CancerResearchVOLUME 47 •NUMBER 22 •CNREA8 •PP 5809-6164

CONTENTSf

Asterisks * preceding page numbers refer to studies using human-derived material.

5809 Editorial. Peter N. Magee.

Special Lecture

5810 The Chemotherapy of Lymphomas: Looking Back, Moving Forward—The Richard and Hinda Rosenthal Foundation Award Lecture. Vincet T. DeVita, Jr., Susan Molloy Hubbard, and Dan L.Longo.

BASIC SCIENCES

5825 Plasma Protein Synthesis in Experimental Cancer Compared toParaneoplastic Conditions, Including Monokine Administration.Marie Ternell, Lyle L. Moldawer, Christina Lonnroth, JohanGelin, and Kent G. Lundholm.

5831 Retinole Acid-induced Rapid Loss of Nuclear Cyclic AMP-de-pendent Protein Kinase in Teratocarcinoma Cells. Ariane Plet,Daniele Evain-Brion, Pascale Gerbaud, and Wayne B. Anderson.

5835 Peroxidase-catalyzed Metabolism of Etoposide (VP-16-213) andCovalent Binding of Reactive Intermediates to Cellular Macro-molecules. Nissim Haim, Josef Nemec, John Roman, andBirandra K. Sinha.

5841 A Unique Tumor Rejection Antigen from the S91 Murine Malignant Melanoma. Lloyd W. Law, Wilfred D. Vieira, KoichiroKameyama, and Vincent J. Hearing.

5846 Antitumor Activity and Pharmacokinetics in Mice of 8-Carba-moyl-3-methylimidazo|5,l-</)-!,2,3,5-tetrazin-4(3//)-one(CCRG 81045; M & B 39831), a Novel Drug with Potential as anAlternative to Dacarbazine. Malcolm F. G. Stevens, John A.Hickman, Simon P. Langdon, David Chubb, Lisa Vickers, RobertStone, Ghousia Baig, Colin Goddard, Neil W. Gibson, John A.Slack, Christopher Newton, Edward Lunt, Christian Fizames, andFrancois Lavelle.

* 5853 Serum Levels and Biochemical Characteristics of Cancer-associated Antigen CA-549, a Circulating Breast Cancer Marker. KunisR. Bray, Joy E. (Coda, and Pramod K. Gaur.

* 5861 Comparison of Human and Rat Hepatocyte Metabolism and Mu-tagenic Activation of 2-AcetyIaminofluorene. Kenneth Rudo,William C. Meyers, Walter Dauterman, and Robert Langenbach.

••'5ShSEffect of Recombinant Tumor Necrosis Factor on Tumoricidal

Activation of Murine Macrophages: Synergism between TumorNecrosis Factor and 7-Interferon. Kazuyoshi 1Inn. M. Jane Ehrke,Kenneth Mace, and Enrico Mihich.

*5875 Chemosensitivity Testing of Human Colorectal Carcinoma CellLines Using a Tetrazolium-based Colorimetrie Assay. Jae-GahbPark, Barnett S. Kramer, Seth M. Steinberg, James Carmichael,Jerry M. Collins, John D. Minna, and Adi F. Gazdar.

5880 Use of Insulation to Reduce Extremity Temperature Nonuniform-ity during Whole Body Hyperthermia in Dogs. Donald E. Thrall,Rodney L. Page, and Deborah A. McLeod.

* 5883 Estrogen Conjugates and Serum Factors Mediating the EstrogenicTrophic Effect on MCF-7 Cell Growth. N. Devleeschouwer, N.Legros, N. Olea-Serrano, R. Paridaens, and G. Leclercq.

t The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS.

''"'5888 Altered Glucocorticoid Binding and Action in Response to Epider

mal Growth Factor in HBL100 Cells. Kanury V. S. Rao, RobertE. Williams, and C. Fred Fox.

5894 Relationship between Modulation of Natural Killer Cell Activityand Antitumor Activity of Bropirimine When Used in Combinationwith Various Types of Chemotherapeutic Drugs. Li H. Li, ThomasF. DeKoning, and Tanya L. Wallace.

5901 Chemoprevention of Colon Carcinogenesis by Dietary Organose-lenium, Benzylselenocyanate, in F344 Rats. Bandai u S. Reddy, S.Sugie, Hiroshi Maruyama, Karam El-Bayoumy, and PatriceMarra.

5905 Influence of D-Glucose upon the Respiratory and Secretory Response of Insulin-producing Tumor Cells to 2-AminobicycIo-(2,2,1)heptane-2-carboxylic Acid. A. Sener, M-H. Giroix, C.Hellerström,and W. J. Malaisse.

5908 Production of Recombinant Rat Viruses as a Method of OncogeneIsolation in Coculture Medium. Shun-ichi Kurata, Nori Kurata,and Yoji Ikawa.

* 5913 Collateral Methotrexate Resistance in Cultured Human Head andNeck Carcinoma Cells Selected for Resistance to cis-Diammine-dichloroplatinum(II). Andre Rosowsky, Joel E. Wright, Carol A.Cucchi, Jennifer L. Flatow, Dorothy H. Trites, Beverly A. Teicher,and Emil Frei III.

5919 Production of Lipolytic and Proteolytic Factors by a MurineTumor-producing Cachexia in the Host. Susan A. Beck andMichael J. Tisdale.

5924 New Coupling Agents for the Synthesis of Immunotoxins Containing a Hindered Disulfide Bond with Improved Stability in Vivo.Philip E. Thorpe, Philip M. Wallace, Phillip P. Knowles, MicheleG. Reif, Alex N. F. Brown, Graham J. Watson, Regina E. Knyba,Edward J. Wawrzynczak, and David C. Blakey.

5932 Intrathecal Administration of 4-Hydroperoxycyclophosphamide inRhesus Monkeys. Carola A. S. Arndt, O. Michael Colvin, FrankM. Balis, Cynthia M. Lester, Gloria Johnson, and David G.Poplack.

* 5935 Effects of 3'-<3-Cyano-4-morpholinyl)-3'-deaminoadriamycin and

Structural Analogues on DNA in HT-29 Human Colon CarcinomaCells. Michael I. Jesson, James B. Johnston, Cynthia D. Anhalt,and Asher Begleiter.

5939 Effects of Chronic Dietary Ethanol on in Vivo and in VitroMetabolism of Methylazoxymethanol and on Methylazoxymeth-anol-induced DNA Methylation in Rat Colon and Liver. EmerichS. Fiala, Ock Soon Sohn, and Stanley R. Hamilton.

5944 Antitumor Activity of 7-Ethyl-10-|4-(l-piperidino)-l-piperidino|-carbonyloxycamptothecin, a Novel Water-soluble Derivative ofCamptothecin, against Murine Tumors. Takehiko Kunimoto,Kazuo Nitta, Tomiko Tanaka, Nobuaki Uehara, Hiroyasu Baba,Mieko Takeuchi, Temo Yokokura, Siego Sawada, TadashiMiyasaka, and Masahiko Mutai.

This One

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5948 Regulation of .V-Nitrosodimetbylamine Demethylase in Rat Liverand Kidney. Jun-yan Hong, Jinmei Pan, Zigang Dong, Shu M.Ning, and Chung S. Yang.

•''5954 Antibody-directed Targeting of Liposomes to Human Cell Lines:

Role of Binding and Internalization on Growth Inhibition. NeilBerinstein, Katherine K. Matthay, Demetrios Papahadjopoulos,Ronald Levy, and Branimir I. Sikic.

5960 Effect of Cycloheximide or Puromycin on Induction of Thermo-toléranceby Heat in Chinese Hamster Ovary Cells: Dose Frac-tionation at 45.5°C.Yong J. Lee and William C. Dewey.

5967 Effects of Intermittent Diethylstilbestrol Diphosphate Administration on the R3327 Rat Prostatic Carcinoma. Paul Russo,Gregory Liguori, Warren D. W. Heston, Robert Huryk, Chi-ReiYang, William R. Fair, Willet F. Whitmore, and Harry W. Herr.

••:5'»7lInhibition of Mammalian DNA Polymerases by Recombinanta-Interferon and 7-Interferon. Masao Tanaka, Kiyoji Kimura,and Shonen Yoshida.

* 5975 Mechanism of Action of 5,8-Dideazaisofolic Acid and Other Quin-azoline Antifols in Human Colon Carcinoma Cells. John J.McGuire, Alberto F. Sobrero, John B. Hynes, and Joseph R.Benino.

5982 Genetics of Multidrug Resistance: Relationship of a Cloned Geneto the Complete Multidrug Resistant Phenotype. James M. Croop,Braydon C. Guild, Philippe Gros, and David E. Housman.

5989 Comparative Activity of Dietary or Topical Exposure to ThreeRetinoids in the Promotion of Skin Tumor Induction in Mice.David L. McCormick, Bryan J. Bagg, and Theresa A. Hultin.

*5994 Adriamycin Resistance in Human Tumor Cells Associated withMarked Alterations in the Regulation of the Hexose Monophos-phate Shunt and Its Response to Oxidant Stress. Grace ChaoYeh, Sandra J. Occhipinti, Ken H. Cowan, Bruce A. Chabner,and Charles E. Myers.

6000 In Vivo Antitumor Effect of Lymphokine-activated Rodent Poly-morphonuclear Leukocytes. Yoichi Fujii, Seishi Kimura, ShigeruArai, and Fujiro Sendo.

6006 Inhibition by Bryostatin 1 of the Phorbol Ester-induced Blockageof Differentiation in Hexamethylene Bisacetamide-treated FriendErythroleukemia Cells. Marie L. Dell'Aquila, Hong T. Nguyen,

Cherry L. Herald, George R. Pettit, and Peter M. Blumberg.

6010 Microbial Iron Chelator-induced Cell Cycle Synchronization inLI 210 Cells: Potential in Combination Chemotherapy. RaymondJ. Bergeron and Michael J. Ingeno.

*6017 Expression of Cloned Sequences in Biopsies of Human ColonieTissue and in Colonie CarcinomaCells Inducedto Differentiate inVitro. Leonard H. Augenlicht, Miryam Z. Wahrman, HeidiHalsey, Leigh Anderson, John Taylor, and Martin Lipkin.

6022 Reduced Levels of Drug-induced DNA Cross-Linking in NitrogenMustard-resistant Chinese Hamster Ovary Cells Expressing Elevated Glutathione S-Transferase Activity. CraigN. Robson, AlexD. Lewis, C. Roland Wolf, John D. Hayes, Andrew Hall, StephenJ. Proctor. Adrian L. Harris, and Ian D. Hickson.

6028 Entrance of SV40-transformed Cells into G0 Phase as Revealedby a Study Using the Go-specific ts Mutant r.v,IT60. JunNinomiya-Tsuji, Sadahiko Ishibashi, and Toshinori Ide.

6033 Association of Persistent Synthesis of Viral DNA with Macrophage Accessory Cell Dysfunction Induced by Avian RetrovirusMyeloblastosis-associated Virus of Subgroup B Inducing Osteo-petrosis in Chickens. Thomas J. Cummins and Ralph E. Smith.

*6040

*6046

6052

6058

*6066

6074

6079

*6086

6093

6100

6104

6111

6118

Glucocorticoid Sensitivity of OVCA 433 Human Ovarian Carcinoma Cells: Inhibition of Plasminogen Activators, Cell Growth,and Morphological Alterations. Waheeda Amin, Beth Y. Karlan,and Bruce A. Littlefield.

Flow Cytometry and Scrape-loading/Dye Transfer as a RapidQuantitative Measure of Intercellular Communication in Vitro.Terranee J. Kavanagh, George M. Martin, Mohamed H. El-Fouly,James E. Trosko, Chia-Cheng Chang, and Peter S. Rabinovitch.

Direct Action of 170-Estradiol on Mouse Mammary Ducts Analyzed by Sustained Release Implants and Steroid Autoradiogra-phy. Charles W. Daniel, Gary B. Silberstein, and PhyllisStrickland.

Molecular Dosimetry of DNA Adduct FormationandCell Toxicityin Rat Nasal Mucosa following Exposure to the Tobacco SpecificNitposamine 4-{Ar-Methyl-A'-nitrosamino)-l-(3-pyridyl)-l-buta-

none and Their Relationship to Induction of Neoplasia. Steven A.Belinsky, Vernon E. Walker, Robert R. Maronpot, James A.Swenberg, and Marshall W. Anderson.

Characterization of Human Uroepithelial Cells Immortalized inVitro by Simian Virus 40. Brian J. Christian, Linda J. Loretz,Terry D. Oberley, and Catherine A. Reznikoff.

Induction of Contact Hypersensitivity to Dimethylbenz(a)an-thracene and Benzo(a)pyrene in C3H/HeN Mice. Jay C. Klemme,Hasan Mukhtar, and Craig A. Elmets.

Immunohistochemical Determination of Inducibility Phenotypewith a Monoclonal Antibody to a Methylcholanthrene-inducibleIsozyme of Cytochrome P-450. Lucy M. Anderson, Jerrold M.Ward, Sang S. Park, Ann B. Jones, James L. Junker, Harry V.Gelboin, and Jerry M. Rice.

Heterogeneity in the Production of Collagens and Fibronectin byMorphologically Distinct Clones of a Human Tumor Cell Line:Evidence for Intratumoral Diversity in Matrix Protein Biosynthesis. Edmond C. Crouch, Kenneth R. Stone, Michele Bloch,and Robert W. McDivitt.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

Immunolymphoscintigraphy and the Dose Dependence of '"In-labeled T101 Monoclonal Antibody in Patients with Cutaneous T-Cell Lymphoma. Andrew M. Keenan, John N. Weinstein, JorgeA. Carrasquillo, Paul A. Bunn, Jr., James C. Reynolds, KennethA. Foon, Neil C. Smarte, Bimal Ghosh, Richard M. Fejka, StevenM. Larson, and James L. Mulshine.

Fate of •y-Interferon-activatedKiller Blood Monocytes AdoptivelyTransferredinto the Abdominal Cavity of Patients with PeritonealCarcinomatosis. Henry C. Stevenson, Andrew M. Keenan. CliveWoodhouse, Reyer T. Ottow, Paul Miller, E. Philip Steller,Kenneth A. Foon, Paul G. Abrams, JoAnn Beman. Steven M.Larson, and Paul H. Sugarbaker.

Phase I Study and Pharmacokinetics of Menogaril (NSC 269148)in Patients with Hepatic Dysfunction. Merrill J. Egorin. BarbaraA. Conley, Alan Forrest, Eleanor G. Zuhowski, Vickie Sinibaldi,and David A. Van Echo.

Pharmacokinetics of "'In-labeled OC-125 Antibody in CancerPatients Compared with the 19-9 Antibody. D. J. Hnatowich, M.Gionet, M. Rusckowski, D. A. Siebecker, J. Roche. D. Shealy,J. A. Mattis, J. Wilson, J. McGann, R. E. Hunter, T. Griffin, andP. W. Doherty.

Presurgical Determination of Estrogen Receptor Status UsingImmunocytochemically Stained Fine Needle Aspirate Smears inPatients with Breast Cancer. Richard A. McClelland, Uta Berger,Patricia Wilson, Trevor J. Powles, Peter A. Trott, Douglas Easton,Jean-Claude Gazet, and R. Charles Coombes.

Continued

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6123 Association of Multiple Copies of the c-erbB-2 Oncogene withSpread of Breast Cancer. Dujin Zhou, Hector Battifora, JunYokota, Tadashi Yamamoto. and Martin J. Cline.

6126 Prognostic Value of Steroid Hormone Receptors: MultivariateAnalysis of Systemically Untreated Patients with Node NegativePrimary Breast Cancer. S. M. Thorpe, C. Rose, B. B. Rasmussen,H. T. Mouridsen. T. Bayer, and N. Keiding on behalf of theDanish Breast Cancer Cooperative Group.

6134 Evaluation of the Pharmacological Benefit and Determination ofthe Influencing Factors of Intraarterial m-Diamminedichloroplatinum Administration in Patients with Uterine Cervical Cancer.Bernard Hecquet. Philippe Vennin, Charles Fournier, andBertrand Poissonnier.

6138 Serum Pseudouridine as a Biochemical Marker in Small CellLung Cancer. Shinsuke Tamura, Hiroshi Fujioka. TakashiNakano, Toshikazu Hada, and Kazuya Higashino.

6142 Plasma Pharmacokinetics and Urinary Excretion of Hexamethyl-ene Bisacetamide Metabolites. Merrill J. Egorin. Eleanor G.Zuhowski, Adam S. Cohen, Linda A. Geelhaar, Patrick S. Gallery,and David A. Van Echo.

6147 Stability and Pharmacokinetics of m-fnil)lodobenzylguanidine in

Patients. Gerhard Ehninger. Thomas KJingebiel,IngridKumbier,Ulrich Schuler, Ulrich Feine, JörnTreuner, and Hans DierckWaller.

6150 Accumulation of 2-Amino-6-methyldipyrido|l,2-a:3',2'-d|imida-zole and 2-Aminodipyrido|l,2-a:3',2'-d]imidazole, Carcinogenic

Glutamic Acid Pyrolysis Products, in Plasma of Patients withUremia. Shigeo Manabe, Hiroyuki Yanagisawa, ShinsukeIshikawa, Yasuhisa Kitagawa. Yoshikatsu Kanai, and OsamuWada.

6156 Expression of an Unusual Isozyme of Lactate Dehydrogenase inthe Serum of Cancer Patients and Comparison with Carcinoem-bryonic Antigen. Kenneth F. Manly, Nicholas Petrelli. Garth R.Anderson, Lawrence J. Emrich, Lemuel Herrera, and ArnoldMittelman.

6161 Announcements

6161 ErratumD. Colcheref al.. 47:4218-4224, 1987.

6162 Author Index

6164 Statement of Ownership, Management and Circulation

NOTE: Application for membership in the American Association for Cancer Research available in the back of this issue.

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Cancer Research

VOLUME 47 - NUMBER 22

CONTENTS Arranged by Subject Category

5809 Editorial. Peter N. Magee.

Special Lecture

5810 The Chemotherapy of Lymphomas: Looking Back, Moving Forward—TheRichardand Hinda Rosenthal FoundationAward Lecture. Vincent T. DeVita, Jr., Susan Molloy Hubbard, and Dan L.Longo.

BASIC SCIENCES

Biochemistry and Biophysics

5825 Plasma Protein Synthesis in Experimental Cancer Compared toParaneoplastic Conditions, Including Monokine Administration.Marie Ternell, Lyle L. Moldawer, Christina Lonnroth, JohanGelin, and Kent G. Lundholm.

5831 Retinole Acid-induced Rapid Loss of Nuclear Cyclic AMP-de-pendent Protein Kinase in Teratocarcinoma Cells. Ariane Plet,Daniele Evain-Brion, Pascale Gerbaud, and Wayne B. Anderson.

5905 Influence of o-Glucose upon the Respiratory and Secretory Response of Insulin-producing Tumor Cells to 2-Aminobicyclo-|2,2,l|heptane-2-carboxylic Acid. A. Sener, M-H. Giroix, C.Hellerström,and W. J. Malaisse.

5919 Production of Lipolytic and Proteolytic Factors by a MurineTumor-producing Cachexia in the Host. Susan A. Beck andMichael J. Tisdale.

* 5975 Mechanism of Action of 5,8-Dideazaisofolic Acid and Other Quin-azoline Antifols in Human Colon Carcinoma Cells. John J.McGuire, Alberto F. Sobrero, John B. Hynes, and Joseph R.Bertino.

*5994 Adriamycin Resistance in Human Tumor Cells Associated withMarked Alterations in the Regulation of the Hexose Monophos-phate Shunt and Its Response to Oxidant Stress. Grace ChaoYeh, Sandra J. Occhipinti, Ken H. Cowan, Bruce A. Chabner,and Charles E. Myers.

Carcinogenesis5901 Chemoprevention of Colon Carcinogenesis by Dietary Organose-

lenium, Benzylselenocyanate, in F344 Rats. Bandura S. Reddy, S.Sugie, Hiroshi Maruyama, Karam El-Bayoumy, and PatriceMarra.

5939 Effects of Chronic Dietary Ethanol on in Vivo and in VitroMetabolism of Methylazoxymethanol and on Methylazoxymeth-anol-induced DNA Methylation in Rat Colon and Liver. EmerichS. Fiala, Ock Soon Sohn, and Stanley R. Hamilton.

5989 Comparative Activity of Dietary or Topical Exposure to ThreeRetinoids in the Promotion of Skin Tumor Induction in Mice.David L. McCormick, Bryan J. Bagg, and Theresa A. Hultin.

6006 Inhibition by Bryostatin 1 of the Phorbol Ester-induced Blockageof Differentiation in Hexamethylene Bisacetamide-treated FriendErythroleukemia Cells. Marie L. Dell'Aquila, Hong T. Nguyen,

Cherry L. Herald, George R. Pettit, and Peter M. Blumberg.

6058 Molecular Dosimetry of DNA Adduci Formation and Cell Toxicityin Rat Nasal Mucosa following Exposure to the Tobacco SpecificNitrosamine 4-(Ar-Methyl-^V-nitrosamino)-l-(3-pyridyl)-l-buta-none and Their Relationship to Induction of Neoplasia. Steven A.Belinsky, Vernon E. Walker, Robert R. Maronpot, James A.Swenberg, and Marshall W. Anderson.

* Indicates studies using human-derived material.

* 6066 Characterization of Human Uroepithelial Cells Immortalized inVitro by Simian Virus 40. Brian J. Christian, Linda J. Loretz,Terry D. Oberley, and Catherine A. ReznikofT.

6079 Immunohistochemical Determination of Inducibility Phenotypewith a Monoclonal Antibody to a Methylcholanthrene-inducibleIsozyme of Cytochrome P-450. Lucy M. Anderson, Jerrold M.Ward, Sang S. Park, Ann B. Jones, James L. Junker, Harry V.Gelboin, and Jerry M. Rice.

Endocrinology* 5883 Estrogen Conjugates and Serum Factors Mediating the Estrogenic

Trophic Effect on MCF-7 Cell Growth. N. Devleeschouwer, N.Legros, N. Olea-Serrano, R. Paridaens, and G. Leclercq.

*6040 Glucocorticoid Sensitivity of OVCA 433 Human Ovarian Carcinoma Cells: Inhibition of Plasminogen Activators, Cell Growth,and Morphological Alterations. Waheeda Amin, Beth Y. Karlan,and Bruce A. Littlefield.

6052 Direct Action of 170-Estradiol on Mouse Mammary Ducts Analyzed by Sustained Release Implants and Steroid Autoradiogra-phy. Charles W. Daniel, Gary B. Silberstein, and PhyllisStrickland.

Immunology

5841 A Unique Tumor Rejection Antigen from the S91 Murine Malignant Melanoma. Lloyd W. Law, Wilfred D. Vieira, KoichiroKameyama, and Vincent J. Hearing.

* 5861 Comparison of Human and Rat Hepatocyte Metabolism and Mu-tagenic Activation of 2-Acetylaminofluorene. Kenneth Rudo,William C. Meyers, Walter Dauterman, and Robert Langenbach.

*5K6S Effect of Recombinant Tumor Necrosis Factor on Tumoricidal

Activation of Murine Macrophages: Synergism between TumorNecrosis Factor and •v-Interferon.Kazuyoshi Hori, M. Jane Ehrke,

Kenneth Mace, and Enrico Mihich.

5894 Relationship between Modulation of Natural Killer Cell Activityand Antitumor Activity of Bropirimine When Used in Combinationwith Various Types of Chemot nera peutic Drugs. Li H. Li, ThomasF. DeKoning, and Tanya L. Wallace.

* 5954 Antibody-directed Targeting of Liposomes to Human Cell Lines:Role of Binding and Internalization on Growth Inhibition. NeilBerinstein, Katherine K. Matthay, Demetrios Papahadjopoulos,Ronald Levy, and Branimir I. Sikic.

6000 In Vivo Antitumor Effect of Lymphokine-activated Rodent Poly-morphonuclear Leukocytes. Yoichi Fujii, Seishi Kimura, ShigeruArai, and Fujiro Sendo.

6074 Induction of Contact Hypersensitivity to Dimethylbenz(a>an-thracene and Benzo(a)pyrene in C3H/HeN Mice. Jay C. Klemme,Hasan Mukhtar, and Craig A. Elmets.

Molecular Biology and Genetics

5948 Regulation of JV-NitrosodimethylamineDemethylase in Rat Liverand Kidney. Jun-yan Hong, Jinmei Pan, Zigang Dong, Shu M.Ning, and Chung S. Yang.

5982 Genetics of Multidrug Resistance: Relationship of a Cloned Geneto the Complete Multidrug Resistant Phenotype. James M. Croop,Braydon C. Guild, Philippe Gros, and David E. Housman.

on April 20, 2021. © 1987 American Association for Cancer Research. cancerres.aacrjournals.org Downloaded from

Preclinical Pharmacology and Experimental Therapeutics

5835 Peroxidase-catalyzed Metabolism of Etoposide (VP-16-213) andCovalent Binding of Reactive Intermediates to Cellular Macro-molecules. Nissim Haim, Josef Nemec, John Roman, andBuandràK. Sinha.

5846 Antitumor Activity and Pharmacokinetics in Mice of 8-Carba-moyl-3-methylimidazo[5,l-(/l-l,2,3,5-tetrazin-4(3W)-one(CCRG 81045; M & B 39831), a Novel Drug with Potential as anAlternative to Dacarbazine. Malcolm F. G. Stevens, John A.Hickman, Simon P. Langdon, David Chubb, Lisa Vickers, RobertStone, Ghousia Baig, Colin Goddard, Neil W. Gibson, John A.Slack, Christopher Newton, Edward Lunt, Christian Fizames, andFrancois Lavelle.

*5X75 Chemosensitivity Testing of Human Colon-rial Carcinoma CellLines Using a Tetrazolium-based Colorimetrie Assay. Jae-GahbPark, Barnett S. Kramer, Seth M. Steinberg, James Carmichael,Jerry M. Collins, John D. Minna, and Adi F. Gazdar.

5880 Use of Insulation to Reduce Extremity Temperature Nonuniform-ity during Whole Body Hyperthermia in Dogs. Donald E. Thrall,Rodney L. Page, and Deborah A. McLeod.

* 5913 Collateral Methotrexate Resistance in Cultured Human Head andNeck Carcinoma Cells Selected for Resistance to cii-Diammine-dichloroplatinum(II). Andre Rosowsky, Joel E. Wright, Carol A.Cucchi, Jennifer L. Flatow, Dorothy H. Trites, Beverly A. Teicher,and Emil Frei III.

5924 New Coupling Agents for the Synthesis of Immunotoxins Containing a Hindered Disulfide Bond with Improved Stability in Vivo.Philip E. Thorpe, Philip M. Wallace, Phillip P. Knowles, MicheleG. Reif, Alex N. F. Brown, Graham J. Watson, Regina E. Knyba,Edward J. Wawrzynczak, and David C. Blakey.

5932 Intrathecal Administration of 4-Hydroperoxycyclophosphamide inRhesus Monkeys. Carola A. S. Arndt, O. Michael Colvin, FrankM. Balis, Cynthia M. Lester, Gloria Johnson, and David G.Poplack.

*5935 Effects of 3'-(3-Cyano-4-morpholinyl)-3'-deaminoadriamycin and

Structural Analogues on DNA in HT-29 Human Colon CarcinomaCells. Michael I. Jesson, James B. Johnston. Cynthia D. Anhalt,and Asher Begleiter.

5944 Antitumor Activity of 7-Ethyl-10-|4-(l-piperidino)-l-piperidino]-carbonyloxycamptothecin, a Novel Water-soluble Derivative ofCamptothecin, against Murine Tumors. Takehiko Kunimoto,Kazuo Nitta, Tomiko Tanaka. Nobuaki Uehara, Hiroyasu Baba,Mieko Takeuchi, Teruo Yokokura, Siego Sawada, TadashiMiyasaka, and Masahiko Mutai.

5960 Effect of Cycloheximide or Puromycin on Induction of Thermo-toléranceby Heat in Chinese Hamster Ovary Cells: Dose Frac-tionation at 45.5°C.Yong J. Lee and William C. Dewey.

5967 Effects of Intermittent Diethylstilbestrol Diphosphate Administration on the R3327 Rat Prostata Carcinoma. Paul Russo,Gregory Liguori, Warren D. W. Heston, Robert Huryk, Chi-ReiYang, William R. Fair, Willet F. Whitmore, and Harry W. Herr.

:':>'»7I Inhibition of Mammalian DNA Polymerases by Recombinant«-Interferon and -y-Interferon. Masao Tanaka. Kiyoji Kimura,

and Shonen Yoshida.

6010 Microbial Iron Chelator-induced Cell Cycle Synchronization in11210 Cells: Potential in Combination Chemotherapy. RaymondJ. Bergeron and Michael J. Ingeno.

6022 Reduced Levels of Drug-induced DNA Cross-Linking in NitrogenMustard-resistant Chinese Hamster Ovary Cells Expressing Elevated Glutathione S-Transferase Activity. Craig N. Robson, AlexD. Lewis. C. Roland Wolf. John D. Hayes. Andrew Hall. StephenJ. Proctor, Adrian L. Harris, and Ian D. Hickson.

Tumor Biology* 5853 Serum Levels and Biochemical Characteristics of Cancer-associ

ated Antigen CA-549, a Circulating Breast Cancer Marker. KurtisR. Bray, Joy E. Koda, and Pramod K. Gaur.

* 5888 Altered Glucocorticoid Binding and Action in Response to Epidermal Growth Factor in 11Kl.10(1Cells. Kanury V. S. Rao, RobertE. Williams, and C. Fred Fox.

*(>OI7 Expression of Cloned Sequences in Biopsies of Human Colonie

Tissue and in Colonie Carcinoma Cells Induced to Differentiate inVitro. Leonard H. Augenlicht, Miryam Z. Wahrman, HeidiHalsey, Leigh Anderson, John Taylor, and Martin Lipkin.

6028 Entrance of SV40-transformed Cells into ( .„Phase as Revealedby a Study Using the Go-specific ts Mutant iv.llhO. JunNinomiya-Tsuji, Sadahiko Ishibashi, and Toshinori Ide.

*(i(l4(> Flow Cytometry and Scrape-loading/Dye Transfer as a RapidQuantitative Measure of Intercellular Communication in Vitro.Terranee J. Kavanagh, George M. Martin, Mohamed H. El-Fouly,James E. Trosko, Chia-Cheng Chang, and Peter S. Rabinovitch.

* 6086 Heterogeneity in the Production of Collagens and Fibronectin by

Morphologically Distinct Clones of a Human Tumor Cell Line:Evidence for Intratumoral Diversity in Matrix Protein Biosynthesis. Edmond C. Crouch, Kenneth R. Stone, Michele Bloch,and Robert W. McDivitt.

Virology

5908 Production of Recombinant Rat Viruses as a Method of OncogeneIsolation in Coculture Medium. Shun-ichi Kurata, Nori Kurata,and Yoji Ikawa.

6033 Association of Persistent Synthesis of Viral DNA with Macrophage Accessory Cell Dysfunction Induced by Avian RetrovirusMyeloblastosis-associated Virus of Subgroup B Inducing Osteo-[H-trosisin Chickens. Thomas J. Cummins and Ralph E. Smith.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

6093 Immunolymphoscintigraphy and the Dose Dependence of "'In-

labeled T101 Monoclonal Antibody in Patients with Cutaneous ICell Lymphoma. Andrew M. Keenan, John N. Weinstein, JorgeA. Carrasquillo, Paul A. Bunn, Jr., James C. Reynolds, KennethA. Foon, Neil C. Smarte, Bimal Ghosh, Richard M. Fejka, StevenM. Larson, and James L. Mulshine.

6100 Fate of 7-Interferon-activated Killer Blood Monocytes AdoptivelyTransferred into the Abdominal Cavity of Patients with PeritonealCarcinomatosis. Henry C. Stevenson, Andrew M. Keenan, CliveWoodhouse, Reyer T. Ottow, Paul Miller, E. Philip Steller,Kenneth A. Foon, Paul G. Abrams, JoAnn Beman, Steven M.Larson, and Paul H. Sugarbaker.

6104 Phase I Study and Pharmacokinetics of Menogaril (NSC 269148)in Patients with Hepatic Dysfunction. Merrill J. Egorin, BarbaraA. Conley, Alan Forrest, Eleanor G. Zuhowski, Vickie Sinibaldi,and David A. Van Echo.

6111 Pharmacokinetics of '"In-labeled OC-125 Antibody in CancerPatients Compared with the 19-9 Antibody. D. J. Hnatowich, M.Gionet, M. Rusckowski, D. A. Siebecker, J. Roche, D. Shealy,J. A. Mattis, J. Wilson, J. McGann. R. E. Hunter, T. Griffin, andP. W. Doherty.

6118 Presurgical Determination of Estrogen Receptor Status UsingImmunocytochemically Stained Fine Needle Aspirate Smears inPatients with Breast Cancer. Richard A. McClelland, Uta Berger,Patricia Wilson, Trevor J. Powles, Peter A. Trott, Douglas Easton,Jean-Claude Gazet, and R. Charles Coombes.

Continued

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6123 Association of Multiple Copies of the c-erbB-2 Oncogene withSpread of Breast Cancer. Dujin Zhou, Hector Battifora, JunYokota. Tadashi Yamamoto, and Martin J. Cline.

6126 Prognostic Value of Steroid Hormone Receptors: MultivariateAnalysis of Systemically Untreated Patients with Node NegativePrimary Breast Cancer. S. M. Thorpe, C. Rose, B. B. Rasmussen,H. T. Mouridsen, T. Bayer, and N. Keiding on behalf of theDanish Breast Cancer Cooperative Group.

6134 Evaluation of the Pharmacological Benefit and Determination ofthe Influencing Factors of Intraarterial c/î-Diamminedichloro-platinumAdministration in Patients with Uterine Cervical Cancer.Bernard Hecquet, Philippe Vennin, Charles Fournier, andBertrand Poissonnier.

6138 Serum Pseudouridine as a Biochemical Marker in Small CellLung Cancer. Shinsuke Tamura, Hiroshi Fujioka, TakashiNakano, Toshikazu Hada, and Kazuya Higashino.

6142 Plasma Pharmacokinetics and Urinary Excretion of Hexamethyl-ene Bisacetamide Metabolites. Merrill J. Egorin, Eleanor G.Zuhowski. Adam S. Cohen, Linda A. Geelhaar, Patrick S. Callery,and David A. Van Echo.

6147

6150

Stability and Pharmacokinetics of m-|IMI]Iodobenzylguanidinein

Patients. Gerhard Ehninger, Thomas Klingebiel, IngridKumbier,Ulrich Schuler, Ulrich Feine, JörnTreuner, and Hans DierckWaller.

Accumulation of 2-Amino-6-methyldipyrido|l,2-a:3',2'-d]imida-zole and 2-Aminodipyrido|l,2-a:.V,2'-d)imidazole, Carcinogenic

Glutamic Acid Pyrolysis Products, in Plasma of Patients withUremia. Shigeo Manabe, Hiroyuki Yanagisawa, ShinsukeIshikawa, Yasuhisa KJtagawa, Yoshikatsu Kanai, and OsamuWada.

Expression of an Unusual isozyme of Lactate Dehydrogenase inthe Serum of Cancer Patients and Comparison with Carcinoem-bryonic Antigen. Kenneth F. Manly, Nicholas Petrelli, Garth R.Anderson, Lawrence J. Emrich, Lemuel Herrera, and ArnoldMittelman.

6161 Announcements

6161 ErratumD. Colcher et al., 47:4218-4224, 1987.

6162 Author Index

6164 Statement of Ownership, Management and Circulation

6156

NOTE: Application for membership in the American Association for Cancer Research available in the back of this issue.

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1987;47:5809-6161. Cancer Res     47 (22)

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