can we really compare and aggregate pro data between people and setting?
TRANSCRIPT
Moderator:Professor Nancy J. DevlinDirector of Research, OHE
ISPOR European Congress, Vienna, 2016
Can we really compare and aggregate PRO data between people and setting?Implications for clinical trials and HTA
ISPOR European Congress, Vienna, 2016
Can we safely assume comparability of PRO data?• Use of PRO instruments to measure health within and between
populations, and the aggregation of those data (e.g. in RCTs) relies on their strict comparability.
Two aspects to this:
(i) Properties of the instruments themselves: conceptual (what attributes of health matter) and linguistic/semantic issues (how to describe health).
(ii) How people respond to the instruments in self-reporting health. Self-perception of health and health problems may depend
on:•Their perception of what is ‘normal’ and expectations
regarding health• Conditioned by social context, education, literacy, income, availability of health care facilities, public health education etc.
ISPOR European Congress, Vienna, 2016
Does ‘no problems’ mean different things to different people?
Might ‘the best health you can imagine’ (and the worst) differ between different sorts of people?
ISPOR European Congress, Vienna, 2016
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Sen (2002) Self reported morbidity has severe limitations and can be extremely misleading BMJ“The internal (self-reported) view of health deserves attention, but relying on it in assessing health care or in evaluating medical strategy can be extremely misleading”
ISPOR European Congress, Vienna, 2016
Nancy Devlin (Moderator): Introduction
Mike Herdman: Conceptual and linguistic issues in cross-cultural comparability of PROs
Paula Lorgelly: Addressing differences in use of PRO response categories: anchoring vignettes
Andrea Manca: Methods for addressing heterogeneity in PRO data
NANCY DEVLINThe Office of Health Economics
Registered address Southside, 7th Floor, 105 Victoria Street, London SW1E 6QT
Website: www.ohe.org Email: [email protected]
THANK YOU FOR YOUR ATTENTION