up menu

• Display contrast adjustment

• Positive feedback tactile input buttons

• Positive feedback tactile entry and function keys

• Visual alarm indicator

• Menu call button

• H2O2 decontamination sequence start key

3

1

2

4

8 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Sterisonic GxP Design and Technology

H2O2 DecontaminationThe unique Sterisonic GxP H2O2 decontamination system limits

downtime to less than three hours when total chamber decontamination is desired.

• All interior components and CO2 sam-pling loop are decontaminated in situ; no need for removal and autoclaving and no component stress associated with high heat cycles.

• Available as standard on the MCO-19AIC(UVH) and MCO-19M(UVH); optional on the MCO-19AIC(UV) and MCO-19M(UV).

• Following decontamination, Panasonic Active Background Contamination Control fights contamination while cell culture protocols are in process.

SafeCell UV SystemSterisonic GxP Models –UVH and –UV include SafeCell UV contam-

ination control technology based on an inte-grated combination of narrow bandwidth, ozone-free ultraviolet light, reliable ceramic infrared CO2 control, inCu-saFe® copper-enriched stainless steel alloy interiors and Direct Heat and Air Jacket heating man-aged by a microprocessor controller.

All Panasonic CO2 incubators feature patented Direct Heat and Air Jacket heating system temperature control for accurate, uniform temperature control and inCu-saFe® for continuous contamination control. Panasonic laboratory CO2 incubators feature selected SafeCell UV with exclusive, patented Active Background Contamination Control.

The patented Direct Heat and Air Jacket heating system distributes proportional energy to the interior chamber through a natural convection air jacketsurrounded by a high density insulation to protect against ambient temperature fluctuations

Direct Heat and Air Jacket Heating System

Zone Location Function Energy Microprocessor Controller

Main (Red) Side, top and rear walls Dominant heat source Variable

Energizes any, all or in combination of heating

elements as required.Base (Yellow) Floor Base heater elevates the humidity reservoir

to achieve 95% RH at 37°C Variable

Front (Green) Outer door

Warms the inner glass in response to ambient conditions; eliminates condensation on glass and around the opening and promotes temperature uniformity

Variable

Air Jacket (White) Side, top and rear walls Sealed. Surrounds interior chamber with natural

air convection and promotes chamber wall uniformity – –

Insulation (Gray) Side, top and rear walls, door Promotes energy efficiency, mitigates effect of

ambient temperature fluctuations on air jacket – –

Direct Heat and Air Jacket Heating SystemThe patented Direct Heat and Air Jacket heating system surrounds the inner walls with a natural convection air-flow that converts to radiant wall heat through thermal conduction to achieve accurate, uniform and highly responsive temperature control within the chamber.

• The microprocessor controller directs proportional distribution of power to independent heating sources sur-rounding the chamber.

• Arranged in three zones, these sources include the side, top and rear walls, the chamber base and the outer door.

• Each zone is controlled by the micro-processor which manages continuous feedback from the incubator chamber sensors.

9

• The MCO-19M includes an automatic gas switchover system that changes from the primary to a secondary gas cylinder for either oxygen or nitrogen; an optional second gas switchover system is available for CO2.

• Cabinet based on MCO-19 platform with inCu-saFe® copper-enriched stain-less steel chamber, continuous con-tamination control, patented D.H.A. multi-point, air-jacketed temperature control system, elevated relative hu-midity with integral water-level sensor.

InCu-saFe® Construction for Germicidal ProtectionPanasonic offers exclusive use

of inCu-saFe® copper-enriched stain-less steel alloy interior surfaces within a technical design created to eliminate contamination sources and to mitigate the effect of airborne contaminates introduced through normal use.

• Selected to provide natural germicidal protection without rust or corrosion, inCu-saFe® expresses a natural ger-micidal attribute to inhibit the growth of molds, fungi, mycoplasma and bacteria.

• All interior components, including the air management plenum, shelf supports, humidity pan and blower wheel assembly are easily removable without tools if required.

• During the H2O2 decontamination cycle interior components can be repositioned within the chamber for in situ decontamination.

• When components are removed, all interior surfaces are exposed for con-ventional wipe down.

• Large curve corners and electropol-ished surfaces are easy to clean.

• Pass thru ports accommodate probes or instrumentation leads as required for specialized cell culture protocols. Each chamber includes a port posi-tioned in the interior, rear wall, upper left, with dual, non-VOC silicone stop-pers inside and outside the cabinet for added protection.

Sterisonic GxP Design and Technology

These incubators offer the industry's most stable cell culture environment and are useful for the most critical applications where continuous contami-nation control is essential to cell viability. Panasonic SafeCell UV Series CO2 incubators offer significant economic benefits by minimizing interruptions for decontamination, by improving cell culture growth and expression under stable, repeatable conditions, and by minimizing the potential for product loss.

• SafeCell UV includes a programmable ultraviolet lamp, isolated from cell cultures, that decontaminates condi-tioned air and humidity reservoir water to prevent contamination without affecting cell cultures in vitro.

• SafeCell UV inhibits the growth of mycoplasma, bacteria, molds, spores, yeasts and fungi without costly HEPA filter air scrubbers which accumulate contaminants in the filter media HEPA filters are also ineffective on particles less than 0.3 microns.

• High temperature decontamination systems, which can actually encour-age in vitro growth of heat resistant thermophilic and hyperthermophilic microorganisms, are avoided, thus eliminating key component stress.

• inCu-saFe® interior surfaces provide natural resistance to contamination.

• The SafeCell UV lamp reduces H2O2 to trace sterile water condensate following the ten-minute vapor decontamination process.

Dual Wavelength Infrared CO2 Control SystemThe Panasonic single beam,

dual detector infrared CO2 system offers unprecedented control accuracy and stability by simultaneously measuring two wavelengths.

The chamber sample and a reference is configured around a ceramic-based sensor linked to the microprocessor controller with a sophisticated P.I.D. (proportional, integral and derivative) algo-rithm. Benefits include ultra-fast recovery

without overshoot and accurate CO2 aver-ages during periods of frequent incubator access with multiple door openings.

• The light frequency based technique is impervious to changes in temperature and relative humidity, highly stable during door openings, and sensitive to restoration of setpoint equilibrium when the door is closed.

• The sensor maintains a continuous auto-zero function for accuracy.

• Actual CO2 is displayed on the main control panel.

• A CO2 sample port mounted on the incubator front permits convenient confirmation of chamber CO2 density.

• An optional automatic CO2 switchover system is available (see Accessories). A two-stage regulator from the supply cylinder to the incubator is required (see Accessories).

MCO-19M Series Multi-Gas Performance O2 Control System In addition to precise CO2

control, the MCO-19M Series incubator delivers exceptional O2 control in support of cell culture processes which require below-ambient or above-ambient oxygen levels. These include in vitro fertilization (IVF), gene research, regenerative medi-cine, hypoxia research and emerging applications that are sensitive to oxygen levels other than ambient.

• A solid zirconia oxygen sensor main-tains sub-ambient O2 levels from 1% to 18%. Additionally, enriched O2 levels from 22% to 80% are enabled with proper safety precautions.

• Concurrently the MCO-19M permits a CO2 range 0% to 20% via infrared sensor.

• Nitrogen gas bubbler accelerates recovery of chamber humidity levels following door openings.

• An electronic P.I.D. control maintains accurate temperature and gas set-points over the entire system range.

10 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Sterisonic GxP Design and Technology

Active Background Contamination ControlA continuous Active Background Con-tamination Control process eliminates contamination without downtime.

At the base of the plenum an isolated beam of high intensity, ozone-free ultraviolet light destroys contaminants in the air and in the humidity water res-ervoir, away from active cell cultures.

• Contaminants trapped within the distilled water pan are destroyed by ultraviolet light.

• Decontaminated, humidified air is released from the lower plenum for vertical convection through and around the perforated shelves. Interior air motion is suspended when the door is opened, minimizing movement of room air contaminants into the chamber.

• UV light is isolated by the plenum cover to protect cell cultures

• Airborne contaminants are eliminated by an automatic UV cycle that au-tomatically turns ON for a specified period after each door opening.

• Trace contaminants that attach to interior surfaces are destroyed by the passive germicidal properties of the inCu-saFe® surfaces.

SANYO

Ozone ReleasePanasonic Lamp Germicidal Effect Eye Sensitivity Sunlight

Chart summarizes test results with four strains of mycoplasma. Results demonstrate how Panasonic inCu-saFe® copper enriched stainless steel alloy offers germicidal properties of conventional C1100 copper while maintaining both corrosion-proof and discoloration-resistant properties of conventional Type 304 stainless steel. Detailed test results are available from Panasonic.

Mycoplasma Survival Results

Mycoplasma Strain

Positive Control

Conventional Type 304 Stainless Steel

Panasonic InCu-saFe®

Conventional Copper C1100

Mycoplasma fermentans PG18 survival no survival no survival survival

Mycoplasma orale CH19299 survival no survival no survival survival

Mycoplasma arginini G230 survival no survival no survival survival

Mycoplasma hominis PG21 survival no survival no survival survival

SafeCell UV Lamp Program Cycles

Mode Function

After H2O2

Vaporization

The UV lamp automatically cycles ON for up to 90 minutes following the ten-minute H2O2 vapor cycle, reducing the H2O2 to water droplets. These droplets automatically condense onto a naturally cooler section of the interior floor for easy wipe-up.

After Door Opening

UV lamp automatically ON for five minutes after door is closed decontaminates incoming room air.

OFF If UV protection is not desired.

24 Hour Continuous ON

Useful for overnight decontamination prior to first use, clinical decontamination protocols between patients, or following total chamber wipe-out after maintenance or service.

The SafeCell UV lamp cycle is factory set for normal use, and can be re-programmed as desired by entering parameters through the central microprocessor control panel. Program parameters for the H2O2 decontamination cycle are non-adjustable for operator safety.

SANYO

Ozone ReleasePanasonic Lamp Germicidal Effect Eye Sensitivity Sunlight

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Sterisonic GxP Series Dimensions, Weights and Capacities

Model NumberVolume (cu.ft.)

Exterior Dimensions (w x f-b x h)

Interior Dimensions (w x f-b x h)

Shelves Net Weight (nominal)

MCO-19AIC-PA MCO-19AICUV-PA MCO-19AICUVH-PA

6.0 170 L

24.4" x 27.9" x 35.4" 620 x 710 x 900 mm

19.3" x 20.6" x 26.2" 490 x 523 x 665 mm

15 max / 4 supplied std. 17.7" x 17.7" (15.4 lbs capacity) 450 x 450 mm (7 kg capacity)

205 lbs 93 kg

MCO-19M-PA MCO-19MUV-PA MCO-19MUVH-PA

6.0 170 L

24.4" x 27.9" x 35.4" 620 x 710 x 900 mm

19.3" x 20.6" x 26.2" 490 x 523 x 665 mm

15 max / 3 supplied std. 17.7" x 17.7" (15.4 lbs capacity) 450 x 450 mm (7 kg capacity)

207 lbs 94 kg

Sterisonic GxP Specifications

Sterisonic GxP Series Energy, Electrical and Utilties

Description

MCO-19AIC-PA MCO-19AICUV-PA

MCO-19AICUVH-PA

MCO-19M-PA MCO-19MUV-PA

MCO-19MUVH-PA

Maximum Power Consumption 310W 310W

Maximum Heat Discharge 1062 BTU/HR 1062 BTU/HR

Electrical Connection 115V,60Hz, 1 phase, NEMA 5-15P plug provided; 115V,60Hz, 1 phase, NEMA 5-15P plug provided;

CO2 Gas Connection ¼" Barb Fitting ¼" Barb Fitting

CO2 Gas Input Pressure Nominal 5 psi from two-stage CO2 regulator Nominal 5 psi from two-stage CO2 regulator

CO2 Gas Cylinder Switchover System Optional Optional

O2 Control System N/A Microprocessor PID, Zirconia Sensor

O2 Range and Variation N/A 1-18%, 22-80%

N2/O2 Inlet Connect/Pressure N/A Nominal 7 psi from two-stage regulator

N2/O2 Switchover System N/A Standard

FRONT SIDE

24.4" (620 mm)

19.3" (490 mm)4.5" (115 mm)

22.8" (580 mm)

4.9"

(1

25 m

m)

24.8" (630 mm)

20.6" (523 mm)

3.1" (80 mm)

18.4" (469 mm)1.7" (44 mm)

26.2

" (66

5 m

m)

0.8"

(2

0 m

m)

34.6

" (88

0 m

m)

1.9" (49 mm)1.3" (34 mm)

12 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Sterisonic GxP CO2 Incubators

Description

Single Chamber Model Number MCO-19AICUVH-PA MCO-19AICUV-PA MCO-19AIC-PA

Dual Chamber Model Number MCO-38AICUVH-PA MCO-38AICUV-PA MCO-38AIC-PA

Major Operating Systems

H2O2 Decontamination System Standard Optional Optional

SafeCell UV System Standard Standard Optional

Single Beam, Dual Detector IR CO2 Sensor Standard Standard Standard

inCu-saFe® Copper Enriched Stainless Steel Interior Standard Standard Standard

LCD Graphical Controller/Display, Door Mounted Standard Standard Standard

Direct Heat, Air (DHA) Air Jacket Standard Standard Standard

Decontamination

H2O2 Decontamination System Vaporization in situ Optional Optional

Interior UV Lamp, Programmable, Ozone Free Standard Standard Optional

Copper Enriched Stainless Steel Interior with Germicidal Protection Standard Standard Standard

Environmental Performance

Temperature Control Range +5ºC above ambient to 50°C

Temperature Control Uniformity Deviation ±0.25ºC (in 25ºC ambient, setting 37ºC, 5% CO2, no load)

CO2 Control Range and Deviation 0% to 20%, ±0.15% in 25ºC ambient, setting 37ºC, 5% CO2, no load

CO2 Sensor Platform Ceramic based, single beam, dual wavelength measurement of actual vs. contrast, with continuous auto-zero calibration.

CO2 Calibration Single point zero automatic; semi-automatic one point span @ reference optional.

Airflow Gentle vertical airflow, continuous with inner door closed.

Interior Humidity 95%RH @ 37°C through evaporation via DHA heating system; reflective optical low water sensor.

Control, Monitoring, Alarm

Temperature and CO2 Control P.I.D., setpoint resolution 0.1% and 0.1°C

Display Alphanumeric LCD digital display messaging.

Data Acquisition Data Acquisition Automatic log function of temperature and CO2.

Communications Remote alarm contacts standard. Optional 4-20mA connection. Optional PC interface, Catalog No. MTR-480 with RS232/RS485 data ports available

Cabinet Design and Construction

Interior, Shelves 4, Copper-enriched stainless steel.

Inner Door Tempered glass.

Insulation Rigid foam polyurethane.

Outer Door Reversible, heated.

Access Port Single opening with interior and exterior 1.18" (30 mm) silicone stoppers.

Leveling Feet 4, adjustable.

Sterisonic GxP CO2 Series Specifications

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Sterisonic GxP CO2/O2 Incubators

Description

Single Chamber Model Number MCO-19MUVH-PA MCO-19MUV-PA MCO-19M-PA

Dual Chamber Model Number MCO-38MUVH-PA MCO-38MUV-PA MCO-38M-PA

Major Operating Systems

H2O2 Decontamination System Standard Optional Optional

SafeCell UV System Standard Standard Optional

Single Beam, Dual Detector IR CO2 Sensor Standard Standard Standard

inCu-saFe® Copper Enriched Stainless Steel Interior Standard Standard Standard

LCD Graphical Controller/Display, Door Mounted Standard Standard Standard

Direct Heat, Air (DHA) Air Jacket Standard Standard Standard

Decontamination

H2O2 Decontamination System Vaporization in situ Optional Optional

Interior UV Lamp, Programmable, Ozone Free Standard Standard Optional

Copper Enriched Stainless Steel Interior with Germicidal Protection Standard Standard Standard

Environmental Performance

Temperature Control Range +5ºC above ambient to 50°C

Temperature Control Uniformity Deviation ±0.25ºC (in 25ºC ambient, setting 37ºC, 5% CO2, no load)

CO2 Control Range and Deviation 0% to 20%, ±0.15% in 25ºC ambient, setting 37ºC, 5% CO2, no load

CO2 Sensor Platform Ceramic based, single beam, dual wavelength measurement of actual vs. contrast, with continuous auto-zero calibration.

CO2 Calibration Single point zero automatic; semi-automatic one point span at reference (optional).

O2 Control Range and Deviation 1-18%, 22-80%, ±0.2% in 25ºC ambient, setting 37ºC, no load

O2 Sensor Platform Zirconia sensor, microprocessor P.I.D. control

Airflow Gentle vertical airflow, continuous with inner door closed.

Interior Humidity 95%RH @ 37°C through evaporation via DHA heating system; reflective optical low water sensor.

Control, Monitoring, Alarm

Temperature and CO2 Control P.I.D., setpoint resolution 0.1% and 0.1°C

Display Alphanumeric LCD digital display messaging.

Data Acquisition Data Acquisition Automatic log function of temperature and CO2.

Communications Remote alarm contacts standard. Optional 4-20mA connection. Optional PC interface, Catalog No. MTR-480 with RS232/RS485 data ports available

Cabinet Design and Construction

Interior, Shelves 3, Copper-enriched stainless steel.

Inner Door 4 separate, gasketed inner doors, tempered glass

Insulation Rigid foam polyurethane.

Outer Door Reversible, heated.

Access Port Single opening with interior and exterior 1.18" (30 mm) silicone stoppers.

Leveling Feet 4, adjustable.

Sterisonic GxP CO2/O2 Series Specifications

14 Sterisonic GxP Series Cell Culture Incubators www.panasonic.com/biomedical

Integrated Cooling Coil (MCO-CL)

Factory installed; specify when ordering. Water bath/circulator not included. Permits stable operation at ambient or below ambient temperatures. Extends performance specifications as follows:• Temperature Range: +18°C to +50°C, distribution

±0.25°C, variation ±0.1°C.• Relative Humidity: +5ºC above ambient to +50ºC, 95%

± 5%RH; 20ºC to 25ºC > 80%RH; 18ºC > 70%RHIncludes temperature mapping results for individual unit per serial number.

Ambient Temperature +24ºC

Without Cooling Coil

With Cooling Coil

+50ºC +50ºC

+5ºC over Ambient

+18ºC

Relative Temperature Performance

Panasonic Biomedical products include a broad range of accessories to meet specific application requirements. For accessories or options not listed herein, contact Panasonic or your authorized Panasonic sales representative.

Sterisonic GxP CO2 Series Accessories

H2O2 Reagent (MCO-H2O2-PV)

Panasonic H2O2 solution is specially formulated for optimal use with the MCO-HP atomizer. Each pre-measured bottle is sufficient for a complete H2O2 decontamination sequence. Unit of issue: six per carton.

H2O2 Vapor Atomizer (MCO-HP-PW)

Shown with connecting cable, standard.

Sterisonic GxP CO2 Series IncubatorsSingle Chamber Model Number

Dual Chamber Model Number

MCO-19AICUVH-PA

MCO-38AICUVH-PA

MCO-19AICUV-PA

MCO-38AICUV-PA

MCO-19AIC-PA

MCO-38AIC-PA

Catalog No. Catalog No. Catalog No.

H2O2 Decontamination Kit Built-in MCO-HL N / A

H2O2 Vapor Atomizer MCO-HP-PW N/A N / A

H2O2 Reagent (Formulated for Panasonic Sterisonic GxP) MCO-H2O2-PV N/A N / A

Automatic CO2 Cylinder Switchover System MCO-21GC-PW MCO-21GC-PW MCO-21GC-PW

Gas Calibration System, semi-automatic one point calibration function. MCO-SG-PW MCO-SG-PW MCO-SG-PW

CO2 Cylinder Regulator, CGA fitting 320 MCO-100L MCO-100L MCO-100L

Roller Base. For use in single or stacked installations. MCO-18RB-PW MCO-18RB-PW MCO-18RB-PW

inCu-saFe® Shelf and Brackets. Includes two shelf brackets. Full shelf MCO-47ST-PW MCO-47ST-PW MCO-47ST-PW

inCu-saFe® Half Tray System MCO-25ST-PW MCO-25ST-PW MCO-25ST-PW

Integrated Cooling Option MCO-CL MCO-CL MCO-CL

Communications Port. Located at rear of chamber. Connector, cable and software not supplied.

MTR-480-PW MTR-480-PW MTR-480-PW

Communications Port. Located at rear of chamber, analog 4-20mA. MCO-420MA-PW MCO-420MA-PW MCO-420MA-PW

SafeCell UV System Kit Narrow-bandwidth 253.7nm lamp and assembly. Built-In Built-In MCO-19UVS

15

Ambient Temperature +24ºC

Sterisonic GxP CO2/O2 Series Accessories

Integrated Cooling Option

Feature

Temperature Range +18ºC to +50ºC, distribution ±0.25ºC, variation ±0.1ºC

Relative Humidity+5ºC above ambient to +50ºC, 95% ± 5%RH; 20ºC to 25ºC > 80%RH; 18ºC > 70%RH

Includes temperature mapping results for individual unit per serial number

Components Stainless Steel Cooling Coil, Interconnection Lines, 6 L, Refrigerated Water Bath & Circulator (Optional/Not Provided)

Sterisonic GxP CO2/O2 Series IncubatorsSingle Chamber Model Number

Dual Chamber Model Number

MCO-19MUVH-PA

MCO-38MUVH-PA

MCO-19MUV-PA

MCO-38MUV-PA

MCO-19M-PA

MCO-38M-PA

Catalog No. Catalog No. Catalog No.

H2O2 Decontamination Kit Built-in N/A N / A

H2O2 Vapor Atomizer MCO-HP-PW N/A N / A

H2O2 Reagent (Formulated for Panasonic Sterisonic GxP) MCO-H2O2-PV MCO-H2O2-PV N / A

Automatic CO2 Cylinder Switchover System MCO-21GC-PW MCO-21GC-PW MCO-21GC-PW

Gas Calibration System, semi-automatic one point calibration function. MCO-SG-PW MCO-SG-PW MCO-SG-PW

CO2 Cylinder Regulator, CGA fitting 320 MCO-100L MCO-100L MCO-100L

N2 Cylinder Regulator, CGA fitting 580 (for low oxygen applications) MCO-100N MCO-100N MCO-100N

O2 Cylinder Regulator, CGA fitting 540 (for high oxygen applications) MCO-100M MCO-100M MCO-100M

Roller Base. For use in single or stacked installations. MCO-18RB-PW MCO-18RB-PW MCO-18RB-PW

inCu-saFe® Shelf and Brackets. Includes two shelf brackets. Full shelf MCO-47ST-PW MCO-47ST-PW MCO-47ST-PW

inCu-saFe® Half Tray System MCO-25ST-PW MCO-25ST-PW MCO-25ST-PW

Integrated Cooling Option (separate recirculating refrigerated water bat required)

MCO-CL MCO-CL MCO-CL

Communications Port. Located at rear of chamber. Connector, cable and software not supplied.

MTR-480-PW MTR-480-PW MTR-480-PW

Communications Port. Located at rear of chamber, analog 4-20mA. MCO-420MA-PW MCO-420MA-PW MCO-420MA-PW

SafeCell UV System Kit Narrow-bandwidth 253.7nm lamp and assembly. Built-In Built-In MCO-19UVS

Product conforms to RoHS (European Restriction of Hazardous Substance directives)

Unique Panasonic Services• On-site consultation

• Specialized documentation for each individual unit

• Customized testing procedures based on personalized customer requirements

Predelivery and On-Site ServicesPredelivery services include factory accep-tance testing, calibration, and temperature mapping. On-site services include installa-tion qualification, operational qualification, performance qualification, calibration and temperature mapping.

Panasonic ConnectPanasonic’s customer-driven biomedical service program guarantees local attention from qualified Panasonic service representatives, whenever and wherever you need it.

• New Unit Installation and Training

• Preventative Maintenance

• Warranty and Non-Warranty Repairs

• Calibration/Validation Services

• Refurbishment and Reconditioning

• Customized Service and Warranty Pro-grams

• In-Stock Parts for Immediate Delivery

Service and Technical Support

Panasonic Healthcare Company of North America1300 Michael Drive, Suite A, Wood Dale, IL 60191Toll Free USA (800) 858-8442, Fax (630) 238-0074www.panasonic.com/biomedical

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