can computer simulations help to unravel the evolution of circadian clocks?
TRANSCRIPT
![Page 1: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/1.jpg)
Can computer simulations help to unravel the evolution
of circadian clocks?
Nicolas Schmelling
![Page 2: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/2.jpg)
React vs. Anticipate
@DerSchmelling
![Page 3: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/3.jpg)
Circadian clocks are ubiquitous
@DerSchmelling
![Page 4: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/4.jpg)
Circadian clocks provide fitness advantage
@DerSchmelling
→ Anticipate is better than react
adapted from Woelfle et al., Adaptive Value of Circadian Clocks. Current Biology, Vol. 14, 1481–1486, August 24, 2004
● Competition experiment with WT and clock mutant
● No effect in constant light● WT has fitness advantage in
oscillating condition
![Page 5: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/5.jpg)
Digital Organisms
@DerSchmelling
![Page 6: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/6.jpg)
Digital organisms are unlimited data sources
@DerSchmelling
Problem Solution● Evolution
happens extremely slowly
● Data collection is hard
Computer simulationwith
digital organisms
Three criteriafor evolution● Replication● Variation
(Mutation)● Competition
![Page 7: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/7.jpg)
Possible solutions for the project
@DerSchmelling
Avida Markov Brains
...suggested by Arend HintzeSoftware platform
for research incomputational
evolutionary biology
![Page 8: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/8.jpg)
Experimental Design
#
evolve under oscillating conditions
## #
##
## #
##
## #
##adapt to new
cyclic environments
## #
###
competition experiments
@DerSchmelling
![Page 9: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/9.jpg)
Open Science Workflow
@DerSchmelling
![Page 10: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/10.jpg)
Sharing is caring
Open Science
@DerSchmelling
FreeRe-Use Rights
ImmediateAvailability
Data
Code
Methods Articles
![Page 11: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/11.jpg)
GitHub in the center of the project
@DerSchmelling
Code
Open Lab Notebook
Documentation &
Background Informations
Roadmap&
Forum
github.com/schmelling/clock_evo
![Page 12: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/12.jpg)
Interested? How can YOU be more open…
@DerSchmelling
?Communicate
Don’t feel the pressure to do everything at once. Even one step towards open science is great.
Publish
Code
Data
PreprintsOA Journals
BlogMethods &
Protocols
YouTube
![Page 13: Can computer simulations help to unravel the evolution of circadian clocks?](https://reader033.vdocuments.us/reader033/viewer/2022042906/589dc9601a28abf45d8b4da3/html5/thumbnails/13.jpg)
Thanks
Ilka Axmann
Daniel Mietchen
@DerSchmelling
Questions?
Arend Hintze
Charles Ofria