ccost sponsored - kalingauniversity.ac.in · development of pharmacy fraternity. i wish the seminar...

CCOST SPONSORED

National Seminar on

“Pharmaceutical Industries in Chhattisgarh:

Needs and Opportunities”

February 24-25, 2018

Abstract Book

Organized by

Kalinga University- Faculty of Pharmacy,

Raipur-492101, Chhattisgarh, India

Email: [email protected]

Phone: +91-9424231025

CCOST Sponsored National Seminar

on “Pharmaceutical Industries in Chhattisgarh: Needs and Opportunities”





Dr. Rajeev Kumar

Chief Patron

Chairman

Kalinga University

New Raipur (C.G.)

MESSAGE

I feel immensely delighted and privileged to welcome all the distinguished guests and

participants of National Seminar entitled “Pharmaceutical Industries in Chhattisgarh: Needs and

Opportunities” organized by Faculty of Pharmacy, Kalinga University, New Raipur (C.G.) on

February 24-25th

2018.

Kalinga University has always been the front runner in taking initiaves required for development

of state, for efforts by Team of Faculty of Pharmacy for selecting a needed discussion for the

betterment of Pharmacy Profession.

This national conference aims to provide specific platform to the budding pharmacists, so that

they can utilize their skills within the state. The event is a fitting reflection of university’s

dedicated efforts in overall development of teaching technique and exposure to latest topics

required for better development of state.

I convey my warm wishes for the success of this seminar, anticipating it to be a memorable one

for the outside participants as well as the hosts.

(Dr. Rajeev Kumar)

Date: 09/02/2018




Dr. Sandeep Arora

Chief Patron

Chancellor

Kalinga University

New Raipur (C.G.)

MESSAGE

We are in the era of scientific revolutions, where we can explore innumerable means to upgrade

our knowledge. This seminar on “Pharmaceutical Industries in Chhattisgarh: Needs and

Opportunities” organized by Faculty of Pharmacy” provides a platform to discuss and point out

the hurdles in the policies which restrict the entry of Pharmaceutical Industries into Chhattisgarh

state.

Chhattisgarh state is potent on herbal production as we are also known as herbal state but still we

are lacking with Pharmaceutical Industries in the state. I hope all the invited guests will educate

regarding latest technologies, opportunities and other untouched areas for the overall

development of pharmacy fraternity.

I wish the seminar a grand success.

(Dr. Sandeep Arora)

Date: 09/02/2018




Dr. Sandeep Gandhi

Patron

Registrar

Kalinga University

New Raipur (C.G.)

MESSAGE

I am glad & Honored as a part of this National Seminar. I extend my hearty welcome to all the

delegates participating in this seminar.

I earnestly hope that this seminar will provide a common platform for academicians, students,

industrialists and various Government Officials and pharmacy professionals to discuss the major

issues regarding not having any pharmaceutical industries in Chhattisgarh till date and will

provide a forum for exchange of knowledge, ideas and their experiences among the

pharmaceutical sectors. I believe this seminar will open new vistas of knowledge for better

opportunities within the state.

I extend my best wishes to the organizers and participants for this conference.

(Dr. Sandeep Gandhi)

Date: 09/02/2018




Dr. Anand Mahalwar

Convener

Faculty of Pharmacy

Kalinga University

New Raipur (C.G.)

MESSAGE

“Pharmaceutical Industries in Chhattisgarh: Needs and Opportunities” organized by Faculty of

Pharmacy is a seminar which is planned with the common goal of removal of problems related to

setup of industries and upgrading knowledge of Pharmaceutical Community. The vision of the

seminar is to nurture the mindset of budding Pharmacist towards big goal-startup of own

pharmaceutical industry.

We hope that this seminar will provide a platform to upgrade the knowledge of budding

pharmacists by interactive speech/lecture sessions with the experts’ views on the technicality,

quality, and regulatory considerations of industrialization in current scenario within

Chhattisgarh.

We look forward to welcoming you and hope that you will be benifited from the speech/lecture

sessions.

With Best wishes.

(Dr. Anand Mahalwar)

Date: 09/02/2018




Mr. Hitesh Kumar

Organizing Secretary

Faculty of Pharmacy

Kalinga University

New Raipur (C.G.)

MESSAGE

I extend a warm welcome to all invited delegates, guests and participants.

It's a great pleasure to welcome you all in National seminar on “Pharmaceutical Industries in

Chhattisgarh: Needs and Opportunities” In modern era innovative approach of learning and

exposure to latest techniques open new way to uphold the responsibilities and make society

healthy.

The theme of this seminar is quite appropriate and matches the present needs of development of

pharmaceutical sector in Chhattisgarh. I am confident that the discussions and deliberations will

generate new concepts and ideas for the betterment of pharmaceutical community and go a long

way in the empowerment of each and every one associated with this profession.

Wishing all the best for the huge success of the seminar.

(Mr. Hitesh Kumar)

Date: 09/02/2018




NATIONAL SEMINAR 2018

Organizing Committee




Organizing Committee

Chief Patrons

Dr. Rajeev Kumar

Chairman, Kalinga University

Dr. Sandeep Arora

Chancellor, Kalinga University

Patron

Dr. Sandeep Gandhi

Registrar, Kalinga University

Convener

Dr. Anand Mahalwar

Principal & Convener,

Kalinga University-Faculty of Pharmacy

Organizing Secretary

Mr. Hitesh Kumar

Assistant Professor,


Joint Secretary

Ms. Shilpa Vaishanava

Assistant Professor,





Scientific committee

Dr. Anand Mahalwar

Dr. Sunil Kumar Kashyap

Dr. Shilpi Shrivastava

Dr. R. Shridhar

Publication committee

Dr. Anand Mahalwar

Mr. Hitesh Kumar

Mr. Umashankar Nirmalkar

Registration committee

Mr. Hitesh Kumar

Mrs. Gagandeep Kaur

Ms. Archana Bharti

Ms. Nirali Budhbhatti

Ms. Ruchi Chandrakar

Food and Catering committee

Mr. Hitesh Kumar


Mr. Devanand Nishad

Mr. Bharat

Stage committee

Ms. Shilpa Vaishnava

Mrs. Shraddha Chaudhary

Mrs. Ankita Shukla

Ms. Snehal Vairagade


Transport committee

Dr. D.M. Sahu

Mr. Chandra Vijay


Certificate committee

Ms. Rituja Jain

Mr. Vinay Kumar Pandey

Mr. Shubham Agrawal

Ms. Sandhya Verma

Welcome and Felicitation committee

Ms. Shilpa Vaishnava

Ms. Aradhana Barman

Ms. Suman Keshwani

Ms. Sana Tak




2 Kalinga University- Faculty of Pharmacy, New Raipur

NATIONAL SEMINAR-2018

Programme Schedule





National Seminar on

“Pharmaceutical Industries in

Chhattisgarh: Needs and Opportunities”


Organized by

Kalinga University- Faculty of Pharmacy

Day 1: Saturday, February 24, 2018

9.00 AM to 10.00 AM : Registration

10:00 AM to 10:15 AM: Welcome of the Chief Guest & other Guests

10:15 AM to 10:30 AM: Inaugural Speech by convener

10:30 AM to 10:45 AM: Speech by Chief Guest

Technical Session- I (10:45 AM-12:00 PM)

Speaker Title

Pharmaceutical Industries in Chhattisgarh:

Needs & Opportunities

Clinical Research and its Scope

Mr. Saurabh Gupta Manager, Medley Pharmaceuticals Ltd,

Mumbai.

Dr. Vikas Chandrakar Director, KV Clinical Research Services,

Raipur.





High Tea (12.00 PM-12:15 PM )

Technical Session- II (12:15 PM- 01:45 PM )

Dr. Devendra Dewangan Head, Cipla Pharmaceuticals Ltd, Indore, M.P.

Dr. A. K. Kulshrestha Deputy Director, Directorate, Aayush, Raipur.

Good Manufacturing Processess & its Impact

Norms & Regulations for opening of Aayush

Industry

Lunch (01:45 PM-2:30 PM)

Technical Session- III (02:30 PM-04:15 PM )

Dr. Amit Roy Principal, Columbia Institute of Pharmacy,

Raipur.

Dr. D. K. Tripathi Principal, Rungta College of Pharmaceutical

Science & Reasearch, Bhilai.

Value addition of herbal products

Industrial & Academic requirments

High Tea (04:15 AM-04:30 PM )





Day 2: Sunday, February 25, 2018

Technical Session- I (10:45 AM-12:00 PM)

Speaker Title

Dr. Deependra Singh Asst. Professor, University Institute of

Pharmacy, Pt. Ravi Shankar Shukla

University, Raipur (C.G.)

Dr. R. Shridhar Professor , Dept. of Commerce and

Management, Kalinga University, New

Raipur.

Dr. Nagendra Singh Scientific Officer, Department of Aayush,

Raipur.

Herbal Formulations: Need and Opportunities

Marketing and Branding of Pharmaceutical

Products: Strategy required

Regulatory Aspect of Phytopharmaceuticals

High Tea (11:45 AM-12:00 PM)

Oral Presentation (12:00 PM-01:00 PM)

Lunch (01:00 PM-02:00 PM)

Poster Presentation (02:00 AM-02:30 AM

Valedictory Function (02:30 PM -04:00 PM)





Seminar

Participants

Abstract





FOP-2018-01

AN UPDATE ON EFFICACY OF ANTIPSYCHOTICS DRUGS IN VARIOUS

DISORDERS

Rakesh1

1Royal college of Pharmacy, Raipur

e-mail - [email protected]

ABSTRACT: Antipsychotic is a class of medications become available for treatment of various

psychiatric disorders in the early 1950’s. Over the last 60 years many antipsychotics have

become available. In line with the west, Indian researchers have evaluated the efficacy of

antipsychotics in various conditions. Trend has turned from custodial care towards restoring the

individual patient to his place in the community. Additionally, researchers have also evaluated

the important safety and tolerability issues. Here, we review data originating from India in the

form of drug trials, effectiveness, usefulness, safety and tolerability of antipsychotics. Research

has been carried out in psychopharmacology and we now have several useful drugs in this

branch of pharmacology. Psychiatric conditions are broadly divided into organic mental

disorder, psychoses, neuroses and personality disorders.

Reasonably good amount of data on the efficacy of antipsychotics in schizophrenia is available

from India. In addition, studies also suggest usefulness of antipsychotics in mania, acute and

transient psychosis, delusional disorders and agitation and violence. Older studies also suggest

that typical antipsychotics have usefulness in anxiety states. Many of the recent studies followed

double blind randomized controlled design and had a reasonable sample size. Further, many

studies have been carried out at multiple sites throughout the country. To some extent, data is

also available with regards to the tolerability of antipsychotics and it shows that extra pyramidal

symptoms and NMS are more common with typical antipsychotics and weight gain is more

common with antipsychotics like olanzapine and risperidone.

However, the major limitation of the research is that there are not many studies on the treatment

of schizophrenia in elderly, in subjects with comorbid physical illnesses and in cases with

comorbid substance abuse. Data on long term efficacy of antipsychotics is also meager. There is

still a need to conduct long term comparative multi-centric studies to evaluate the efficacy,

effectiveness, tolerability and side effects of antipsychotics.

KEYWORDS: Antipsychotic, olanzapine, schizophrenia, transient psychosis.

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FOP-2018-02

CONCEPT OF GOOD MANUFACTURING PRACTICES (GMP) IN AYURVEDIC

PHARMACEUTICALS

Amzad Ali Ansari1, Kavita

1, S.M. Parhate

2, T. R. Singh

3

1 Scholar,

2 Professor & HOD,

3 Lecturer, P.G. Dept. of Rasashastra and Bhaishajya kalpana,

Govt. Ayurved College Raipur.(C.G.)


ABSTRACT: GMP is an essential and significant step taken by the Government in improving

the quality and standard of ASU (Ayurveda, Siddha and Unani) drugs being manufactured in

about 9000 Licensed ASU Pharmacies in our country. Gazette notification GSR 561 (E) Dated:

23 June, 2000 SCHEDULE-T under Rule 157 of Drug & Cosmetic Act 1940 applicable to whole

of the country with effect from 23 June, 2000 for new ASU Manufacturing units. The Indian

traditional medicines like Ayurveda are 1000 years old & became household remedies.

Pharmacy or Ausadha nirmana kendra is always expected to be a quite hygienic and workable

place with all facilities. We put up many rules and regulations for its establishment under the

umbrella of GMP now days. In ancient times the physicians himself was collecting genuine

herbs preparing the medicines & dispersing so there was no problem of adulteration or hygiene.

But with the growing demands for production on large scale manufacture being started by

industries. With the industrialization & manufacture on large scale many factors like collection ,

cultivation, use of pesticides & pollution, hygiene & adulteration, which affects the quality of

medicines, become important factors & for the production of quality medicines GMP became

important. “GMP describes the planning, documents & equipment that is put into place in a

manufacturing plant to make sure that the medicine turns out the same quality every time”. The

standards and specifications in the GMP have been kept moderate, keeping in view the interest of

small scale industries in this sector. However the consumer’s interest has been taken care of. The

implementation of GMP will increase the faith in public in the quality of ASU drugs.

KEYWORDS: GMP, Pharmacy or Ausadha nirmana kendra, Quality, ASU drugs.

FOP-2018-03

PHARMACEUTICAL INDUSTRIES IN CHHATTISGARH: CLUSTER

DEVELOPMENT PROGRAMME FOR PHARMA SECTOR (CDP-PS)

Pankaj Kumar1

1 School of Pharmacy, CEC, Bilaspur (C.G.) India


2





ABSTRACT: Cluster Development Programme for Pharma Sector (CDP-PS) with Ministry of

Chemicals & Fertilizers is a vision to catalyze and encourage quality, productivity and

innovation in pharmaceutical sector and to enable the Indian Pharmaceutical Industry especially

SMEs to play a leading role in a competitive global market and reduce the dependency on import

of Bulk Drugs. The CDP-PS is a Central Sector Scheme. For this, world class quality

manufacturing facilities with high level of productivity with innovative capabilities are required.

The objectives of this scheme are as under: Increasing the competitiveness, easy access to

standard testing and infrastructure facilities, value addition in the domestic Bulk Drug Industry

through creation of common world class facilities, Strengthening the existing infrastructure

facilities in order to make Indian Bulk Drug Industry a global leader in Bulk Drug Exports,

Reducing the cost of production by 20-25% in the Bulk Drug Park leading to better availability

and Exploiting the benefits arising due to optimization of resources and economies of scale.

Some of the indicative activities under the Common facilities are required for cluster

development of Pharmaceutical industries: Common Testing Facilities, Training Centre, Effluent

Treatment Plant, R&D Centres, Common Logistics Centre, Effluent Treatment Plants,

Incubation facilities, Steam and Cooling and water systems, Captive Power Plant, Advance

common testing centre and Regulatory awareness facility centre. The Future Prospects of

projects investments in the drugs and pharmaceuticals industry we expect project completions to

pick-up in the coming years. Apart from formulations, the industry is investing to expand its

capacity to manufacture active pharmaceuticals ingredients (API) or bulk drugs manufacturing

with an aim to become self-sufficient with respect to API requirements.

KEYWORDS: Pharmaceutical industries, CDP-PS, Chhattisgarh.

FOP-2018-04

A REVIEW ON INDIAN PHARMACEUTICAL INDUSTRY

Ruchita Jaiswani1



ABSTRACT: Indian pharmaceutical industry evolved in true sense only after independence.

Health is defined both as cause and effect of economic development and pharmaceutical industry

is especially recognized in the ‘UN Millennium Development Goals’ to contribute in the

economic development. Indian pharmaceutical industry is classified as one of the most high-tech,

capital intensive and life line industry because it product plays crucial role in remedifying the

suffering of diseased person. Indian pharmaceutical industry is one of the world’s largest and

most developed ranking fourth in terms of volume and thirteen in terms of value. Indian

3





industries contribute 10% of global production in world pharmaceutical market. Pharmaceutical

consumption in India is expected to grow substantially over the next five years, driven by rise in

disposable income, an ageing population and improving medical infrastructure. It has over the

years made significant progress in infrastructure, development, technical capability and hence

produced a wide range of pharmaceutical products. The industry now produces bulk drugs under

all major therapeutic groups. It has a sizable technically skilled manpower with prowess in

process development and processing. There is a increasing interest and investment in R&D. Bulk

drugs have grown approximately 14% and formulation by 24% in nineties. It provides

employment to 29 million people. Some of the indo-global industries like Cipla, Sun Pharma and

Dr.Reddy’s are showing rapid and consistent growth with their impact worldwide. India is also

turning out to be a prime destination for clinical trials. Industry today is governed by wide range

of regulations and different regulatory bodies. The objective of this study is to focus on all the

aspects related to Indian pharmaceutical industries with regulations for new drugs, medical

devices and imports.

KEYWORDS: Pharmaceutical industries, Clinical trials, Regulations, Bulk drugs,

Formulations.

FOP-2018-05

FABRICATION, CHARACTERIZATION AND IN VITRO EVALUATION OF

NIZATIDINE LOADED MUCOADHESIVE MULTIPARTICULATE SYSTEM

Pravin Kumar Sahu1, Utpal Jana

1



ABSTRACT: Multiparticulate systems play an important role for delivery of drug in a

systematic manner to achieve the desire therapeutic activity. Microparticles possess good

advantages in terms of sustained, oral and parenteral controlled release and drug targeting. Drugs

with low bioavailability and poor stability are also improved by the multiparticulate systems.

Mucoadhesion is a property gaining popularity now-a-days in the design of novel drug delivery

systems having prolonged residence time at absorption site. This is helpful for effective

therapeutic performance of the drugs with minimum side effects by reducing the dose, dosing

frequency. Nizatidine is a competitive, reversible H2-receptors inhibitor, particularly in the

gastric parietal cells. By inhibiting the action of histamine on stomach cells, nizatidine reduces

too much stomach acid production, which is widely used for the treatment of peptic ulcers,

gastro-esophageal reflux diseases and healing of active duodenal ulcers.

4





Nizatidine is also used to treat or prevent occasional heartburn, acid indigestion, or sour stomach.

Chitosan is a natural polymer used for the development of controlled release system. The bio-

adhesive property of chitosan made it more convenient for developing the mucoadhesive drug

delivery system. In the present study Nizatidine loaded mucoadhesive chitosan micrparticles

were fabricated by using different methods, characterized and assessed by keeping in the view to

get more prolonged and effective delivery of Nizatidine having very short half-life (1-2 hours),

slightly water solublity (0.0386 mg/mL) & good absorption in gastic pH.

KEYWORDS: Nizatidine, Microparticles, Mucoadhession, Sustained release.

FOP-2018-06

ISOLATION AND CHARACTERIZATION OF FLAVONOIDS FROM THE LEAVES

EXTRACT OF PONGAMIA PINNATA COLLECTED FROM ROADSIDE REGION OF

ACHANAKMAR AREA, BILASPUR, CHHATTISGARH, INDIA.

SK Lanjhiyana1, Sweety Lanjhiyana

2

1Institute of Pharm. Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur-C.G.-495009.

2 School of Pharmacy, Chouksey Engg. College, Bilaspur-495001.


ABSTRACT: Pongamia pinnata is a medicinal plant, used by herbalist for treating various

diseases, in various regions of chhattisgarh, india. However, its pharmacological activity and

phytochemical profile has not been scientifically investigated so far. Therefore we planned to

estimate the phytochemical profile of leaves of pongamia pinnata and further isolation and

characterization of bioactive compounds accountable for various pharmacological activities. The

phytochemical profile of ethyl acetate extracts of Pongamia pinnata estimated by thin layer

chromatography, column chromatography. And UV spectroscopy, FTIR spectroscopy, 1H-NMR

spectroscopy, 13C-NMR spectroscopy and MASS spectroscopy techniques were employed to

isolate, characterize and identify the bioactive components from fractions of ethyl acetate

extract. Two compounds were purified and identified as flavonoid with an unusual linkage.

KEYWORDS: Elaeodendron Glaucum Pers, Phytoconstituents, Antioxidants, HPTLC.

FOP-2018-07

POLYMERIC NANOCARRIERS: A NEW HORIZON FOR THE BREAST CANCER

Neetu Sherawat1, Komal Kumari

2, Hitesh Kumar

2

1 NKBR College of Pharmacy Noida UP

2 School of Pharmacy and Chemical Science, Central University of Rajasthan, Bandarsindri

5

s






ABSTRACT: Delivery of chemotherapeutic drugs for the diagnosis and treatment of cancer is

becoming advanced day by day. However, the challenge of the effective delivery system still

does exist. In various types of cancers, breast cancer is the most commonly diagnosed cancer

among women. Breast cancer is a combination of different diseases. It cannot be considered as

only one entity because there are many specific patient factors, which are involved in the

development of this disease. Nanotechnology has opened a new area in the effective treatment of

breast cancer due to the several benefits offered by this technology.Polymeric nanocarriers are

among one of the effective delivery systems, which has given promising results in the treatment

of breast cancers. Nanocarriers does exert their anticancer effect either through active or passive

targeting mode.The use of nanocarriers has been resolute about the adverse effects of

chemotherapeutic drugs such as poor solubility and less penetrability in tumor cells.The present

review is focused on recent developments regarding polymeric nanocarriers, such as polymeric

micelles, polymeric nanoparticles, dendrimers, liposomes, nanoshells, fullerenes, carbon

nanotubes (CNT) and quantum dots, etc. for their recent advancements in breast cancer therapy.

KEYWORDS: Nano-carriers; breast cancer; dendrimers; liposomes; nanoshells; polymeric

nanoparticles.

FOP-2018-08

INTRANASAL DRUG DELIVERY: A NOVEL APPROACH FOR THE DELIVERY OF

NEUROTHERAPEUTICS

Gaurav Mishra1, Anand Maurya

1

1 NKBR College of Pharmacy Noida UP


ABSTRACT: The convoluted pathophysiology of brain disorders along with penetration issue

of drugs to brain represents major hurdle that requires some novel therapies. The blood-brain

barrier (BBB) denotes a rigid barrier for delivery of therapeutics in vivo; to overcome this

barrier, intranasal delivery is an excellent strategy to deliver

the drug directly to brain via olfactory and trigeminal nerve pathways that originate as olfactory

neuro-epithelium in the nasal cavity and terminate in brain. Kind of therapeutics like low

molecular weight drugs can be delivered to the CNS via this route. In this review, we have

outlined the anatomy and physiological aspect of nasal mucosa, certain hurdles, various

strategies including importance of muco-adhesive polymers to increase the drug delivery and

possible clinical prospects that partly contribute in intranasal drug delivery. Exhaustive literature

6





survey related to intranasal drug delivery system revealed the new strategy that circumvents the

BBB, based on non-invasive concept for treating various CNS disorders. Numerous advantages

like prompt effects, self-medication through wide-ranging devices, and the frequent as well

protracted dosing are associated with this novel route. Recently few reports have proven that

nasal to brain drug delivery system bypasses the BBB. This novel route is associated with

targeting efficiency and less exposure of therapeutic substances to non-target site. Nevertheless,

this route desires much more research into the safe transferring of therapeutics to the brain. Role

of muco-adhesive polymer and surface modification with specific ligands are area of interest of

researcher to explore more about this.

KEYWORDS: Blood-brain barrier; CNS; dosage form; intranasal delivery.

FOP-2018-09

FARMULATTION OF GLYCIN LINKED PLGA BASED POLYMERIC MICEELES

FOR INTRACELLULAR DELIVERY OF METHOTRXATE

Madhwi1,

1 School Of Pharmaceutical Sciences, Jaipur National University, Jaipur

e-mail: [email protected]

ABSTRACT: Methotrexate (MTX) is a widely used drug for the management of various kinds

of cancers. However, numerous challenges are associated with MTX like poor aqueous

solubility, dose-dependent side effects and poor-bioavailability. With an aim to explore the

potential benefits in drug delivery of MTX, it was intended to fabricate glycine-PLGA-based

polymeric micelles. Glycine was chemically linked to PLGA and the linkage was confirmed by

FT-IR, and NMR-Spectroscopy. The developed polymeric micelles offered substantial loading to

MTX with a pH-dependent drug release profile. The drug was released maximally at the cancer

cell pH vis-à-vis blood plasma pH. The cytotoxicity of drug against MDA-MB-231 cell lines was

enhanced by approx. 100% and the confocal laser scanning microscopy confirmed the

localization of dye-tagged nanocarriers in the interiors of cancer cells. The bioavailable fraction

of the drug was increased by approx. 4-folds, whereas elimination half-life was enhanced by

around two-folds in Wistar rats. The novel approach offers a biodegradable and promising carrier

for the better delivery of anticancer agents with immense promises of efficacy enhancement,

improved delivery and better pharmacokinetic profil

KEYWORDS: Bioavailability; Cytotoxicity; Drug delivery; Glycine

FOP-2018-10

DRUG DELIVERY THROUGH CHITOSAN-PAMAM DENDRIMERS TO IMPROVE

IN VIVO BRAIN PHARMACOKINETICS OF TEMOZOLOMIDE

Hitesh Kumar1

7





1 Faculty of Pharmacy, Kalinga University, Raipur, Chhattisgarh-492101, India

email: [email protected]

ABSTRACT: To establish a platform for the possibility of effective and safe delivery of

Temozolomide (TMZ) to brain via surface engineered (polyamidoamine) PAMAM dendrimer

for the treatment of glioblastoma. The present study aims to investigate the efficacy of PAMAM-

chitosan conjugate based TMZ nanoformulation (PCT) against gliomas in vitro as well as in

vivo. The prepared nanoconjugated formulation was characterized by 1H NMR, FT-IR

spectroscopy and for surface morphological parameters. The reported approach was also

designed in such a way to ensure toxicity before in vivo delivery through conducting the

hemolytic study.Surface morphology was found as per nanoformulation via size, pdi and zeta

potential measurement. PCT was more efficacious in terms of IC50 values compared to pure

TMZ against U-251 and T-98G glioma cell lines. The in vivo pharmacokinetic parameters

proved sustained release fashion such as half-life (t1/2) of 22.74 h (PCT) rather than15.35 h

(TMZ) only. Higher concentration was found in heart than brain in bio-distribution studies. This

study exhibits the potential applicability of dendrimer and CS in improving the anticancer

activity and delivery of TMZ to brain.The attractive ex vivo cytotoxicity against two glioma cell

lines; U-251 and T-98G and phase solubility studies of TMZ revealed remarkable results. In vivo

studies of prepared nanoformulation were significant and promising that explored the double

concentration of TMZ in brain due to surface functionality of dendrimer. The reported work is

novel and non- obvious as none of such approaches using chitosan anchored dendrimer for TMZ

delivery has been reported earlier

KEYWORDS: PAMAM; TMZ; bio-distribution; brain delivery; chitosan; solubility.

FOP-2018-11

NANO PHYTOSOMES AS ANTIOXIDANT: A REVIEW

Pooja Pandey1*, Tapas Panigrahi

1

1Royal College of Pharmacy, Raipur


ABSTRACT: Phytoconstituents such as flavanoids has potential for many therapeutic uses such

as treatment of skin disorder, different type of carcinoma, anti aging etc and other preventive

measures. Due to their poor absorption in gut, hydrophilic nature and complex chemical structure

they have limited effectiveness as well as poor bioavailability. These can be overcome by

PHYTOSOMETM technology. Phytosomes are lipophilic molecular complex resulting from

reaction of stoichiometric amount of phospholipids principally phophatidylcholine with

standardised non polar solvent extract. Phospatidylcholine is molecular building block of cell

membrane. They show excellent oral absorption. The transition of these little cells from

hydrophilic to lipophilic environment of enterocyte cell membrane takes place easily in turn

8





enhancing the bioavailability. They are prepared by solvent evaporation method and thin layer

hydration method.

Quericitin is a polyphenolic flavanoid. It can be used for cardiovascular protection by reducing

oxidative damage. Quericitin phytosome showed promising potential for fortification of food

product having water soluble antioxidant. It had lower particle size and higher encapsulation

efficiency percent (98%). Improvement in physical stability was observed on incorporation of

cholesterol. Improvement in bioavailability was observed.

The umbelliferone contains polyhydroxy group and shows antioxidant activity. Umbelliferone

phytsome showed better solubility in both water and oil phase. It had better permeation, better

anti oxidant as well as photo protective activity when compared to umbelliferone.

KEYWORDS: Phytosomes, quericitin, umbelliferon, flavanoids, phophatidylcholine.

FOP-2018-12

PULSATILE DRUG DELIVERY SYSTEM: AN OVERVIEW

Afreen Qureshi1*, Lukeshwari Sahu

1, Suraj Vishwas

1, Tapas Panigrahi

1

1Royal College of Pharmacy, Raipur


ABSTRACT: Pulsatile drug delivery systems (PDDS) are gaining importance in the field of

pharmaceutical technology as these systems deliver the right dose at specific time at a specific

site. It is gaining increasing attention as it offers a more sophisticated approach to the traditional

sustained drug delivery i.e. a constant amount of drug released per unit time or constant blood

levels. Pulsatile drug delivery systems are developed to deliver drug according to circadian

behavior of diseases. This means that these systems will deliver drug at time when disease

display it’s most morbid and mortal state within a circadian cycle (24 hrs.). Diseases wherein

pulsatile drug delivery systems are promising include asthma, peptic ulcer, cardiovascular

diseases, arthritis, attention deficit syndrome in children, and hypercholesterolemia. Various

capsular, osmotic, single and multiple unit systems that are modulated by soluble or erodible

polymer coatings, rupturable membranes are available in market. These systems are beneficial

for diseases showing chronopharmacological behavior where night time dosing is required or for

the drugs having high first pass effect or having site specific absorption in GIT, or for drugs with

high risk of toxicity or tolerance. These systems also improve patient compliance by decreasing

dosing frequency.

KEYWORDS: Pulsatile drug release, Time Controlling Systems, circadian cycle, patient

compliance.

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FOP-2018-13

REVIEW ON DIGITAL MEDICINE

Sunil Kumar Kashyap1

1 Centre for Research and Development, Kalinga University, Raipur, Chhattisgarh-492101, India


ABSTRACT: This paper presents an idea on digital medicine. The classical medicine interacts

with the classical diagnosis system. The proposed medicine lies with the mapping to body and

digit. The characteristic of human body classifies over the digital norms. The following formula

is proposed to develop such medicine:

The proposition and illustration are presented in this paper.

KEYWORDS: Digital, Medicine, Diagnosis, Mapping.

FOP-2018-14

OPPORTUNITIES IN CLINICAL RESEARCH

Krishna Kumar1, Seema Thakur

1



ABSTRACT: Over the last decade there has been a significant increase in the number of clinical

trials worldwide and this has opened up a range of new opportunities for those wishing to work

in the research industry. The research pharmacist can play a fundamental role in the way clinical

trials are conducted and contribute in different forms in the research process. Positions starting as

research coordinator to Director of clinical research are available based on knowledge and

experience. Hence, Pharmaceutical Education is the prime motive and should be well promoted.

10





This education even deals with the genomic technologies and challenges to have a better place in

future where world will have less disease and easy cure with upgraded technologies. Research

pharmacy is considered a nonprofit service center within the university. This means there is no

interaction with third-party payers or insurance companies. As project pharmacists expand their

role from dispensing study medication to providing cognitive input throughout the life cycle of a

clinical research project, opportunities are created for the pharmacist to be a co-investigator for

the research protocol.

The pharmacist is in turn regarded by the principal study investigator as an essential member of a

multidisciplinary research team. The pharmacist serves as the study medication expert. In terms

of grant applications, having a pharmacist as a co-investigator provides a more robust submission

to the various funding agencies. The increasing numbers of clinical trials also highlight that more

trained personnel will be required and that pharmaceutical companies and research centers will

need to appreciate the importance of this professional to a greater extent.

KEYWORDS: Clinical research, Clinical trials, Pharmacy.

FOP-2018-15

NANOTECHNOLOGY-BASED APPROACHES FORTHE EFFECTIVE TREATMENT

OF BACTERIAL

Varsha Rawat 1, Nagendra Bhuwane

1

1 University Institute of Pharmacy, Pt. Ravishankar Shukla University Raipur C.G


ABSTRACT: Bacterial keratitis is a condition that involves an infection of the cornea. This is

the clear dome that covers the iris and pupil of the eye, it is a serious ocular infection that can

most commonly caused by Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus

pneumoniae, or Serratia species. Depending on the invading organism, bacterial keratitis can

progress rapidly, leading to corneal destruction and potential blindness. Common risk factors for

bacterial keratitis include contact lens wear, ocular trauma, ocular surface disease, ocular

surgery, and lid deformity, chronic use of topical steroids, contaminated ocular medications and

systemic immunosuppression. The pathogenesis of bacterial keratitis, which depends on the

bacterium-host interaction and the virulence of the invading bacterium, topical nonsteroidal anti-

inflammatory drugs (NSAIDs), steroids, antibiotics and tissue transplantation are currently used

to treat corneal pathological conditions. However barrier properties of the ocular surface

necessitate high concentration of the drugs applied in the eye repeatedly. This often results in

poor efficacy and several side-effects. Nanoparticle-based molecular medicine seeks to

overcome these limitations by enhancing the permeability and pharmacological properties of the

drugs. Numerous polymeric, metallic and hybrid nanoparticles capable of transporting genes into

desired corneal cells to intercept pathologic pathways and processes leading to blindness have

been identified.Nanocarrier, such as nanoparticles, have the capacity to deliver ocular drugs to

11

11





specific target sites and hold promise to revolutionize the therapy of many anterior and posterior

segment eye diseases. Nanoparticle drugdeliverysystems can prolong medication residence time

on the corneal surface, enhancing the absorption and effectiveness of medications. Improving

drug-delivery can decrease the frequency of injections, lead to reduced side effects, and improve

patient compliance.

KEYWORDS: Keratitis, Neovascularization, Nanoparticles, Nanomedicine,Corneal

Destruction, Antibiotics.

.FOP-2018-16

PROBLEMS AND SUGGESTIONS OF INDUSTRIAL ESTATES IN CHHATTISGARH

Krishna Kumar1

1 Faculty of Pharmacy, Kalinga University, New Raipur, Chhattisgarh-492101, India


ABSTRACT: Industrialization does not automatically leads to rapid economic development.

One of the principal inhibiting factors with which the small industrialist has to contend with is

lack of suitable factory space with adequate facilities for water and power. Acquiring land,

constructing factory building and procuring other facilities like power and water not only takes a

great deal of time and energy but also locks up a substantial portion of the meager capital

available with the small entrepreneurs and industrialists. Four major challenges facing the

complex Pharma Industry are highlighted and discussed. These include the decline in the

discovery, approval and marketing of new chemical entities (NCE) with fewer and fewer

blockbuster drugs making it to the market, competition from generics drugs, regulatory pressures

and the weak growth in the US market.

Apex controlling institution life MCI, DCI, INC, Ayurvedic & Homeopathic Councils have

control over infrastructure, equipments and staff. They have no control over starting new

institutions and number of students. This is responsible for many problems at later stages and is

resulting in sub optimal institutions and lower standard of education. Like pharma companies,

AYUSH Industries too are affected. The survey result showed that scarcity of medicinal plants

was the biggest problem faced by the Ayurvedic industry in the state. Other problem like

capacity utilization, financial constrains, labor problems, marketing problems and problems due

to government policies are discussed too. It is concluded that the problems faced by the AYUSH

Industries manufacturing units in the state are diverse. In common, all the firms face. Similar

problems irrespective of their size, but the manner in which these problems affect each category

of firms is different.

KEYWORDS: AYUSH, Industries, New Chemical Entities.

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FOP-2018-17

DEVELOPMENT OF LIPOSOME’S BASED ON UREASE INHIBITOR FOR

EFFECTIVE TREATMENT OF H. pylori INFECTION

Mahendra Chouhan1

Rajesh Sharma1, Kamlesh Dashora

2

1 School of Pharmacy Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh, India

2 Institute of Pharmacy, Vikram University, Ujjain Madhya Pradesh, India

ABSTRACT: Helicobacter pylori (H. pylori) remain one of the most common worldwide human

infections and are associated with a number of important upper gastrointestinal (GI) conditions.

Urease inhibitors are extensively studied as a therapy for H. Pylori infection. In the given study

to overcome the limitations of the use of conventional liposomes chitosan coated mucoadhesive

drug delivery system were prepared, which is able to improve the bioavailability of poorly

absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating

the intimate contact of the delivery system with the absorption membrane. Liposome containing

model drug amoxicillin were prepared by the modified ethanol injection. Liposomes prepared by

the modified ethanol injection method were of satisfactory size with 1.62µm and the drug

entrapped was 82.99 %. So the given work recommends the better sustained method of the

prepared liposome.

KEYWORDS: H. pylori, Chitosan, Mucoadhesive , Liposomes.

FOP-2018-18

MAJOR ROLE OF NOVEL DRUG DELIVERY SYSTEM IN HERBAL MEDICINES

V. Kusum Devi1, Nimisha Jain

1, Archana Dewangan

1, Roshni Sharma

1

1 Rungta College of Pharmaceutical Science & Research, Kohka, Bhilai

ABSTRACT: Novel drug delivery system is a new approach to drug delivery that addresses the

limitations of the traditional drug delivery systems.Our country has a vast knowledge on the

basis of Ayurveda whose potential is only being realized in the recent years. However,the drug

delivery system used for administering the herbal medicine to the patient is traditional and out-

of-date,resulting in reduced efficacy of the drug. If the novel drug delivery technology is applied

in herbal medicine, it may help in increasing the efficacy and reducing the side effects of various

herbal compounds and herbs .The main aim behind incorporating novel method of drug delivery

in herbal medicines. Thus, it is important to integrate novel drug delivery system and Indian

Ayurvedic medicines to combat more serious diseases. However, modern phytopharmaceutical

research can solve the scientific needs such as determination of pharmacokinetics, mechanism of

action, site of action, accurate dose required of herbal medicines.

13





KEYWORDS: Herbal Medicine, Herbs, Novel Drug Delivery System And

Phytopharmaceuticals.

FOP-2018-19

PRESENTATION TITLE: PHARMACIST-CENTRIC MODEL (PCMaarav): CONCEPT

TO MAKE PATIENT THINKS PHARMACIST AS A CONSULTANT/COUNSELOR

Ravi Kishor Agrawal1

1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur

ABSTRACT: The purpose of this project was to redefine the current physician-patient

relationship by incorporating pharmacists’ role and to look into the challenges to implement the

Pharmacist Centric Model (PCMaarav). Principally PCMaarav model is different from

traditional model as it is based on value, not necessarily volume. Through aarav (Affordable,

Accessible, Reliable, Affable, Valuable), Registered pharmacist is

responsible for providing affordable pharmaceutical services which is accessible and reliable for

every individual who are looking for affable and valuable service and it will address the current

need of developing the image of pharmacists in the society as consultant/counselor. The problem

with the current system of dispensing a medicine or educating the patients can be addressed by

PCMaarav model. The model is different from the Physician-centered care; Patient-centered

care; and Patient-centric care as this is focused on Medication-Oriented (5C); Privacy-Oriented

(5P) Patient-Oriented (5A); Business-Oriented (5D). The model has challenges also such as

additional time and effort is required by pharmacists on the part of his practices and proper

coordination with the physicians. So, to maintain the quality outcome Prescription-In:Medicine-

Out (PIMOcheck) Check Method would be helpful to have a value based result.

KEYWORDS: PCMaarav, Business-Oriented, Patient-centric care, PIMOcheck, aarav.

FOP-2018-20

PHARMACY CARE CALL PRACTICE AND EMBRACE PROVIDER’S ROLE

Vikram Vikas Nigam1

1 Director, Creatrix Health Private Limited

ABSTRACT: Pharmacy care is an evolutionary and revolutionary way of practicing pharmacy.

It requires complete rethinking about how Pharmacists in India have traditionally worked so far.

Despite some Pharmacists confusing with pharmacy care with patient counseling and/or disease

state management, pharmacy care is far more complex and occurs many more challenges and

opportunities. It requires that pharmacists take responsibility for preventing and solving drug

14





related problems and optimizing drug therapy. It does not end when the patient leaves the

pharmacy. Assessing (patients understanding of illness and treatment plan), monitoring,

documenting care and progress and follow-up care are integral part of providing pharmacy care.

It is our job to create this demand for pharmacy care and for the mission of pharmacy. We are a

profession in search of a savior. We are waiting for someone else to ‘sell’ our mission. Yet,

experience tells us that no one would really care about pharmacy except pharmacists. Therefore,

it is up to every pharmacist to market pharmacy care. Notwithstanding our optimism, it is hard to

see how pharmacy and its practitioners will survive if they do not embrace the changes we are

facing. Merely selling drugs will not keep pharmacists afloat. Are we behaving morally and

ethically as a profession? When patients do not receive important information about their

medicine or when their understanding of the illness and treatment is not assessed, we are putting

people at risk. Equally, if not more importantly, do we realize that we are jeopardizing the

relevance of our profession to the society.

When we practice pharmacy, are we able to answer patient’s questions? If the answer is no, then

we are really getting to the root of the problem. Why don’t we know these things? Pharmacy

Practice Guidelines aim to set standards for practice of pharmacy as a profession in India. It is

also an affirmative statement conveying that we ourselves control our profession’s standards, not

anyone else.

KEYWORDS: Pharmacists, Pharmacy Practice.

FOP-2018-21

MEDICINAL PLANT OF INDIA: CURRENT STATUS AND FUTURE STRATEGIES

Abhishek Kumar Pandey1, Sapna Sahu

1, Munmun Majumdar

1

1 Assistant Professor, Department of Botany Kalinga University New Raipur, Chhattisgarh-

492101, India

email- [email protected]

ABSTRACT: India has an over 3000 year old medicinal heritage whose main resource base is

medicinal plants. The vast and diverse agro climatic condition of India provides congenial

environmental condition for growing wide variety of plant species in diverse natural habitats.

Medicinal plants are being used in Indian subcontinent since ancient time. The WHO estimated

that about 80% of people of developing countries still rely on traditional plant and animals for

their primary healthcare. India has one of the oldest indigenous systems of traditional medicine

in the world. The indigenous system of medicine in India flow mainly two streams, viz. 1)

Documented and well codified system (i.e., Ayurveda, Siddha, Unani, Amchi, and Homeopathy)

and 2 orally transmitted system (i.e., Ethno medicines/ folk medicines). In India , medicinal plant

are widely used by all section of the population and it has been estimated that, over 8000 species

of plants are being used by several ethnic and folk communities for the treatment of human as

well as animal diseases. Medicinal plants play a vital role for the development of new drugs.

15





There are 121 modern medicines are derived from ethno botanical sources. The use of herbal

medicines becoming popular day by day due to toxicity and side effect of allopathic medicines .

Medicinal plants play a central role not only as traditional medicine but also as trade

communities meeting the demand of distant markets the commercial demand for the botanical

raw drugs has put the medicinal plant resources under great stress. Where as many of the wild

medicinal plants species are facing serious threat of extinction. India has a very small share

(1.6%) of this ever growing global market. To complete with the growing global market there is

urgency to expeditiously utilize and scientifically validate more medicinally useful plants. The

medicinal plants have been the object of research in both classical and advanced areas of

sciences. The first decades of 21st century has witnessed the use of modern methods of

propagation analysis , manipulation , pharmacological testing and metabolic engineering for

herbal products in general and therapeutically active compound in particular. Since the

engineering of the 20th century, more than half of the India's forest area has been destroyed. It is

estimate that only 700 plants in the country have systematically investigated for their

pharmacological activity. Many of them are threatened in the natural habitats. A strong strategy

in terms of conservation through biotechnological and legal matters has to be developed. Several

research institutes and universities have established herbaria and medicinal plant garden and

developed packages for cultivation of economically important medicinal plants with modern

techniques including tissue culture, and genetic engineering. To address the need for

conservation of native medicinal plant species of India, the country needs to establish a network

of forest sites across the biographic region of the country. However, a network of in situ (field)

gene banks, in the forest habitats is the most cost- effective way to manage the intra- and inter

specific diversity. Various institutes under central and stated government and NGOs are working

on useful species for the conservation of germplasm. The work carried out by the author in this

regard will be presented during conference.

KEYWORDS: Medicinal Plant, Herbal drugs, Conservation and Cultivation.

FOP-2018-22

THE INDIGENOUS PLANTS OF CHHATTISGARH AS SUSTAINABLE

ETHNOBOTNICAL RESOURCES FOR THE MANAGEMENT OF DERMAL DISEASE

Krishna Yadav1, Deependra Singh

1, Manju Rawat Singh

1

1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (CG), India


ABSTRACT: Cassia tora or Senna tora are indigenous in tropic areas of Chhattisgarh. It chiefly

develops as a weed on street sides and waste ground in the dry locales and is normally known as

Panwarh, Chakunda, Chakramard, Reli, Elwan, Edagaja, Dadrughna, Sickle senna, Sickle unit,

Tora, Tovara, chakvad, Thakara, rank cassia or Ringworm plant. Cassia tora is an essential

therapeutic plant of Ayurveda. It is known as Chakramarda and Dadrughna due will be because

of its helpful adequacy to treat ringworm. Seeds are laxative, tonic and febrifuge. The seeds are

having great diuretic whereas decoction of the powdered seeds has a gentle laxative.

16





Chakramarda has nutritive values and also working as poison remover. It is demonstrated in skin

ailments and respiratory hypersensitivity. The leaves of plant are utilized as a part of the

treatment of Malaria, ring worm, ceaseless irritation of the skin and other skin diseases. Home

grown concentrate is utilized to plan restorative arrangements to treat distinctive skin issue,

enlarging magnificence. Home grown concentrates give a plan to grow new home grown

detailing for hyperpigmentation. Topical creams are utilized to improve the dissolvability and

bioavailability of remedial medications. The plant Cassia tora L. is assured to be useful in the

management of Psoriasis and other skin ailments. Cassia tora L. leaves improved in glycosides

and furthermore containing aloe-emodin might be gainful for the skin illnesses. Be that as it may,

there are no settled logical reports for its antipsoriatic action. Henceforth, the plant Cassia tora L.

has been set up logical information for its conventional claim as antipsoriatic.

KEYWORDS: Senna tora, Chhattisgarh, Antipsoriatic, Skin.

FOP-2018-23

ANTI-INFLAMMATORY ACTIVITY OF CURCUMA LONGA IN RATS

Parwati Chouhan1

1 School of Pharmacy Chouksey Engineering College, Bilaspur Chhattisgarh, India


ABSTRACT: Present research with the anti-inflammatory activity of ethnomedically

important herbal plants. Infammation plays an important role in various diseases with high

prevalence within populations such as rheumatoid arthritis, atherosclerosis and asthma. Aqueous,

ethanolic and methanolic extracts of curcuma longa were investigated for anti-inflammatory

activity in carrageenan induced paw edema in wistar male rats. Mature albino rats were taken for

this purpose. curcuma significantly suppressed the incidence and severity of arthritis by

increasing/decreasing the production of anti-inflammatory/pro-inflammatory cytokines,

respectively, and activating the anti-oxidant defence system. The herbal plants used in my work

because active components from individual plants can be isolated with potent bioactivity and

formulations consisting of these formulations with crude extracts.

KEYWORDS: Inflammation,carrageenan,Pawedema.

FOP-2018-24

SYNTHESIS AND IN-VITRO EVALUATION OF BIODEGRADABLE

GALACTOSYLATED GELATIN NANOPARTICLES FOR THE HEPATOCYTE

DELIVERY OF PRIMAQUINE

Hitesh Kumar1, Anand Mahalwar

1, Avinash Giothwal

2


17





2 School of Pharmacy and Chemical Science, Central University of Rajasthan, Bandarsindri


ABSTRACT: Biodegradable polymeric nanoparticles have most increasing interest for drug

delivery applications. Polymeric nanoparticles (NPs) have unique features such as nano size,

higher entrapment efficiency, mono-dispersity and targeting potential etc. Due to these unique

properties, these are widely used as effective carriers for drug delivery and targeting.

Biodegradable gelatin protein has been used as nanocarriers for the targeted and effective

delivery of drug Primaquine Phosphate (PP). Gelatin was conjugated with the galactose moiety

intended for the improvement of pharmacological properties and liver targeting of incorporated

drug. We have synthesized and characterized Galactosylated Gelatin co-polymer (Gel-LA) and

further drug loaded co-polymeric nanoparticles (Gel-LA-PP-NPs) were formulated using one

step desolvation technique. The prepared formulations were well characterized in terms of

particle size, zeta potential, polydispersity index (PDI), percent drug entrapment, in vitro drug

release, hemolytic toxicity and electron microscopy etc. The mean particle size of final

formulation (NPs) were found less than 100 nm with a zeta potential of 4.80±0.20 mV and

higher entrapment efficiency then Non-galactosylated gelatin NPs (Gel-PP-NPs) as 69.90±1.53

%. Electron microscopy results demonstrated that the prepared NPs were spherical in shape and

uniformly distributed. The in vitro drug release study revealed that the drug release from

galactosylated co-polymer in a sustained and controlled release pattern more than 24 hours as

compared to naïve drug. The prepared nanoparticles (Gel-LA-PP-NPs) were significantly

(p<0.0001) less hemolytic than the naïve drug. Conclusively, the prepared galactosylated gelatin

nanocarrier hold the promising biocompatibility and targeting.

KEYWORDS: Gelatin, Nanoparticals, Biodegradable , Malaria

FOP-2018-25

EXTRAXTION, FORMULATION AND ESTIMATION OF HERBAL COSMETIC

PREPARATION Diksha Sahu

1, Anand Agrawal

1

1 Faculty of Pharmacy, Kalinga University, New Raipur,

Chhattisgarh-492101, India


ABSTRACT : In the present study we have to formulate the cream by using the various

concentration of Safed Musli extract, along with the other ingredients like stearic acid, cetyl

alcohol, mineral oil, triethanol amine, glycerin, Safed Musli, perfume, preservative, and distilled

water, to choose out the best concentration ratio for the creams which will give the better anti-

ageing result we have selected the ratio of 7: 2: 20: 2:10: 3.5: 1 0.5 .this single formulation

18





(cream) is used as anti-ageing .

KEYWORD: Safed musli, Cream, Anti-ageing, Herbal cosmetics.

FOP-2018-26

NANO TECHNOLOGY IN DIAGNOSIS OF TUBERCULOSIS

Sangalap Mallick1, Ashu Keshwani

1, Hemlata Dewangan

1

1 Faculty of Pharmacy, Kalinga University, New Raipur,

Chhattisgarh-492101, India


ABSTRACT: Tuberculosis (TB) remains one of the most devastating infectious diseases and its

eradication is still unattainable given the limitations of current technologies for diagnosis,

treatment and prevention. The World Health Organization's goal to eliminate TB globally by

2050 remains an ongoing challenge as delayed diagnosis and misdiagnosis of TB continue to

fuel the worldwide epidemic. Despite considerable improvements in diagnostics for the last few

decades, a simple and effective point-of-care TB diagnostic test is yet not available. The

mainstay for TB diagnostics in endemic developing countries is sputum smear microscopy.

However, the sensitivity of this technology is low as it can only detect roughly half of all active

cases of tuberculosis when properly used in people with co-infections and in children the

sensitivity is even lower. New diagnostic tools for drug resistant TB are urgently needed for

reducing diagnostic time from months to days. Nanotechnology has triggered the development

of new and cheaper approaches for biomolecular recognition that may circumvent the current

limitations of conventional molecular diagnostic methods used in the global fight against TB.

The new era of molecular nanodiagnostics may provide a rapid and sensitive detection of the

main TB etiologic agent in humans, i.e. Mycobacterium tuberculosis. Different nanodiagnostics

systems have been developed for the molecular diagnostics of TB. Despite the wide range of

nanoscale systems being used for biomolecular assays in general (e.g. electromechanical,

electrochemical), nanoparticle based systems, such as gold, silver, silica and quantum dots

(QDs), have been the most widely used for TB diagnostics due to their unique physicochemical

properties, that offer greater sensitivity than conventional reporter molecules and can be easily

tuned and functionalized by simple chemistry modulation and derivatization. Nanoparticle-

based systems have significant prospective for diagnosis, treatment and prevention of TB.

KEYWORD: Tuberculosis, Nanotechnology, Biomolecular.

19





FOP-2018-27

A REVIEW: COUGH & TREATMENTS

Gajendra Singh1,

1 School School of chemical Science and Pharmacy, Central University of Rajasthan,

Bandarsindri


ABSTRACT: Tuberculosis (TB) remains one of the most devastating infectious diseases and its

eradication is still unattainable given the limitations of current technologies for diagnosis,

treatment and prevention. The World Health Organization's goal to eliminate TB globally by

2050 remains an ongoing challenge as delayed diagnosis and misdiagnosis of TB continue to

fuel the worldwide epidemic. Despite considerable improvements in diagnostics for the last few

decades, a simple and effective point-of-care TB diagnostic test is yet not available. The

mainstay for TB diagnostics in endemic developing countries is sputum smear microscopy.

However, the sensitivity of this technology is low as it can only detect roughly half of all active

cases of tuberculosis when properly used in people with co-infections and in children the

sensitivity is even lower. New diagnostic tools for drug resistant TB are urgently needed for

reducing diagnostic time from months to days. Nanotechnology has triggered the development

of new and cheaper approaches for biomolecular recognition that may circumvent the current

limitations of conventional molecular diagnostic methods used in the global fight against TB.

The new era of molecular nanodiagnostics may provide a rapid and sensitive detection of the

main TB etiologic agent in humans, i.e. Mycobacterium tuberculosis. Different nanodiagnostics

systems have been developed for the molecular diagnostics of TB. Despite the wide range of

nanoscale systems being used for biomolecular assays in general (e.g. electromechanical,

electrochemical), nanoparticle based systems, such as gold, silver, silica and quantum dots

(QDs), have been the most widely used for TB diagnostics due to their unique physicochemical

properties, that offer greater sensitivity than conventional reporter molecules and can be easily

tuned and functionalized by simple chemistry modulation and derivatization. Nanoparticle-

based systems have significant prospective for diagnosis, treatment and prevention of TB.

KEYWORD: Tuberculosis, Nanotechnology, Biomolecular.

FOP-2018-28

EVALUATION OF ANTIULCER ACTIVITY OF CLITORIA TERNATEA LEAVES

Aditya Giri1

1 School School of chemical Science and Pharmacy, Central University of Rajasthan, Bandar

Sindri

20






ABSTRACT: The effect of alcoholic leaf extract of clitoria ternatea was studied in pyrolic

ligated ulceration model in rats. Phyotochemical result showed the presence of alkaloids,

flavones, triterpenes, lactones, and steroids. A dose of about 300 mg/kg was selected for this

model. The parameters investigated were the ulcer index, volume of gastric content, total acidity

and free acidity. In pyrolus ligated control animals, large ulcers with perforation and streaks were

observed in various parts of mucosa of rat. The ulcer index of control pyrolus ligated animals

was about (3.71±0.00) and after administration of leaf extracts a significant reduction in ulcer

index (1.6±0.012) was observed. Only hemorrhagic lesions were observed in treated group either

reduction in ulcer and perforations. Volume of gastric content in control animal was about

(4.80±0.008) ml. Leaf extract treated animals showed a significant reduction in volume of gastric

content (2.92±0.16) ml. A significant reduction was observed in both total acidity and free

acidity in leaf extract treated animals when compared to controlled group animals.

KEYWORD: Clitoria ternatea, Alcoholic leaf extract, Pyrolus ligated, Hemorrhagic lesions.

FOP-2018-29

A REVIEW: BIODIVERSITY OF INDIA FOR GLOBAL PROMOTION OF HERBAL

MEDICINE

Anand Maurya1

1 NKBR Collegeg of Pharmacy, Noida UP


ABSTRACT: There is great demand for herbal medicine in the developed as well as developing

countries, because of their wide biological activities, higher margin of safety than the synthetic

drugs and lesser costs. India is sitting on gold mine of well recorded and traditionally well

practiced knowledge of herbal medicine. Traditional home remedies have been reported as

treasure trove of a rich biodiversity of plant species including medicinal plants used for

traditional home remedies of various ailments. Given the increased use of traditional medicines,

possibilities that would ensure its successful integration into a public health framework should be

explored. This review discusses some of the links between biodiversity and traditional medicine,

and addresses their implications to public health. We explore the importance of biodiversity and

ecosystem services to global and human health, the risks which human impacts on ecosystems

and biodiversity present to human health and welfare.

KEYWORD: Herbal Medicine, Home Remedies, Biochemical Impact, Traditional Medicine,

Biodiversity.

21





FOP-2018-30

APPLICATIONS OF BIODEGRADABLE PHARMACEUTICAL PACKAGING

MATERIALS: A REVIEW

Anupma Singh1

1 School of chemical Science and Pharmacy, Central University of Rajasthan, Bandar Sindri


ABSTRACT: Exploitation of plastic packaging films at large scale lead to ecological trouble

because of their non-biodegradability. Utilization of plastics as packaging material has to be

controlled to protect environment. Asupporting pollution free environment can be created by use

of eco-friendly packaging. Consequently, the ideaof biodegradability has the benefits of both

user-friendly and eco-friendly features. Eco-friendly packagingmaterials are safe to enclose

pharmaceutical products as they are non-toxic. There are various packagingmaterials to pack

different dosage forms. Starches are widely used as eco-friendly packaging material, as it is from

natural resources. They cause no harm to the environment and living species. In this review

article,functions and selection factors of packaging eco-friendly materials are overviewed and

also their future needis also highlighted.

KEYWORD: Packaging Material, Eco-Friendly, Biodegradable.

FOP-2018-31

RECENT NANOTECHNOLOGY APPROACHES FOR PREVENTION AND

TREATMENT OF BIOFILM-ASSOCIATED OCULAR INFECTIONS

Nagendra Bhuwane1*

, Preeti K Suresh1

1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur C.G.


ABSTRACT: Bacteria are the major contributor of ocular infections worldwide. Ocular

infections, if left untreated, can damage the structures of the eye with possible Bacteria are

generally associated with many types of ocular infections such as conjunctivitis, keratitis,

endophthalmitis, blepharitis, orbital cellulitis and dacryocystitis manifestations.A biofilm is a

functional consortium of microorganisms organised within an extensive exopolymer matrix.

Organisms within a biofilm are difficult to eradicate by conventional antimicrobial therapy and

can cause indolent infections.Formation of biofilms is also implicated in delayed post-operative

endophthalmitis and crystalline keratopathy. Bacteria within biofilms are 20-1000 times less

sensitive to antibiotic than free-living planktonic organisms.These may have clinical

applications, as potential adjunctive therapies to antibiotic treatment, for these resistant

22





infections. Novel strategies are needed to deal with these. Biofilm-encased bacteria are relatively

resistant to antibiotics and biocides.Developing new strategies to prevent their formation or to

eradicate them at the site of infection, has become a priority.Surface engineered nanoparticles

representa novel, unconventional approach for disruption of biofilms and targeting of bacterial

pathogens. Herein, we describe the role of surface charge of gold nanoparticles, silver

nanoparticle, zinc oxide nanoparticle, copper nanoparticle etc. on biofilm disruption and

bactericidal activity. Application of biocompatible nanomicrobials, particularlyliposomal-

associated nanomicrobials, presents a promising approach for improved drug delivery to

bacterial cells and biofilms.Drug delivery by lipid or polymer nanoparticles is also considered a

promising strategy for overcoming biofilm resistance. These particles are able to improve the

delivery of antibiotics to the bacterial cells, thereby increasing the efficacy of the treatment.Lipid

and polymer nanoparticles were found to increase the antimicrobial efficacy in many cases.

KEYWORD: Ocular infections, Bacterial Biofilm,Metal Nanoparticles, Liposome, Antibiotics.

FOP-2018-33

INDIGENOUS HERBAL MEDICINE USED FOR TREATMENT OF

GYNECOLOGICAL PROBLEMS BY TRIBAL OF CHHATTISGARH STATE

Bhupendra Kumar1*

, Tapas Panigrahi 1

1 Royal college of pharmacy, Raipur (C G)


ABSTRACT: The indigenous herbal plants used by the tribes of various region of Chhattisgarh

state. The tribal depend on the herbal medicine for treatment of various gynecological problems.

Tribal do not approach to physicians due to lack of awareness and hesitation .the successful use

of herbal drugs like milk secretion, menstrual problems, leucorrhea ,infertility and sex problems

in male female. Herbal drugs and their patient who receive the treatment for any gynecological

complication enquired to local name, parts used and methods of administration. The binomial

names enumerated with utilization of these plant. Which are helpful for researchers to

development new herbal formulation to scientifically treatment for gynecological problems.

KEYWORD: Gynecology, Leucorrhea, Infertility.

23





Author Index





A

Abhishek Kumar Pandey-15

Aditya Giri- 20

Afreen Qureshi- 9

Amzad Ali Ansari- 2

Anand Maurya- 6, 21

Anand Agrawal- 17

Anand Mahalwar-17

Anupma Singh- 21

Archana Dewangan-13

Ashu Keshwani- 19

Avinash Gothwal- 19

B

Bhupendra Kumar- 23

D

Deependra Singh- 16

Diksha Sahu- 18

G

Gajendra Singh-19

Gaurav Mishra- 6

H

Hemlata Dewangan- 19

Hitesh Kumar- 5, 7, 17

K

Kamlesh Dashora-13

Kavita- 2

Komal Kuamri- 5

Krishna Kumar- 10, 12

Krishna Yadav- 16

L

Lukeshwari Sahu- 9

M

Madhwi-7

Mahendra Chouhan- 13

Manju Rawat Singh-16

Munmun Majumdar- 15

N

Nagendra Bhuwane- 11, 22

Neetu Sherawat- 5

Nimisha Jain- 13

P

Pankaj Kumar- 2

Parwati Chouhan- 17

Pooja Pandey- 8

Pravin Kumar Sahu- 4

Preeti K Suresh- 22

R

Rajesh Sharma-13

Rakesh- 1

Ravi Kishor Agrawal- 14

Roshni Sharma- 13

Ruchita Jaiswani- 3

S

S.M. Parhate- 2

Sangalap Mallick- 19

Sapna Sahu- 15

Seema Thakur- 10

SK Lanjhiyana- 5

Sunil Kumar Kashyap- 10

Suraj Vishwas- 9

Sweety Lanjhiyana- 6

T

T. R. Singh -2

Tapas Panigrahi- 8, 9, 23

U

Utpal Jana- 4

V

V. Kusum Devi- 13

Varsha Rawat- 11

Vikram Vikas Nigam- 14

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