cancer imaging shared resource - · pdf filewell as project-specific image analysis tools....

Cancer Imaging Shared Resource Directors: Ron Lynch and Andrew Rouse Manager: Brenda Baggett Clinical MRI support: JP Galons Bioluminescence, fluorescence, and planar x-ray imaging. Integrated anesthesia system. Low background noise for accurate quantitative analysis. Small animal CT scanner with variable zoom X-ray source to visualize bone and soft tissue, with or without contrast agents. Down to 20 micron resolution. Image analysis software designed for histologic slides, immuno-stained slides (DAB, HRP), or immunofluorescence. Allows for high throughput automated analysis of multiple images. p = 0.016 Spectral Imaging Instruments Lago X Seimens Inveon µCT Definiens Tissue Studio Software Leukemia cells injected IV are followed over time, and treatment monitored. Satish Padi, Libia Leuvano, and Andrew Kraft Above: Intracardiac injected cells are monitored for formation of metastases to bone. Adam Watson and Gus Mouneimne Left: Intracranial injection of glioma tumors in rat brains monitored for growth Jeffrey R Watson, Nikolay Martirosyan, Summer Garland, G Michael Lemole Jr, and Marek Romanowski Bone on left is tumor bearing, bone on right is contralateral control. Left image: Three dimensional reconstruction showing external surface of bone Right image: Longitudinal slice showing internal structure. Yanxia Chen, Jennifer Xie, and Frank Porreca 3D reconstructions allows for viewing samples in multiple planes, and scanning through slices within that plane. Sample shown is contrast enhanced. Nathan Sweeney and Jesse Martinez. Clockwise from top left: MICROFIL enhanced cast of mouse lungs. Haiyang Tang and Jason Yuan Komodo dragon hatchling, multiple bed positions, imaged sample approximately 8 inches long. Andrew Lee Aberrant set of lower incisors in a mouse mandible. David G Besselsen Region segmentation, nuclear detection, cell boundaries, and grading of positive stain. (Right) Nadia Hassounah and Kimberly McDermott Nuclear detection of two different stains, and co- localization of the stains in a series of tissues, and related numerical analysis. (Far-Right) Thomas Doetschman and David Galbraith Background removal and nuclei detection, of DAPI stained cells. (Below) Brett Stanton and Klearchos Papas Longitudinal measurement of tumor burden Monitoring of non-palpable tumors High resolution ex vivo bone scans Multiple views for analysis Anatomical scans Histological analysis Clinical MRI: Protocols & Analysis http://uacc.arizona.edu/research/shared-resources/cisr The core provide support for imaging protocols design on clinical and research MRI scanners as well as project-specific image analysis tools. Above: Breast density as a risk factor for breast cancer (J. Rosado, T. Hagio, M. Altbach, C. Thompson, P. Chalasani, S. Chow). Right: Liver stiffness measurement for risk assessment of hepatocellular carcinoma using MR elastography. (D. Martin, B. Kalb, Altbach) *Coming soon: µPET system For: Drug Deposition and in vivo Metabolic Analyses http://medicalimaging.medicine.arizona.edu/research/research-labs/cgri

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Page 1: Cancer Imaging Shared Resource - · PDF filewell as project-specific image analysis tools. Above: Breast density as a risk factor for breast cancer (J. Rosado, T. Hagio, M. Altbach,

Cancer Imaging Shared ResourceDirectors: Ron Lynch and Andrew Rouse Manager: Brenda Baggett Clinical MRI support: JP Galons

Bioluminescence, fluorescence, and planar x-ray imaging. Integrated anesthesia system. Low background noise for accurate quantitative analysis.

Small animal CT scanner with variable zoom X-ray source to visualize bone and soft tissue, with or without contrast agents. Down to 20 micron resolution.

Image analysis software designed for histologic slides, immuno-stained slides (DAB, HRP), or immunofluorescence. Allows for high throughput automated analysis of multiple images.

p = 0.016

Spectral Imaging Instruments Lago X Seimens Inveon µCT Definiens Tissue Studio Software

Leukemia cells injected IV are followed over time, and treatment monitored. Satish Padi, Libia Leuvano, and Andrew Kraft

Above: Intracardiac injected cells are monitored for formation of metastases to bone.Adam Watson and Gus Mouneimne

Left: Intracranial injection of glioma tumors in rat brains monitored for growthJeffrey R Watson, Nikolay Martirosyan, Summer Garland, G Michael Lemole Jr, and Marek Romanowski

Bone on left is tumor bearing, bone on right is contralateral control.

Left image: Three dimensional reconstruction showing external surface of bone

Right image: Longitudinal slice showing internal structure.Yanxia Chen, Jennifer Xie, and Frank Porreca

3D reconstructions allows for viewing samples in multiple planes, and scanning through slices within that plane.

Sample shown is contrast enhanced. Nathan Sweeney and Jesse Martinez.

Clockwise from top left:MICROFIL enhanced cast of mouse lungs.Haiyang Tang and Jason Yuan

Komodo dragon hatchling, multiple bed positions, imaged sample approximately 8 inches long.Andrew Lee

Aberrant set of lower incisors in a mouse mandible.David G Besselsen

Region segmentation, nuclear detection, cell boundaries, and grading of positive stain. (Right)Nadia Hassounah and Kimberly McDermott

Nuclear detection of two different stains, and co-localization of the stains in a series of tissues, and related numerical analysis. (Far-Right)Thomas Doetschman and David Galbraith

Background removal and nuclei detection, of DAPI stained cells. (Below)Brett Stanton and Klearchos Papas

Longitudinal measurement of tumor burden

Monitoring of non-palpable tumors

High resolution ex vivo bone scans

Multiple views for analysis

Anatomical scans

Histological analysis

Clinical MRI: Protocols & Analysis

http://uacc.arizona.edu/research/shared-resources/cisr

The core provide support for imaging protocols design on clinical and research MRI scanners as well as project-specific image analysis tools.

Above: Breast density as a risk factor for breast cancer (J. Rosado, T. Hagio, M. Altbach, C. Thompson, P. Chalasani, S. Chow). Right: Liver stiffness measurement for risk assessment of hepatocellular carcinoma using MR elastography. (D. Martin, B. Kalb, Altbach)

*Coming soon: µPET systemFor: Drug Deposition and in vivo

Metabolic Analyseshttp://medicalimaging.medicine.arizona.edu/research/research-labs/cgri

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