carboni, … dichiara et al. j neurosci 20:rc102(1-5), 2000 what do we know about addictive drugs...
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Carboni, … DiChiara et al. J Neurosci 20:RC102(1-5), 2000
What do we know about addictive drugs from animal studies?
“… cocaine, morphine, nicotine, and ethanol share the property of increasing DA transmission in the BNST. This effect may be related to an action at the level of neuronal circuits activated by natural reinforcers … suggest[ing] that DA transmission of the BNST plays a role in the mechanism of drug abuse and addiction.”
aaarrrggghhhh!!!!! – show me BP
what phenomenon is this?
No CS
CS
CS
unexpectedreward
predictedreward
absence of predicted reward
from
: S
chul
tz,
Day
an,
& M
onta
gue,
199
7,
Sci
ence
.
does everyone understand what they are showing here?
40 50-12 -2
de-nic cig nic cig
mu
mu D2
Brody Barrett Scott
tracer 11C-raclopride 11C-raclopride 11C-raclopride (and carfentanil)
injection protocol Bolus + infusion Bolus (x2) bolus + infusion
tracer dose ? 10 mCi 10-15 mCi
Kbol (ml/[ml/min]) 100 min infinite 90? (half and half in 90 min study)
scanner (resolution) ECAT 953 (5.6 mm FWHM) HR+ (4.2 mm FWHM) HR+ (5.5 mm?)
design inter-subject (1 scan) intra-subject (s scan) intra-subject (1 scan – 2 different cigs)
phenomenon to test smoking smoking nicotine (only)
subjects 10 smokers 20 smokers(control, smoking)
6 smokers (m)
smoking characteristics >15 cigs/day >18 cigs/day 16.7
time from last cig 2 hrs (in w/d from caffeine, alcohol))
12 hrs overnight
protocol smoke 1 cigarette OUTSIDE scanner
smoke 3-6 cigarettes INSIDE scanner
in scanner nic--- and denic (control) cigs
timing smoke-break @ t=50min – 60 min
smoke every 12 min start@ -15 mn
-12-8 (denic) and 40-60 (nic)
self-admin yes forced smoking(some aversion)
yes
cigarette type high/low nic own brand high nic / low nic (research)
finding in Ventr Str BP corr w/ craving (reduction? all +)
none yes “ventr basal ganglia”corr with dependence score
finding in Dorsal Str none? BP related to pleasure (+,-) no
Brody Barrett Scott
limitations •movement•low n•low resolution scanner
•forced smoking•aversion to cigs•low n
forced smoking? not regular brandvery low n.
model srtm ? srtm Logan plot (use Logan slope from 5-40 and 45-90)
other calculations correlation images
questions reward-prediction error?some foiund cigs aversive – DA went down – tha towuld hurt the differece
reward-prediction error?got de-nic cig first, if DA went down that would help the difference
order effects? yes no yes
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