PR

Separation ofplasmid andchromosomal DNA

Run conditions:CsCl-ethidium bromidegradient, homogeneous start-ing density 1.55 g/mL.VTi 65.2 vertical tube rotorspun at 65,000 rpm in anL8M or L7 Ultracentrifuge.Temperature 20°C. Sixteen5.1-mL Quick-Seal s poly-allomer tubes.

This full-speed run can onlybe achieved in a BeckmanVTi 65.2 rotor. Send for pro-tocol. Beckman Instruments,Inc., Spinco Division, 1050Page Mill Road, Palo Alto,CA 94304. (800) 742-2345.Offices worldwide.Circle No. 126 on Readers' Serv

BECKIMA

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After centuries of practice,

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INTERIM REFERENCEREAGENTS FOR HUMAN

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The Biological Response Modi-fiers Program, NCI, USA, and theNational Institute for BiologicalStandards and Control (NIBSC), UK,a World Health Organization Lab-oratory for Biological Standards,have made available InterimReference Reagents for humancytokines.

These materials, of definedunitage, are available for calibrationof laboratory standards. One vial ofeach lyophilized reference materialwill be sent to any laboratory onreceipt of a written request.

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Outside the United States ofAmerica, contact:

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Circle No. 169 on Readers' Service Card

WILL AMERICANS BESCIENTIFICALLY LITERATEBEFORE COMET HALLEYRETURNS IN 2061?

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The first phase of this massive nation-wide effort to reform U.S. scienceeducation has produced six reports thatrecommend in detail what all citizensshould know about science, mathematics,and technology.

They consist of an integrated report,Science for All Americans (AAAS order no.89-01S), by the National Council on Sci-ence and Technology Education, andreports by five independent panels:Biological and Health Sciences (#89-02S),Mathematics (#89-03S), Physical andInformation Sciences and Engineering(#89-04S), Social and Behavioral Sciences(#89-05S), and Technology (#89-06S).Send orders giving titles and AAAS

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This new book, based on a AAAS Annual Meetingsymposium, explores the connections between cellular

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Circle No. 152 on Readers' Service Card

Studies in History and Philosophy of Science, vol. 7.From a symposium, Sydney, Australia, 1985.Confirmation Learning Theory. Raymond E. Hart-

ley and Carl D. Williams. Lang, New York, 1989. x, 409pp., illus. $50.50. American University Studies 8, vol.12.Continua with Microstructure. G. Capriz. Springer-

Verlag, New York, 1989. x, 92 pp. $49. Springer Tractsin Natural Philosophy, vol. 35. From a lecture series,Ravello, Italy, 1986.Controlled Release of Drugs. Polymers and Aggre-

gate Systems. Morton Rosoff. VCH, New York, 1989.xii, 315 pp., illus. $65.The Correspondence of Charles Darwin. Vol. 4,

1847-1850. Frederick Burkhardt and Sydney Smith,Eds. Cambridge University Press, New York, 1989.$37.50.

Critical Factors in Haemostasis. Evaluation andDevelopment. C. E. Williams et al., Eds. Horwood,Chichester, U.K., and VCH, New York, 1989. xii, 285pp., illus. $137. Ellis Horwood Series in Biomedicine.Development of the Vertebrate Retina. Barbara L.

Finlay and Dale R. Sengelaub, Eds. Plenum, New York,1989. xx, 287 pp., illus. $59.50. Perspectives in VisionResearch. From a conference, Ithaca, NY, June 1987.A Dictionary of Ethology. Klaus Immelmann and

Colin Beer. Harvard University Press, Cambridge, MA,1989. xvi, 336 pp., illus. $35. Translated from theGerman edition (Berlin, 1982).The Ecology of Australia's Wet Tropics. R. L.

Kitching, Ed. Published for the Ecological Society ofAustralia by Beatty, Chipping Norton, New SouthWales, 1988. vi, 326 pp., illus. $53. Proceedings of theEcological Society of Australia, vol. 15. From a sympo-sium, Brisbane, Australia, Aug. 1986.

Health Policies and Black Americans. David P.Willis, Ed. Transaction, New Brunswick, NJ, 1989. vi,531 pp. Paper, $19.95. Reprinted from The MilbankQuarterly, vol. 65, supplement 1 (1987).

High-T. Superconductors. Harald W. Weber, Ed.Plenum, New York, 1988. xii, 363 pp. illus. $79.50.From a meeting, Salzburg, Austria, Feb. 1988.

International Handbook of Pollution Control. Ed-ward J. Kormondy, Ed. Greenwood, Westport, CT,1989. xviii, 466 pp. $85.Introduction to Crystal Chemistry. Student Edi-

tion. Howard W. Jaffe. Cambridge University Press,New York, 1988. xii, 161 pp., ilus. Paper, $24.95.Reprinted from Crystal Chemistry and Refractivity, partI.An Introduction to Genetic Analysis. David T.

Suzuki et al. 4th ed. Freeman, New York, 1989. xiv, 768pp., illus. $39.95.

Introduction to Plant Nematology. Victor H.Dropkin. 2nd ed. Wiley-Interscience, New York, 1989.xii, 304 pp., illus. $44.95.

Introduction to Power Electronics. Eiichi Ohno.Clarendon (Oxford University Press), New York, 1988.x, 290 pp., illus. $95. Monographs in Electrical andElectronic Engineering, vol. 20.

Introduction to the Optical Transfer Function.Charles S. Williams and Orville A. Becklund. Wiley-Interscience, New York, 1989. xiv, 412 pp., illus.$44.95. Wiley Series in Pure and Applied Optics.

Introduction to the Practice of Sitatistics. David S.Moore and George P. McCabe. Freeman, New York,1989. xx, 790 pp., illus., + appendix. $38.95.Inverse Problems in Quantum Scattering Theory.

K. Chadan and P. C. Sabatier. 2nd ed. Springer-Verlag,New York, 1989. xxxii, 499 pp. $79. Texts and Mono-graphs in Physics.Laser Chemical Processing for Microelectronics.

K. G. Ibbs and R. M. Osgood, Eds. Cambridge Univer-sity Press, New York, 1989. x, 172 pp., illus. $49.50.Cambridge Studies in Modem Optics, vol. 7.

Manipulating Secondary Metabolism in Culture.Richard J. Robins and Michael J. C. Rhodes, Eds.Cambridge University Press, New York, 1989. xii, 312pp., illus. $49.50. From a meeting, Norwich, U.K., Sept.1987.The Materials Revolution. Superconductors, New

Materials, and the Japanese Challenge. Tom Forester,Ed. MIT Press, Cambridge, MA, 1989. xvi, 397 pp.,illus. Paper, $16.95.Mathematical Modeling in Ecology. A Workbook

for Students. Clark Jeffries. Birkhauser Boston, Cam-bridge, MA, 1989. x, 193 pp., illus. $49.50. Mathemati-cal Modeling, no. 3.The Melancholy Anatomy of Plagiarism. K. R. St.

Onge. University Press of Amnerica, Lanham, MD, 1988.xii, 106 pp. $24.75; paper, $10.25.Model Discrimination for Nonlinear Regression

Models. Dale S. Borowiak. Dekker, New York, 1989.xiv, 177 pp. $89.75. Statistics, vol. 101.

The Multiplicity of Dreams. Memory, Imagination,and Consciousness. Harry T. Hunt. Yale UniversityPress, New Haven, CT, 1989. xii, 271 pp. $27.50.

Multivectors and Clifford Algebra in Electrody-namics. Bernard Jancewicz. World Scientific, Teaneck,NJ, 1989. xiv, 316 pp., illus. $63.Neuropeptides. A Methodology. G. Fink and A. J.

Harmar, Eds. Wiley-Interscience, New York, 1989. xvi,345 pp., illus. $99. IBRO Handbook Series, vol. 11.Nonlinear Evolution Equations and Painlev6

Test. W.-H. Steeb and N. Euler. World Scientific,Teaneck, NJ, 1988. x, 333 pp. $54.

Nuclear Endings. Stopping War on Time. Stephen J.Cimbala. Praeger, (Greenwood), New York, 1989. xxiv,295 pp. $47.95.Oceanography. An Introduction. Dale E. Ingman-

son and William J. Wallace. 4th ed. Wadsworth, Bel-mont, CA, 1989. xiv, 511 pp., illus. $39.25.

Organizational Ecology. Michael T. Hannan andJohn Freeman. Harvard University Press, Cambridge,MA, 1989. xvi, 366 pp., illus. $29.50.Owls of the Northern Hemisphere. Karel H.

Voous. MIT Press, Cambridge, MA, 1989. 320 pp.,illus. $55.Packet Switched Networks. Theory and Practice.

Richard Bamett and Sally Maynard-Smith. Sigma,Wilmslow, U.K., and Halsted (Wiley), New York, 1989.viii, 274 pp., illus. $39.95.

Parallel Models of Associative Memory. GeoffreyE. Hinton and James A. Anderson, Eds. 2nd ed. Erf-baum, Hillsdale, NJ, 1989. x, 339 pp., illus. $49.95;paper, $19.95. The Cognitive Science Series.

Particle Physics in the Cosmos. Readings fromScientific American Magazine. Richard A. Carrigan, Jr.,and W. Peter 9. Trower, Eds. Freeman, New York,1989. x, 228 pp., illus. Paper, $9.95.Properties of Selected]Ferrous Alloying Elements.

Y. S. Touloukian and C. Y. Ho, Eds. McGraw-Hill, NewYork, 1989. xviii, 268 pp., illus. $80. CINDAS DataSeries on Material Properties, vol. 3-1.Radon. Risk and Remedy. David J. Brenner. Free-

man, New York, 1989. xii, 225 pp., illus. $17.95; paper,$10.95.The Rational Infant. Learning in Infancy. T. G. R.

Bower. Freeman, New York, 1989. xii, 176 pp., illus.$21.95; paper, $13.95. A Series of Books in Psychology.Reactions and Movement of Organic Chemicals

in Soils. B. L. Sawhney and K. Brown, Eds. Soil ScienceSociety of America and American Society of Agronomy,Madison, WI, 1989. xviii, 474 pp., illus. Paper, $42.SSSA Special Publication no. 22. From a symposium,Atlanta, GA, Nov.-Dec. 1987.Regulatory Peptides. J. M. Polak, Ed. Birkhauser

Boston, Cambridge, MA, 1989. xii, 406 pp., illus. $168.Experientia Supplementum, vol. 56.Research and Development in Expert Systems V.

B. Kelly and A. L. Rector, Eds. Published for the BritishComputer Society by Cambridge University Press, NewYork, 1989. vi, 359 pp., illus. $59.50. The BritishComputer Society Workshop Series. From a conference,Brighton, U.K., Dec. 1988.The Restless Sun. Donat G. Wentzel. Smithsonian

Institution Press, Washington, DC, 1989. xiv, 279 pp.,illus. $27.95. Smithsonian Library of the Solar System.Rock Engineering. John A. Franklin and Maurice B.

Dusseault. McGraw-Hill, New York, 1989. x, 600 pp.,illus. $62.50.75 Years of Scientific Thought. Significant Read-

ings from the Journal of the Washington Academy ofSciences. Committee on Scholarly Activities, Compilers.Washington Academy of Sciences, Arlington, VA, 1987.xii, 377 pp., illus. Paper, $20.Sharks in Question. The Smithsonian Answer Book.

Victor G. Springer and Joy P. Gold. Smithsonian Institu-tion Press, Washington, DC, 1989. 187 pp., illus.$39.95; paper, $15.95.Some Aspects of Polaron Theory. N. N. Bogolu-

bov and N. N. Bogolubov, Jr. World Scientific, Teaneck,NJ, 1988. viii, 122 pp. $32; paper, $18. World ScientificLecture Notes in Physics, vol. 4.STATAL. Statistical Procedures in Algol 60. R. van

der Horst and R. D. Gill, Eds. Centrum voor Wiskundeen Informatica, Amsterdam 1988. 3 vols. Part 1, xviii pp.+ pp. 1-200. Paper, Dfl. 33. CWI Syllabus 20. Part 2, ivpp. + pp. 201-398. Paper, Dfl. 30.40. CWI Syllabus 21.Part 3, iv pp. + pp. 399-626. Paper, Dfl. 35.40. CWISyllabus 22.The Structure of Biological Theories. Paul

Thompson. State University ofNew York Press, Albany,1989. x, 148 pp., illus. $39.50; paper, $12.95. SUNYSeries in Philosophy and Biology.Urban Surface Water Management. Stuart G. Wa-

lesh. Wiley-Interscience, New York, 1989. xx, 518 pp.,illus. $59.95.

2S AUGUST 1989

BIOLOGICALSAVAILABLE FROM THENATIONAL CANCERINSTITUTE (NCI)

The repository of theBiological Response ModifiersProgram (BRMP), Division ofCancer Treatment, NCI, NIH,announces the availability ofrecombinant human lymphokinesIL-la, IL-15 and IL-2 and themonoclonal antibody, 1 1B. 1 1,against mouse IL-4.

These biologicals are availableto investigators with peer-reviewed support. However,manufacturers' restrictionsprohibit distribution of thesematerials to for-profit institutionsor commercial establishments.Monoclonal antibody, 1 1B. 11, isavailable in either 3 mg or 50 mgvials. The lymphokine materialsare aliquoted in 100 ,ug amounts.Use of these materials is limitedsolely to in vivo and in vitro basicresearch studies, and are notintended for administration tohumans.

Investigators wishing to obtainany of these materials shouldsend requests to:

Dr. Craig ReynoldsBiological Resources BranchBiological Response Modifiers

ProgramNCI-FCRF, Building 321,

Room 6Frederick, MD 21701-1013All requests should be

accompanied by: (1) A briefparagraph outlining the purposefor which materials are to beused, (2) the amount desired,(3) description of investigator'speer-reviewed support. Recipientswill be required to sign aMaterials Transfer Agreement andto pay shipping and handlingcosts.

National Cancer Insitute-Frederick Cancer Research Facilty

Circle No. 171 on Readers' Service Card