caliciviridae for veterinary students
TRANSCRIPT
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FAMILY CALICIVIRID
AEKasahun Delenee VAR/5994/05
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CALICIVIRUS• from the Latin calyx “chalice” or
Cup• Often referred as “Small round
structured viruses”
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VIRION AND NUCLEIC ACID PROPERTIES
• non-enveloped• 27-40 nm in diameter• Icosahedral symmerty• Some have characteristic appearance with
32 cup shaped depressions on their surface
• Linear• Positive sense single-stranded RNA viruses
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VIRION AND NUCLEIC ACID PROPERTIES
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VIRION AND NUCLEIC ACID
PARTICLESEncompasses 4 clinical syndromes:• Swine Vesicular Exanthema• San Miguel Sea Lion Virus• Feline Calicivirus• Rabbit Hemorrhagic Disease
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TAXONOMYGroup IV; single stranded RNA positive-strand virusesFamily: CaliciviridaeGenus: Lagovirus
Nebovirus Norovirus Sapovirus Vesivirus
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REPLICATION1.Attachement to ho
st receptors mediates endocytosis of the virus into the host cell.
2.Uncoating, and release of the viral genomic RNA into the cytoplasm.
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3.VPg is removed from the viral RNA, which is then translated into a processed ORF1polyprotein to yield the replication proteins.
4.Replication occurs in viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
REPLICATION
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REPLICATION5. The dsRNA genome
is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
6. Subgenomic RNA translation gives rise to the capsid protein and VP2.
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REPLICATION7. Assembly of new
virus particles and release by cell lysis.
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DISEASES• Swine Vesicular Exanthema• San Miguel Sea Lion Virus• Feline Calicivirus• Rabbit Hemorrhagic Disease
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Vesicular Exanthema infection of Porcine
DISEASES
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Rabbit Hemorrhagic Disease
DISEASES
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FELINE CALICIVIRUS
(FCV)
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FELINE CALICIVIRUS(FCV)
a common respiratory disease in cats virus attacks the respiratory tract -- lungs and
nasal passages -- the mouth, with ulceration of the tongue, the intestines, and the musculoskeletal system
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FELINE CALICIVIRUS (FCV)
Causative agent: Vesivirus
Clinical Signs: conjunctivitis rhinitistracheatis pneumona and
vesiculation,ulceration of the oral epithelium fever anorexia lethargy stiff gait
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Nasal discharge and vesicles & ulcers on the tongue of a cat infected with FCV.
FELINE CALICIVIRUS (FCV)
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Tongue ulcerative glossitis from a FCV case.
FELINE CALICIVIRUS (FCV)
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Lesions: on muzzle and tongue, respiratory tract, oral cavity and eyes.
Pathogenesis: natural transmission occurs via aerosol and fomites; the virus is often carried to susceptible cats by human handlers.
FELINE CALICIVIRUS (FCV)
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Radiographs of interstitial pneumonia.
FELINE CALICIVIRUS (FCV)
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Histopathology & gross pathology of interstitial pneumonia from a FCV case.
FELINE CALICIVIRUS (FCV)
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Lymphocytic-plasmacytic stomatitis in a cat.
FELINE CALICIVIRUS (FCV)
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Lesions in the eyes
FELINE CALICIVIRUS (FCV)
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SAMPLES AND TESTSDISEASES
CAUSATIVE
AGENT
SAMPLE/s DIAGNOSTIC TEST
SWINE VESICULA
R EXANTHEM
A
VESIVIRUS Vesicular fluid, mucous membranes
SEROLOGIC TESTELECTRON MICROSCOPY
FELINE CALICIVIR
US
VESIVIRUS oral swabs, blood, skin scrapings or lung
tissue
PCR, IMMUNOFLOURESCENCEENZYME IMMUNOASSAY
RABBIT HEMORRH
AGIC DISEASE
LAGOVIRUS Spleen, liver , blood IMMUNOFLOURESCENCEENZYME IMMUNOASSAY
SAN MIGUEL
SEA LION VIRUS
INFECTION
VESIVIRUS Tissue samples, fecal samples
ELISAImmunoflourescencePCR
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CONTROL AND TREATMENT
FELINE CALICIVIRUS There is no specific treatment for FCV Antibiotics are used for secondary bacterial
infections, and immune modulators, such as lymphocyte T-cell immune modulator, have been used for immune support.
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Nursing care and rehydration are used for dehydrated and anorexic cats
Routine vaccination.
Avoiding overcrowding of feline populations, reducing stress.
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THE END