ca1 briefing - · pdf fileembryology unlikely to come out for meqs for now (since...
TRANSCRIPT
![Page 1: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/1.jpg)
CA1 Briefingby the Academic Directorate of the Class of 2021
![Page 2: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/2.jpg)
Notice: Change of Syllabus
● Addition of Cell Signalling and Immunology
○ Relevant documents have been added into your Dropbox folder:
■ Basic Immunology (Abbas) in “Textbooks (M1)”
■ Immunology (folder) in “Senior’s Notes”
■ Immunology (folder) in “CA1 Revision Questions by topics”
● Removed Membrane Physiology
● Carbohydrate Metabolism shifted to CA3
○ If you don’t know anything about glycolysis, don’t worry (yet)
![Page 3: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/3.jpg)
Examination Format
M1 CA1 AY2016-17
Type Subject Marks Total
MCQ Carb Metab 16 90x1m
Foundational Biochem
24
Upper Limb 20
Lower Limb 15
Embryology 2
Histology 8
Physiology 5
MEQ Ethics 10 2x10m
Med & Soc 10
M1 CA1 AY2017-18
Type Subject Marks Total
MCQ Cell Signalling ? 50x1m
Foundational Biochem
?
Upper Limb ?
Lower Limb ?
Embryology ?
Histology ?
Immunology ?
MEQ Ethics ? 2x10m
Med & Soc ?
![Page 4: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/4.jpg)
Colour-coding
● Red text means there’s an important take-home message
● Black text is for the normal contents that you expect from this briefing
● Grey text means the content is out there but is not the most important
![Page 5: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/5.jpg)
Embryology
● Unlikely to come out for MEQs
○ For now (since developmental abnormalities
in the limbs are not too common clinically)
● Learn the Trilaminar Germ Disc well!
○ Given a structure, you should be able to tell
which layer(s) it originates from
● Correlate with Gross Anatomy
○ When learning Embryology in future, if you
see similarities with Gross Anatomy, do
take note, it’ll make learning both easier!
“Embryonic Development, Organogenesis”Lecture by Prof. Frank Voon (11th September)
![Page 6: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/6.jpg)
Neuroanatomy
● Unlikely to come out in MEQs
○ You aren’t expected to know much
○ There are better things to test you
● Know the locations of cell bodies
for different types of neurons
● Understand the concept of
spinal nerves and how they
exit the vertebral canal
“Spinal Cord and Spinal Nerve”Lecture by Prof. Ng Yee Kong (4th September)
![Page 7: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/7.jpg)
Overview of Gross Anatomy
● Basic Knowledge
○ Bones & Joints (know movements at joints)
○ Muscles (learn by grouping)
○ Nerves & Vessels (diagrams help!)
● Compartments
○ Cubital Fossa (TAN)
○ Carpal Tunnel
○ Femoral Triangle (NAVL)
○ Popliteal Fossa (NVA)
An example of a checklist you can make to help yourself study (this checklist is for Thorax though)
![Page 8: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/8.jpg)
Bones
● Not every bony landmark is important, you should know:
○ Attachment sites for major muscles (eg. Medial epicondyle, ASIS, etc.)
○ Related to nerves/arteries/veins (eg. Radial groove, medial malleolus, etc.)
○ Have clinical significance (eg. Surgical neck of humerus, neck of fibula, etc.)
○ MOST IMPORTANTLY: Those mentioned repeatedly by the lecturers (NOT tutors)
■ Your lecturers set your papers, so. This is a recurring theme!
![Page 9: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/9.jpg)
E.g. “...linear roughening for the attachment of the lateral head of the triceps... “ -- not important!
IMPORTANT: Deltoid tuberosity: insertion of the deltoid
muscle; radial groove: contains radial nerve
![Page 10: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/10.jpg)
Joints (& Ligaments)
● Basic Theory of Joints
○ Classification of joints (fibrous/cartilaginous/synovial)
○ Types of synovial joints (non-axial: plane, uniaxial: hinge/pivot,
biaxial: condyloid/ellipsoid/saddle, triaxial: ball and socket)
○ Components of a synovial joint (capsule, articular disc, ligaments)
● Joints in the Upper and Lower Limbs
○ Know which joints the major movements occur at, notable examples (NOT EXHAUSTIVE):
■ Supination/Pronation of Forearm at Radio-ulnar joints
■ Locking mechanism (rotation) at Knee joint
■ Dorsi/plantarflexion of Foot at Talocrural (ankle) joint
![Page 11: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/11.jpg)
Joints
● You can make a table to help you organise info if it helps :)
Joint Type Articulation Movements Stabilising factors Features which allow for wide range of movement
Gleno-humeral joint
Triaxial ball and socket
Head of humerus + glenoid cavity of the scapula
Flexion, extension, abduction, adduction, medial rotation, lateral rotation, circumduction
● Glenoid labrum deepens the glenoid cavity
● Ligaments: Extracapsular, coracohumeral
● Muscles: long head of the biceps brachii, rotator cuff, deltoid
● Synovial membrane loose inferiorly
● Shallow glenoid cavity receives only ⅓ of humeral head
![Page 12: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/12.jpg)
Trivia, sometimes useful
● Note special features of joints, for example,
○ Elbow joint involves 3 separate articulations (humerus-radius, humerus-ulna, radius-ulna),
with all 3 sharing a common synovial cavity
○ Wrist can be ADducted to a greater degree than it can be ABducted (due to styloid process)
○ Carpometacarpal joint of thumb is a saddle joint unlike the others which are gliding joints
○ Locking mechanism of knee joint
○ Ankle joint is more stable when dorsiflexed
○ Support for arches of the foot (Medial Longitudinal Arch, etc.)
○ ... and so on
![Page 13: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/13.jpg)
Ligaments
● Compartmentalise your knowledge of ligaments according to region,
take note of the important ones and their function:
○ Hip → iliofemoral, pubofemoral, ischiofemoral ligaments
○ Knee → collateral ligaments (MCL, LCL); cruciate ligaments (ACL, PCL)
○ Ankle → deltoid ligament
○ Foot → spring ligament
● It is easier to understand the cause of
ligament injuries if you draw them out!
(eg. MCL injury shown on the right)
MCL injury
![Page 14: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/14.jpg)
Muscles
● A note about muscle attachments
○ Which is the origin and which is the insertion
is not important, just say ‘attachment’
○ Don’t obsess over the exact attachments, where
on the bone isn’t as important as which bone
○ A picture speaks a thousand words,
and is easier to remember anyway
○ Usually will not be tested in detail, if tested
at all it will only be for the major muscles
● Can make tables to test yourself if you like
(eg. muscle | origin | insertion | action)
Too much info...
![Page 15: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/15.jpg)
Muscles (& Nerves)
● Group the muscles (eg. Anterior and posterior thigh, adductor group)
○ Muscles in the same group produce similar actions and
are usually innervated by the same nerve branches!
○ It is advisable to generalise then learn the exceptions
■ “1.5 muscles”, “LOAF” as exceptions for Median, Ulnar nerve groups
● Know the nerve supply of the various muscles
○ It is sufficient to know the main nerve branch supplying the muscle:
■ Your textbook may mention ‘posterior interosseous nerve’ as the nerve innervating
the extensor digitorum, but actually ‘radial nerve’ will suffice :)
![Page 16: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/16.jpg)
Studying Muscles in Groups
![Page 17: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/17.jpg)
Muscles (& Nerves)
● Know the actions of the various muscles○ Rationalise the movement of a muscle based on its location (or group) and its attachments
○ Muscles can only act on the joints that it crosses, for example:■ Adductor Magnus does not produce any action on the knee joint because
it inserts onto the adductor tubercle which is found on the femur
■ Sartorius will produce an action on the knee joint because it inserts onto
the tibia (which is ‘beyond’ the knee joint)
● Also know the clinical significance of certain muscles○ eg. Vastus Medialis for patellar stability, Gluteus Medius + Minimus for strong hip abduction to
support the hip when standing on one leg (when compromised, results in Trendelenburg’s sign)
![Page 18: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/18.jpg)
Overview of Nerves
● Approach in order of priority:
○ Muscular innervation by nerve branch
○ Cutaneous innervation by nerve branch
○ Course of nerve branches in upper/lower limb
○ Muscular innervation by spinal root (myotome)
○ Cutaneous innervation by spinal root (dermatome)
● Limbs primarily function for movement, hence muscle innervation is most important
![Page 19: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/19.jpg)
Nerves - Upper Limb
![Page 20: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/20.jpg)
Nerves - Lower Limb
Only 3 main nerves:
1) Obturator n. → medial thigh compartment
(adductor muscles)
2) Femoral n. → anterior thigh compartment
(extensor muscles)
3)Sciatic n. (tibial + common fibular n) →
everything else!
Studying about cutaneous nerves such as sural
n. and saphenous n. can come in later!
![Page 21: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/21.jpg)
Nerves: Course
● Keep practicing drawing
the brachial plexus and
naming the branches
and muscles supplied
● A lumbosacral plexus
exists for Lower Limb,
but it is not necessary to
learn unless it helps you
![Page 22: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/22.jpg)
Nerves: Course
● Course of nerves - understand using landmarks
○ E.g Ulnar nerve passes posterior to medial epicondyle
→ enter anterior forearm → passes lateral to pisiform
and above flexor retinaculum (does not enter carpal
tunnel)
○ Less important to remember things like “ulnar n. runs
between FCU and FDP”
● Have a big picture of nerve root values +
course + its sensory & motor innervation (draw
it out if it helps)
![Page 23: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/23.jpg)
Nerves: Myotomes
● Not necessary to know spinal root (eg. C5, C6) innervation of every muscle!
● Know generally the spinal roots involved for each major action or reflex:
○ 1, 2, Buckle my shoe (S1, 2 - Calcaneal tendon reflex)
○ 3, 4, Shut the door (L3, 4 - Quadriceps tendon reflex)
○ 5, 6, Pick up sticks (C5, 6 - Biceps tendon reflex, also Brachioradialis)
○ 7, 8, Shut the gate (C7, 8 - Triceps tendon reflex)
![Page 24: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/24.jpg)
Nerves
● Sensory
innervation
○ Dermatomes
○ Areas of skin
innervated by
nerves (esp. Skin
overlying hand,
forearm, leg, foot)
![Page 25: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/25.jpg)
Nerves
● Hilton’s Law - The nerve supplying the muscles extending directly across and
acting at a given joint also innervate the joint.
● Higher-order questions (nerve palsies, ulnar paradox, etc.)
● E.g. Erb’s Palsy
○ C5,C6 lesion (axillary, musculocutaneous, suprascapular nerves damaged)
○ Arm - medially rotated, hangs by side (i.e. cannot abduct)
○ Forearm - extended, pronated
![Page 26: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/26.jpg)
Arteries
● Start from major arteries → branch to smaller arteries (Try to
draw them if you’re unsure!)
● Know the boundaries demarcating the name change (e.g. ext.
Iliac → femoral → popliteal)
○ Then add in main branches of the major arteries
● Have a general idea of the course, noting down major
landmarks nearby
○ E.g Pec. minor separates axillary a. into 3 parts
● Know locations of feel for pulses (e.g. radial, brachial, dorsalis
pedis, posterior tibial, etc)
![Page 27: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/27.jpg)
Veins
● Superficial and deep circulations - sometimes similar
names as the arteries/nerves they travel with
● Important features of the course of the vein (drainage +
important landmarks)
○ Basilic v. + brachial v. → axillary v. (at inf. border of
teres major)
● Clinical relevance
○ Median cubital v. for venipuncture
○ Deep circulation in LL associated with DVT
○ Superficial circulation in LL assoc. with varicosities
![Page 28: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/28.jpg)
Lymphatics
Lymphatics - trace the flow!
- Pectoral, subscapular, humeral →
central → apical lymph nodes →
subclavian lymphatic trunk
- R. subclavian lymphatic trunk →
right lymphatic trunk → venous
angle (junction of internal jugular
vein and subclavian vein)
- Left subclavian lymphatic trunk →
thoracic duct
![Page 29: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/29.jpg)
- Superficial lymphatics (follow saphenous
veins and their branches) → drains into
superficial inguinal LNs → ext iliac LNs.
- Deep inguinal nodes - located on medial
aspect of femoral v. under deep fascia
- Popliteal LNs receive:
- 1. Lymphatics accompanying small
saphenous v.
- 2. Deep lymphatics of leg
- Drains up to deep inguinal nodes →
ext and common iliac nodes → lumbar
Lymphatics
![Page 30: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/30.jpg)
Important spaces (e.g Anatomical Snuffbox, Cubital
Fossa)● Boundaries
● Contents
○ Using mnemonics can help
○ Important to know arrangement
of contents within compartments
(e.g medial or lateral)
● Clinical relevance
○ E.g Venipuncture via median
cubital vein → separated from
![Page 31: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/31.jpg)
Focus on clinically significant stuff!
● Fractures → lead to other problems → nerve/artery affected → clinical
presentations
○ E.g Midshaft fracture of humerus → radial nerve affected → wrist drop
■ Don’t study blindly! Understand and picture why a midshaft fracture will result in radial
nerve being affected. Again, understand why wrist drop occurs when the radial nerve is
affected.
○ Fractures → avascular necrosis
● Nerve problems → clinical presentations
○ Work out the clinical presentation from the sensory/motor function of the nerve
○ E.g Long thoracic nerve affected → no serratus anterior → ‘winging’ of scapula
![Page 32: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/32.jpg)
Fractures
Q. A fracture to the neck of the fibula is LIKELY to damage the common fibular (peroneal) nerve, and results in
a) Inability to flex distal phalanx of the great toeb) Inability to evert footc) Loss of plantar flexion of footd) Loss of sensation to sole of the foote) Inability to flex metatarsophalangeal joints
![Page 33: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/33.jpg)
Some mnemonics to help you along● Bones
○ Carpal bones - Straight Line To Pinky Here Comes The Thumb
● Muscles
○ Anterior compartment of arm - BBC - innervated by musculocutaneous nerve
● Arteries
○ Axillary artery branches - Screw The Lawyers Save A Patient
● Nerves
○ Brachial plexus - Rugby Teams Drink Cold Beer
○ MARMU
○ Tendon reflex - 1 2 buckle my shoe, 3 4 kick the door, 5 6 pick up sticks, 7 8 shut the gate
![Page 34: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/34.jpg)
Histology
![Page 35: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/35.jpg)
Histology
● Topics tested
○ Basic cytology
○ Epithelium
○ Connective tissue
○ Bone
○ Muscle
○ Nervous system
○ Lymphoid
○ Skin
![Page 36: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/36.jpg)
Epithelium
● Stratified vs. Simple
● Squamous vs. Cuboidal vs. Columnar
● Keratinised vs. Non-keratinised
● Special: Pseudostratified; Transitional
Things to note:
● Differentiating factors
● Major function
● Major locations
![Page 37: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/37.jpg)
Cartilage
● Hyaline
● Fibrocartilage
● Elastic cartilage
● Types of cells
Things to note:
● Characteristics of each type
● Major functions
Major locations
![Page 38: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/38.jpg)
Bone
● Difference between bone and cartilage
● Intramembranous ossification vs. endochondral ossification
○ Clavicle is the ONLY long bone that is formed by intramembranous ossification
○ Process of endochondral ossification
● Types of cells
● Periosteum, endosteum
● Primary bone vs. Secondary bone
![Page 39: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/39.jpg)
Muscle
● Skeletal muscle
● Cardiac muscle
● Smooth muscle
Things to note:
● Differentiating features
● Locations
![Page 40: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/40.jpg)
Nervous Tissue
● White matter vs. Grey matter
● Types of cells
○ Neuroglial cells
○ Oligodendrocytes, Schwann cells
○
● Structural organisation of a nerve
● Types of receptor organs (eg: Pacinian corpuscles, etc)
○ Might be less relevant now but good to know
● Oligodendrocytes vs. Schwann cells
![Page 41: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/41.jpg)
Lymphoid Tissue
● Types of cells
○ Monocytes
○ Basophils
○ Eosinophils
○ Neutrophils
○ Lymphocytes
● Thymus
○ HASSALL’S CORPUSCLES
○ Blood-thymus barrier
Things to note:
● LINK TO IMMUNOLOGY
● Types of cells in each organ
● Characteristic features of each
organ
● How the B cells and T cells are
arranged in each organ
![Page 42: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/42.jpg)
Skin
● Epidermis and dermis
● Accessory structures
○ Hair follicles
○ Sebaceous glands (EXOCRINE)
○ Sweat glands (EXOCRINE)
■ Merocrine
■ Aporcrine
● Mammary glands
○ Nails
● Thick skin vs. thin skin
● Cell types in the epidermis (eg:
melanocytes)
○ Likely to be less important
● Dermis
○ Papillary layer
○ Reticular layer
![Page 43: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/43.jpg)
Question Types
● What kind of cells are not present in ___?
○ Know what kind of cells ARE present in each tissue
● ___ is found in all of the following EXCEPT?
○ Know where each type of cartilage/bone/epithelium is found
● Characteristic features
○ Helps to differentiate different tissue types from each other
○ In terms of appearance, function, etc.
○ Commonly tested in factual questions
● Exceptions
![Page 44: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/44.jpg)
Sample Questions
Which of the following statements about the histology of lymph nodes is not true?
A. T lymphocytes are present in the lymphoid paracortex
B. Efferent lymphatic vessels are present in the hilum
C. The germinal centres of lymphatic follicles contain Hassall’s corpuscles
D. Lymphatic follicles are absent in the medulla
E. Macrophages are present in the sinuses
Answer: C. The germinal centres of lymphatic follicles contain Hassall’s corpuscles
NOTE: Hassall’s corpuscles are characteristic of the thymus.
![Page 45: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/45.jpg)
Biochemistry
Congrats, you are not tested this! For now
![Page 46: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/46.jpg)
JC Biology and Chemistry stuff
● pH and buffers
● Proteins and enzymes
● Enzyme kinetics
● Cellular energetics
● Central Dogma (Replication,
transcription, translation)
![Page 47: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/47.jpg)
Types of questions
● Factual questions
● Calculation questions (Henderson-Hasselbalch equation etc.)
● Amino acid questions
● Content-heavy options questions (read them carefully!)
● Higher-order thinking questions (application of knowledge to a case
scenario/data-based question)
![Page 48: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/48.jpg)
NEW!! Cell Signalling
● Broad picture
○ Types of signalling
○ Types of receptors
○ Clinical relevance
● Details on signalling pathways
○ Possible factual questions
○ Possible to come out as application questions
- case scenarios involving defects in
signalling pathways and the anticipated effect
Trust in Prof Kenneth Ban’s slides
![Page 49: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/49.jpg)
Basic ImmunologyM1 CA1 Academic Briefing AY2017/18
![Page 50: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/50.jpg)
What You Need to Know
IN PRESENCE OF PATHOGEN• Innate Immune Response• Adaptive Immune Response
• Cell-Mediated Immunity (CD8+ CTL)• Humoral Immunity (B + CD4+ T Helper)
• Important Cytokines & Receptors• Inflammation• MHC Expression• Effector T cells • CD28-B7 vs. CTLA4-B7 Interaction• PD1-PD1L Interaction• CD40-CD40L Interaction
• Downregulation of Response (Return to Homeostasis)
IN ABSENCE OF PATHOGEN
• Anatomical Organisation of Immune System• Primary (Generative) Lymphoid Organs• Lymph Node – epithelial pathogens• Spleen – blood borne pathogens
• T Cell Development (Haematopoiesis) • VDJ Recombination - Combinatorial & Junctional Diversity• Positive & Negative Selection
• B Cell Activation (Haematopoiesis)• Somatic Hypermutation • Affinity Maturation• Isotype (Heavy-Chain Switching)
![Page 51: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/51.jpg)
What You Need to Know
IN PRESENCE OF PATHOGEN• Innate Immune Response• Adaptive Immune Response
• Cell-Mediated Immunity (CD8+ CTL)• Humoral Immunity (B + CD4+ T Helper)
• Important Cytokines & Receptors• Inflammation• MHC Expression• Effector T cells • CD28-B7 vs. CTLA4-B7 Interaction• PD1-PD1L Interaction• CD40-CD40L Interaction
• Downregulation of Response (Return to Homeostasis)
IN ABSENCE OF PATHOGEN
• Anatomical Organisation of Immune System• Primary (Generative) Lymphoid Organs• Lymph Node – epithelial pathogens• Spleen – blood borne pathogens
• T Cell Development (Haematopoiesis) • VDJ Recombination - Combinatorial & Junctional Diversity• Positive & Negative Selection
• B Cell Activation (Haematopoiesis)• Somatic Hypermutation • Affinity Maturation• Isotype (Heavy-Chain Switching)
![Page 52: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/52.jpg)
Primary Lymphoid Organs (Generative)
1. Fetal Liver 2. Bone Marrow (Adult)
• B Cell Development• Lymphocyte & Myeloid
Progenitors3. Thymus (Adult)
• Migration of precursors from bone marrow into thymus
• T Cell Development
“T cells mature in ThymusB cells mature in Bone Marrow”
![Page 53: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/53.jpg)
Secondary Lymphoid Organs (Peripheral)Lymph Node
• Migration of Dendritic Cells (APC) carrying antigens from epithelial tissue
• Occurs via High Endothelial Venules
Spleen• Filters blood – old RBC &
blood-borne antigens• Red Pulp - RBC • White Pulp - Lymphoid
Cutaneous/Mucosal• Common Sites of Infection
(e.g. Peyer’s; Tonsils)• Many lymphocytes with memory cells
→ Fast response• Does not respond to commensal flora
Lymphocyte Compartmentalisation• Follicles: B cell + FDC• Paracortex: T cell• Germinal Centre:
Plasma cell (differentiated B cell)
![Page 54: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/54.jpg)
Immature T Cell
Immature B Cell
Naïve T Cell(CD 4+ or CD 8+)
Naïve B Cell(Centerocyte)
Effector B Cell
Effector T Cell
Th1
Th2
Th17
Tfh
TReg
IgM
IgG
IgE
IgA
Development
Development
IMMATURE MATURE
![Page 55: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/55.jpg)
What You Need to Know
IN PRESENCE OF PATHOGEN• Innate Immune Response• Adaptive Immune Response
• Cell-Mediated Immunity (CD8+ CTL)• Humoral Immunity (B + CD4+ T Helper)
• Important Cytokines & Receptors• Inflammation• MHC Expression• Effector T cells • CD28-B7 vs. CTLA4-B7 Interaction• PD1-PD1L Interaction• CD40-CD40L Interaction
• Downregulation of Response (Return to Homeostasis)
IN ABSENCE OF PATHOGEN
• Anatomical Organisation of Immune System• Primary (Generative) Lymphoid Organs• Lymph Node – epithelial pathogens• Spleen – blood borne pathogens
• T Cell Development (Haematopoiesis) • VDJ Recombination - Combinatorial & Junctional Diversity• Positive & Negative Selection
• B Cell Activation (Haematopoiesis)• Somatic Hypermutation • Affinity Maturation• Isotype (Heavy-Chain Switching)
![Page 56: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/56.jpg)
T Cell DevelopmentA. VDJ Recombination• Aim: Diversify T Cell Repertoire• Process in a Nutshell
1. Combinatorial Diversity – Different V-D-J combinations
2. Junctional Diversity – Addition of non-coded nucleotides at recombined joints between V-D-J segments
B. Positive & Negative Selection
• Aim: Naïve T cells that are committed to either CD4+ or CD8+ & only bind weakly to host MHC
![Page 57: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/57.jpg)
What You Need to Know
IN PRESENCE OF PATHOGEN• Innate Immune Response• Adaptive Immune Response
• Cell-Mediated Immunity (CD8+ CTL)• Humoral Immunity (B + CD4+ T Helper)
• Important Cytokines & Receptors• Inflammation• MHC Expression• Effector T cells • CD28-B7 vs. CTLA4-B7 Interaction• PD1-PD1L Interaction• CD40-CD40L Interaction
• Downregulation of Response (Return to Homeostasis)
IN ABSENCE OF PATHOGEN
• Anatomical Organisation of Immune System• Primary (Generative) Lymphoid Organs• Lymph Node – epithelial pathogens• Spleen – blood borne pathogens
• T Cell Development (Haematopoiesis) • VDJ Recombination - Combinatorial & Junctional Diversity• Positive & Negative Selection
• B Cell Activation (Haematopoiesis)• Somatic Hypermutation • Affinity Maturation• Isotype (Heavy-Chain Switching)
![Page 58: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/58.jpg)
B Cell ActivationA. Somatic Hypermutation• Centroblasts
Polymutations are introduced to antibodies expressed by proliferating B cells → Antibodies with Δ specificity to antigen
• Follicular Dendritic Cells (FDC) express iccosomes –“antigen packages”to centrocytes upon exposure to pathogen
B. Affinity Maturation• Centrocytes are made to compete against each other
for binding to iccosomes• Centroblasts with high affinity receptors outcompete those
with low affinity receptors• As amount of antigen ↓
Large number of B cells compete for small number of iccosomes → only strongest B cells can outcompete
![Page 59: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/59.jpg)
What You Need to Know
IN PRESENCE OF PATHOGEN• Innate Immune Response• Adaptive Immune Response
• Cell-Mediated Immunity (CD8+ CTL)• Humoral Immunity (B + CD4+ T Helper)
• Important Cytokines & Receptors• Inflammation• MHC Expression• Effector T cells • CD28-B7 vs. CTLA4-B7 Interaction• PD1-PD1L Interaction• CD40-CD40L Interaction
• Downregulation of Response (Return to Homeostasis)
IN ABSENCE OF PATHOGEN
• Anatomical Organisation of Immune System• Primary (Generative) Lymphoid Organs• Lymph Node – epithelial pathogens• Spleen – blood borne pathogens
• T Cell Development (Haematopoiesis) • VDJ Recombination - Combinatorial & Junctional Diversity• Positive & Negative Selection
• B Cell Activation (Haematopoiesis)• Somatic Hypermutation • Affinity Maturation• Isotype (Heavy-Chain Switching)
![Page 60: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/60.jpg)
![Page 61: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/61.jpg)
![Page 62: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/62.jpg)
![Page 63: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/63.jpg)
Inflammation: TNF; IL1, 6, 12
3 STAGES OF INFLAMMATION1. Dilation of capillaries to increase blood flow2. Microvascular structural changes and escape of
plasma proteins (antibodies, complements)3. Leukocyte (neutrophils, monocytes) transmigration
through endothelium
PROCESS OF LEUKOCYTE TRANSMIGRATION1. Rolling: Endothelial expression of selectin → tethering of
neutrophils to the endothelium2. Adhesion: Leukocytes express integrins
• ↑ Chemokines → ↑ integrin-endothelium affinity 3. Migration: Chemokine gradient stimulates motility
Cytokines are the signalling molecules of the immune system
![Page 64: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/64.jpg)
![Page 65: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/65.jpg)
MHC Expression
MHC Class I - Intracellular Antigen MHC Class II – Extracellular Antigen
Aim: Antigen needs to be broken up into small peptides for display on MHC molecules → activation of T cells
All nucleated cells
Only Antigen Presenting Cells
![Page 66: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/66.jpg)
![Page 67: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/67.jpg)
3 Signals for Activation & Proliferation of T Cells1. MHC-Antigen Complex: Recognised by T Cell Receptor
(CD4+/CD8+)
2. Costimulatory Signals: CD28-B7 Interactions• Without costimulation, the T cell is anergised (i.e. deactivated forever)
3.Release of IL-2• Clonal Expansion• Autocrine Effect:
Activated T cells increase secretion of IL-2 & increase expression of IL-2 receptors
![Page 68: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/68.jpg)
![Page 69: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/69.jpg)
Activation of Naïve T Cells → Effector T Cells
![Page 70: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/70.jpg)
Summary of Important Cytokines
1. Inflammation: TNF, IL-1, -6, -12
2. Th1: IFN-Y → Activation of Macrophages (M1)
3. Th2: IL-4 → Helminth Response
4. Th17: IL-22, IL-17 → Amplification of Leukocyte Recruitment + Barrier Response
5. IL-2: Proliferation of Naïve T Lymphocytes into Effector T Lymphocytes• Also maintains Effector Treg cells
6. Treg: IL-10, TGF-β → Shut-down of immune response (negative feedback)
![Page 71: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/71.jpg)
What You Need to Know
IN PRESENCE OF PATHOGEN• Innate Immune Response• Adaptive Immune Response
• Cell-Mediated Immunity (CD8+ CTL)• Humoral Immunity (B + CD4+ T Helper)
• Important Cytokines & Receptors• Inflammation• MHC Expression• Effector T cells • CD28-B7 vs. CTLA4-B7 Interaction• PD1-PD1L Interaction• CD40-CD40L Interaction
• Downregulation of Response (Return to Homeostasis)
IN ABSENCE OF PATHOGEN
• Anatomical Organisation of Immune System• Primary (Generative) Lymphoid Organs• Lymph Node – epithelial pathogens• Spleen – blood borne pathogens
• T Cell Development (Haematopoiesis) • VDJ Recombination - Combinatorial & Junctional Diversity• Positive & Negative Selection
• B Cell Activation (Haematopoiesis)• Somatic Hypermutation • Affinity Maturation• Isotype (Heavy-Chain Switching)
![Page 72: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/72.jpg)
http://tinyurl.com/M1CA1immunoRESOURCES
![Page 73: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/73.jpg)
Ethics & MedSoc
![Page 74: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/74.jpg)
Ethics
A pain to study but defines who
you are as a doctor
![Page 75: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/75.jpg)
To cover
● Professional attributes
● Sample question for Ethics MEQ
![Page 76: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/76.jpg)
CHIRPERS
C - Compassion
H - Honesty
I - Integrity
R - Responsibility
P - Participation
E - Empathy
R - Respect
S - Sensitivity
![Page 77: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/77.jpg)
CHIRPERS
HONESTY
● Frank
● Truthful
INTEGRITY
● Non-corruptible
● Principled
![Page 78: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/78.jpg)
HONESTY
Prof. Ng: “Did you go for histo lab”
Honest Harriet: “No I went to play Overwatch, sorry…”
![Page 79: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/79.jpg)
INTEGRITY
Sneaky Sherilyn: “Please sign histo lab attendance for me cos I fomo wanna go
Waacow”
Integrity Ivan: “Nope sorry I got morals one”
![Page 80: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/80.jpg)
CHIRPERS
RESPONSIBILITY
● Fulfilling duty
PARTICIPATION
● Engage in learning and
fellowship willingly
![Page 81: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/81.jpg)
RESPONSIBILITY
Skiving Sioh Huang: “I’m not going for histo lab”
Responsible Raj: “It’s my duty to go histo lab”
![Page 82: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/82.jpg)
PARTICIPATION
Unethical Uma: “LOL what a waste of time looking at the histo labs”
Participatory Pek Yan: “OMG if I actually try I think I can practice for SPOTS”
![Page 83: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/83.jpg)
CHIRPERS
RESPECT
● Recognise another’s worth - be it
patient or a fellow healthcare
worker
SENSITIVITY
● Understanding another’s
emotion
![Page 84: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/84.jpg)
RESPECT
Uncouth Ursula: “Prof. talks super funnily LOL what a clown”
Respectful Ralph: “Prof. DOES talk funny, but he is making time to teach us how
to look at the histo slides so maybe I should listen and not mock him”
![Page 85: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/85.jpg)
SENSITIVITY
(to Blur Beth)
Callous Clair: “hahahahaha can’t you see the lamina propria it’s so damn obvious”
Sensitive Shuo Ling: “I think I missed that part out too… OH wait here it is! Let me
show you Beth”
![Page 86: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/86.jpg)
CHIRPERS
COMPASSION
● Moved by another’s suffering
EMPATHY
● Appreciate another’s emotions
● “To put yourself in the other
person’s shoes”
![Page 87: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/87.jpg)
COMPASSION
Unkind Ulrich: “hahahahaha I got the earlier histo lab slot”
Compassionate Carissa: “you got the later histo lab slot didn’t you? Oh man :/”
![Page 88: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/88.jpg)
EMPATHY
Cold Caleb: “...............................(silence).................................”
Empathetic Eric: “I can see that you are upset… If I didn’t know about histo I’d be
upset too… Thank you for telling me… We will study histo together”
(Use NURS)
![Page 89: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/89.jpg)
CHIRPERSC - Compassion
H - Honesty
I - Integrity
R - Responsibility
P - Participation
E - Empathy
R - Respect
S - Sensitivity
![Page 90: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/90.jpg)
● A preamble
● One question, split into subparts
○ Professional Attributes (in the context of the preamble)
○ YOUR judgement and analysis with respect to a certain action or decision
○ +/- 4 Pillars of Medical Ethics
■ Usually only one part, in the context of the scenario
A typical Ethics MEQ will consist of...
![Page 91: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/91.jpg)
M, a student in medical school, met P, a sixteen-
year-old girl in the programme who suffers from a
severe facial rash. Keen to find out more about
the rash, M took a photograph of P's face. P,
visibly shocked, thought it was for her treatment
and did not protest. M subsequently found out
that the rash was due to a rare genetic disorder.
Intending to share his knowledge, he uploaded
the picture on his blog.
![Page 92: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/92.jpg)
What do you understand by the terms respect and
sensitivity with respect to the professionalism
undertaking? (2m)
Respect: recognize another’s intrinsic worth
Sensitivity: to be aware of the other’s feelings and motives
![Page 93: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/93.jpg)
Give 2 reasons why M might have failed to
demonstrate respect towards P. (2 m)(remember, get straight to the point)
Took photograph without permission – did not see her as a patient but object to
be studied
Uploaded her picture – did not RESPECT her privacy
NOT: took her photograph – did not understand she was suffering
DEFINITELY NOT: should have asked her permission before posting on the blog
![Page 94: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/94.jpg)
Give 2 reasons why M might have failed to
demonstrate sensitivity towards P. (2 marks)Took photograph – did not appreciate she might be self-conscious
Did not notice her shock – not attuned to her emotions
DEFINITELY NOT: did not get her good side
![Page 95: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/95.jpg)
Name one other professional attribute (other than
respect and sensitivity) that was inconsistent with
M's behaviour. Explain why this is so. (2 marks)
● Compassion – was not moved by her suffering; instead, M’s overriding
concern was to study P’s condition
![Page 96: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/96.jpg)
Would it have been acceptable if M uploaded the
photo on a private blog accessible only to his close
friends? (2 marks)
NO! NO! NO!
Still... NOOOOO!!!!!
(give 2 reasons)
Integrity: Would have involved deception (she didn’t know so it’s okay...?) – on
principle unacceptable
Respect: No respect for her right to privacy
![Page 97: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/97.jpg)
MedSoc
Because social studies just
wasn’t enough...
![Page 98: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/98.jpg)
The focus...
Changing Health Behaviour
![Page 99: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/99.jpg)
Tony & Joel’s on Dropbox
![Page 100: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/100.jpg)
Health Belief Model
Focuses on the perception of an individual
Perceived:
● Benefits
● Costs
● Barriers
● Susceptibilities/Risks
![Page 101: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/101.jpg)
Social Cognitive Theory
People around you and the environment affects your behaviour
● Relatives
● Workplace
● Society
Behaviour
Personal Environment
![Page 102: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/102.jpg)
Trans-Theoretical Model
Precontemplation: Unaware there is a problem → Point out the problem
Contemplation: Aware there is a problem → Help to weigh pros and cons
Preparation: Planning to do stuff → Encourage + Move onto action
Action: Doing stuff → Reduce negative influence and temptations + Accountability
Prevent Relapse: May happen at any time → Need for accountability
![Page 103: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/103.jpg)
● A preamble - usually involves the main character having to make a
DECISION but isn’t doing it e.g. mammogram
● One question, split into subparts
○ Possible reasons for not proceeding with the decision → HEALTH BELIEF MODEL
○ How to persuade/encourage the main character to proceed with the decision → HEALTH
BELIEF MODEL +/- (TRANS-THEORETICAL MODEL)
A typical MedSoc MEQ will consist of...
![Page 104: CA1 Briefing - · PDF fileEmbryology Unlikely to come out for MEQs For now (since developmental abnormalities in the limbs are not too common clinically) Learn the Trilaminar Germ](https://reader033.vdocuments.us/reader033/viewer/2022042800/5a726a237f8b9aa2538d9092/html5/thumbnails/104.jpg)
What to take note of for MedSoc...
Overall approach to Medicine & Society Question:
●The Health Belief Model is especially relevant to health screening scenarios, and thus should be
used. Other models may also be used, and credit will be given if used appropriately.
●Remembering the structure of the Health Belief Model is helpful in the structuring of your
answer for both parts of this question. The Health Belief Model outlines various factors that
affect the person’s willingness to go for a screening, and these can be tackled individually to help
to convince the person to go for screening.
Review Pointers:
●It is crucial to apply the theory in the given scenario. Basic format to follow - cite the theory
then explain it in the given context.
●DO NOT MAKE UP THE NAME OF THE BEHAVIOURAL THEORY!!!
If you don’t know what it’s called, just explain its usage.