c argentina arg-1 - iaea9 country: argentina arg-2 [1] institute: fundación escuela de medicina...
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COUNTRY: ARGENTINA ARG-1 [1] INSTITUTE: Comisión Nacional de Energia Atómica (CNEA)
Avenida del Libertador 8250 1429 Buenos Aires
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+54 11 4379 8250 [email protected] +54 11 4480 0615
[2] PERSON IN CHARGE: POSITION:
Mr. Carmelo Rocco Head of the Facility
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Roberto Strangls, in charge of Operation Mr. Eduardo Haro, in charge of Maintenance Mr. Guillermo Casale, in charge of Radiochemistry
[3] TYPE OF CYCLOTRON: Isochronous, negative ion
YEAR OF: (I) INSTALLATION: 1994
MANUFACTURER: The Cyclotron Corporation
(II) UPGRADE: Beam current increase
MODEL: CP - 42 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 25/42 Yes No Maximum beam available (µA) 150 Typical beam employed (µA) 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
29 22 - 7 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 18F, 123I, 18FDG, 123I iodide and other compounds [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s and how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
8
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 55 weekly Yes No Yes No US$ 310 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) The production of high purity 123I is a project that was carried out under the IAEA’s Technical Co-operation Programme (ARG/4/085). The IAEA supported the CNEA efforts to set up required facilities including different system provision of expert and personnel training.
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COUNTRY: ARGENTINA ARG-2 [1] INSTITUTE: Fundación Escuela de Medicina Nuclear
Garibaldi 405, CP 5500 Mendoza 1429
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+54 261 4201 615 (1ext. 564; 2ext. 562; 3 ext. 508) [email protected] +54 261 4203 288
[2] PERSON IN CHARGE: POSITION:
Ing. Enrique R. Noya1 Electronic Engineer – Head of Operation and Maintenance
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Fernando Spigatin2, Head of Radiochemical Laboratory Ing. Norma Acosta3, Head of Radiological Security
[3] TYPE OF CYCLOTRON: Negative ion hospital cyclotron
YEAR OF: (I) INSTALLATION 1997
MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS:
This cyclotron is not self-shielded. This is installed inside a bunker. All the support equipment is located in different rooms. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 8 2 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 15O, 11C [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
10
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 20 >97 0.330 100
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 10 5/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 4 6/week p+ H20 Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
11
COUNTRY: AUSTRALIA AUL-1 [1] INSTITUTE: Austin and Repatriation Medical Centre
Studley Road Heidelberg, VIC 3084
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+61 3 9496 3995 [email protected] +61 3 9496 5892
[2] PERSON IN CHARGE: POSITION:
Dr. Henri Tochon-Danguy Senior Radiochemist
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. John Sachinidis, Radiochemist Dr. Uwe Ackermann, Radiochemist Mr. Stan Poniger, Cyclotron/Robotic Engineer
[3] TYPE OF CYCLOTRON: Negative ion accelerator
YEAR OF: (I) INSTALLATION 1992
MANUFACTURER: IBA, s.a. (II) UPGRADE: 1996 (new sources) MODEL: Cyclone 10/5 2001 (remote start-up & control) [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 50 20 Typical beam employed (µA) 25 8 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
18 16 1 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 16 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 124I, 18F-MPPF, 18F – A 85380, 18F- Thymidine analogue [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 6 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
12
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 40 97 0.6 100
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 24 7/week Yes No Yes No 18F MISO 2 1/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Flumazenil 4 1/week Yes No Yes No SCH23390 4 1/week Yes No Yes No AG 957 2 1/month Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 4 1/month 16O[p, ά] 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
O2 4/min 1/week 14N[d, n] 15O Water 1/min 1/week 14N[d, n] 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
13
COUNTRY: AUSTRALIA AUL-2 [1] INSTITUTE: Australian Nuclear Science & Technology Organization (ANSTO)
Radiopharmaceutical Division New Illawarra Road
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+61 2 9717 9079 [email protected]
[2] PERSON IN CHARGE: POSITION:
Dr. S. Carr Director, Radiopharmaceuticals
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
D. Arnott
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: IBA, s.a. (II) UPGRADE: 1997 MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
140 90 60 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
14
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
15
COUNTRY: AUSTRALIA AUL-3 [1] INSTITUTE: Peter MacCallum Cancer Institute
12 Cathedral Place East Melbourne 3002, Victoria
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+61 3 9656 1852 [email protected] +61 3 9656 1826
[2] PERSON IN CHARGE: POSITION:
Dr. Rodney J. Hicks Associate Professor/Director, PET Centre
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Peter Eu, Radiochemist
[3] TYPE OF CYCLOTRON: Superconducting YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: Oxford (II) UPGRADE: MODEL: 12 MeV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
13 12 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 18F-AZA, 18F-LT [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F, Wesley Private Hospital/ 2-3 times/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 2 – Small animal 1
(Jan. 2002 delivery)
– Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
16
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 55 95 5 500
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 6.5 1-2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
17
COUNTRY: AUSTRIA AUS-1 [1] INSTITUTE: ARGOS Zyklotron
Betriebs-Ges.m.b.H. LKH Klagenfurt, PET-Zentrum NMSE St. Veiter Str. 47, A-9026 Klagenfurt
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+43 (0) 463 500 705 +43 (0) 463 500 705 14
[2] PERSON IN CHARGE: POSITION:
Dr. Michael W. Nader Chemist
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Stefan Weber, Leading Technician
[3] TYPE OF CYCLOTRON: PT YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: GE Medical Systems (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8.5 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
25 25 3 2 22 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Isotope production [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): (18F) FLT, 124I, 86Y [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
18
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 120 95-96
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
FDG 65 Yes No Yes No DOPA Yes No Yes No MISO 30 Yes No Yes No Fluoride 150 Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionin Yes No Yes No Cholin Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
19
COUNTRY: AUSTRIA AUS-2 [1] INSTITUTE: Österreichisches Forschungszentrum Seibersdorf
Department of Radiopharmaka A-2444 Seibersdorf
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+43 0 50 550 3470 [email protected] +43 0 50 550 3473
[2] PERSON IN CHARGE: POSITION:
Dr. Peter Angelberger Department Head
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Herbert Kvaternik, Deputy
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: GE Uppsala (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
15 10 4 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Further 18F radiopharmaceuticals [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
20
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 130 95 250
Yes No
20Ne (d, α) 18F 20 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 65 5/week Yes No Yes No FDOPA 2 2/month Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
21
COUNTRY: BELGIUM BEL-1 [1] INSTITUTE: Erasme Hospital
PET/Biomedical Cyclotron Unit Brussels Free University 808, Route de Lennik
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+32 2 555 4711 [email protected] +32 2 555 4701
[2] PERSON IN CHARGE: POSITION:
Dr. Serge Goldman
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Damhaut M. Monshus J. Van Naemen
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS:
1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
9 2 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) 11( for PET) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
22
18
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 65 > 94 1.3 150 - 200
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 40 4 - 5 batch/week Yes No Yes No [18F] MPPF 20/year Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionin ~ 9 8/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 3.7 6/week 16O (p, α) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 3.7 only for research 16O( p, pn) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
23
COUNTRY: BELGIUM BEL-2 [1] INSTITUTE: Institute of Nuclear Sciences
University of Ghent Proeftuinstraat 86, B-9000 Gent
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+32 9 264 6616 [email protected] +32 9 264 6699
[2] PERSON IN CHARGE: POSITION:
Professor Dr. Karel Strijckmans Professor
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1977 MANUFACTURER: CGR-MeV (France) (II) UPGRADE: 1982 MODEL: 520 [4] CYCLOTRON CHARACTERISTICS:
1H 2H 3He 4He Dual Beams Beam energies (MeV) 2.5 – 24 3 – 14.5 6 – 32 10 – 29 Yes No Maximum beam available (µA) 100 100 60 60 Typical beam employed (µA) 20 5 - - [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20-30 10 10-20 <1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: <1 Activation analysis: <1 Other (specify) PIXE 10-20 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Tracers 1
207Bi 0.4 MBq Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En = 7MeV [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
24
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 15 97 0.8 50
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 4 3-4/week Yes No Yes No seronotin receptor antagonist
Yes No Yes No
Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
PK 11195 4 <1/week Yes No Yes No CAMPRAL 4 <2/week Yes No Yes No new research molecules
Yes No Yes No
Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED
Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on line (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
O2 4 GBq min-1 <1/week 14N(d, n) 15O CO2 4 GBq min-1 <1/week 14N(d, n) 15O CO 2 GBq min-1 <1/week 14N(d, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
81Rb 81mKr 0.6 2/week Yes No Yes No 48V <1/week Yes No Yes No 114In <1/week Yes No Yes No 75Se <1/week Yes No Yes No 74As <1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
25
COUNTRY: BELGIUM BEL-3 [1] INSTITUTE: MDS Nordion S.A.
Zone Industrielle B-6220 Fleurus
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+32 10 829 211 +32 10 829 696
[2] PERSON IN CHARGE: POSITION:
Dr. Claude Pirarat Manager, Radiochemical Production
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: Isochronous Cyclotron H-
YEAR OF: (I) INSTALLATION 1992
MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS:
1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 - 30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 400 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
160 160 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Bulk 201Tl – Europe, North and South America, 123I, 201Tl – Europe (OEM manufacturing)
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
26
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No 123I 100 – 250 4/week Yes No Yes No 201Tl 150 - 300 5/week Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
27
COUNTRY: BELGIUM BEL-4 [1] INSTITUTE: Universite catholique de Louvain
Centre de Recherches du Cyclotron 2, Chemin du Cyclotron, B-1348 Louvain-la-Neuve
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+32 10 472 998 [email protected] +32 10 452 183
[2] PERSON IN CHARGE: POSITION:
Mr. Guido Ryckewaert Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Daniel Labar – Head of Radiochemistry
[3] TYPE OF CYCLOTRON: Compact H- YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: UCL/IBA, s.a. (II) UPGRADE: MODEL: Prototype
Cyclone 30
[4] CYCLOTRON CHARACTERISTICS:
1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 – 30 Yes No Maximum beam available (µA) 350 Typical beam employed (µA) 50/300 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30 - 4 15 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 15 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
28
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 80 95 2 200
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 40 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 5 monthly Yes No Yes No Methionine 5 weekly Yes No Yes No Flumazenil 5 monthly Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
NH4OH 5 weekly 16O(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 10 2/week 16O (p, pn)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 1 weekly Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
29
COUNTRY: BELGIUM BEL-5 [1] INSTITUTE: Universite catholique de Louvain
Centre de Recherches du Cyclotron 2, Chemin du Cyclotron, B-1348 Louvain-la-Neuve
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+32 10 472 998 [email protected] +32 10 452 183
[2] PERSON IN CHARGE: POSITION:
Mr. Guido Ryckewaert Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Daniel Labar – Head of Radiochemistry
[3] TYPE OF CYCLOTRON: Isochronous multiparticle variable energy
YEAR OF: (I) INSTALLATION 1969-1972
MANUFACTURER: Thomson – CSF. (II) UPGRADE: MODEL: Cyclone [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 – 85 10 – 55 15 – 145 20 - 110 Yes No Maximum beam available (µA) 30 20 5 20 Typical beam employed (µA) 20 10 5 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
150 8 - 4 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? To two centres, sporadically. Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
30
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
28Mg 20 MBq Al (100%) Yes No Yes No 52Fe 0,2 – 2 MBq Mn (100%) Yes No Yes No 94,95,96Tc 0,1 – 0,01 MBq Mo (nat) Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
31
COUNTRY: BELGIUM BEL-6 [1] INSTITUTE: Universite de Liege
Centre de Recherches du Cyclotron Sart Tilman, B-4000 Liege
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+32 4 366 2360 [email protected] +32 4 366 2946
[2] PERSON IN CHARGE: POSITION:
Dr. A. Luxen Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
C. Brihaye, Senior Radiochemist G. Del Fiore, Senor Radiochemist C. Lemaire, Senior Radiochemist A. Plenevaux, Senior Radiochemist, Aerts/Pharmacist
[3] TYPE OF CYCLOTRON: H-/D- YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 50 35 Typical beam employed (µA) 50 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30 10 20 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) PET/30 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Several radiopharmaceuticals specific for receptoe and gene expression imaging. [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
32
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 4 Ci 95 2 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 75 250/year Yes No Yes No FTyrosine 11 12/year Yes No Yes No FDopa 11 12/year Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 0.37 4000/year
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
33
COUNTRY: BELGIUM BEL-7 [1] INSTITUTE: University of Leuven (KUL)
Department of Nuclear Medicine, U.Z. Gasthuisberg Herestraat 49 B-3000 Leuven
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+32 16 34 3715 [email protected] +32 16 34 3759
[2] PERSON IN CHARGE: POSITION:
Luc Mortelmans, MD, PhD. Head of Nuclear Medicine
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 10/5 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 70 50 Typical beam employed (µA) 45 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
5 4 0 1 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 0 Gamma camera 3 Single photon tomography (SPET) 3 Positron emission tomography (PET) 2 – Clinical 0 – Small animal 0 – Plant biochemistry 0 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
34
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F #1 — 20 GBq
#2 — 70 GBq 97 #1 — 0,5 mL
#2 — 2 mL Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 350 GBq 1-2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 2 1/week Yes No Yes No Acetate 2 0,5/week Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13N H3 2 3/week 16O(p,x) Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
H215O 2 2-3/week 14N(d,n)
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
35
COUNTRY: BELGIUM BEL-8 [1] INSTITUTE: Vrije Universiteit Brussels
Eenheid Cyclotron Laarbeeklaan 103, B-1090 Brussels
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+32 2 4774 864 or +32 2 477 4860 [email protected] [email protected] +32 2 477 4855
[2] PERSON IN CHARGE: POSITION:
Professor A. Hermanne Head, Cyclotron Department
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Professor P. Van den Winkel Professor J. Mertens
[3] TYPE OF CYCLOTRON: AVR YEAR OF: (I) INSTALLATION 1983 MANUFACTURER: CGR France (II) UPGRADE: MODEL: 560 [4] CYCLOTRON CHARACTERISTICS: All beams are extracted with an electrostatic deflector – average 50%.
1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-42 10-22 20-50 20-43 Yes No Maximum beam available (µA) 100 100 10 20 Typical beam employed (µA) 2-30 8 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
2 3 2 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 7 Proton therapy: Physics: 3 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En > 25 MeV. Thin targets
neutron TOF spectroscopy [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Neurotensin analogues; 18F peptides and aromatic amino acids; Pd- 103 for research labelling and rodent studies;
188Rh 186Rh [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? RUG , SCK Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? In academic hospitals – Nuclear Medicine
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera > 3 Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical From June 2001 – Small animal collaboration with RUG – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience Yes No
36
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 16 95 0.45 40 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 8 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED
Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 37 2-4 /week Yes No Yes No Stopped in 1996 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) Additional labelled compounds: 77Br, 56Co, 123I , 111In, 206Tl neurotensin analogues, 123I peptides and aromatic amino acids
37
COUNTRY: BRAZIL BRA-1 [1] INSTITUTE: Instituto de Engenharia Nuclear (IEN)
Caixa Postal 68550, Cidade Universitária S/N – Ilha do Fundão 21945-970 – Rio de Janeiro – RJ
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+55 21 560-4113 ext. 2184 [email protected]
[2] PERSON IN CHARGE: POSITION:
Dr. Julio Cezar Suita Head, Radiopharmaceutical Division
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Ana Maria Silveíra Braghirolli José Antônio Dias Furlaneto Jackson Louis Queiroz de Britto Migual Ângelo Valle Bastos
[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1975 MANUFACTURER: The Cyclotron
Corporation (II) UPGRADE:
MODEL: CV-28 [4] CYCLOTRON CHARACTERISTICS: Variable energy and multiparticle 1H 2H 3He 4He Dual Beams Beam energies (MeV) 24 14 36 28 Yes No Maximum beam available (µA) 50 75 30 25 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
32 20 4 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Occasionally Mössbauer sources? (specify which & quantity) Yes No Occasionally X ray sources? (specify which & quantity) Yes No Occasionally Intense neutron beam? (specify average En = ?) 17 MeV Yes No Occasionally [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): n-isopropyl para-iodine anphetamine labelled with 123I [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for agricultural
applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
38
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (ml)
18O2 (l) 18O (p, n) 18F 11 96 0.3 30 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 6 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 15 3/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) Meta – iodinebenzilguanine labelled with 123I has also been produced.
39
COUNTRY: BRAZIL BRA-2 [1] INSTITUTE: Instituto de Pesquisas Energéticas e Nucleares – IPEN/CNEN-SP
Travesa , R, 400, Cidade Universitária CEP – 05508-900, São Paulo, SP
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+55 11 3816 9275/ 9265 [email protected] +55 11 3816 9263
[2] PERSON IN CHARGE: POSITION:
Dr. Wanderley de Lima Head, Cyclotron Laboratory
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dra. C. Pagano G. da Silva, Head – Radioisotope Department Uylton Matsoda Valdir Sciani
[3] TYPE OF CYCLOTRON: Fixed field, fixed frequency
YEAR OF: (I) INSTALLATION 1998
MANUFACTURER: TBA, S.A. (II) UPGRADE: MODEL: Cyclone - 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 500 Typical beam employed (µA) 200 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 18 - 2 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 201Tl, 111In [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Hospitals and medical centers/ weekly
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
40
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37 94 2 200 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
FDG 500 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 50 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 20 1/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) As of June 2001, MIBG 123I, HEPPURAN 123I and radiopharmaceutical for neuroreceptors are produced.
41
COUNTRY: BRAZIL BRA-3 [1] INSTITUTE: Instituto de Pesquisas Energeticas e Nucleares - IPEN - CNEN/SP
Travessa R. 400, Cidade Universitaria CEP 05508 – 900, São Paulo, SP
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+55 11 3816 9185/9000 [email protected] +55 11 3816 9257
[2] PERSON IN CHARGE: POSITION:
Dr. C. Pagano G. da Silva Head, Radioisotope Department
OTHER SENIOR STAFF: NAME/POSITION
Dr. Wanderley de Lima, Head – Cyclotron Laboratory
[3] TYPE OF CYCLOTRON: Isochronous compact, variable
YEAR OF: (I) INSTALLATION 1981
MANUFACTURER: The Cyclotron Corp. (II) UPGRADE: MODEL: CV-28 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 2-14 4-14 6-36 8-28 Yes No Maximum beam available (µA) 200 300 135 90 Typical beam employed (µA) 10-20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
1.7 0.5 0.2 1.0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 0.5 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 0.5 Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No 0.5 Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
42
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) All the radiopharmaceuticals are produced with the Cyclone – 30.
43
COUNTRY: CANADA CAN-1 [1] INSTITUTE: Clark Institute of Psychiatry
250 College Street Toronto, ON M5T 1R8
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 416 979 4651 +1 416 979 4656
[2] PERSON IN CHARGE: POSITION:
Dr. Sylvain Houle Head, PET Centre
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Allan A. Wilson Jean Da Silva
[3] TYPE OF CYCLOTRON: Fixed energy isochronous
YEAR OF: (I) INSTALLATION 1991
MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 15-60 20-25 Typical beam employed (µA) 10-40 10-12 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20-25 20-22 2-3 (additional 1-week maintenance/year
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
44
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18F-FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C-raclopride Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
15O-water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
45
COUNTRY: CANADA CAN-2 [1] INSTITUTE: Cross Cancer Center
University of Alberta Edmonton, Alberta
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 403 492 2905
[2] PERSON IN CHARGE: POSITION:
Dr. Steve McQuarrie
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: TR19, (p,d) YEAR OF: (I) INSTALLATION October, 2001 MANUFACTURER: EBCO. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 200 µA beam 1H 2H 3He 4He Dual Beams Beam energies (MeV) 19 9 Yes No Maximum beam available (µA) 200 100 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron usefor education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
46
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
47
COUNTRY: CANADA CAN-3 [1] INSTITUTE: Hamilton Health Sciences Corporation
Department of Nuclear Medicine Mc Master Site, 1200 Main Street West, Room 1 P 6 Hamilton, ON L8N3Z5
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 905 521 2100 ext. 76893/73025 [email protected] +1 905 546 1125
[2] PERSON IN CHARGE: TITLE/POSITION:
Dr. Raman Chirakal Radiochemist
OTHER SENIOR STAFF: NAME/POSITION
Jia Juen Chen
[3] TYPE OF CYCLOTRON: RDS 112 YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: Negative ion cyclotron 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
5 3 2 1 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 3 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Research - 2 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Ottawa Heart Institute, 1/week Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
48
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 18.5 94 0.8 14 200 10
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
FDG 10 6/week Yes No Yes No J6 – F MT 1.12 1/week Yes No Yes No J6 - FDOPA 0.3 2/month Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
ACETATE 0.3 2/month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
AMMONIA 0.8 4/week 16O(p, α) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
WATER 5.6 9/month
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
49
COUNTRY: CANADA CAN-4 [1] INSTITUTE: Montreal Neurological Institute
McGill University 3801, University Street Montreal, Quebec H3A2BA
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 514 398 8526 [email protected] +1 514 398 8540
[2] PERSON IN CHARGE: POSITION:
Prof. Mirko Diksic
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Dean Jolly
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1993 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 100 60 Typical beam employed (µA) 30-40 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20-30 20-30 2-3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for agricultural
applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
50
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18F-FDG Yes No Yes No 18F-DOPA Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C-RO Yes No Yes No Deprenyl Yes No Yes No α-methyl- L-trypotophan
Yes No Yes No
Bensotropine Yes No Yes No PK-11195 Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)
51
COUNTRY: CANADA CAN-5 [1] INSTITUTE: TRIUMF
4004 Westbrook Mall Vancouver, BC V6T 2A3
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 604 222 1047 [email protected] +1 604 222 1074
[2] PERSON IN CHARGE: POSITION:
Dr. Stefan K. Zeisler Manager, Applied Technology Groups
OTHER SENIOR STAFF: NAME/POSITION
Mr. R. Van Den Elzen
[3] TYPE OF CYCLOTRON: H- / sector-focused YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: EBCO (II) UPGRADE: 1995 MODEL: TR30 [4] CYCLOTRON CHARACTERISTICS 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 1200 Typical beam employed (µA) 1000 [5] CYCLOTRON OPERATION:
Total hours (h)/ week h/week for radionuclide production
h/week for research
h/week for maintenance
h/week for applications
168 148 - 20 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
52
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd ~7/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 3/week Yes No Yes No 201Tl ~5/week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) Yields and prices of commercial products are confidential and cannot be reported.
53
COUNTRY: CANADA CAN-6 [1] INSTITUTE: TRIUMF
4004 Westbrook Mall Vancouver, BC V6T 2A3
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 604 222 1047 [email protected] +1 604 222 1074
[2] PERSON IN CHARGE: POSITION:
Dr. Stefan K. Zeisler Manager, Applied Technology Group
OTHER SENIOR STAFF: NAME/POSITION
Mr. R. Van Den Elzen
[3] TYPE OF CYCLOTRON: 520 MeV H-/ sector-focused
YEAR OF: (I) INSTALLATION 1962
MANUFACTURER: TRIUMF (II) UPGRADE: 1997 MODEL: [4] CYCLOTRON CHARACTERISTICS: Isotope production beam line only 1H 2H 3He 4He Dual Beams Beam energies (MeV) 500 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 70 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
144 4 months/year [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
54
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 82 Sr/ 82Rb, Mo(p, spall) — ~ 8 targets/year
55
COUNTRY: CANADA CAN-7 [1] INSTITUTE: TRIUMF
4004 Westbrook Mall Vancouver, BC V6T 2A3
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 604 222 1047 [email protected] +1 604 222 1074
[2] PERSON IN CHARGE: POSITION:
Dr. Stefan K. Zeisler Manager, Applied Technology Group
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. R. Van Den Elzen
[3] TYPE OF CYCLOTRON: H-/sector-focused YEAR OF: (I) INSTALLATION 1980 MANUFACTURER: The Cyclotron
Corporation (II) UPGRADE: 1991
MODEL: CP42 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 42 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 180 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
168 158 1 9 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? University of British Columbia, Botany Department, 1-2 times/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
56
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13N – NO3 7 1/week 16O(p, α) Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 5/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/month Yes No Yes No 123I 3/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Yields and prices of commercial products are confidential and cannot be reported.
57
COUNTRY: CANADA CAN-8 [1] INSTITUTE: UBC/TRIUMF PET Programme
4004 Westbrook Mall Vancouver, BC V6T 2A3
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 604 222 1047 [email protected] +1 604 222 1074
[2] PERSON IN CHARGE: POSITION:
Dr. Thomas Ruth PET Director/Senior Research Scientist
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Ken Buckley, PET Project Engineer
[3] TYPE OF CYCLOTRON: Negative ion, sector focused
YEAR OF: (I) INSTALLATION 1994
MANUFACTURER: EBCO (II) UPGRADE: MODEL: TR13 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 13 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
25 15 10 4 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 2 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? University of Alberta - 18 F, 1 /week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
58
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F F 2 – 18.5
F -26 >90 0.5 500 50 1
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 3.7 1/week Yes No Yes No 18F SETOPERONE 1.8 1/week Yes No Yes No 18F DOPA 0.8 3/week Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Raclopride 1.1 3/week Yes No Yes No Schering 1.1 3/week Yes No Yes No Methylphenidate 1.1 3/week Yes No Yes No Pk 11195 1.1 3/week Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
NOX 3.0 3/week 16O (p, α ) Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C PMP, 1.1 GBq, 1/week
59
COUNTRY: CANADA CAN-9 [1] INSTITUTE: University of Ottawa Heart Institute
TELEPHONE NO.:
E-MAIL ADDRESS: FAX NO.:
+1 613 761 5296
[2] PERSON IN CHARGE: POSITION:
Dr. Rob Beanlands Director, Cardiac PET Centre
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Gunter Firnau Dr. Rob deKemp
[3] TYPE OF CYCLOTRON: RDS-111 YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: CTF, Inc. (II) UPGRADE: MODEL: RDS-111 [4] CYCLOTRON CHARACTERISTICS: Protons only, 11 MeV 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30-40 [5] CYCLOTRON OPERATION:
Total hours (h)/week h/week for radionuclide production
h/week for research
h/week for maintenance
h/week for applications
10 8 2 0.5 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Target research [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Ottawa General Hospital — FDG, 2/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence (Ottawa General Hospital) — ADAC 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical — ECAT – ART 1 ECAT – MR 1 – Small animal (in next phase) – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
60
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37 96 1.1 ~300 -
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
FDG 22.2 1/day Yes No Yes No Fluoronovadrenalin
Yes No Yes No
Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 3.7 1/day Yes No Yes No HED 3.7 2/week Yes No Yes No Ligand for β-receptor
Yes No Yes No
Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED
Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia ~ 5 daily 16O (p, α ) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 3.7 1/week 15N(p, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc only target
research Yes No Yes No
103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I only target
research Yes No Yes No
201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) – The Ottawa Heart Institute PET Centre is dedicated to the development of cardiac PET imaging. – We are not working on oncology problems. – Basic research in the Heart Institute will be combined with PET imaging (e.g. Angiotensin II receptor ligand). – Target development for 124I and 94mTc.
61
COUNTRY: CHINA, PEOPLE'S REPUBLIC CPR-1 [1] INSTITUTE: China Institute of Atomic Energy
P.O. Box 275 (99) Beijing 102413
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+86 01 69358090 +86 01 69357195
[2] PERSON IN CHARGE: POSITION:
Dr. Li Da Kang
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Zhao Gui Zhi; Zhao Zhen Lu Shen de Heng Xu Shu He
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: IBA sa (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) Typical beam employed (µA) 100-220 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
4 days/week 4 days/week 1 day/week [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123I, 186Re [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 57Co to USA 1 per month Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
62
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F
Yes No
Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
63
COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-2 [1] INSTITUTE: Guangdong Province People's Hospital
96 Dong Chuan Road Guangzhou 5 10 100
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+11 86 20 8382 7812 +11 86 20 8382 5453
[2] PERSON IN CHARGE: POSITION:
Dr. Tang Au-Wu
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.1 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 38.5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
18 12 2 2 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
64
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 1.2 260
Yes No
Ne (d,α) 18F 16O (α , d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
FDG 30 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
AMMONIA 4 1/week 16O (p , α ) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 22 3/month 15N (p , n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
65
COUNTRY: CHINA, PEOPLE’S REPUBLIC OF CPR-3 [1] INSTITUTE: Hong Kong Sanatorium & Hospital, Ltd.
Department of Radiology & Radiotherapy 2 Village Road, Happy Valley Hong Kong
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+11 852 2835 8989 +11 852 2835 8825
[2] PERSON IN CHARGE: POSITION:
Dr. C.L. Ho Director, Department of Nuclear Medicine and PET
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. David W.C. Young, Deputy Director Mr. Steve H.Q. Sitt, Manager Dr. M.K. Cheung, Radiochemist
[3] TYPE OF CYCLOTRON: - YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: CTI, Inc. (II) UPGRADE: - MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
6 5 – 18F; 1 – 11C 1 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O-oxygen; 18F-Fluoroestradiol, 18F-choline, 18F-fluoro-α-methyltyrosine, 18F-DOPA [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
66
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F ~ 37 95 1100
Yes No
Ne(d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG ~ 15 5 batches/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate ~ 3.7 1-2/week Yes No Yes No Choline ~ 3.7 1/month Yes No Yes No Methionine ~ 3.7 1/ month Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia ~ 1.8 1/month O(p, α) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
67
COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-4 [1] INSTITUTE: Institute of Applied Chemistry
Beijing Normal University Bejing Cyclotron Produced Radiopharmaceutical Laboratory 100875 Beijing
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+86-01-6220 7786 or 8396 [email protected] +86-01-62200567
[2] PERSON IN CHARGE: POSITION:
Professor Bo Li Liu Dean
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Huang Zheng Xing Professor Liu Zheng Hao Zhang Hui Xing Chen Ru Yi
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: TCC (II) UPGRADE: MODEL: CS-22 [4] CYCLOTRON CHARACTERISTICS: Our CS-22 will be used to produce radiopharmaceuticals in 2002. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 22 11 29 Yes No Maximum beam available (µA) 50 50 50 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18 F, 67 Ga, 111In, 18 FDG, 18F - DOPA [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
68
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 95 0.3
Yes No
Ne (d, α) 18F 16O (α , d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No 18F - DOPA Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
69
COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-5 [1] INSTITUTE: Institute of Applied Chemistry
Beijing Normal University Bejing Cyclotron Produced Radiopharmaceutical Laboratory 100875 Beijing
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+86 01 6220 7786 or 8396 [email protected] +86 01 6220 0567
[2] PERSON IN CHARGE: POSITION:
Professor Bo Li Liu Dean of Radiochemistry
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Huang Zheng Xing Professor Liu Zheng Hao Zhang Hui Xing Chen Ru Yi
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1986 MANUFACTURER: TCC (II) UPGRADE: MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 26 15 30 Yes No Maximum beam available (µA) 200 200 100 Typical beam employed (µA) 110 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
70
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α , d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
71
COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-6 [1] INSTITUTE: Peking Union Medical College Hospital
Nuclear Medicine Department PET Centre Beijing 100730
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+86 10 652 33129 +86 10 652 33129
[2] PERSON IN CHARGE: POSITION:
Dr. Chien Chou
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 35-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
4 – 8 2 - 3 1 - 2 1 - 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence EXACT HR + Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
72
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 14.8 - 29.6 > 94 1.1 Yes
No Ne (d, α) 18F 16O (α , d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 7.4 – 11.1 2-3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 18F-F–Ethyl–tyrosine: not in clinical trial yet.
73
COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-7 [1] INSTITUTE: Shanghai Institute of Nuclear Research
P.O. Box 800-204 201800 Shanghai
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+86 21 5955 3634 [email protected] +86 21 5955 2509
[2] PERSON IN CHARGE: POSITION:
Professor Wang Yongxian Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Cao Benhong Gao Wenzhao Yuyi
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 150 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
50 50 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
74
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α ,d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 5500 - 7400 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 12950 - 14800 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 14800- 16650 2/week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
75
COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-8 [1] INSTITUTE: The PLA General Hospital
28 Fuxing Road Beijing 100853
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+86 10 6693 9424 [email protected] or [email protected] +86 10 681 31142
[2] PERSON IN CHARGE: POSITION:
Professor Jia-he Tian
OTHER SENIOR STAFF: NAME/POSITION
Jinming Zhang
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
8 4 1 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
76
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37 1.1 150
Yes No
Ne (d,α) 18F 16O (α ,d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
FDG 18.5 2-4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 3.7 1-2/week Yes No Yes No Methioine 2 0-1/week Yes No Yes No RACLOPRIDE 2 0-1/week Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
AMMONIA 1.5 2/week 16O(p, α ) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
WATER 74 0-1/week 15N(p, n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
77
COUNTRY: CHINA, PEOPLE'S REPUBLIC OF CPR-9 [1] INSTITUTE: Zibo Wanjie Hospital
Boshan, Zibo Shandong
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+86 533 4650 000 8730 +86 533 4650 830
[2] PERSON IN CHARGE: POSITION:
Dr. Sun Qiyin
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Wang Ming Fang Zhao Jun Wang Changqing Li Jiamin
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
6 5 7 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 15O, 82Rb [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried
out on-site? Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
78
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
79
COUNTRY: CZECH REPUBLIC CZR-1 [1] INSTITUTE: Nuclear Physics Institute
Rez near Prague 25068 Rez
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+420 2 6617 3613 [email protected] +420 2 20941130
[2] PERSON IN CHARGE: POSITION:
Ing. Jan Stursa, MSc. Head of the Cyclotron Division
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
J. Kucera, Deputy Head J. Lacman, Control System M. Cihak, Beam Dynamics
[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1977 First beam MANUFACTURER: JINR Dubna, Russia (II) UPGRADE: 1992 Axial injection MODEL: U-120M 1997 H-, D- Beams, [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-38 10-20 17-53 20-40 Yes No Maximum beam available (µA) 30 25 3 3 Typical beam employed (µA) 20 3 3 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
62.5 53 6.5 1 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) - Stent
activation 1
[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) = 15 MeV Yes No 2 [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 86Y, 123I [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) Clinical Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
80
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 60 95 1.5 750
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 25 12/week Yes No Yes No 335 USD Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 4 1-2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 4 1/week Yes No Yes No 211At 1 1/month Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb/81mKr – radionuclide generator: not used on site; distribution – yes.
81
COUNTRY: CZECH REPUBLIC CZR-2 [1] INSTITUTE: Nuclear Research Institute Rez plc
250 68 Rez
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+42 02 572 16 982 or +42 02 570 90 616 mailto:[email protected] or ami@ ujv.cz +4202 572 15 949
[2] PERSON IN CHARGE: POSITION:
Ing. Michal Antos Head, Department of PET Radiopharmaceuticals
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Ing. Karel Mudra, Cyclone Operator Ing. Petr Kopecky, Vice Director – Division of Radiopharmaceuticals
[3] TYPE OF CYCLOTRON: IBA cyclone YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: IBA Belgium (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 40 Typical beam employed (µA) 33 20 [5] CYCLOTRON OPERATION:
Total hours (h)/ week h/week for radionuclide production
h/week for research
h/week for maintenance
h/week for applications
Not periodically operated 5 3 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 18F -5 GBq/year Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 18F- FDG, - DOPA 15O-H2O-O2 [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 Clinical Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
82
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 150/2hrs >95 2000 100
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 60 Not periodically Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 14 Under testing and tuning 14N(d,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We are in a registrationm process. We do not produce FDG for routine commercial purpose. The data provided here is from testing and tuning runs.
83
COUNTRY: DENMARK DEN-1 [1] INSTITUTE: PET Centre, Aarhus University Hospital
Nørrebrogade 44 DK-8000 Aarhus C
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+45 89 49 3034 [email protected] +45 89 49 3020
[2] PERSON IN CHARGE: POSITION:
Professor Albert Gjedde
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Dirk Bender, Head of Radiochemistry Søren B. Hansen, Chief Physicist
[3] TYPE OF CYCLOTRON: Negative ion, self-shielded
YEAR OF: (I) INSTALLATION 1993
MANUFACTURER: GEMS (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8 Yes No Maximum beam available (µA) 60 60 Typical beam employed (µA) 25-40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 36 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify)
PET – Radiotracer 36
[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
84
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 60
(40A,60min) 95 0.8 150
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 6-8 3/week Yes No Yes No FMISO 1-2 1/week Yes No Yes No FDOPA 0.6 1/week Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Raclopride 1-2 4/week Yes No Yes No PK - 11195 2 1/week Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 4-6 6x/week 16O (p, α ) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 6 10/week 14N (d, n ) 15O Oxygen 10 5/week 14N (d, n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Fluoride, Way – 100635, NMSP, NS2381, NS 2456, CO. In all, more than 50 different radiotracers are currently available at the Aarhus PET – Centre.
85
COUNTRY: DENMARK DEN-2 [1] INSTITUTE: University Hospital of Copenhagen
Cyclotron and PET Unit, KF 3982 Blegdamsvej 9, DK – 2100 Copenhagen
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+45 3545 3915 [email protected] +45 3545 3898
[2] PERSON IN CHARGE: POSITION:
Dr. Mikael Jensen Physicist-in-Chief
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Holger Jensen, Physicist Nic Gillings, Chemist Jacob Madsen, Chemist
[3] TYPE OF CYCLOTRON: Negative ion, sector-focused
YEAR OF: (I) INSTALLATION 1992
MANUFACTURER: Scandinotrix (II) UPGRADE: 1994 – Addition of positive ions and 4He
MODEL: MC 32-NI [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 32 16 - 32 Yes No Maximum beam available (µA) 100 80 30 Typical beam employed (µA) 20 10 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30-40 25 5 2 0-8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 1 Neutron therapy: Activation analysis: Other (specify) Space component tests [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C – FLB 457 [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 6 Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
86
18F RADIONUCLIDE PRODUCTION Production Typical
production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 40 >95 1.2 200
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 25 2-3/week Yes No Yes No ~600 Euro 18F -ALTANSERIN 4 1/week Yes No Yes No ~400 USD
per. patient dose
Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 2 2-8/week 16O (p, α) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water on line 8 hours/week 14N (d, n ) 15O CO on line 14N (d, n ) 15O OO on line 14N (d, n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.1 5/year Yes No Yes No 201Tl Yes No Yes No 211At 1 1/week Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) – The home of : gas phase Methyl iodine - 11C, 10C - carbon dioxide – Production of 81Rb/ 81mKr generators 16/week – 12 GBq/week.
87
COUNTRY: EGYPT EGY-1 [1] INSTITUTE: Atomic Energy Authority
AEA Post Office, Postal Code 13759 Cairo
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+202 469 0840 +202 469 8414
[2] PERSON IN CHARGE: POSITION:
Professor Dr. A.H. Azzam Supervisor
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Professor Dr. M.N.H. Comasan Professor Dr. Z.A. Saleh Professor Dr. F.I. Asfour
[3] TYPE OF CYCLOTRON: AVE YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: NIIEFA (II) UPGRADE: MODEL: MGC-20 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-18 3-10 8-24 6-20 Yes No Maximum beam available (µA) 200 50 Typical beam employed (µA) 45 17 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
The machine is under installation
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 67Ga, 111In and 123I [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Planning to supply to radiomedical institutes.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
88
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/week Yes No Yes No 123I 3/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
89
COUNTRY: FINLAND FIN-1 [1] INSTITUTE: Laboratory of Radiochemistry
University of Helsinki, Department of Chemistry P.O. Box 55, 00014 University of Helsinki
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+358 9191 50133 [email protected] +358 9191 50121
[2] PERSON IN CHARGE: POSITION:
Dr. Kerttuli Helariutta , Senior Laboratory Manager
OTHER SENIOR STAFF: NAME/POSITION
Martti Hakanen, Laboratory Manager
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 10/5 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 80 40 Typical beam employed (µA) 10-20 Not yet used [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
~ 4.5 ~ 4 ~ 0.5 ~ 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: A couple of times Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No 57Co X ray sources? (specify which & quantity) Yes No 109Ag Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 124I, 64Cu , 86Y [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Hospitals (Helsinli, Tampere, Lahti, Kuojno) 1-3 times/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
90
8F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 1-5 0.4, 2.0
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 1-3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We are still in the beginning of using Cyclotron. Probably this year, the production of radionuclides will increase significantly.
91
COUNTRY: FINLAND FIN-2 [1] INSTITUTE: Turku PET Centre
Turku University Central Hospital Kiinamyllynkatu 4-8 FIN-20520 Turku
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+358 2 261 1860 [email protected] +358 2 261 2882
[2] PERSON IN CHARGE: POSITION:
Mr. Hannu Sipilä Chemist
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mika Teräs, Hospital Physicist Kari Lindberg, Technician Kalevi Eklund, Technician
[3] TYPE OF CYCLOTRON: Positive ion 2H YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: IBA, s.a. Belgium (II) UPGRADE: MODEL: Cyclone 3 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3-7 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 5-35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
14 14 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: 14 Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 4 Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
92
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
H2 O 0.2 – 1.4 4 days/week 14N (d, n) 15O CO 2.6 3 days/week O2 1.2 1 day/week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
93
COUNTRY: FINLAND FIN-3 [1] INSTITUTE: Turku PET Centre
Accelerator Laboratory Äbo Akademi, Porthansgatan 3 FIN-20500 Turku
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+358 2 2654 608 [email protected] +358 2 2654 912
[2] PERSON IN CHARGE: POSITION:
Dr. Sven-Johan Heselius Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Olof Solin; Jörgen Bergman; Jan-Olof Lill; Ulf Hällsten; Stefen Johansson; Erkki Stenvall; Per Olof Eriksson
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1974 MANUFACTURER: D.V. Efremov
Institute (II) UPGRADE:
MODEL: MGC-20 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3-20 6-10.5 9-28 12-21 Yes No Maximum beam available (µA) 30 30 20 20 Typical beam employed (µA) 300 300 80 80 [5] CYCLOTRON OPERATION:
Total hours (h)/ week h/week for radionuclide production
h/week for research h/week for maintenance h/week for applications
42 32 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? ……. Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 2 Gamma camera 4 Single photon tomography (SPET) 4 Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
94
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced ……………………….
95
COUNTRY: FINLAND FIN-4 [1] INSTITUTE: University of Jyväskylä
Department of Physics, P.O. Box 35 40351 Jyväskylä
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+358 14 260 2350 [email protected] +358 14 260 2351
[2] PERSON IN CHARGE: POSITION:
Professor Esko Liukkonen Professor
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Pauli Heikkinen, in charge of Accelerator Physics Hannu Koivisto, in charge of Ion Sources Teuvo Poikolainen, Radiation Safety Officer
[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1990-92 MANUFACTURER: JYFL, Scandinotrix (II) UPGRADE: 2000 for H- acceleration MODEL: [4] CYCLOTRON CHARACTERISTICS: E = q2 m 130 MeV 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-70 5-65 15 - 168 Yes No Maximum beam available (µA) 100 50 20 Typical beam employed (µA) 30-50 0.1 - 10 0.1 - 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 120 18 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 20 Proton therapy: Physics: 120 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? ……. Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
96
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 150 1/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced
97
COUNTRY: FRANCE FRA-1 [1] INSTITUTE: Centre Antoine Lacassagne
Laboratoire du Cyclotron 227, Avenue de la Lanterne 06200 Nice
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+33 4 920 31070 [email protected] +33 4 920 31095
[2] PERSON IN CHARGE: POSITION:
Dr. Pierre Mandrillon Head of Cyclotron Laboratory
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Donadey Trimud Giusto
[3] TYPE OF CYCLOTRON: Compact isochronous - negative ion
YEAR OF: (I) INSTALLATION 1991
MANUFACTURER: Centre Antoine Lacassagne
(II) UPGRADE:
MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 65 65 65 65 Yes No Maximum beam available (µA) 40 40 40 40 Typical beam employed (µA) 0.1 - 25 0.1 - 25 0.1 - 25 0.1 - 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30 10 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: 20 Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
98
18F RADIONUCLIDE PRODUCTION Production Typical
production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 150 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
99
COUNTRY: FRANCE FRA-2 [1] INSTITUTE: Centre National de la Recherche Scientifique
Centre d'Etudes et de Recherches par Irradiation (CNRS-CERI), 3a rue de la Ferolerie
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+33 2 3825 5410
[2] PERSON IN CHARGE: POSITION:
Mr. G. Blondiaux Director, CERI
OTHER SENIOR STAFF: NAME/POSITION
J. Briaud
[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1974 MANUFACTURER: CGR MeV (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-35 5-25 10-60 10-50 Yes No Maximum beam available (µA) 70 40 40 Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
64 6 26 8 24 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 4 Proton therapy: Physics: 10 Neutron therapy: 24 Activation analysis: 12 Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) 15 MeV Yes No 1012n/cm2/s [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
100
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No 81mKr 0.1 – 0.5 2/week Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Production of 211At ; industrial applications with thin and ultra thin layer activation; application in the field of waste management.
101
COUNTRY: FRANCE FRA-3 [1] INSTITUTE: Centro d'Exploration et de Recherche Medicales
par Emission de Positrons (CERMEP) Cyclotron Biomedical de Lyon 59 Boulevard Pinel, F-69003 Lyon
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+33 4 726 88600 [email protected] +33 4 726 88610
[2] PERSON IN CHARGE: POSITION:
Dr. D. Le Bars Head of Radiochemistry
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
G. Galy P. Lanai D. Comar
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: CGR-MeV (II) UPGRADE: MODEL: Cypris 325 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) >50 >50 Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
>15 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-FDG one per/month to one per week.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
102
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
103
COUNTRY: FRANCE FRA-4 [1] INSTITUTE: CERMEP - Hospital Neurocardiologique
59 Bd Pinel F - 69003 Lyon
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+33 4 72 688600
[2] PERSON IN CHARGE: POSITION:
Dr. Pujol
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. D. Le Bars Dr. L. Zimmer Dr. S. Guillouet
[3] TYPE OF CYCLOTRON: CYCLONE 18/9 YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 40 Typical beam employed (µA) 15-35 5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20-30 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
104
18F RADIONUCLIDE PRODUCTION Production Typical
production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 25-75 >95 0.5 50-100
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 10 3/week Yes No Yes No DOPA 6 1/week Yes No Yes No MPPF 3 1/week Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 2 1/week Yes No Yes No Flumazenil 2 1/week Yes No Yes No Raclopride 2 1/week Yes No Yes No MHED 2 1/month Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 0.33 2/week 14N(d, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
105
COUNTRY: FRANCE FRA-5 [1] INSTITUTE: Service Hospitalier Frederic Joliot
C.E.A. Direction des Sciences du Vivant 4, Place du General Leclerc F-91406 Orsay
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+33 1 698 67704 [email protected] +33 1 698 07768
[2] PERSON IN CHARGE: POSITION:
Dr. C. Crouzel
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
F. Dolle D. Roeda M. Ponchant/C. Loch
[3] TYPE OF CYCLOTRON: Compact cyclotron (variable energy)
YEAR OF: (I) INSTALLATION 1975
MANUFACTURER: CGR-MeV (II) UPGRADE: 1996, 1997 MODEL: 520 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 14.5 30 29 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 30 15-20 15-20 [5] CYCLOTRON OPERATION:
Total hours (h)/ week h/week for radionuclide production
h/week for research
h/week for maintenance
h/week for applications
25-30 25-30 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Supply of 18F-FDG to hospitals with the help of Cis-Bio (ORIS-Industry)
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 3 Positron emission tomography (PET) 3 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
106
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Dopa Yes No Yes No Oliganuclides Yes No Yes No Spiperone Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Flumazenyl Yes No Yes No MQNB Yes No Yes No CGP Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
107
COUNTRY: GERMANY GER-1 [1] INSTITUTE: Cyclotron Laboratory
Forschungszentrum Karlsruhe Technik und Umwelt Hauptabteilung Zyklotron P.O. Box 3640, 76021 Karlsruhe
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 7247 82 2433 [email protected] +49 7247 82 3156
[2] PERSON IN CHARGE: POSITION:
Dr. H. Schweickert Director, Cyclotron Laboratory
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Dr. V. Bechtold, in charge of Radioisotope Production Dr. P. Fehsenfeld, RTM, Radionuclide Technique in Mechanical Engineering
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1984 MANUFACTURER: Cyclotron
Corporation (II) UPGRADE: Continuous
MODEL: CP 42 H- [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-40 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
140 50 70 when needed 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) TLA [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? To hospitals and industry Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
108
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 75-150 >95
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 37 - 75 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Planned Yes No Yes No 94mTc Planned Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 175 1/day Yes No Yes No 124I 3.7 1/week Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
109
COUNTRY: GERMANY GER-2 [1] INSTITUTE: Cyclotron Laboratory
Forschungszentrum Karlsruhe Technik und Umwelt Hauptabteilung Zyklotron P.O. Box 3640, 76021 Karlsruhe
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 7247 82 2433 [email protected] +49 7247 82 3156
[2] PERSON IN CHARGE: POSITION:
Dr. H. Schweickert Director, Cyclotron Laboratory
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Dr. V. Bechtold, in charge of Radioisotope Production Dr. P. Fehsenfeld, RTM, Radionuclide Technique in Mechanical Engineering
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1964 MANUFACTURER: AEG (II) UPGRADE: Continuous MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 52 104 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
15 5 5 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
110
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F >95
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At 1/week Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
111
COUNTRY: GERMANY GER-3 [1] INSTITUTE: Eberhard-Karls-University Tübingen
Interdisciplinary PET Centre Department of Nuclear Medicine Röntgenweg 15, D-72076 Tübingen
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 7071 29 87443 [email protected] +49 7071 29 5264
[2] PERSON IN CHARGE: POSITION:
Professor Dr. H.-Juergen Machulla
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Professor R. Bares, Director of Nuclear Medicine
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8 Yes No Maximum beam available (µA) 75 Typical beam employed (µA) 35-55 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
15-20 10-15 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
112
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 75 95 1.6 1000
Yes No
20Ne (d, α) 18F 8 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 30 5/week Yes No Yes No FLT 10 3/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Raclopride 2 2/week Yes No Yes No NMSP 4 1/week Yes No Yes No SCH 23390 3 1/week Yes No Yes No Methionin 8 1/month Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 3 1/month 16O(p, α ) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 20 1/month 14N(d, n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 1 2/month Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No On request 123I Yes No Yes No 124I 0.4 1/month Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): 11C CARFENTANIL 3 GBq 1/week, 11C METHYL PHENIDAT 4 GBq 1/week, 11C FLB 457 2GBq 1/week 124I mIBG 0.2GBq 1/3month
113
COUNTRY: GERMANY GER-4 [1] INSTITUTE: Euro-PET GmbH
Hugstetlerstrasse 55 D-79106 Freiburg
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 761 270 9204 [email protected] +49 761 270 9200
[2] PERSON IN CHARGE: POSITION:
Professor Dr. Peter Reuland
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Ursula Sahm, Chief Chemist Kenneth Stalmo, Technician Bernd Morasch, Chemist Dagmar Hentschel, Engineer
[3] TYPE OF CYCLOTRON: Negative Ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: GE. (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: ……. 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) 75 75 Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
3 0.25 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C-carbon monoxide and carbon dioxide, 15O–water, carbon monoxide and oxygen. [9] Do you supply radionuclides to other institutions? To different institutions
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
114
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 110 >95 1.2 1000
Yes No
20Ne (d, α) 18F 25 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 35-45 8-10/week Yes No Yes No Fluoride Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
(see comments) Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13NH3 10-13 10/year Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
N213O 8-10 50/year
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We’ll produce 11C radiopharmaceuticals starting November 2001.
115
COUNTRY: GERMANY GER-5 [1] INSTITUTE: Forschungszentrum Rossendorf
Institut für Bioanorganische undRadiopharmazische Chemie P.O. Box 510119, 01314 Dresden
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 351 260 3170 [email protected] +49 351 260 3232
[2] PERSON IN CHARGE: POSITION:
Professor habil. Bernd Johannsen Director of the Institute
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
F. Wuest, Head of PET Tracer Department St. Preusche, Head of Cyclotron Unit
[3] TYPE OF CYCLOTRON: Negative Ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: Beam – beam on the targets. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 35 20 Possible for 1H, 2H,
but not used Typical beam employed (µA) 30 15-18 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10-20 10-120 for PET routine and research
2-5
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) RN production: 10-20
beam on the targets [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Solid target under construction [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Radiopharmaceutical company, daily
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
116
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 60-90 94-96 1.4 500
Yes No
20Ne (d, α) 18F 12-13 600ml Ne/F2 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 33-45 1/day Yes No Yes No Customer dependent
[F-18] 16 alpha-Fluoroertradiole
20 1/week Yes No Yes No
[F-12] Fluoro-Dopa
1.2 1/week Yes No Yes No
[F-JP]3-0-Methyl-F-Dopa
1.2 2/month Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C-NeN5652 8-9 on request Yes No Yes No on request Yes No Yes No Various research
products Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED
Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 2 1/week 160(p,∝)13N Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 5-6 2-5/week 14N(din)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): Broad biomedical research programs using various radiotracers as well as radiochemical research have been carried out. Our internet home pages: http:/www.fz-rossendorf.de; http:/www.fz-rossendorf.de/FWB2; http:/www.fz-rossendorf.de/FWB/usercom/usucom1.html/3. 1-Forschungszentrum Rossendorf; 2-Radiopharmazeutische Chemie. 3-Cyclone 18/9 & 10/5 USU Community.
117
COUNTRY: GERMANY GER-6 [1] INSTITUTE: Forschungszentrum Rossendorf
Institut für Bioanorganische und Radiopharmazische Chemie P.O. Box 510119, 01314 Dresden
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 351 260 3170 [email protected] +49 351 260 3232
[2] PERSON IN CHARGE: POSITION:
Professor habil. Bernd Johannsen Director of the Institute
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
F. Wuest, Head of PET Tracer Department St. Preusche, Head of Cyclotron Unit
[3] TYPE OF CYCLOTRON: U-120 YEAR OF: (I) INSTALLATION 1958 MANUFACTURER: NIIEFA St.
Petersburg (II) UPGRADE: 1989
MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 7 14 28 Yes No Maximum beam available (µA) Typical beam employed (µA) 50 50 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
50 10 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? External application of radionuclides generally
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
118
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
119
COUNTRY: GERMANY GER-7 [1] INSTITUTE: German Cancer Research Centre (DKFZ)
Im Neuenheimer Feld 280 D-69120 Heidelberg
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 6221 550 3 [email protected] +49 6221 422 572
[2] PERSON IN CHARGE: POSITION:
Dr. Gerd Wolber, Head, Cyclotron Operation Group Professor Dr. Wolfhard Semmler, Head - Biophysics
OTHER SENIOR STAFF: NAME/POSITION
Professor Dr. Michael Eisenhut, Head – Radiochemistry
[3] TYPE OF CYCLOTRON: Isochronous, negative ion
YEAR OF: (I) INSTALLATION 1991
MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 32 NI [4] CYCLOTRON CHARACTERISTICS: Average magnetic field: 1.59 T; pole face diam.: 135 cm; accel. freq: 24.3 MHz; 2 Dees 90º;
dual cold cathode ion source; total weight: 53 tons; total power dissipation: 185 kva. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16-32 8-16 Yes No Maximum beam available (µA) 100 100 Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
50 (aver), 1997-2000 25 15 2-5 45 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 1 Radiography: Materials science: 2-3 Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Neutron dosimetry - 2 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 140 Pr Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No εn= 14MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): see comments [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Dept. of Nuclear Medicine, Radiological Clinic of the University of Heidelberg; daily
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
Both [11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical 1 – Small animal planned – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
120
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 50-70 >95 1 16 at 30
bar 300 1
Yes No
20Ne (d, α) 18F 20-30 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 15-20 1-2/day Yes No Yes No FLT 1.7 on demand Yes No Yes No
Yes No Yes No Others, see comments Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Others, see comments Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 5-6 2-3/week 14N(d, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu rare Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I in preparation Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 18F – DOPA, FU, FET, 2F-Throsine,Choline 11C – AIB, ethanole, doxorubicine, dacarbacine, acetate, choline In preparation : Iodinated compounds (124I, 121I) 140 Pr ( 20%β +,via 141Pr (p, 2n) 140 Nd is used for calibration of PET systems.
121
COUNTRY: GERMANY GER-8 [1] INSTITUTE: Institut für Molekulare, Radiopharmazie u. Nuklearmedizin
Universitaetsklinik der Ruhr-Universitaet Bochum Georgstrasse 11. D-32535 Bad Öynhausen
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 5731 97 1308 [email protected]/[email protected]/[email protected] +49 5731 97 1819
[2] PERSON IN CHARGE: POSITION:
Professor W. Burchert Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Ms. Petra Hadjilazaros Mr. Harald Henneken
[3] TYPE OF CYCLOTRON: Negative Ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: d P 3He 4He Dual Beams Beam energies (MeV) 9 18 Yes No Maximum beam available (µA) 40 80 Typical beam employed (µA) 12 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O-Water 11C-MHEO [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 4 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
122
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 25
50 95 0.6
1.6 400
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 20 5-7/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 3.7 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 4.5 4/day 16O(p, α ) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water the first tests
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
123
COUNTRY: GERMANY GER-9 [1] INSTITUTE: Institut für Nuklearchemie
Forschungszentrum Jülich GmbH D-52425 Juelich
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 2461 614141 [email protected] +49 2461 612535
[2] PERSON IN CHARGE: POSITION:
Professor H.H. Coenen
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Professor S.M. Qaim Dr. M. Holschbach
[3] TYPE OF CYCLOTRON: Fixed energy, two particle
YEAR OF: (I) INSTALLATION 1997
MANUFACTURER: General Electric (II) UPGRADE: 1999 MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30 30 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.?
(radiochemistry) Yes No
[16] Does your institute accept IAEA research fellows for training/experience? Yes No
124
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Flumazenil 3 2/week Yes No Yes No Raclopride 3 2/week Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 15 daily 14N(d, n) 15O Butanol 5 daily 14N(d, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
125
COUNTRY: GERMANY GER-10 [1] INSTITUTE: Institut für Nuklearchemie
Forschungszentrum Jülich GmbH D-52425 Juelich
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 2461 614141 [email protected] +49 2461 612535
[2] PERSON IN CHARGE: POSITION:
Professor H.H. Coenen
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Professor S.M. Qaim Dr. J. Ermert Dr. K. Hamacher
[3] TYPE OF CYCLOTRON: Baby Cyclotron YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE:
MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
35 20 15 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry 1 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.?
(radiochemistry) Yes No
[16] Does your institute accept IAEA research fellows for training/experience? Yes No
126
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 60 96 1.5 200
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 30 4/week Yes No Yes No CPFPX 15 1/week Yes No Yes No FET 15 occasionally Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 1-3 occasionally Yes No Yes No Flumazenil 1-3 occasionally Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 1 occasionally 16O(p, α ) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
127
COUNTRY: GERMANY GER-11 [1] INSTITUTE: Institut für Nuklearchemie
Forschungszentrum Jülich GmbH D-52425 Juelich
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 2461 614141 [email protected] +49 2461 612535
[2] PERSON IN CHARGE: POSITION:
Professor H.H. Coenen
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Professor S. Qaim Dr. B. Scholten
[3] TYPE OF CYCLOTRON: Variable energy compact
YEAR OF: (I) INSTALLATION 1976
MANUFACTURER: The Cyclotron Corporation
(II) UPGRADE: 1986, 1991, 1997
MODEL: CV 28 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6-22 4-14 18-36 10-28 Yes No Maximum beam available (µA) 30 20 10 20 Typical beam employed (µA) 30 20 10 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
56 12 16 7 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 28 Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 86Y, 94mTc and 12yI to several clinics under co-operative research
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
128
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 35 95 50 5
Yes No
20Ne (d, α) 18F 15 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 2 on demand Yes No Yes No 94mTc 2 on demand Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.5 ½ weeks Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
129
COUNTRY: GERMANY GER-12 [1] INSTITUTE: Institute for Medical Radiation Physics
Hufelandstrasse 55 D-45122 Essen
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 201 723 4182 +49 201 723 5907
[2] PERSON IN CHARGE: POSITION:
Professor Dr. A. Bochisch Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
G. Hudepohl, Technician/Engineer
[3] TYPE OF CYCLOTRON: Positive Ion, sector-focused
YEAR OF: (I) INSTALLATION 1975
MANUFACTURER: The Cyclotron Corporation
(II) UPGRADE:
MODEL: CV 28 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 24 14 36 28 Yes No Maximum beam available (µA) 100 100 50 50 Typical beam employed (µA) 100 100 50 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 20 10 5 Neutrons 5 patient treatment
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: research 5 Radiography: Materials science: Proton therapy: Physics: research 5 Neutron therapy: 5 Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
130
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 16O (3He,p)18F
37
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 18.5 3/week Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11CO2 37 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
O2 15/min 3/week 14N(din)15O CO2 15/min 3/week 14N(din)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y temporary Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 7.4 temporary Yes No Yes No 124I 3.7 temporary Yes No Yes No 201Tl Yes No Yes No 211At temporary Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
131
COUNTRY: GERMANY GER-13 [1] INSTITUTE: Institute of Radiology and Nuclear Medicine
Adickes-Allee 51-53 60322 Frankfurt am Main
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 69 95961 626 +49 69 95961 630
[2] PERSON IN CHARGE: POSITION:
Professor G. Hoer
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. W.T. Kranert
[3] TYPE OF CYCLOTRON: Negative ion H YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: CTI. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 20 15 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Nuclide production
for Nuclear Medicine [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 94mTc, 124I [9] Do you supply radionuclides to other
institutions? If yes and available, name of institution/s & how often? We can give addresses, after the cyclotron is established.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 3 Single photon tomography (SPET) 2 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
132
18F RADIONUCLIDE PRODUCTION Production Typical
production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 80 0.8
Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 40 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
CO 5 1/week Yes No Yes No CO2 5 1/week Yes No Yes No Amino acids 5 1/week Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 5 2/week Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 1/week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) The cyclotron is not established so far.
133
COUNTRY: GERMANY GER-14 [1] INSTITUTE: Max-Planck-Institut fuer Neurologische Forschung
Gleueler Strasse 50 D-50931 Koeln (Lindenthal)
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 221 4726 220 +49 221 4726 298
[2] PERSON IN CHARGE: POSITION:
Professor Wolf-Dieter Heiss Director
OTHER SENIOR STAFF: NAME/POSITION
Professor Dr. Klaus Wienhard
[3] TYPE OF CYCLOTRON: Baby cyclotron YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 16 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 20 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other
institutions? If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 3 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
134
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 15 95 1.2 100
Yes No
20Ne (d, α) 18F 10 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 10 4/week Yes No Yes No Dopa 1 2/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 12 3/week Yes No Yes No Raclopride 5 2/week Yes No Yes No Flumazenil 10 1/week Yes No Yes No MPHA 8 1/week Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 6 25/week 14N(d,n) 15O CO 5 1/month 14N(din)15O O2 5 3/month 14N(din)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): 124I – FIAU with 124I from outside.
135
COUNTRY: GERMANY GER-15 [1] INSTITUTE: Medizinische Hochschule Hannover (MHH)
Klinik für Nuklearmedizin Carl Neuberg-Strasse 1 D-30623 Hannover
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 511 532 5606/3085 +49 511 532 2315
[2] PERSON IN CHARGE: POSITION:
Dr. Helmeke Head of the Cyclotron Group
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. G.-J. Meyer
[3] TYPE OF CYCLOTRON: Isonochronous, variable energy
YEAR OF: (I) INSTALLATION 1976/1977
MANUFACTURER: Scanditronix (II) UPGRADE: MODEL: MC 35 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 7.5-35 3.8-18 5.6-47 7.5-35 Yes No Maximum beam available (µA) 65 65 30 30 Typical beam employed (µA) 40 35 - 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
14 (pure beam time) 11-12 2-3 0.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 66Ga [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 10 Single photon tomography (SPET) 5 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
136
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 31 80-94 1.5 500 Yes
No 20Ne (d, α) 18F 1-3 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 14 1/day Yes No Yes No Fluoride 1.3 30/year Yes No Yes No Dopa 0.3 30/year Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 7-15 200/year Yes No Yes No Methionine 3.5 - 8.5 200/year Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 6-7 120/year 15O(p, α ) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 4.4 220/year 14N (d, n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At 0.02 1-2/week Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
137
COUNTRY: GERMANY GER-16 [1] INSTITUTE: Rheinisch-Westfaelische Technische Hochschule
Klinik fuer Nuklearmedizin, Universitaetsklinikum Pauwelsstrasse 30 D-52057 Aachen
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 241 808 8741 [email protected]/ [email protected] +49 241 888 8520
[2] PERSON IN CHARGE: POSITION:
Dr. Udalrich Büll
OTHER SENIOR STAFF: NAME/POSITION
Dr. Berthold Müller
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
22 20 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F, 11C [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
138
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 1 20/day 15N(p,n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
139
COUNTRY: GERMANY GER-17 [1] INSTITUTE: Technische Universität. München
Nuklearmedizinische Klinik u. Poliklinik Ismaningerstrasse 22 D-81675 München
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 89 4140 4575 +49 89 4140 4841
[2] PERSON IN CHARGE: POSITION:
Professor M. Schwaiger
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. I. Wolf Dr. G. Reidel M. Herz
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: Dual beam 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
33 26 5 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Nuclear
Medicine [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): FLT, Epinephrine, Diprenorphine [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 3 Single photon tomography (SPET) 5 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
140
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37 95-98 0.7 525 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 17 3/day Yes No Yes No 18F-PET 3.7 1/week Yes No Yes No 18F- 3.7 2/month Yes No Yes No 18F-FDPN 1.0 2/month Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 3.7 1/week Yes No Yes No FM2 1.9 2/week Yes No Yes No Methionine 2.7 1/week Yes No Yes No HGD 1.9 1/week Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 1.5 36/week 15N(pin)15O Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 0.8 36/week 15N(pin)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
141
COUNTRY: GERMANY GER-18 [1] INSTITUTE: Universitätsklinikum Hamburg-Eppendorf
Klinik u. Poliklinik für Radiologie, Abteilung für Nuklaermedizin Bereich Zyklotron u. Radiopharmazie Luruper Chaussee 149 D-22761 Hamburg
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 40 8998 2968 [email protected] +49 40 8998 2960
[2] PERSON IN CHARGE: POSITION:
Dr. Bruno Nebeling Head
OTHER SENIOR STAFF: NAME/POSITION
Uve Kirchner
[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1968 MANUFACTURER: Philips (II) UPGRADE: MODEL: 140/IV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 16 42 30 Yes No Maximum beam available (µA) 130(internal) Typical beam employed (µA) 20(external) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 30 2 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 5-7/week Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for agricultural
applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
142
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 28 75-95 0.9 500 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 15 10/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
McN 5652z 1-3 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
143
COUNTRY: GERMANY GER-19 [1] INSTITUTE: Universitätsklinikum Ulm
Abteilung Nukleamedizin Robert-Koch-Strasse 8 D-89081 Ulm
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 731 500 24981 [email protected] +49 731 500 24979
[2] PERSON IN CHARGE: POSITION:
Dr. Bernd Neumaier Head of PET Chemistry
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Andreas Vogg, Radiochemist Christoph Solbach, Radiochemist Dr. Michaela Schmid, Chemist
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 40 20 Typical beam employed (µA) 30 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 16 3 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) 20 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Research, still not specified. [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Munich, Nuklearneclizimsche und Polikline, KRI & in cases of cyclotron maintenance
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
e.g. with FLP, FDOpa [11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 5 Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience?
The candidate can only visit our cyclotron site, self-operation is impossible. Yes No
144
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 50 95 2 600 Yes
No 20Ne (d, α) 18F 6 21 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 22 4/week Yes No Yes No Dopa 0.8 2/week Yes No Yes No FLT 3 1/week Yes No Yes No Fluoride 6 1/week Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 7 2/week Yes No Yes No Acetate 2.5 2/week Yes No Yes No Raclopride 4 2/week Yes No Yes No PK11195 1 0-1/week Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonic 16 0/week 16O(p,α) Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 8 0/week 14N(din)
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): – 18F micliosides by electrophilic fluorination. 0.4GBq, occasionaly for research – 11C chlorine, 6GBq/batch, 0.1/week – 11C alpha-methyl-tryptophane, 1.5 GBq/batch, 0.1/week – 11C carfentanil, 4GBq/batch, 0-1/week – 11C flumazenile, 4GBq/batch, 0.1/week.
145
COUNTRY: GERMANY GER-20 [1] INSTITUTE: University of Frankfurt
Department of Nuclear Medicine Klinikum der Johann Wolfgang Goethe-Universität Theodor-Stern-Kai 7, Jaus 21 D D-60590 Frankfurt am Main
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 69 6301 4330 [email protected] +49 69 6301 6805
[2] PERSON IN CHARGE: POSITION:
Professor Dr. Frank Grünwald Chairman and Director
OTHER SENIOR STAFF: NAME/POSITION
Professor Dr. Christian Menzel, Deputy Director
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION MANUFACTURER: (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? ……. Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
146
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced ……………………….
147
COUNTRY: GERMANY GER-21 [1] INSTITUTE: Westfaelische Wilhelms Universitaet
Klinik und Poliklinik fuer Nuklearmedizin Domagkestrasse 5 48189 Münster
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 251 83 473 76 or 473 62 [email protected] +49 251 83 473 63
[2] PERSON IN CHARGE: POSITION:
Professor Dr. O. Schober Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Jörg Eckardt, Physicist Dr. Markus Knickmeier, Chemist
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
11 10 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 10 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
148
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 40 97 1.1 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 20 Daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 2 weekly 15N(p,n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
149
COUNTRY: GERMANY GER-22 [1] INSTITUTE: Zentralklinik Bad Berka GmbH
PET Centre Humbold Strasse 2A
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+49 364 585 2200 [email protected] +49 364 585 3515
[2] PERSON IN CHARGE: POSITION:
Professor Dr. Richard P. Baum Chairman, Clinic of Nuclear Med./Centre for PET
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
Installation underway [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 13N, 15O, 18F [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals caried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
150
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced):
151
COUNTRY: HUNGARY HUN-1 [1] INSTITUTE: Institute of Nuclear Research
of the Hungarian Academy of Sciences Bem ter 18/c, P.O. Box 51
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+36 52 417 266 +36 52 416 181
[2] PERSON IN CHARGE: POSITION:
F. Tarkanyi Head, Cyclotron Department
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. L. Trón, Head of PET Centre Z. Kormany P. Kovacs Z. Szucs
[3] TYPE OF CYCLOTRON: Compact isochronous YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: NIIEFA Russia (II) UPGRADE: 1997 MODEL: MGC 20E [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 10 26 20 Yes No Maximum beam available (µA) 200 300 50 50 Typical beam employed (µA) 50 50 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
94 28 (56 every 2nd week) 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 13N-Ammonia, 15O-Water, 11C-Flumezinil, 111In-DTPA, 123I-mIBG, 123I-Imoazine [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Na123I-every 2 weeks; 67Ga-citric acid – every 2 weeks.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
152
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced): Neutron source (radiobiology, radiation hardness test, neutron activation, Thin Layer Activation (TLA), wear measurements, activation analysis (charged particle) Basic nuclear physics (in beam nuclear spectroscopy, astrophysical nuclear reactions)
153
COUNTRY: INDIA IND-1 [1] INSTITUTE: Radiation Medicine Centre
Bhabha Atomic Research Centre (BARC), Dept. of Atomic Energy Trombay, Mumbai 400 085
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+91 22 550 5326 [email protected] +91 22 550 5326
[2] PERSON IN CHARGE: POSITION:
Dr. A.M. Samuel Director, Bio-Medical Group, BARC, Mumbai Dr. N. Ramamoorthy Chief Executive, BRIT, Mumbai
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. B.N. Karkers, Head, MD & PDS Dr. M.R.A. Pillai, Head, Radiopharmaceuticals Division Dr. N. Nair, Head, Radiation Medicine Centre
[3] TYPE OF CYCLOTRON: Medical YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: Wipro GE, Mumbai (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: Dual particle (16.5 MeV Proton and e MeV Deuteron) 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.5 Yes No Maximum beam available (µA) 80 80 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10-12 10-12 Not yet decided [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions? If yes and available, name of
institution/s & how often? Planned to supply 18F to Nuclear Medicine Departments Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 4 Single photon tomography (SPET) 3 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
154
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): This is the first facility to be set up in the country with expertise in accelerations, radiopharmaceuticals, radiation biology and nuclear medicine. It is anticipated that apart from the routine PET radiopharmaceuticals, research in the development of new PET labeled compounds will be initiated.
155
COUNTRY: INDIA IND-2 [1] INSTITUTE: Variable Energy Cyclotron Centre (VECC)
1/AF, Bidhan Nagar Calcutta - 700 064
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+91 33 3371 230 +91 33 3346 871
[2] PERSON IN CHARGE: POSITION:
Dr. B.C. Sinha Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: Sector-focused (pole diameter 224 cm)
YEAR OF: (I) INSTALLATION 1997
MANUFACTURER: VEC Centre (II) UPGRADE: MODEL: (Individual design) [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6.30 12.30 25.80 Yes No Maximum beam available (µA) 200 200 200 Typical beam employed (µA) 20 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
160 24 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 201Tl [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Regional Radiation Medicine Centre, Thakurpukur, Calcutta – weekly, Radiation Medicine Centre Mumbai - monthly
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
156
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
157
COUNTRY: INDONESIA INS-1 [1] INSTITUTE: National Atomic Energy Agency, BATAN
PPR-Batan Kawasan Puspiptek Serpong 15310
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+21 756 3141 [email protected]
[2] PERSON IN CHARGE: POSITION:
Mr. Silakhuddin Head, Cyclotron Division
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Tonny Heryanto Budi Tarigan
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: CTI, Inc. (II) UPGRADE: 1995 (modified to negative ion
by IBA) MODEL: CS 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 24-27 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
6 4 2 2 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): We would like to produce 123I. Unfortunately we have no experts and facility. [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Hospitals, 1-2/week Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
158
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 1/2week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): We are planning to produce 18FDG in 2002.
159
COUNTRY: IRAN IRA-1 [1] INSTITUTE: Nuclear Research Centre for Agriculture
and Medicine (NRCAM) P.O. Box 31585-4395 Karaj
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+98 261 313 0676 +98 261 411 105
[2] PERSON IN CHARGE: POSITION:
Professor Hossein Afarideh
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Satari; Partovi Rafii; Akbari; Shafiei
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: IBA, Belgium (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 7-15 Yes No Maximum beam available (µA) Typical beam employed (µA) 500 150 175 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20-25 12-17 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 81mKr - Rb generator, 18F - FDG , 123In [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? To all nuclear medicine centres - Once a week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
160
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 0.1 0.5/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 0.5 0.5/week Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 0.037 1/week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
161
COUNTRY: ISRAEL ISR-1 [1] INSTITUTE: Hadassah Medical Organization
Ein Karem Il-91 120 Jerusalem
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+972 2 6777 197 [email protected] +972 2 6438 506
[2] PERSON IN CHARGE: POSITION:
Dr. Eyal Mishani Head of Cyclotron Unit
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Desideriu Laky, Cyclotron Operator Ms. Iris Pauker Ben-David, Research Ms. Yulia Rozen, Research Mr. Daniel Wajnblum, Engineer
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 30 20 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
12 5 5 13 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F – FDG, DOPA, Uracil; 11C – Choline ; 15O - Water [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
162
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 52 97 2 400 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 25 1/day Yes No Yes No Dopa Yes No Yes No ML 01 Yes No Yes No ML 03 Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Choline Yes No Yes No Deprenyl Yes No Yes No Methionine Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 8 16O(p,α ) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 4 -8 1/week 14N (d, n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
163
COUNTRY: ISRAEL ISR-2 [1] INSTITUTE: Soreq NRC
81800 Yavne
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+97 2 8943 4615 [email protected] +97 2 8943 4133
[2] PERSON IN CHARGE: POSITION:
Engineer Yosef Shohet Head of Facility
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Dr. M.B. Goldberg, Head, Steering Committee Dr. D. Berkovits, Chief Physicist Bs. Phrm. B. Hoch, Chief Radiochemist Mr. T. Arbel, Head of Operation Staff
[3] TYPE OF CYCLOTRON: Cyclone series YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: IBA, Belgium (II) UPGRADE: MODEL: 10/5 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (µA) 80 80 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20-25 15-20 1-2 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 15-20 Radiography: Materials science: 1-2 Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C 66-68Ga 15F-DOPA [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
164
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 15000 94 2 600 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 50 1-2 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
165
COUNTRY: ITALY ITA-1 [1] INSTITUTE: Azienda Ospedaliera di Bologna
Policlinico S. Orsola - Malpighi Via Massarenti, 9 40138 Bologna
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+39 051 636 3575 [email protected] +39 051 349 920
[2] PERSON IN CHARGE: POSITION:
Professor Nino Monetti Professor of Nuclear Medicine
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Mario Marengo, Medical Physicist, responsible for the Cyclotron Dr. Stefano Boschi, Chemist, responsible for Radiopharmacy
[3] TYPE OF CYCLOTRON: Pet trace YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: GE (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
25 20 4 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often? Distribution is planned in the third quarter of 2002.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
166
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 80 >94 1.1 500 Yes
No 20Ne (d,α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 30 Daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
CO2 100 weekly Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 20 weekly 16O(p, α) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
O2 70 weekly 14N(d,n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): The cyclotron will start operation by end of 2001. Productivity and workload data are based on typical values reported by General Electric.
167
COUNTRY: ITALY ITA-2 [1] INSTITUTE: Azienda Ospedaliera 5. Maria Nuova
Servizio di Medicina Nucleare V. le Risorgimento 80, Reggio Emilia
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+39 0522 296 284 [email protected] +39 0522 296 392
[2] PERSON IN CHARGE: POSITION:
Dr. Diana Salvo Department Chief
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: Minitrace GE 10 Mev
YEAR OF: (I) INSTALLATION October 2001
MANUFACTURER: General Electric (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 9.6 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
15 13 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Maybe 11C [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? In 2002 Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
168
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37 95 0.8 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 37 2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
169
COUNTRY: ITALY ITA-3 [1] INSTITUTE: CNR Institute of Clinical Physiology
Via Moruzzi, 1 I-56100 Pisa
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+39 050 315 3384 [email protected] +39 050 315 2166
[2] PERSON IN CHARGE: POSITION:
Piero A. Salvadori Head – PET/Cyclotron Facility
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Luca Menichetti, Radiopharmacist Debora Petroni, Radiopharmacist Michela Poli, Pharmacist
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: GE Medical Syst. (II) UPGRADE: 2001 MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 5 beam ports used (6 available); targets resident on beam ports, no beam transport lines. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.7 8.4 Yes No Maximum beam available (µA) 75 50 Typical beam employed (µA) 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
27 15 10 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal planned – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
170
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 55 97 1 150 Yes
No 20Ne (d, α) 18F 11 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 11 1/day Yes No Yes No Fluoride 3.7 2/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methyl iodide 37 Development Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 2 1/day Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
O Development Water Development
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Development Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Development Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Development Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): Additional activities planned for near future: - use of cyclotron for research in Boron neutro capture therapy - FDG manufacturing site - research in molecular imaging applied to genomic and proteonomic.
171
COUNTRY: ITALY ITA-4 [1] INSTITUTE: Consiglio Nazionale delle Ricerche
Institute Pascale (CNR) Via M. Semmola I-80131 Napoli
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+39 81 5903 528/527 +39 81 5465 797
[2] PERSON IN CHARGE: POSITION:
Professor Marco Salvatore
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Antonello Green
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 75 50 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 15 25 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O - Water , 11C – CH3 I [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
172
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Fluoride Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
173
COUNTRY: ITALY ITA-5 [1] INSTITUTE: Istituto Naziónale per lo Studío e la Çura dei Tumori
Via G. Venezian 1 I-20133 Milano
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+39 2 2390 2220 [email protected] +39 2 2367 874
[2] PERSON IN CHARGE: POSITION:
Dr. Emilio Bombardieri Director, Nuclear Medicine Department
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Flavio Crippa, Co-ordinator, Clinical PET Dr. Claudio Pascali, Co-ordinator, Radiopharmacy Eng. Vinicio De Sanctis, Responsible for the Cyclotron
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: Scanditronix (II) UPGRADE: MODEL: MC 17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 85 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 25 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
12 6 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) PET 35 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 9-10
patients/day
– Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
174
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 4500 94-97 ~ 1 250 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 10-15 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 2 - 10 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
175
COUNTRY: ITALY ITA-6 [1] INSTITUTE: Istituto Scientifico H. San Raffaele
Servizio di Medicina Nucleare Via Olgettina, 60 I-20132 Milano
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+39 02 2153 056 [email protected]
[2] PERSON IN CHARGE: POSITION:
Professor Ferruccio Fazio
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mario Matarrese Francesco Perugini Sergio Todde
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1988 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: Negative hydrogen ions 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
27 20 5 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 5 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 3 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
176
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 26 > 94 0.65 500 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 13 2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methyl choline 3 2/week Yes No Yes No FE - CIT 1 2/week Yes No Yes No Raclopride 1.5 1/week Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 370 MBq 3/week 15N (p, n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
177
COUNTRY: ITALY ITA-7 [1] INSTITUTE: Joint Research Centre (European Commission)
Institute for Health and Consumer Protection I-21020 Ispra (VA)
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+39 0332 785 281 [email protected] +39 0332 789 385
[2] PERSON IN CHARGE: POSITION:
Dr. Rien Stroosnijder Section Head
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
K. Abbas D. Gilliland U. Holzwarth M. Hoffman
[3] TYPE OF CYCLOTRON: Variable energy positive ion
YEAR OF: (I) INSTALLATION 1980
MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 20 40 Yes No Maximum beam available (µA) 60 60 30 Typical beam employed (µA) 30 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18FDG in setting up phase. Several others for research purposes. In
[9] Do you supply radionuclides to other institutions? If yes and available, name of institution/s & how often? Commercial and research purposes.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
178
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F In setting up
stage > 95 1 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG in set-up stage Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 40 2/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): Applications of cyclotron: Biomedical radioisotope production, for release testing of medical devices and biological studies. Very keen on training possibilities.
179
COUNTRY: ITALY ITA-8 [1] INSTITUTE: Ospedale Civile de Castelfranco Veneto
Reparto Medicina Nucleare Via Ospedale 18 – 31033 Castelfranco Veneto - TV
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+39 423 732 326 +39 423 732 426
[2] PERSON IN CHARGE: POSITION:
Dr. Franca Chierichetti Physician – responsible for the PET Centre
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Alberto Fini, Radiochemist, responsible for Cyclotron & Radiopharmacy
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS:
1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20-30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
12 9 2 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - DOPA, ESTRODINOL, PRESYNAPTIC RADIOAGENT
11C - METHIONINE, CHOLINE [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
180
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 20/hour >94 0.33 200 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 20 8/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 2.22 2/year Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 0.89 5/week 16O(p,α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 4.44 90/year 15N(p, n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
181
COUNTRY: ITALY ITA-9 [1] INSTITUTE: Ospedale Maggiore di Milano
Servizio di Medicina Nucleare Via Francesco Sforza 35 Pad. Granelli, I-20133 Milano
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+39 02 5503 3340 +39 02 5503 5510
[2] PERSON IN CHARGE: POSITION:
Dr. Paolo Gerundini Gherardi Primario
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Fabio Riccardo Colombo Rosangela Casati
[3] TYPE OF CYCLOTRON: PET Trace YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: (II) UPGRADE: MODEL: PT GEMS [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 8 2 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) PET [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O - Water, 13N - Ammonia, 11C - Radiopharmaceuticals to be decided. [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 3 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
182
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 44.4 95 1.2 400 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 22.2 Daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
183
COUNTRY: ITALY ITA-10 [1] INSTITUTE: Ospedale San Raffaele, Universita Degli Studi
Cattedra di Medicina Nucleare Via Olgettina 60 I-20132 Milano
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+39 2 2153056/2643/ 2716 [email protected] +39 2 2640390
[2] PERSON IN CHARGE: POSITION:
Professor Ferruccio Fazio
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mario Matarrese, in charge of the Cyclotron Francesco Perugini, in charge of Operations Sergio Todde, in charge of Radiochemistry
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: Protons and deuterons beam. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 50 40 Typical beam employed (µA) 25 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
32 5 25 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE:
Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other
institutions? If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 5 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 3 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
184
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 74 >94 2 700 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 37 1 run/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
185
COUNTRY: JAPAN JAP-1 [1] INSTITUTE: Biomedical Imaging Research Centre
Fukui Medical University 23-3 Shimoaizuki, Matsuoka, Yoshida, Fukui, 910-1193
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 776 61 8430 [email protected] +81 776 61 8170
[2] PERSON IN CHARGE: POSITION:
Yoshiharu Yonekura Director, Professor of Medical Imaging
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Yasuhisa Fujibayashi, Professor of Molecular Imaging Sadahiko Nishizawa, Associate Professor Atsuo Waki, Assistant Professor
[3] TYPE OF CYCLOTRON: OSCAR 5, superconducting, negative-ion
YEAR OF: (I) INSTALLATION 1994
MANUFACTURER: NKK (II) UPGRADE: MODEL: Oxford [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
26 16 2 8 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 18F — 0.5/week Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal 2 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
186
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37 96 4.2 200 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 10 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 20 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 4 1/month 16O(p,α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 0.37 20/week 15N(p,n) 15O CO CO2 O2
0.37 0.37 0.37
1/week 1/week 1/week
15N(p,n) 15O 15N(p,n) 15O 15N(p,n) 15O
OTHER ISOTOPES PRODUCED
Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu 0.37 1- 2/week Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): 64Cu - ATSM (Hypoxia), 62Cu - ATSM (Hypoxia) and 67Cu - PTSM (Perfusion)
187
COUNTRY: JAPAN JAP-2 [1] INSTITUTE: Daiichi Radioisotope Laboratories, Ltd.
453-1 Shimo-okura Matsuo-machi Sanbu-gun Chiba 289-1592
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 479 86 4721 [email protected] +81 479 86 5112
[2] PERSON IN CHARGE: POSITION:
Mr. Takashi Syogenji Manager, RI Production Group
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Yasuharu Sato
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 350 Typical beam employed (µA) 300 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
120 120 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
188
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 5/week Yes No Yes No 124I Yes No Yes No 201Tl 1/week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
189
COUNTRY: JAPAN JPN-3 [1] INSTITUTE: Daiichi Radioisotope Laboratories, Ltd.
453-1 Shimo-okura Matsuo-machi Sanbu-gun Chiba 289-1592
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 479 86 4721 [email protected] +81 479 86 5112
[2] PERSON IN CHARGE: POSITION:
Mr. Takashi Syogenji Manager, RI Production Group
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Yasuharu Sato
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1984 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 180 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
120 120 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
190
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 4/week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
191
COUNTRY: JAPAN JPN-4 [1] INSTITUTE: Department of Radiology
University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 3 381 55411 ext. 5129 +81 3 5800 8935
[2] PERSON IN CHARGE: POSITION:
Toshimitsu Momose, MD Assistant Professor
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Shinya Oku
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1988 MANUFACTURER: Sumitmo Heavy
Industries, Ltd. (II) UPGRADE:
MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) PET clinical
applications [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
192
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No DOPA Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
NHSP Yes No Yes No NHPB Yes No Yes No Methionine Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammpnia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
O2 CO2 Water CO
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
193
COUNTRY: JAPAN JPN-5 [1] INSTITUTE: Gunma University School of Medicine
39-15 Showa-machi 3-chome Maebashi-shi, Gunma-ken 371
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 27 220 8661 [email protected]
[2] PERSON IN CHARGE: POSITION:
Professor Keigo Endo Chairman
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Tomio Inoue, M.D. Kunio Matsubara, PhD. Katsumi Tomiyoshi, PhD.
[3] TYPE OF CYCLOTRON: Baby cyclotron YEAR OF: (I) INSTALLATION 1983 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE:
MODEL: BC 1700 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 30 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
16 10 5 0.5 0.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0.5 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - α- Methyl - Tryptophan, 11C - Annexine [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
194
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 4 -5 60 2.0 50 Yes
No 20Ne (d, α) 18F 4 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 4 -5 5/week Yes No Yes No FAMT 4 1/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Choline 10 - 15 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 10 1/month 16O(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
O2 21 1/week 15N(p, n) 15O Water 10 1/month 15N(p, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
195
COUNTRY: JAPAN JPN-6 [1] INSTITUTE: HIMEDIC Imaging Center at Lake Yamanaka
562-12 Yanagihara, Hirano Yamanakako-mura, Minamitsuru-gun
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 555 65 9135 [email protected] +81 555 20 3007
[2] PERSON IN CHARGE: POSITION:
Dr. Michiru Ide President
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1993 MANUFACTURER: Sumitomo Heavy
Industries, Ltd. (II) UPGRADE:
MODEL: HM 18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 70 50 Typical beam employed (µA) 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
7 6 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 3 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
196
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 29 94 1.3 450 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 10 5/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 3 20/week 16O(p,α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
197
COUNTRY: JAPAN JPN-7 [1] INSTITUTE: Hokkaido University, Graduate School of Medicine
Department of Tracer Kinetics Kita 15 Nishi 7 Kita-ku, Sapporo 060-8638
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 11 706 5150 [email protected] +81 11 706 7155
[2] PERSON IN CHARGE: POSITION:
Nagara Tamaki Professor and Chairman
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Yuji Kuge, Associate Professor
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: Sumitomo Heavy
Industries, Ltd. (II) UPGRADE:
MODEL: CYPRIS-HM 18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 20 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 15 2 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C - NHSP, 18F DOPA, 11C Palmitic Acid , 11C CGFI 2177 [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 2 Gamma camera Single photon tomography (SPET) 5 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
198
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 50 95 1.8 240 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 10 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 8 2/week Yes No Yes No Methyonine 7 1/week Yes No Yes No Flumazenil 5 1/week Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 2 Occasionally 16O(p,α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 1.5 2/week 14N(d,n) 15O O2 0.5 2/week 14N(d,n) 15O CO CO2
2.0 1.0
3/week 2/week
14N(d,n) 15O 14N(d,n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
199
COUNTRY: JAPAN JPN-8 [1] INSTITUTE: Hyogo Institute for Aging Brain and Cognitive Disorders
520 Saisho-ko, Himeji Hyogo 670
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 792 95 5511 [email protected] +81 792 95 8199
[2] PERSON IN CHARGE: POSITION:
Dr. Masahiro Sasaki Chief, Nuclear Pharmacology Laboratory
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Superconducting negative ion cyclotron
YEAR OF: (I) INSTALLATION 1992
MANUFACTURER: Oxford (II) UPGRADE: MODEL: OSCAR-2 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
6 5 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C MPHA [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
200
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 15 50 5 25/ 95% Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 4 2 - 3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 2 - 3/year Yes No Yes No NMSP 2 - 3/year Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 5 6 - 10/week 13N(p, n ) 15O O2 5 2 - 5/month 13N(p, n ) 15O CO 5 2 - 5/month 13N(p, n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
201
COUNTRY: JAPAN JPN-9 [1] INSTITUTE: Institute for Biofunctional Research
5-7-1 Fujishiro-dai, Suita-shi Osaka 565
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 6 834 7000 [email protected] +81 6 872 8761
[2] PERSON IN CHARGE: POSITION:
Dr. Naoto Hashimoto Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Norimasa Ejima
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: Sumitomo Heavy
Industries, Ltd. (II) UPGRADE:
MODEL: HM 18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 25 20 Typical beam employed (µA) 15-20 10-15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
~24 810 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Specific to animal PET studies.
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
202
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C - N2 40-50 1 per month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13N – H2
16O+5mM EtOH
1.7 1 per 3 months Yes No
Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
15O – N2+O2 (0.4%)
7.5 (2-3) × (5-7)
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
203
COUNTRY: JAPAN JPN-10 [1] INSTITUTE: International Medical Centre of Japan
Radiology Department 1-21-1 Toyama, Shinjaku-ku
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 3 3202 7181 [email protected] +81 3 3202 7181
[2] PERSON IN CHARGE: POSITION:
Toshihiko Hara, MD Chief - Nuclear Medicine
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Noboru Kosaka, MD }three technologists
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE:
MODEL: BC 2010N [4] CYCLOTRON CHARACTERISTICS: p.d. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 1 Yes No Maximum beam available (µA) 50 30 Typical beam employed (µA) 30 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 10 5 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 1 Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
204
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 18.5 70 2 260 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 7.4 Yes No Yes No Choline 3.7 Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Choline 14.8 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 3.7
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
205
COUNTRY: JAPAN JPN-11 [1] INSTITUTE: Japan Atomic Energy Research Institute (JAERI)
1233 Watanuki, Takasaki Gunma 370-1292
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 27 346 9420 [email protected] +81 27 346 9688
[2] PERSON IN CHARGE: POSITION:
Dr. Toshiaki Sekine Deputy Director Department of Radiation Research for Environment and Resources
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Ms. Noriko Shigeta Ishikoka Mr. Sutoshi Watanabe
[3] TYPE OF CYCLOTRON: AVF Cyclotron, K-110
YEAR OF: (I) INSTALLATION 1990
MANUFACTURER: Sumitomo Heavy Industries
(II) UPGRADE:
MODEL: 930 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 90 50 100 Yes No Maximum beam available (µA) 5 7 7 Typical beam employed (µA) 5 5 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
101 15 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 32 Radiography: Materials science: 28 Proton therapy: Physics: 12 Neutron therapy: Activation analysis: Other (specify) 29,cyclotron technology
development [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 76Br, 77Br [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry 2 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
206
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F 0.1
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 0.03 1/month Yes No Yes No 18F - WATER 0.1 2/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Mehionine 0.4 3/week Yes No Yes No CO2 3 8/week Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
NO-3 0.3 15/week 16O(p,α) 13N Yes No
Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): – Products with our cyclotron are used in plant physiology only. Once, we have produced 186Re for medical research. – Production of this radionuclide, for medical purposes may be done again. – Metallic positron emitters 48V, 52 Mn, 52 Fe and 62 Zn are also produced.
207
COUNTRY: JAPAN JPN-12 [1] INSTITUTE: Kanazawa Cardiovascular Hospital
Ha 16 Tanaka, Kanazawa Ishikawa
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 76 253 8000 [email protected] +81 76 253 0008
[2] PERSON IN CHARGE: POSITION:
Mr. Toshihiko Morikawa
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Baby cyclotron for medical use
YEAR OF: (I) INSTALLATION 1991
MANUFACTURER: The Japana Steel Works Ltd.
(II) UPGRADE:
MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) 60 60 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
~ 20 ~ 4 ~ 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
208
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): …………
209
COUNTRY: JAPAN JPN-13 [1] INSTITUTE: Kyoto University Hospital
Kawahara-cho-54, Shogoin, Sakyo-ku Kyoto 606-8507
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 75 753 4567 [email protected] +81 75 751 3306
[2] PERSON IN CHARGE: POSITION:
Takahiro Mukai, PhD.
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Haruhiro Kitano
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1982 MANUFACTURER: Sumitomo Heavy
Industries (II) UPGRADE: 1997 (change of electronic
circuit) MODEL: Cypris 325 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 25 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
14 13 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other: Radiopharmaceuticals
for clinical and animal studies 13
[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C Raclopride, 11C SCH 23390, 18F DOPA, 18F FLT [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
210
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 40 95 4 350 Yes
No 20Ne (d, α) 18F 17 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 14 75/year Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 4.6 14/year Yes No Yes No Flumazenil 2.5 18/year Yes No Yes No Methionine 6.9 2/year Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 2.3 2/year 16O(p,α) )13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
Water 1 100/year 14N(d, n ) 15O CO 1.5/min 100/year 14N(d, n ) 15O O2 CO2
1.5/min 1.5/min
100/year 100/year
14N(d, n ) 15O 14N(d, n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
211
COUNTRY: JAPAN JPN-14 [1] INSTITUTE: Kyushu University
Department of Radiology, Faculty of Medicine Maidashi 3-1-1, Higashi-ku Fukuoka 812-8582
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 92 6425 788 +81 92 642 5833
[2] PERSON IN CHARGE: POSITION:
Dr. Yasuo Kuwabara Chief, Nuclear Medicine Section
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Masayuki Sasaki Isuyoshi Yoshida Toshimitsu Fukumura
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1983 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE: 1998
MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 30 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
11 7 2 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
212
18F RADIONUCLIDE PRODUCTION Production Typical
production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 10 95 2 40 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 2/week Yes No Yes No DOPA Yes No Yes No Estiradiol Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Raclopride 1/week Yes No Yes No Methionine 1/week Yes No Yes No NMPB 1/week Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq) Frequency of production Nuclear reaction used
Price/GBq if available
H2O 1/week 14N(d, n ) 15O CO 1/week 14N(d, n ) 15O O2 CO2
1/week 1/week
14N(d, n ) 15O 14N(d, n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
213
COUNTRY: JAPAN JPN-15 [1] INSTITUTE: Medical School of Nagoya University
Department of Radiology 65 Tsurumaicho, Showa-ku Nagoya City 466
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 52 741 2111 or 733 9415
[2] PERSON IN CHARGE: POSITION:
Mr. Masanori Tadokoro
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Takeo Ishigaki Masanari Nishino
[3] TYPE OF CYCLOTRON: Baby cyclotron YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE:
MODEL: BC 2211 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 22 11 Yes No Maximum beam available (µA) 60 60 Typical beam employed (µA) 100 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 6 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 2 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
214
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 16 3 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C–Methionine 100 1 per month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
15O-Water 100 1 per week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
215
COUNTRY: JAPAN JPN-16 [1] INSTITUTE: Nagoya City Rehabilitation and Sports Center
1-2 Mikanyama, Yatomi-cho Mizuho-ku, Nagoya 467-8622
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 52 83 4573 [email protected] +81 52 835 3745
[2] PERSON IN CHARGE: POSITION:
Yoshihiro Ito
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Noriyuki Kato Katsumi Araki
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: Sumitomo Heavy
Industries (II) UPGRADE:
MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 40 40 Typical beam employed (µA) 20 5 - 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
8 2 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C Raclopride , Na 18H [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
216
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 18 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 1.8 1day/week Yes No Yes No DOPA 1 Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
NMSP 2.5 5 days/year Yes No Yes No Methionine 2.5 3days/year Yes No Yes No Palmitic Acid 2.5 6 days/year Yes No Yes No Acetic Acid Flumazenil
2.5 2.5
6 days/year 1 day/month
Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 4 days/week 14N(d,n )15O CO, CO2 & O2 1.5 days/week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
217
COUNTRY: JAPAN JPN-17 [1] INSTITUTE: National Cardiovascular Centre
5-7-1 Fujishirodai, Suita Osaka 565
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 6 833 5012 [email protected] +81 6 872 7486
[2] PERSON IN CHARGE: POSITION:
Dr. Yoshio Ishida Director of Nuclear Medicine
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Yoshinori Miyake
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: Sumitomo Heavy
Industries (II) UPGRADE:
MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS:
1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 70 70 Typical beam employed (µA) 20 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 1 2 5 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: 12 Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 3 Gamma camera 5 Single photon tomography (SPET) 5 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
218
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F
In future 22 94 0.7 60 Yes
No 20Ne (d, α) 18F 18.5 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 1.5 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 3.3 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 1.4 5/week Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 3.3 3- 9/week 14N(d, n ) 15O CO,CO2,O2 0.01 9/week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
219
COUNTRY: JAPAN JPN-18 [1] INSTITUTE: National Centre of Neurology and Psychiatry
4-1-1 Ogawahigashi-cho 4-chome, Kodaira, Tokyo 187
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 423 412 711 [email protected] +81 423 446 745
[2] PERSON IN CHARGE: POSITION:
Dr. Hiroshi Matsuda Director, Radiological Division
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Yutaka Takayama; Satoru Horikoshi Kenichi Ogawa; Masato Kobayashi
[3] TYPE OF CYCLOTRON: Superconducting compact
YEAR OF: (I) INSTALLATION 1997
MANUFACTURER: Oxford (II) UPGRADE: MODEL: OSCAR, SCC12P [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 11.4 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
7 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
220
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 20 1-2 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
15O-Water 18
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
221
COUNTRY: JAPAN JPN-19 [1] INSTITUTE: National Institute for Longevity Sciences
Gengo, Morioka Obu 474-8522
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 562 46 2311 [email protected] +81 562 44 6 596
[2] PERSON IN CHARGE: POSITION:
Dr. Kengo Ito
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Kentaro Hatano Dr. Takashi Kato
[3] TYPE OF CYCLOTRON: Negative ion acceleration AVF
YEAR OF: (I) INSTALLATION 1995
MANUFACTURER: Sumitomo Heavy Industries
(II) UPGRADE:
MODEL: HM-18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 50 40 Typical beam employed (µA) 20 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
8 4 3 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 18F, 370MBq Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
222
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 17 >93 2 80 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 2.4 1/week Yes No Yes No DOPA 0.875 1/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Raclopride 0.37 24/year Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 17.4 30/year 14N(d, n )15O CO 3.7 5/year
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - SCH 23390 and B-CFT are used for animal experiments (including PET). Some novel radiopharmaceuticals are produced for drug development research.
223
COUNTRY: JAPAN JPN-20 [1] INSTITUTE: National Institute of Radiological Sciences
Advanced Technology Division for Medical Imaging Anagawa 4-9-1, Inage-ku
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 43 206 3262 [email protected] +81 43 206 3261
[2] PERSON IN CHARGE: POSITION:
Dr. Kazutoshi Suzuki Head
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Toshiaki Irie, Head Mr. Kiyoshi Fukushi, Senior Researcher Mr. Terushi Haradahira, Senior Researcher
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE:
MODEL: BC - 2010 BC-2010 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 10 Yes No Maximum beam available (µA) 70 50 Typical beam employed (µA) 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 36 10 4 26 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No for PET Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) 3 – Clinical – Small animal 2 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
224
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 1 - 10 50 1.5 30 Yes
No 20Ne (d, α) 18F 3 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 3 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 4 8/week Yes No Yes No McN5652X 1-2 3/week Yes No Yes No Raclopride 1-2 1/week Yes No Yes No MP4A 2 1/week Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 2-3 1/week 16O(p,α) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 2 6/week 14N(d, n )15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - Ro 15-1788, Ro 15- 4513, NMSP and SCH 23390
225
COUNTRY: JAPAN JPN-21 [1] INSTITUTE: National Institute of Radiological Sciences
Advanced Technology Division for Medical Imaging Anagawa 4-9-1, Inage-ku
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 43 206 3262 [email protected] +81 43 206 3261
[2] PERSON IN CHARGE: POSITION:
Dr. Kazutoshi Suzuki Head
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Toshiaki Irie, Head Mr. Kiyoshi Fukushi, Senior Researcher Mr. Terushi Haradahira, Senior Researcher
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: Sumitomo Heavy
Industries (II) UPGRADE:
MODEL: HM-18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 50 40 Typical beam employed (µA) 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 34 18 6 16 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No PET Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) 3 – Clinical – Small animal 2 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
226
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 1- 10 20 - 50 1.5 30 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 1 - 10 1 - 2/week Yes No Yes No Labeled Compd. 1 1/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Ro15 - 4513 3 1 - 2/week Yes No Yes No Methionine 4 6/week Yes No Yes No WAY 100635 1 -2 2 - 3/week Yes No Yes No MP4A 1 - 2 1/week Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 2-3 1/week 16O(p,α) 13N Yes No NPC 1 1/month Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 2 12/week 14N(d, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - NMSP, McN 5652X(+),McN 5652, Ro15 - 1788, SCH 23390, Raclopride, FLB 457, NMPB and Cyanoimipramine
227
COUNTRY: JAPAN JPN-22 [1] INSTITUTE: National Institute of Radiological Sciences
Advanced Technology Division for Medical Imaging Anagawa 4-9-1, Inage-ku
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 43 206 3262 [email protected] +81 43 206 3261
[2] PERSON IN CHARGE: POSITION:
Dr. Kazutoshi Suzuki Head
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Toshiaki Irie, Head Mr. Kiyoshi Fukushi, Senior Researcher Mr. Terushi Haradahira, Senior Researcher
[3] TYPE OF CYCLOTRON: AVF multi-particle YEAR OF: (I) INSTALLATION 1973 MANUFACTURER: Thomson CSF (II) UPGRADE: MODEL: AVF-930 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 90 55 145 110 Yes No Maximum beam available (µA) 20 20 10 10 Typical beam employed (µA) 20 15 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 9 6 6 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 4 Radiography: Materials science: Proton therapy: 3 Physics: 16 Neutron therapy: Activation analysis: Other (specify) 2 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) 3 – Clinical – Small animal 2 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
228
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 1-10 20-50 1.5 30 Yes
No 20Ne (d, α) 18F 3 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 1-10 1-2/week Yes No Yes No Labeled Compd 1 1/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
WAY 100635 1-2 1-2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 2-3 1/week Yes No NPC 1 1/month Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 2 6/week 14N(d, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 3 1/month Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - NMSP, MCN 5652X(+), MCN 5652, RO15-1788, SCH 23390, RACLOPRIDE, FLB457, NMPB, CYANOIMIPRAMINE, 38K
229
COUNTRY: JAPAN JPN-23 [1] INSTITUTE: National Research Institute for Metals
1-2-1 Sengen, Tsukuba Ibaraki 305
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 298 592 014 [email protected] +81 298 592 014
[2] PERSON IN CHARGE: POSITION:
Mr. Johsei Nagakawa Group Leader
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Norikazu Yamamoto, Subgroup Leader Mr. Yoshiharu Murase, Researcher Mr. Toshimitsu Fukuzawa, Researcher
[3] TYPE OF CYCLOTRON: AVF (fixed energy) YEAR OF: (I) INSTALLATION 1986 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE:
MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 26 20 Yes No Maximum beam available (µA) 50 50 20 20 Typical beam employed (µA) 30 30 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
50 40 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 40 Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
230
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We use our cyclotron only for studying radiation damage in nuclear reactor materials and not for RADIONUCLIDE PRODUCTION
231
COUNTRY: JAPAN JPN-24 [1] INSTITUTE: Nihon Medi-Physics Co. Ltd. Chiba Facility
3-1 Kitasode, Sodegaura City Chiba Pref., 299-0266
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 438 634 771 +81 438 633 306
[2] PERSON IN CHARGE: POSITION:
Dr. Masaji Takahashi Manager of Technical Section 1
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1986 MANUFACTURER: Sumitomo Heavy
Industries (II) UPGRADE:
MODEL: 750 PV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 30 Yes No Maximum beam available (µA) 130/55 Typical beam employed (µA) 120/50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
130 90 40 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? — everyday to hospitals. Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
232
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 500(@EOB) 3/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb
233
COUNTRY: JAPAN JPN-25 [1] INSTITUTE: Nihon Medi-Physics Co. Ltd. Chiba Facility
3-1 Kitasode, Sodegaura City Chiba Pref., 299-0266
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 438 634 771 +81 438 633 306
[2] PERSON IN CHARGE: POSITION:
Dr. Masaji Takahashi Manager of Technical Section 1
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: Sumitomo Heavy
Industries, Ltd. (II) UPGRADE: 1999 (H- acceleration)
MODEL: 480P [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 28 Yes No Maximum beam available (µA) 55 Typical beam employed (µA) 55 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
120 80 40 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? — everyday, to hospitals. Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
234
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 300(@EOS) 5/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb
235
COUNTRY: JAPAN JPN-26 [1] INSTITUTE: Nihon Medi-Physics Co. Ltd., Hyogo Facility
9-1 Techno Park, Sanda City Hyogo Pref., 669-1339
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 795 684 771 +81 795 683 071
[2] PERSON IN CHARGE: POSITION:
Mr. Shigeaki Kataoka Manager of Technical Section 1
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: Fixed field, fixed frequency, accelerating H-ions
YEAR OF: (I) INSTALLATION 1992
MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS:
1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 360 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
132 120 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F [9] Do you supply radionuclides to other
institutions? If yes and available, name of institution/s & how often? Everyday, to Hospitals
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
236
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 120(EOB) 1/2week Yes No Yes No 123I 500(EOS) 2-3/week Yes No Yes No 124I Yes No Yes No 201Tl 400(EOS) 2-3/week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
237
COUNTRY: JAPAN JPN-27 [1] INSTITUTE: Nihon Medi-Physics Co. Ltd., Hyogo Facility
9-1 Techno Park, Sanda City Hyogo Pref., 669-1339
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 795 684 771 +81 795 683 071
[2] PERSON IN CHARGE: POSITION:
Mr. Shigeaki Kataoka Manager of Technical Section 1
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: Fixed field, fixed frequency, accelerating H-ions
YEAR OF: (I) INSTALLATION 1990
MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16-30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 360 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
132 120 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Everyday, to Hospitals Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
238
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 120(EOB) 1/2week Yes No Yes No 123I 500(EOS) 2-3/week Yes No Yes No 124I Yes No Yes No 201Tl 400(EOS) 2-3/week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
239
COUNTRY: JAPAN JPN-28 [1] INSTITUTE: Nikko Memorial Hospital
Shintomi-cho 1-5-13 Muroran-shi, Hokkaido 51
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 143 24 1331 +81 143 22 5296
[2] PERSON IN CHARGE: POSITION:
Masahiro Shinohara Chief of Radiology
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Takafumi Mochizuki, Radiology
[3] TYPE OF CYCLOTRON: Deep valley fixed energy proton
YEAR OF: (I) INSTALLATION 1996/7
MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
240
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 11 40% 1.1 100 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 3.7 1 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
241
COUNTRY: JAPAN JPN-29 [1] INSTITUTE: Nishidai Clinic Diagnostic Imaging Center, Inc.
1-83-8 Takashimadaira, Itabashi-ku Tokyo 175-0082
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 3 5922 0700 [email protected] +81 3 5922 0701
[2] PERSON IN CHARGE: POSITION:
Kimiichi Uno, M.D. Chairman
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Keiichi Nakagawa, M.D. Katsumi Tomiyoshi, PhD., M.D.
[3] TYPE OF CYCLOTRON: Baby cyclotron YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: Sumitomo Heavy
Industries, Ltd. (II) UPGRADE:
MODEL: HM-18 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 20 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
11 10 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - α - Methyl Tyrosine (18F AMT) [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 5 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
242
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 20 95 2.0 100 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 10-15 1-2/day Yes No Yes No 18F 10 1/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
MET 5 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 10 3/day 16O(p,α) ) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 5 1/week 13N(p, n) 15O CO, O2 & C O2 10 1/week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced We carry out clinic diagnostic studies only, in collaboration with Gunma University School of Medicine.
243
COUNTRY: JAPAN JPN-30 [1] INSTITUTE: Nishijin Hospital
1035 Mizomae-cho, Kamigyo-ku Kyoto 602
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 75 4615514 [email protected]
[2] PERSON IN CHARGE: POSITION:
Dr. Takahiro Kanatsuna President
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Akira Fijii Hitoshi Horii Kazuo Wakita
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE:
MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) 10 ~ 50 Typical beam employed (µA) 70 ~ 80 extracting
efficiency: (60 ~ 65%)
[5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
6 ~10 6 ~10 4 ~ 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
244
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
245
COUNTRY: JAPAN JPN-31 [1] INSTITUTE: Nishina Memorial Cyclotron Centre
348-58 Tomegamori, Takizawa Iwate 020-0173
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 19 688 6071 [email protected] +81-19 688 6072
[2] PERSON IN CHARGE: POSITION:
Tsuneo Takahashi Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Shoji Futatsugawa, General Manager Kouichiro Sera, Professor Satoru Hatakeyama, Manager
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: Shimazu (II) UPGRADE: MODEL: MCY 1750 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.9 8.3 Yes No Maximum beam available (µA) 30 30 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 6 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
246
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 14.5 1 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Oxygen Carbon dioxide Water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
247
COUNTRY: JAPAN JPN-32 [1] INSTITUTE: Osaka City University Medical School
Division of Nuclear Medicine 1-4-3 Asahi-machi, Abenoku Osaka 545-8585
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 6 6645 3885 [email protected]
[2] PERSON IN CHARGE: POSITION:
Dr. Hironobu Ochi Professor, Division of Nuclear Medicine
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Masaji Okamoto Susumu Shiomi, Associate Professor
[3] TYPE OF CYCLOTRON: Compact superconducting, negative ion
YEAR OF: (I) INSTALLATION 1992
MANUFACTURER: Oxford-NKK (II) UPGRADE: 1993 MODEL: OSCAR SCC12P [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
8 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
248
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 5 50 5 50 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 5 15/month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 5 2/month Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 2 10/month Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
CO2 2 2/month O2 4 CO 4
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
249
COUNTRY: JAPAN JPN-33 [1] INSTITUTE: Research Institute for Brain & Blood Vessels Akita
6-10 Senshu-Kubota-machi Akita City
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 188 330 115 [email protected] +81 188 332 104
[2] PERSON IN CHARGE: POSITION:
Dr. Kazuhiro Takahashi Head
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Masanobu Ibaraki
[3] TYPE OF CYCLOTRON: Baby cyclotron YEAR OF: (I) INSTALLATION 1983 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE:
MODEL: BC-168 [4] CYCLOTRON CHARACTERISTICS:
1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 30 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
14 2 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
250
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2
(g)
18O2 (l)
18O (p, n) 18F 20 60 1.5 40 Yes No
20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 4 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 6 2/week Yes No Yes No 3NHPB 2 15/year Yes No Yes No NMSP 2 15/year Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
H2O 4 20/week 14N(d, n )15O O2 20 6/week CO 10 6/week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
251
COUNTRY: JAPAN JPN-34 [1] INSTITUTE: Tohohu University
Cyclotron and Radioisotope Center (CYRIC) Aramaki, Aoba-ku Sendai 980-7
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 217 7798 [email protected] +81 263 5358
[2] PERSON IN CHARGE: POSITION:
Professor Tsutomu Shinozuka
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: AVF multi particle YEAR OF: (I) INSTALLATION 1977 MANUFACTURER: Sumitomo Heavy
Industries (II) UPGRADE:
MODEL: 680 AVF [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 25 65 50 Yes No Maximum beam available (µA) 15 12 5 5 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
87 ~ 96 16 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
252
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 11 3-4 per week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine Yes No Yes No Doxepin Yes No Yes No Nemonapride Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water ~ 30 2 per week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
253
COUNTRY: JAPAN JPN-35 [1] INSTITUTE: Tokyo Metropolitan Institute of Gerontology
35-2 Sakaecho Itabashi Tokyo 173-0015
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 3 3964 3241 ext. 3505 [email protected] +81 3 3964 2188
[2] PERSON IN CHARGE: POSITION:
Dr. Kiichi Ishiwata Head, Positron Medical Center
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Yuichi Kimura, Senior Research Scientist Dr. Toru Sasaki, Research Scientist Kenji Ishii, M.D., Research Scientist Keiichi Oda, Research Scientist
[3] TYPE OF CYCLOTRON: AVF, positive ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: Sumitomo Heavy
Industries, Ltd. (II) UPGRADE:
MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 24 (not
routinely used)
18 (not routinely
used)
Yes No
Maximum beam available (µA) Typical beam employed (µA) 30 10 ~ 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
24 24 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
254
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No 18F-DOPA Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine Yes No Yes No Flumazenil Yes No Yes No N-methyl spiperone
Yes No Yes No
Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED
Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Oxygen Carbon dioxide Carbon monoxide
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
255
COUNTRY: JAPAN JPN-36 [1] INSTITUTE: University of Tokyo
Department of Radiology 7-3-1 Hongo Bunkyo-ku Tokyo 113
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+81 3 3815 5411 ext. 5129 +81 3 5800 8678
[2] PERSON IN CHARGE: POSITION:
Professor Johru Ontoke
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Toshimitsu Momose Shinya Oku
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1988 MANUFACTURER: Sumitomo Heavy
Industries, Ltd. (II) UPGRADE:
MODEL: Cypris 370 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 Yes No Maximum beam available (µA) Typical beam employed (µA) 50 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
32 32 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 1 Single photon tomography (SPET) 3 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
256
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No 18F-DOPA Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine Yes No Yes No N-Methyl- spiperone
Yes No Yes No
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water Oxygen C. monoxide Carbon dioxide
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
257
COUNTRY: KAZAKHSTAN KAZ-1 [1] INSTITUTE: Institute of Nuclear Physics
480082 Almaty-82, Ibragimov str., 1
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+7 327 2 546 433 [email protected] +7 327 2 546 517
[2] PERSON IN CHARGE: POSITION:
Professor A.A. Arzumanov Head, Accelerator Laboratory
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Sychikov Gennadi Popov Yuri Batischev Viktor
[3] TYPE OF CYCLOTRON: Variable energy isochronous K=50 MeV
YEAR OF: (I) INSTALLATION 1965
MANUFACTURER: Efremov Institute, Leningrad
(II) UPGRADE: 1972, converted to variable energy isochronous
MODEL: U 150 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6-30 12-25 18.5-62 25-50 Yes No Maximum beam available (µA) 500 200 50 100 Typical beam employed (µA) 300 100 20 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 16.5 15.7 4.3 3.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 1.8 Proton therapy: Physics: 15.7 Neutron therapy: Activation analysis: Other (specify) Neutron Source, 1.7 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 57Co, (5) Mössbauer sources? (specify which & quantity) Yes No 57Co, (1) X ray sources? (specify which & quantity) Yes No 57Co, (4)
109Cd, (6) Intense neutron beam? (specify average En = ?) Yes No 2 MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 201Tl Chloride, 67Ga Citzate, 57Co, 109Cd, 111In, 237Pu, 88Y, 85 Sr [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Hospitals, central clinics, on request.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
258
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 13 Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 3.0 Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 3.3 On request. Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
259
` COUNTRY: KOREA, REPUBLIC OF ROK-1 [1] INSTITUTE: Asan Medical Center
Seoul
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+82 2 2224 4590 [email protected] +82 2 2224 4588
[2] PERSON IN CHARGE: POSITION:
Dr. Seung Jun Oh
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: H-/D- YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: IBA, s.a., Belgium (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 50 25 Typical beam employed (µA) 38 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
12 9 3 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 12 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C-neuroreceptor imaging radiopharmaceuticals [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Two-three times in a week. Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 5 Single photon tomography (SPET) 2 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
260
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 185 95 2.0 480 Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 55 2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methonine 18.5 3-4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 18.5 1-2/week 160 (p,a)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 18.5 1-2/week 14n(D,N)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
261
COUNTRY: KOREA, REPUBLIC OF ROK-2 [1] INSTITUTE: Korea Cancer Centre Hospital
Korea Atomic Energy Research Institute 215-4 Gongneung-Dong Nowon-Ku, Seoul
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+82 2 970 1331 [email protected] +82 2 970 1332
[2] PERSON IN CHARGE: POSITION:
CHAI, Jong-Seo Senior Researcher/Project Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
KIM, Yu-Seok, Senior Engineer HONG, Seong-Seok, Engineer LEE, Min-Yong, Engineer
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: KCCH (II) UPGRADE: MODEL: KCCH-13 [4] CYCLOTRON CHARACTERISTICS: H+ 13 MeV, 4 sector magnet, 4th harmonics, PIG internal ion source, GUI computer
control. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 13 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
24 18 6 4 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): F-18, FDG [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? National Cancer Center; Ajou University Hospital, Yonsei University Hospital.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 2 Gamma camera 4 Single photon tomography (SPET) 4 Positron emission tomography (PET) 2 – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
262
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
263
COUNTRY: KOREA, REPUBLIC OF ROK-3 [1] INSTITUTE: Korea Cancer Centre Hospital
Korea Atomic Energy Research Institute 215-4 Gongneung-Dong Nowon-Ku, Seoul
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+82 2 970 1331 [email protected] +82 2 970 1332
[2] PERSON IN CHARGE: POSITION:
CHAI, Jong-Seo Senior Researcher/Project Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
KIM, Yu-Seok, Senior Engineer HONG, Seong-Seok, Engineer LEE, Min-Yong, Engineer
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 50 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 50 25 50.5 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 60 low current low current [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 20 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F production by 20Ne target; High purity 123I production by 124Xe target; on plan: 11C, 45Ti, 211At, 186Re, 124I [9] Do you supply radionuclides to other
institutions? If yes and available, name of institution/s & how often? 67Ga-citrate, 201TICI, Na123I, 123I-mIBG – 1 per week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 6 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
264
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
265
COUNTRY: KOREA, REPUBLIC OF ROK-4 [1] INSTITUTE: Samsung Medical Centre
Department of Nuclear Medicine Sungkyunkwan University School of Medicine 50 Ilwon-Dong, Kangnam-Ku Seoul 135-710
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+82 2 3410 2623 [email protected] +82 2 3410 2639
[2] PERSON IN CHARGE: POSITION:
Yearn Seong Choe Assistant Professor/Senior Research Scientist
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: GEMS (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 75 60 Typical beam employed (µA) 20 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
15 6 1 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 5 Single photon tomography (SPET) 5/5 Positron emission tomography (PET) 1 – Clinical 1/1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
266
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37 97 1.5 ~ 310 Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 7 -11 6/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
CFT Yes No Yes No Methionine 1/week Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia > 1.9 1/week 16O (p, α) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water > 3.7 1/week 14N(d, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
267
COUNTRY: KOREA, REPUBLIC OF ROK-5 [1] INSTITUTE: Seoul National University Hospital
Department of Nuclear Medicine 28 Yungun-Dong, Chongro-Ku Seoul 110-744
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+82 2 760 3805 [email protected] +82 2 745 7690
[2] PERSON IN CHARGE: POSITION:
Dr. Jae Min Jeong Director, Cyclotron and Radiochemistry; Associate Professor
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
In Won Lee, Chief Technologist
[3] TYPE OF CYCLOTRON: Proton only YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: EBCO Technology (II) UPGRADE: MODEL: TR-13 [4] CYCLOTRON CHARACTERISTICS:
1H 2H 3He 4He Dual Beams Beam energies (MeV) 13 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
44 25 10 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yunsei University Hospital — 5/week; National Cancer Center — 2/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
268
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 18 97 0.5 200 Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 7 2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Methionine 1 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 1.5 2/week 15N(p, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
269
COUNTRY: MEXICO MEX-1 [1] INSTITUTE: Unidad PET, Facultad de Medicina
Univesidad Nacional Autónoma de México Circuito Escolar S/N, Ciedad Universitaria Del. Coyoacán 04510 México, D.F.
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+52 5623 22 88 or 5623 22 99 [email protected] +52 5623 21 15 or 5623 22 41
[2] PERSON IN CHARGE: POSITION:
Dra. Nora E. Kerik Rotenberg Chief of Department
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. René Drucker Colín, Scientific Committee Member M. en C. Adolfo Zárate Morales, Cyclotron Operator M. en C. Martha Pedraza López, Radiopharmacist Q.F.I. Irma Martínez Hernández, Radiopharmacist Fís. Miguel Angel Avila Rodríguez, Cyclotron Operators
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
13 8 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F - DOPA and Raclopride [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? To hospitals in the future Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
270
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37 95-97 0.8 7 250 Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 14 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
HCN 33.3 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 3.7 2/week 16O(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 28 15N(p,n ) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
271
COUNTRY: NETHERLANDS NET-1 [1] INSTITUTE: Accrec B.V.
Eindhoven University of Technology (TUE) Cyclotron Building Postbus 513, NL-5600 MB Eindhoven
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+31 40 247 4048 [email protected] +31 40 243 8060
[2] PERSON IN CHARGE: POSITION:
Professor Dr. M.J.A. de Voight/Professor Dr. M.J. u.d. Wiel Directors, Accrec B.V.
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION Planned during 2002 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18-30 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
272
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
273
COUNTRY: NETHERLANDS NET-2 [1] INSTITUTE: Accrec B.V.
Eindhoven University of Technology (TUE) Cyclotron Building Postbus 513, NL-5600 MB Eindhoven
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+31 40 247 4048 [email protected] +31 40 243 8060
[2] PERSON IN CHARGE: POSITION:
Professor Dr. M.J.A. de Voight/Professor Dr. M.J. u.d. Wiel Directors, Accrec B.V.
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: 2nd harmonic dees with 6th harmonic flat top dees
YEAR OF: (I) INSTALLATION 1989
MANUFACTURER: Home-made (II) UPGRADE: MODEL: ILEC [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3 Yes No Maximum beam available (µA) Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
274
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
275
COUNTRY: NETHERLANDS NET-3 [1] INSTITUTE: Accrec B.V.
Eindhoven University of Technology (TUE) Cyclotron Building Postbus 513, NL-5600 MB Eindhoven
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+31 40 247 4048 [email protected] +31 40 243 8060
[2] PERSON IN CHARGE: POSITION:
Professor Dr. M.J.A. de Voight/Professor Dr. M.J. u.d. Wiel Directors, Accrec B.V.
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1963 MANUFACTURER: Philips (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3- 30 2-20 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
~ 80 ~ 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Yes Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Catalysis/
radiochemistry [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 (PEP) Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
276
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C alkanes weekly Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
NO 16O(p, α)13N Yes No Ammonia 16O(p, α)13N Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
N2 150 14N (d, n) 15O
OTHER ISOTOPES PRODUCED
Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) – Commercial isotope production for Nycomed, Amersham and Cygne – Production of short - lived positron emitters for University Research in catalysis using PEP – Beam analysis techniques for material research (University related) – This AVF Cyclotron will be shut - down in 2002 - 03 and a new Negative ion , IBA, Cyclone 30, 18-30 MeV is planned.
277
COUNTRY: NETHERLANDS NET-4 [1] INSTITUTE: Groningen University Hospital
PET Centre P.O. Box 30.001 NL-9700 RB Groningen
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+31 50 361 3311 +31 50 361 1687
[2] PERSON IN CHARGE: POSITION:
Professor William Vaalburg
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
A.M.J. Paans P.H. Elsinga
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8.5 Yes No Maximum beam available (µA) 780 750 Typical beam employed (µA) 20 - 30 20 - 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 3.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
278
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 20 > 94 1 300 Yes
No 20Ne (d, α) 18F 7 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG > 8 200/year Yes No Yes No DOPA 0.5 60/year Yes No Yes No MPPF 0.5 10/year Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Choline > 3 60/year Yes No Yes No Tyrosine 2-3 40/year Yes No Yes No Raclopride 0.5 30/year Yes No Yes No Verapamil Bicarbonate Acetate CSP - 12388
2 > 3 > 3 1
20/year 20/year 10/year 20/year
Yes No Yes No Yes No Yes No
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 0.8 - 1.0 500/year 16O (p, n) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 2-4 600/year
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
279
COUNTRY: NETHERLANDS NET-5 [1] INSTITUTE: Mallinckrodt Medical
P.O. Box 3 NL-1755 ZG Petten
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+31 224 567 890 [email protected] +31 224 563 566
[2] PERSON IN CHARGE: POSITION:
Eng. (Ir.) H. Buurlage General Manager
OTHER SENIOR STAFF: NAME/POSITION
Eng. (Ir.) F. de Lange, Head of Cyclotron Operations
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 400 Typical beam employed (µA) 2×180 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
130 130 0 10 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0 Radiography: 0 Materials science: 0 Proton therapy: 0 Physics: 0 Neutron therapy: 0 Activation analysis: 0 Other (specify) 0 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): None [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 0 Gamma camera 0 Single photon tomography (SPET) 0 Positron emission tomography (PET) 0 – Clinical 0 – Small animal 0 – Plant biochemistry 0 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
280
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/week Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 5/week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
281
COUNTRY: NETHERLANDS NET-6 [1] INSTITUTE: Mallinckrodt Medical
P.O. Box 3 NL-1755 ZG Petten
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+31 224 567 890 [email protected] +31 224 563 566
[2] PERSON IN CHARGE: POSITION:
Eng. (Ir.) H. Buurlage General Manager
OTHER SENIOR STAFF: NAME/POSITION
Eng. (Ir.) F. de Lange, Head of Cyclotron Operations
[3] TYPE OF CYCLOTRON: AVF – Positive ion YEAR OF: (I) INSTALLATION 1966 MANUFACTURER: Philips (II) UPGRADE: 1996 MODEL: AVF [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-30 Yes No Maximum beam available (µA) 150 Typical beam employed (µA) 120 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
100 100 0 10 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0 Radiography: 0 Materials science: 0 Proton therapy: 0 Physics: 0 Neutron therapy: 0 Activation analysis: 0 Other (specify) 0 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 0 Gamma camera 0 Single photon tomography (SPET) 0 Positron emission tomography (PET) 0 – Clinical 0 – Small animal 0 – Plant biochemistry 0 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
282
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 2/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 1/week Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 5/week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
283
COUNTRY: NETHERLANDS NET-7 [1] INSTITUTE: Vrije Universiteit
BV Cyclotron VU De Boelelaan 1085c NL-1081 HV Amsterdam
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+31 20 4449 123 [email protected] +31 20 4449 128
[2] PERSON IN CHARGE: POSITION:
Dr. P.J. Van der Jagt CEO
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
P.J. van Leuffen, Manager – Daily Operations R. Mooy, Chief Cyclotron Operator Dr. Ing. F. van Langevelde, (Health) Physicist Dr. P. Kruyer, Chemist
[3] TYPE OF CYCLOTRON: H- YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
25 22 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F, 11C, 13N, 15O [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-FDG planned Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 1 Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
284
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Flumazenil Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
285
COUNTRY: NETHERLANDS NET-8 [1] INSTITUTE: Vrije Universiteit
BV Cyclotron VU De Boelelaan 1085c NL-1081 HV Amsterdam
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+31 20 4449 123 [email protected] +31 20 4449 128
[2] PERSON IN CHARGE: POSITION:
Dr. P.J. Van der Jagt CEO
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
P.J. van Leuffen, Manager – Daily Operations R. Mooy, Chief Cyclotron Operator Dr. Ing. F. van Langevelde, (Health) Physicist Dr. P. Kruyer, Chemist
[3] TYPE OF CYCLOTRON: H+ YEAR OF: (I) INSTALLATION 1965 MANUFACTURER: Philips (II) UPGRADE: MODEL: AVF [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 6-28 3-16 10-45 6-32 Yes No Maximum beam available (µA) 200 Typical beam employed (µA) 35 15 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
85 75 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) 2 Positron emission tomography (PET) 2 – Clinical 1 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
286
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb is produced nine times per week for the production of rubidum/krypton generators.
287
COUNTRY: NORWAY NOR-1 [1] INSTITUTE: University of Oslo
Department of Physics P.O. Box 1048, Blindern N-0316 Oslo
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+47 22 856 460 +47 22 856 422
[2] PERSON IN CHARGE: POSITION:
Professor Magne Guttormsen
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
John Rekstad Svein Messelt
[3] TYPE OF CYCLOTRON: Sector focusing YEAR OF: (I) INSTALLATION 1979 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 35 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 35 17 47 35 Yes No Maximum beam available (µA) 100 80 10 20 Typical beam employed (µA) 70 50 5 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
5 2 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
288
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
289
COUNTRY: PHILIPPINES PHI-1 [1] INSTITUTE: Positron Emission Tomography and Cyclotron Facility
St. Luke’s Medical Center E. Rodriguez Avenue Quezon City 1102
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+63 2 725 6717 [email protected] +63 2 725 6717
[2] PERSON IN CHARGE: POSITION:
Jonas Y. Santiago, MD, FACNP Chief, Section of PET
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Nathaniel B. de Vera, Manager, PET & Cyclotron Facility and Medical Physicist Katheryn S. Mandap, Radiochemist
[3] TYPE OF CYCLOTRON: Negative Ion YEAR OF: (I) INSTALLATION 2001 (September) MANUFACTURER: GE (II) UPGRADE: MODEL: Minitrace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 9.6 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
290
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) This is the first cyclotron in the country; will be dedicated to produce 18F FDG and 13N Ammonia for use in PET procedures of the Medical Center and supply to other users on request. Detailed information will be supplied when the unit becomes operational. .
291
COUNTRY: POLAND POL-1 [1] INSTITUTE: Henryk Niewodnicanczanski Institute of Physics
(HNIP), Radzikowskiego 152 PL-31-341 Krakow
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+48 12 637 0222 [email protected] +48 12 637 5441
[2] PERSON IN CHARGE: POSITION:
Mr. Edmund Makewicz, MSc., EE Head of Cyclotron Unit
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Henryk Doruch, MSc., EE/Mr. Marek Talach, MSc., EE Dr. Ryszard Taraszkiewicz, Cyclotron Research Dr. Barbara Petelenz, head – Laboratory of Physical Chemistry Dr. Ewa Ochab, Deputy Head, Laboratory of Physical Chemistry
[3] TYPE OF CYCLOTRON: AVF isochronous YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: HNIP (II) UPGRADE: 2001 MODEL: AIC-144 [4] CYCLOTRON CHARACTERISTICS: K-factor = 60; extraction radius R = 0.62 M. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20-60 15-30 30-60 Yes No Maximum beam available (µA) 100/45
MeV 100 30
Typical beam employed (µA) 2-5 n/a 3-5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
Variable [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: planned Radiography: Materials science: Proton therapy: planned Physics: variable Neutron therapy: planned Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No variable X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No planned [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 111In, 211At [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
292
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In variable Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 57Co — occasionally, used on site in test of Si strip detectors, 99Rh — occasionally, used on site for Mössbauer research, 173Hf — occasionally, used on site in model studies of chemistry of transuranium elements, 178W, 181W — occasionally, used on site in model studies of chemistry of transuranium elements.
293
COUNTRY: POLAND POL-2 [1] INSTITUTE: Henryk Niewodnicanczanski Institute of Physics
(HNIP), Radzikowskiego 152 PL-31-341 Krakow
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+48 12 637 0222 [email protected] +48 12 637 5441
[2] PERSON IN CHARGE: POSITION:
Mr. Edmund Makewicz, MSc., EE Head of Cyclotron Unit
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Henryk Doruch, MSc., EE/Mr. Marek Talach, MSc., EE Dr. Ryszard Taraszkiewicz, Cyclotron Research Dr. Barbara Petelenz, head – Laboratory of Physical Chemistry Dr. Ewa Ochab, Deputy Head, Laboratory of Physical Chemistry
[3] TYPE OF CYCLOTRON: Isochronous, K-factor = 60
YEAR OF: (I) INSTALLATION 1994
MANUFACTURER: HNIP (II) UPGRADE: 1997 MODEL: AIC-144 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-60 15-30 30-60 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 5 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
Variable [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: variable Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
294
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG daily Yes No Yes No F-Dopa Yes No Yes No ML01 Yes No Yes No ML03 Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Chlorine Yes No Yes No Deprenyl Yes No Yes No Methionine Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia O16(p, α)N13 Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water weekly N14(p, α)O15
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In variable Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At variable Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 173Hf, 175Hf — occasionally, used on site in model studies of chemistry of transuranium elements, 178W, 181W — occasionally, used on site in model studies of chemistry of transuranium elements.
295
COUNTRY: POLAND POL-3 [1] INSTITUTE: Warsaw University
Heavy Ion Laboratory uL Pasteura 5A PL-02-097 Warszawa
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+48 22 658 2021 +48 22 659 2714
[2] PERSON IN CHARGE: POSITION:
Professor Dr. hab. Jan Kowracki
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Tomasz Czosnyka Mr. Jerzy Jastrzebski
[3] TYPE OF CYCLOTRON: AVF, 4-sector, 2-dee, 2 m diameter
YEAR OF: (I) INSTALLATION 1994
MANUFACTURER: Magnet - Dubna, rest all Polish parts
(II) UPGRADE: ECR installation, 1997
MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) * Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
100 24 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123I, 111In [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Planned after the ECR installation Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
296
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) – Basic research, e.g. Coulomb excitation, Giant Dipole Resonances – In-beam high-spin spectroscopy – Radioactive decays in He-jet system and isotope separation in-line.
297
COUNTRY: ROMANIA ROM-1 [1] INSTITUTE: National Institute for Physics and Nuclear Engineering
IFIN-HH Bucharest, Str. Atomistilor 407 Com Magurele, jud. Iiflov., POB MG-6, 76900 Bucharest-Magurele
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+40 1 404 23 00/4406 [email protected] +401 4023 1701
[2] PERSON IN CHARGE: POSITION:
Dipl. Eng. Dorin Dudu Head of the Cyclotron Accelerator
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Dip. Eng. Nicolae Tetcu, Deputy Head Dr. Eugen Ivanov Dr. Petru Mihai Racolta Dipl. Eng. Dana Voiculescu
[3] TYPE OF CYCLOTRON: Classical, var. energy, 60 cm magnetic pole radius
YEAR OF: (I) INSTALLATION 1957/1958
MANUFACTURER: URSS - Petrograd/Leningrad
(II) UPGRADE: 1970 - development of 7 beam transport lines 1999 – upgrading of RF controls
MODEL: U-120/1956 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-15 10-13 - 20-27 Yes No Maximum beam available (µA) 25 25 - 10 Typical beam employed (µA) 55 10 - 3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
45 10 10 10 15 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: - Radiography: - Materials science: 15 Proton therapy: - Physics: 5 Neutron therapy: - Activation analysis: 5 Other (specify) - [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) 22Na/1 mCi Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) 5 MeV Ø –
1012n/cm2s typically for d (13 MeV) on Be target. Yes No
[8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18f, 103Pd, 22Na, 67Ga, 111In, 123I, 68Ge [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical; – Small animal; – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
298
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) …
299
COUNTRY: RUSSIA RUS-1 [1] INSTITUTE: Bakoulev Scientific Centre for Cardiovascular Surgery
Roubevsekoe sh 135 121552 Moscow
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+7 095 414 7917 [email protected] +7 095 414 7782
[2] PERSON IN CHARGE: POSITION:
Dr. Evgeny Derevyanko, PhD. Head of PET Radiochemistry
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Professor Leo Bokeria, Director of Bakoulev Cardiosurgery Dr. Iracly Aslanidis, Head of Nuclear Diagnostics Dr. Vladimir Leonov, Cyclotron Engineer Dr. Tatiana Katunina, Cyclotron and Radiochemistry Engineer
[3] TYPE OF CYCLOTRON: Self-shielded, proton cyclotron
YEAR OF: (I) INSTALLATION 1998 - mounter
MANUFACTURER: CTI, Inc. (II) UPGRADE: 2001 - accepted MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 nil nil nil Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
6 2 - 4 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 15O, 11C - acetate, 11C - methinione, 15O - water [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence - Gamma camera - Single photon tomography (SPET) 2 Positron emission tomography (PET) – Clinical 1 – Small animal - – Plant biochemistry - [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
300
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 10 70-95 1.1 - 100 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 4 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13N - ammonia 1 1/month 16O(p,a) Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): ………………
301
COUNTRY: RUSSIA RUS-2 [1] INSTITUTE: Central Research Institute of Roentgenology and Radiology
189646 St. Petersburg Pesochny-2 Leningrad ul., 70
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+7 812 596 6609 [email protected] or [email protected] +7 812 596 6609
[2] PERSON IN CHARGE: POSITION:
Oleg A. Shtukovski, PhD. Head of the Department of Cyclotron Radiopharmaceuticals
OTHER SENIOR STAFF: NAME/POSITION
Mikhail Korsakov, Scientific Expert
[3] TYPE OF CYCLOTRON: Isochronous cyclotron with variable energy
YEAR OF: (I) INSTALLATION 1991
MANUFACTURER: Efremov Institute, St. Petersburg, Russia
(II) UPGRADE:
MODEL: MGC-20P [4] CYCLOTRON CHARACTERISTICS: H- and D- energy beam 16.4 MeV. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 4-18 7-10 10-28 4-20 Yes No Maximum beam available (µA) 100 50 30 25 Typical beam employed (µA) 30 - - - [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
60 40 12 8 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 67Ga, 111In [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 11 different clinical institutions in St. Petersburg, 2times/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 2 Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
302
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 15-18 95+ 1,4 nil 150 Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 5-10 2/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C – butyrate 4-6 2/week Yes No Yes No 11C – acetate 2-3 validation for
patient studies Yes No Yes No
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13N – ammonia 3-5 1 runday/week Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 2/week Yes No Yes No 124I 1/week Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): 123I - iodide, 123I – iodo hippurate, 123I – iodo bengal rose, 123I – iodo iodopentadecanoic acid.
303
COUNTRY: RUSSIA RUS-3 [1] INSTITUTE: Cyclotron Co. Ltd.
Bondarenko Sq. 1, Obninsk, Kaluga Region 249033
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+7 95 255 2385 [email protected] +7 95 255 2326
[2] PERSON IN CHARGE: POSITION:
Professor N.N. Krasnov Director General
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
A.A. Ponomarev, Chief Engineer Dr. Yuri Sevastianov, Deputy Director General
[3] TYPE OF CYCLOTRON: lsochronic YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: Scientific Institute,
Electrophysics (II) UPGRADE:
MODEL: RIC - 14 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 14 Yes No Maximum beam available (µA) 1000 Typical beam employed (µA) 850 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
52 weeks 130 8 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) 57Co, 109Cd
, 68Ge
[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 68Ge Mössbauer sources? (specify which & quantity) Yes No 57Co X ray sources? (specify which & quantity) Yes No 57Co,109Cd Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
304
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α)18F 16O (α,d)18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Upto 30 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Upto 200 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
305
COUNTRY: RUSSIA RUS-4 [1] INSTITUTE: Cyclotron Co. Ltd.
Bondarenko Sq. 1, Obninsk, Kaluga Region 249033
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+7 95 255 2385 [email protected] +7 95 255 2326
[2] PERSON IN CHARGE: POSITION:
Professor N.N. Krasnov Director General
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
A.A. Ponomarev, Chief Engineer Dr. Yuri Sevastianov, Deputy Director General
[3] TYPE OF CYCLOTRON: Classical cyclotron YEAR OF: (I) INSTALLATION - 1963 MANUFACTURER: Scientific Institute
Electrophysics (II) UPGRADE: 1993
MODEL: U - 150 - 1 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 22 22 Yes No Maximum beam available (µA) 1000 1000 Typical beam employed (µA) 700 700 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
52 weeks in year 2000 144 hours 4 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) 57Co,
109Cd, 68Ge
[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 68Ge Mössbauer sources? (specify which & quantity) Yes No 57Co X ray sources? (specify which & quantity) Yes No 57Co,109Cd Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
306
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α)18F 16O (α,d)18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Up to 30 1/week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Up to 200 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
307
COUNTRY: RUSSIA RUS-5 [1] INSTITUTE: Institute of Human Brain RAS
9 Pavlov Street St. Petersburg 197376
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+7 812 234 9347 [email protected] +7 812 234 3247
[2] PERSON IN CHARGE: POSITION:
Demianov Alexandr Cyclotron Engineer
OTHER SENIOR STAFF: NAME/POSITION
Krasikova Raisa, Head of Radiopharmacy
[3] TYPE OF CYCLOTRON: Medical YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 85 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 15-40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
16 7 4 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): PET 16 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
308
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 14.8 95 1.0 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 8.8 1/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
L-11C – methyl methionine
4.4 4/week Yes No Yes No
Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13N[NH3] 2.6 1/month 15O(p,a)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
15O[H2O] 4.4 25/week 14N(d,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
309
COUNTRY: RUSSIA RUS-6 [1] INSTITUTE: Kurchatov Institute of Atomic Energy (KIAE)
Moscow 123 182
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+7 095 196 9782 or +7 095 196 9977* +7 095 737 0600
[2] PERSON IN CHARGE: POSITION:
Unezhev Vitaly
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Oglobin Alexei* V.E. Jarosh
[3] TYPE OF CYCLOTRON: KIAEC YEAR OF: (I) INSTALLATION 1976 MANUFACTURER: (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 32 30 70 60 Yes No Maximum beam available (µA) 30 15 15 20 Typical beam employed (µA) 25 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
60 35 4 15 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 2 Proton therapy: Physics: 4 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En=30MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
310
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 98.6 1.5 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No On request Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 37 3 days/week Yes No Yes No On request 124I Yes No Yes No 201Tl 10 2 days/month Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
311
COUNTRY: RUSSIA RUS-7 [1] INSTITUTE: Nuclear Physics Institute at Tomsk Polytechnic University
Lenina 2-1 St., P.O. Box 25 634050 Tomsk
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+7 3822 417 953 or +7 3822 424 003* [email protected] +7 3822 423 934
[2] PERSON IN CHARGE: POSITION:
V.M. Golovkov Deputy Director
OTHER SENIOR STAFF: NAME/POSITION
A.I. Komov*, Chief of the Cyclotron Department
[3] TYPE OF CYCLOTRON: Tomsk(U-120) YEAR OF: (I) INSTALLATION 1959 MANUFACTURER: “Electrosila” St.
Petersburg (II) UPGRADE: 1971
MODEL: R - 7M [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 14 30 28 Yes No Maximum beam available (µA) 35 50 20 55 Typical beam employed (µA) 30 45 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
35 19 5 11 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: 6 Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En=7.5 MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123 I, Sodium Iodide, Iod - O - gippurate, MIBG, Iodophen [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Institute of Cardiology of Tomsk Research Centre (TRC) of Siberian Branch of Russian Academy Medical Sciences (SB RAMS)- 2 per week; Institute of Oncology of TRC SB RAMS- 2 per week; Siberian State Medical University- 2 per week.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
312
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Since 1990, TI-199 isotope is produced as analog of TI-201. The “Thallium Chloride, TI-99” radiopharmaceutical is provided to some medical institutes. Deliverables are realized twice per week. Quantity of the supplying radiopharmaceutical with the TI-11 is equal to 5-6 Ku/year.
313
COUNTRY: RUSSIA RUS-8 [1] INSTITUTE: Research Institute of Nuclear Physics
St. Petersburg Technical University 194223 St. Petersburg, ul. Kurchatova 10
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+812 552 98 96 [email protected] +812 552 98 31
[2] PERSON IN CHARGE: POSITION:
V.N. Lomasov Director, Research Institute of Nuclear Physics (RINP)
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
B.V. Zabrodin, Director of the Cyclotron Laboratory, RINP
[3] TYPE OF CYCLOTRON: MGC-20 YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: SRIEPhA, Russia (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 10 27 20 Yes No Maximum beam available (µA) 50 50 20 25 Typical beam employed (µA) 20 20 5 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
0 – 50 0 - 50 0 - 20 2 - 5 50 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 0 - 20 Proton therapy: Physics: 0 - 20 Neutron therapy: Activation analysis: sometimes Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 67Ga, 124I, 85Sr. [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? As required. Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
314
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 1 - 10 As required Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 1 - 10 as required Yes No Yes No 124I 0,5 - 4 as required Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 85Sr
315
COUNTRY: RUSSIA RUS-9 [1] INSTITUTE: V.G. Khlopin Radium Institute
2nd Murinski Prospect 28 149 021 St. Petersburg
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+7 812 247 [email protected] +7 812 237 6181
[2] PERSON IN CHARGE: POSITION:
L.M. Solin, PhD. Head of Laboratory
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1988 MANUFACTURER: Efremov NIIEFA (II) UPGRADE: MODEL: MGC-20 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 5-18 3-10 8-24 8-20 Yes No Maximum beam available (µA) 50 50 20 20 Typical beam employed (µA) 5-15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
60 48 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Sodium iodide, 123I; Sodium-Iodohippurate, 123I; 123I -MIBG; 123I -BMIPP; 67Ga Citrate: [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
316
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 3.5 1/ month Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 10 2-3 / week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
317
COUNTRY: SAUDI ARABIA SAU-1 [1] INSTITUTE: King Faisal Specialist Hospital and Research Centre
P.O. Box 3354 Riyadh 11211
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+966 1 442 7856 [email protected] +966 1 442 4743
[2] PERSON IN CHARGE: POSITION:
Eng. Salman Melibari Head of, Cyclotron Operations
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Eng. Salam Rahma, Senior Engineer Ahmad Algaith, Engineer Faisal Alromayanman, Engineer
[3] TYPE OF CYCLOTRON: Positive ion, AVF, electrostatic extraction
YEAR OF: (I) INSTALLATION 1981
MANUFACTURER: The Cyclotron Corporation
(II) UPGRADE:
MODEL: CS 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 28.5 15 38 30 Yes No Maximum beam available (µA) 200 300 135 90 Typical beam employed (µA) 100 100 100 80 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
45 < 10 < 10 < 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: 25 (on hold) Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En =14 MeV [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 103Pd, and 123I [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No 124I, 203Pb
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 5 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
318
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 28 > 95 0.33 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 15 Every day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 3.7 1-2/week Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 44.0 Every week Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 16.7 Occasionally Yes No Yes No 123I 28.0 Every day Yes No Yes No 124I 16.0 Occasionally Yes No Yes No 201Tl 34.0 Every Week Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Kr81m generator production everyday.
319
COUNTRY: SLOVAKIA SLR-1 [1] INSTITUTE: Slovak Office for Standards, Metrology and Testing
Cyclotron Centre of the Slovak Republic Stefanovicova 4, P.O. Box 76, SK-81005 Bratislava
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+421 7 524 91085 [email protected] +421 7 524 91050
[2] PERSON IN CHARGE: POSITION:
Dr. Dusan Podhorsky Chairman
OTHER SENIOR STAFF: NAME/POSITION
Dr. Peter Kovac, Senior Operators Dr. Josef Kristiak, Senior Scientist Professor Fedor Macasek, Senior Scientist Professor Jan Ruzicka, Scientific Secretary Professor Stefan Saro, Senior Scientist
[3] TYPE OF CYCLOTRON: Fixed energy H- and D- ions
YEAR OF: (I) INSTALLATION 2001 - 2002
MANUFACTURER: IBA, s.a., Belgium (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 35 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 5 (Planned) Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F – FDG, 11C - Raclopride [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
320
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 2 x 50 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 2 x 20 Yes No Yes No 18F-DOPA Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Raclopride 40 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 4 16O(p,α) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
CO2 (10) 14N(p,n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
321
COUNTRY: SOUTH AFRICA SAF-1 [1] INSTITUTE: National Accelerator Centre (NAC)
Radionuclide Production Group P.O. Box 72, Faure, 7131
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+27 21 843 3820 [email protected] or [email protected]* +27 21 843 3525
[2] PERSON IN CHARGE: POSITION:
Professor J.F. Sharpey-Schafer Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. M.E. Murphy, Deputy Director Dr. T.N. Van der Walt*, Head-Radionuclide Production Dr. L. Conradie, Head-Accelerator Group
[3] TYPE OF CYCLOTRON: Separated sector w/ solid pole injector cyclotron
YEAR OF: (I) INSTALLATION 1986
MANUFACTURER: NAC (II) UPGRADE: 1994 (2nd injector) MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 66 - 200 Yes No Maximum beam available (µA) 180 Typical beam employed (µA) 90 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
144 38 24 24 ~20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: 12 Physics: 24 Neutron therapy: 10 Activation analysis: Other (specify)
Radionuclide production 38
[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F and 18F FDG; 103Pd; 68Ge; 82Sr [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Nuclear medicine centres in South Africa and Namibia — on a weekly basis.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
322
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga weekly Yes No Yes No $ 372 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I weekly Yes No Yes No $ 405 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
323
COUNTRY: SPAIN SPA-1 [1] INSTITUTE: BARNATRON
Anselm Clave, 100 08950 Espluges de Llobregar Barcelona
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+34 93 473 5144 [email protected] +34 93 473 4839
[2] PERSON IN CHARGE: POSITION:
Isabel R. de Arellano Radiochemist, responsible for Installation
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Carlos Piera, responsible for Quality Control Pedro Larroza, Technician – Production Martin Vargas, Technician – Quality Control
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: H- and D- energy beam 16.4 MeV. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.4 MeV Yes No Maximum beam available (µA) Typical beam employed (µA) 36 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
11 7 - 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 Advanced GE – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
324
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F >95.5 1.6 mL Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 65/2 MR bomb 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
325
COUNTRY: SPAIN SPA-2 [1] INSTITUTE: Centro Andaluz de Díagnóstíco PET (CADPET)
Ronda de Capuchinos, 11 41009 Sevilla
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+34 954 432 537 administrací[email protected]/[email protected]/[email protected] +34 954 435 5850
[2] PERSON IN CHARGE: POSITION:
Mr. Miguel Perez Consejero Delegado (Managing Director)
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Mr. Miguel Cantero, Radiochemist Mrs. Rocío Iglesias, Radiopharmacist
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace 2132402 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 Yes No Maximum beam available (µA) 75 Typical beam employed (µA) 36 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
2 2 n/a [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify)
Radiopharmaceuticals
2/week [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? CADPET Málaga: 4/week; Hospital Universitaria Virgen del Rocío (Sevilla): 4/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
326
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 95 1,5 mL Yes
No 20Ne (d, α) 18F 16O (α,d )18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 32 4/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
327
COUNTRY: SPAIN SPA-3 [1] INSTITUTE: Centro PET Complutense (CPC)
Manuel Bartolome Cossio, 10 E-28040 Madrid
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+34 91 534 4896 [email protected] +34 91 553 0845
[2] PERSON IN CHARGE: POSITION:
José Miguel Alfonso President
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Antonio Maldonado, Medical Director Magdalena Melgarejo Icaza, Laboratory Director José Manuel Nieto, Administrative Director
[3] TYPE OF CYCLOTRON: Superconducting, negative ion
YEAR OF: (I) INSTALLATION 1994
MANUFACTURER: Oxford Intr. (II) UPGRADE: MODEL: OSCAR IV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
15 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify):
FDG fabrication
[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? IVO (Valencia): 3-4/week; Hospital del Rocío (Sevilla: 5-9/week; Hospital Dr. Peset (Valencia): 2-3/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
328
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 25 >95 5 ± 400 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 25 2-4/day Yes No Yes No P45,000/ injection to patient
Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Centro PET Complutense S.A. is dedicated only in the production and utilization of 1`8FDG for clinical use. During this utilization it participates in diverse projects of clinical investigation.
329
COUNTRY: SPAIN SPA-4 [1] INSTITUTE: Clinica Universitaria de Navarra
Facultad de Medicina Apartado, 4029 31080 Pamplona
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+34 948 255 400 ext. 4941 [email protected] +34 948 296 500
[2] PERSON IN CHARGE: POSITION:
José A. Richter MD, PhD. Chief of Nuclear Medicine
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Josep M. Marti-Climent, PhD. Iván Peñuelas, PhD. Javier Arbizu, MD María J. García-Velloso, MD, PhD.
[3] TYPE OF CYCLOTRON: Double particle YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 35 Typical beam employed (µA) 30 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
330
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d,a) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
331
COUNTRY: SPAIN SPA-5 [1] INSTITUTE: MOLYPHARMA
Avenida Dr. Severo Ochoa, 37-41-1 28100 Alcobendas Madrid
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+34 91 490 5730 [www.molypharma.es] +34 91 490 5740
[2] PERSON IN CHARGE: POSITION:
Mr. Rafael Jimenez Shaw Director de Operaciones
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Tomas Arroyo, Radiopharmacist
[3] TYPE OF CYCLOTRON: GE Minit-11 YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 9.6 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: (ESTIMATION) Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 19 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 5 during 2001 (expected) Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
332
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 52 96 0.5 Yes
No 20Ne (d,α)18F 16O (α, d)18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 37 Daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 5 Daily 16O(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
333
COUNTRY: SWEDEN SWE-1 [1] INSTITUTE: Uppsala Universitet
PET-Centrum UAS, S-75185 Uppsala
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+46 18 471 5388 [email protected] +46 18 471 53890
[2] PERSON IN CHARGE: POSITION:
Joachim Schultz Engineer
OTHER SENIOR STAFF: NAME/POSITION
Mr. Gunnar Antonio, Senior Chemist
[3] TYPE OF CYCLOTRON: Isochron, deflector YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17 [4] CYCLOTRON CHARACTERISTICS: 17 MeV protons, 8,5 deuterons, mx 50 µA on target 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 17 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 45 45 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
60 57 0 2 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 3 – Small animal 2 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
334
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37 95 0.9 1.2 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 15 3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
CO2 ~20 5/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
15O water 1 5/week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
335
COUNTRY: SWITZERLAND SWI-1 [1] INSTITUTE: Paul Scherrer Institute
CH-5232 Villigen-PSI
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+41 56 310 2813 [email protected] +41 56 310 2849
[2] PERSON IN CHARGE: POSITION:
Professor P.A. Schubiger Head of Centre for Radiopharmacy
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Simon Ametamey Peter Bläuenstein Roger Schibli
[3] TYPE OF CYCLOTRON: PSI construction YEAR OF: (I) INSTALLATION 1974 MANUFACTURER: Philips (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: Total beam is 200 Micro Amp; a splitter divides into main beam and a small part for the
radiopharmacy; this sheet is filled out with respect to RPH applications 1H 2H 3He 4He Dual Beams Beam energies (MeV) 72 - - - Yes No Maximum beam available (µA) 70 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
140 150 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
336
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 50 >80 2 50 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Dopa Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Flumazenil Yes No Yes No Raclopride Yes No Yes No Methionine Yes No Yes No Ketamine Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 20 2/month Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We are concentrating on research of new radiopharmaceuticals for brain imaging and tumour therapy. The products are investigated in vitro and in vivo (animals). If good results are obtained, first clinical tests are started, but there is no regular distribution to hospitals anywhere. In addition to 18F, we are producing 11C, 67Cu and 76Br.
337
COUNTRY: SWITZERLAND SWI-2 [1] INSTITUTE: University Hospital of Geneva
Department of Radiology, Cyclotron Unit 24, rue Micheli-du-Crest CH-1211 Geneva
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+41 22 37 27 580 [email protected] +41 22 37 27 585
[2] PERSON IN CHARGE: POSITION:
Professor Gerd-Jürgen Beyer Dr. habil, Head of Cyclotron Unit
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Dmitri Soloviev, PhD., Radiochemist Claire Tamburella, PhD., Cyclotron Physicist
[3] TYPE OF CYCLOTRON: PET YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 80 40 Typical beam employed (µA) 35 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 10 5 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): – 124-I via 124-Te(p,n)124-I with optimized targetry and dedicated module,
– 86-Y via 86-Sr(p,n) reaction, – 64-Cu and probably 67-Cu.
[9] Do you supply radionuclides to other institutions? If yes and available, name of institution/s & how often? Distribution is planned — to be organized via a private company; integration into a network system is foreseen.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) 4 Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
338
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 150 95 2.5 600 Yes
No Ne (d, α) 18F 10 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 80 daily Yes No Yes No See comments FDOPA planned Yes No Yes No Other tracers planned Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Planned Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
H2O N(d,n)
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu planned Yes No Yes No 67Ga Yes No Yes No 86Y planned Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 0.8 weekly Yes No Yes No planned 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Comment concerning pricing:The philosophy is to charge for individual injection doses, and not for delivered activities. Fixed tracer price is important for harmonization of the costs per PET study to be reimbursed. We just became operational, legislation procedure I under way. Most of the mentioned activities are according to plan. Given activities are results of related tests. First priority has reliable large scale FDG production.
339
COUNTRY: SWITZERLAND SWI-3 [1] INSTITUTE: University Hospital of Geneva
Department of Radiology, Cyclotron Unit 24, rue Micheli-du-Crest CH-1211 Geneva
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+41 22 37 27 580 [email protected] +41 22 37 27 585
[2] PERSON IN CHARGE: POSITION:
Professor Gerd-Jürgen Beyer Dr. habil, Head of Cyclotron Unit
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dmitri Soloviev, PhD., Radiochemist Claire Tamburella, PhD., Cyclotron Physicist
[3] TYPE OF CYCLOTRON: Negative ion, fixed energy
YEAR OF: (I) INSTALLATION 1997
MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 30 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C, 13N, 15O, 18F, 64Cu, 67Cu, 86Y, 120I, 123I, 124I [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18FDG to 8 Centres daily beginning in September, 1997.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 2 Single photon tomography (SPET) 2 Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
340
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
341
COUNTRY: SWITZERLAND SWI-4 [1] INSTITUTE: University Hospital Zürich, PET Center
Raemistrasse 100 CH-8081 Zürich
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+41 1 255 1111 [email protected] +41 1 255 4428
[2] PERSON IN CHARGE: POSITION:
Professor A. Schubiger
OTHER SENIOR STAFF: NAME/POSITION
Dr. G. Westera
[3] TYPE OF CYCLOTRON: Fixed energy, negative ion
YEAR OF: (I) INSTALLATION 1994
MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.5 Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 Stand-by 20 Beam on target 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F – DOPA, FLT, 11C - Various [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 2 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
342
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 110 95 1.6 600 Yes
No Ne (d, α) 18F 600 MBq 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 45 1/day Yes No Yes No SFR 200 18FET 2.5 1/week Yes No Yes No 18F- 1.5 1/week Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Raclopride 2.5 1/2 weeks Yes No Yes No Flumarenil 2.5 1/2 weeks Yes No Yes No Acetate 2.5 1/month Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13NH3 10 10 / week 16O (p, a) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
H2O Continuous 10 / week 15N(p.n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
343
COUNTRY: SYRIAN ARAB REPUBLIC SYR-1 [1] INSTITUTE: Atomic Energy Commission of Syria (AECS)
P.O. Box 6091 Damascus
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+963 11 391 2896 or 391 3923 +963 11 611 2289
[2] PERSON IN CHARGE: POSITION:
Dr. Abdul Hamid Al-Reyyes
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Negative ion, variable energy
YEAR OF: (I) INSTALLATION 2001
MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 350 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 123I, 111In, 103Pd, 11C, 15O [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Not yet. Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
344
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F ~ 90 97 1.3 250 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 30 3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
345
COUNTRY: TURKEY TUR-1 [1] INSTITUTE: Monrol Isotopes Services
Perpa Ticaret Merkezi, A Blok Kat 2 No. 9/0006 Okmeydani
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+909 212 222 3828 [email protected] +909 212 222 3817
[2] PERSON IN CHARGE: POSITION:
Mr. Ugur Bozluolcay General Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Ayse Sungur, PhD., Manager Harun Kügükmidil, Technical Service Manager Güleren Albak, MSc., Radiation Safety Officer Baris Çakir, Cyclotron Operator
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
8 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify)
Radiopharmaceutical production [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Istanbul, International Hospital Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
346
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 33.3 95 1.2 500 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 12.6 8/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
347
COUNTRY: UNITED KINGDOM UK-1 [1] INSTITUTE: Douglas Cyclotron Unit
Clatterbridge for Oncology Bebington, Wirral L63 4JY
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+44 151 334 6366 [email protected] +44 151 334 2845
[2] PERSON IN CHARGE: POSITION:
Dr. Andrzej Kacperek Head, Cyclotron Unit
OTHER SENIOR STAFF: NAME/POSITION
B. Marsland
[3] TYPE OF CYCLOTRON: AVF, single particle, fixed energy
YEAR OF: (I) INSTALLATION 1984
MANUFACTURER: Scandinotrix (II) UPGRADE: 1988 (beamline of proton therapy)
MODEL: MC-62 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 62 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20 - 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 5 2 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: 15 Physics: 2 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 22Na Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 64Cu, 55Co [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Paterson Institute, Christie Hospital, (4-8/month) Manchester, M20 4BX, U.K.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
348
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 40 95 1 Mostly
recycled Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 1 1/month Yes No Yes No (Research
contract) 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) We only produce isotopes, not pharmaceuticals.
349
COUNTRY: UNITED KINGDOM UK-2 [1] INSTITUTE: Imaging Research Solutions Limited
Cyclotron Building Hammersmith Hospital Ducane Road, London W12 ONN
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+44 (0) 208 383 3162 [email protected] +44 (0) 208 383 2029
[2] PERSON IN CHARGE: POSITION:
Dr. John Thornback Managing Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Bruce Mackay, Cyclotron Operations Manager Mike Renton, Chief Cyclotron Engineer Dave Turton, Radiochemistry Production Manager David Ellison, Commercial Director
[3] TYPE OF CYCLOTRON: O-15 generator YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 3D [4] CYCLOTRON CHARACTERISTICS: Positive ion, fixed energy, fixed frequency, internal beam only. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 3.8 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30 28 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 5 – Clinical 4 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
350
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
15H2O continuous daily 14N(d,n)15O 15CO continuous daily 14N(d,n)15O 15O continuous weekly 14N(d,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
351
COUNTRY: UNITED KINGDOM UK-3 [1] INSTITUTE: Imaging Research Solutions Limited
Cyclotron Building Hammersmith Hospital Ducane Road, London W12 ONN
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+44 (0) 208 383 3162 [email protected] +44 (0) 208 383 2029
[2] PERSON IN CHARGE: POSITION:
Dr. John Thornback Managing Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Bruce Mackay, Cyclotron Operations Manager Mike Renton, Chief Cyclotron Engineer Dave Turton, Radiochemistry Production Manager David Ellison, Commercial Director
[3] TYPE OF CYCLOTRON: Positive ion, variable energy
YEAR OF: (I) INSTALLATION 1986
MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 40 Mark II [4] CYCLOTRON CHARACTERISTICS: Isochronous cyclotron for acceleration of light ions, delivers high quality external beams
via a beam transport system with seven (7) lines to more than 20 installed targets. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10-40 5-20 12-53 10-40 Yes No Maximum beam available (µA) 65 65 50 60 Typical beam employed (µA) 30 30 30 55 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
110 65 40 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Daily Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 5 – Clinical 4 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
352
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 10/F2; 55/F- 95 1.2 150 400 10 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 20 daily Yes No Yes No Wide range of compounds
Yes No Yes No
Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Extensive range of compounds
daily Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
15CO continuous daily 14N(d,n)15O 15CO2 continuous daily 14N(d,n)15O 15H2O continuous daily 14N(d,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.3 Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 81Rb/Kr generators
353
COUNTRY: UNITED KINGDOM UK-4 [1] INSTITUTE: John Mallard Scottish PET Centre
University of Aberdeen Department of Biomedical Physics and Bioengineering Foresterhill, Aberdeen, AB9 2ZD
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+44 1 22484 0907 [email protected] +44 1 22484 9179
[2] PERSON IN CHARGE: POSITION:
Dr. Andrew Welch Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
M.G. Dodd, Cyclotron Engineer Dr. Lutz Schweiger, Senior Chemist
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
17 12 4 0.2 0.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 16 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): Target dev. 1 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
354
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 12 30 1.1 180 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 4 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Choline 2 weekly Yes No Yes No Methylene blue weekly Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 3 as required 16O(p, α)13Ν Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 3 weekly 15N(p,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
355
COUNTRY: UNITED KINGDOM UK-5 [1] INSTITUTE: St. Thomas Hospital
The Clinical PET Centre Guy’s, King’s, St. Thomas School of Medicine Lambeth Palace Road London SE1 7EH
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+44 207 922 8068 +44 207 922 0790
[2] PERSON IN CHARGE: POSITION:
Professor M.N. Maisey Chairman, Division of Radiological Sciences
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Ms. Margaret Dakin Ms. Julie Sutcliffe-Goulden Mr. Paul Halstead Mr. Paul Marsden
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.5 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
19 15 4 As required [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 64Cu – In development; 18F – FLT – In development; 18F –Peptides – In development [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Fluoride for scanner applications Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 2 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
356
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F > 95 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 2 /day Yes No Yes No £ 325/ patient
dose FLT Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C Metnionine Yes No Yes No 11C Fumazenl Yes No Yes No 11C Methyl acetate
Yes No Yes No
Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED
Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13NH3 16O(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 15N(p,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
357
COUNTRY: UNITED KINGDOM UK-6 [1] INSTITUTE: University of Cambridge
Wolfson Brain Imaging Centre Box 65, Addenbrook's Hospital Cambridge CB2 2QQ
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+44 1223 33 1820 [email protected] +44 1223 33 1826
[2] PERSON IN CHARGE: POSITION:
John C. Clark, DSc. PET Science Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Professor John D. Pickard, Clinical Director and Chairman Dr. Franklin I. Aigbirhio, Radiopharmaceutical Chemist Dr. Peter J. Johnstrom, Radiopharmaceutical Chemist Mr. Paul Burke, Cyclotron Engineer
[3] TYPE OF CYCLOTRON: Negative ion, fixed energy
YEAR OF: (I) INSTALLATION 1994
MANUFACTURER: GE (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8.5 Yes No Maximum beam available (µA) 100 40 Typical beam employed (µA) 45 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
28 6 10 4 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): PET [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F peptides; 11C ligands and substrates; 64Cu antibody fragments/chelates [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 3/week to two centres. Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) – Clinical 1 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
358
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water CO O2
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) …
359
COUNTRY: UNITED STATES OF AMERICA USA-1 [1] INSTITUTE: Bowman Gray School of Medicine
Medical Centre Boulevard Winston-Salem, NC 27157
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 910 716 7461
[2] PERSON IN CHARGE: POSITION:
Dr. Richard L. Witcofski Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Richard Ehrenkaufer Henry Chilton
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS-112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
15 15 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-FDG, daily Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
360
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18F – FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C - methionine Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
15O - water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
361
COUNTRY: UNITED STATES OF AMERICA USA-2 [1] INSTITUTE: Brookhaven National Laboratory
Chemistry Department, Bldg. 901 Upton, NY 11973
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+631 344 4587 [email protected] +631 344 4587
[2] PERSON IN CHARGE: POSITION:
David J. Schlyer Manager, BNL Cyclotron Facility
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Joanna Fowler, Programme Director Richard Ferrieri, Chemist Michael Schueller, Assistanct Chemist
[3] TYPE OF CYCLOTRON: Isochronous YEAR OF: (I) INSTALLATION 1981 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE:
MODEL: BC 1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 10 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 35 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30 30 0 4 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 1 Positron emission tomography (PET) 2 – Clinical – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
362
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 13.5 95 3.1 45 Yes
No 20Ne (d, α)18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 3.5 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Cocaine 0.5 3/week Yes No Yes No Raclopride 0.5 3/week Yes No Yes No Deprenyl 0.5 2/week Yes No Yes No Clorgyline 0.5 2/week Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 1.0 On demand 160(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 195m Pt
363
COUNTRY: UNITED STATES OF AMERICA USA-3 [1] INSTITUTE: Brookhaven National Laboratory
Chemistry Department, Bldg. 901 Upton, NY 11973
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+631 344 4587 [email protected] +631 344 4587
[2] PERSON IN CHARGE: POSITION:
David J. Schlyer Manager, BNL Cyclotron Facility
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Joanna Fowler, Programme Director Richard Ferrieri, Chemist Michael Schueller, Assistanct Chemist
[3] TYPE OF CYCLOTRON: Collins Radio YEAR OF: (I) INSTALLATION 1958 MANUFACTURER: (II) UPGRADE: 1968 MODEL: [4] CYCLOTRON CHARACTERISTICS: Four particle, variable energy. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 35 23 57 46 Yes No Maximum beam available (µA) 20 15 10 10 Typical beam employed (µA) 15 10 10 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
5 5 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
364
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 7.4 95 2 5 Yes
No 20Ne (d, α)18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 1 monthly Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I On demand Yes No Yes No 124I On demand Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
365
COUNTRY: UNITED STATES OF AMERICA USA-4 [1] INSTITUTE: Carolinas Medical Center
Department of NM & PET 1000 Blyth Blvd., P.O. Box 32861 Charlotten NC 28232
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 704 355 2276 [email protected]
[2] PERSON IN CHARGE: POSITION:
Dr. Ron Borchert
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1993 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.5 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
80 80 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Confidential Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 6 Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
366
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F ~ 37 95 0.5 500 Yes
No 20Ne (d, α)18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 400-450 2-4/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 15 - 22 1-2/week 16O(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
367
COUNTRY: UNITED STATES OF AMERICA USA-5 [1] INSTITUTE: Case Western Reserve University
and University Hospitals of Cleveland Division of Radiology 11100 Euclid Avenue, Cleveland, OH 44139
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 216 844 7350 [email protected]
[2] PERSON IN CHARGE: POSITION:
Dr. Marc Berridge Associate Professor
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Lei Zheng Ken Voelker
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17 8 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
25 25 average: 6 (some weeks, none)
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-Fluoride; 13N-Ammonia; 18F-FDG
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 2 Single photon tomography (SPET) 3 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
368
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
369
COUNTRY: UNITED STATES OF AMERICA USA-6 [1] INSTITUTE: Childrens Hospital of Michigan
PET Center 3901 Beaubien Boulevard Detroi, MI 48201
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 313 993 2618 [email protected] +1 313 993 3845
[2] PERSON IN CHARGE: POSITION:
Dr. Thomas J. Mangner Director, PET Chemistry
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Harry T. Chugani, Medical Director
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1993 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 20 - 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 20-24 10 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 20 - 24 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C – leucine; 11C - DWAY [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
370
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 22 >95 0.35 150 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 12 5-6/week Yes No Yes No 18F FLT 2 1/week Yes No Yes No 18F FMAU 1.5 1/monoth Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C FMZ 15 2-3/week Yes No Yes No 11C AMT 6 2-3/week Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13N NH3 2 5-10/week 16O(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
15O Water 4 5-6/month 15N(p,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Other radiopharmaceuticals produced on an irregular basis: C-11 acetate, C-11 m-hydroxyephedrine (HED), 2-C-11 thymidine, C-11 methionine, F-18 FAU, F-18 FIAU, F-18 FBAU.
371
COUNTRY: UNITED STATES OF AMERICA USA-7 [1] INSTITUTE: Columbia Presbyterian Medical Centre
Milstein Hospital Building 622 W. 168th Street New York, NY 10032
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 212 305 8815
[2] PERSON IN CHARGE: POSITION:
Jerry Strugala Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Tom Boland Michael Sanfilippo
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
25 25 ~ 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-FDG to 15 external institutions, 5 × per week.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Off-site, too.
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
372
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18F-FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C-methionine Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13N-ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
11O-water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
373
COUNTRY: UNITED STATES OF AMERICA USA-8 [1] INSTITUTE: Creighton University
Center for Metabolic Imaging 901 Dorcas Street Omaha, NE 88106
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 402 346 4181
[2] PERSON IN CHARGE: POSITION:
Dr. Marc Wrichelt Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Mike Harrington Mr. Steve Torres
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
~ 7 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other
institutions?
If yes and available, name of institution/s & how often? 18F-FDG
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
374
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
375
COUNTRY: UNITED STATES OF AMERICA USA-9 [1] INSTITUTE: Crocker Nuclear Laboratory
University of California, Davis 1 Bainer Drive Davis, CA 95616
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 916 752 1460 [email protected] +1 916 752 0952
[2] PERSON IN CHARGE: POSITION:
Dr. Manuel C. Lagunas-Solar Senior Radiochemist
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Nolan X. Zeng Mr. Carlos M. Castaneda Ms. Krystyna Trzepla-Nabaglo Mr. Omar F. Carvacho
[3] TYPE OF CYCLOTRON: 76 inch isochronous YEAR OF: (I) INSTALLATION 1964-1966 MANUFACTURER: W.M. Brobeck &
Associates (II) UPGRADE:
MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 4-68 15-45 20-90 16-90 Yes No Maximum beam available (µA) Typical beam employed (µA) 30 40 1 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
112 4-8 ~ 16 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Food irradiation &
conservation [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F; 205Bi; 206Bi; 67Cu [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Benedict Nuclear Pharmaceuticals, CO. USA – 4/w; University of California, Irvine, CA, USA – 1-2/w; University of California, Berkley, CA, USA –1-2/w; VA Hospital, Palo Alto CA. USA – 1-2/w; National Institute of Health, MD, USA – 2-4/y; NeoRx Corporation, WA, USA – 2-4/y
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical; – Small animal; – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
376
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I 3.7 – 7.4 4/week Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced): 205Bi, 206Bi
377
COUNTRY: UNITED STATES OF AMERICA USA-10 [1] INSTITUTE: Downstate Clinical PET Center
Methodist Medical Center 221 North East Glen Oak Ave. Illinois 61606
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 309 6724 191 +1 309 6712 166
[2] PERSON IN CHARGE: POSITION:
Dr. Danny Bingham Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Brenda Shields
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 20 0.5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often?18F-FDG, 5/week Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
378
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
379
COUNTRY: UNITED STATES OF AMERICA USA-11 [1] INSTITUTE: Duke University Medical Centre
Department of Radiology Box 3808 Durham, NC 27710
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 919 684 7708 [email protected] +1 919 684 7121
[2] PERSON IN CHARGE: POSITION:
Dr. Bruce Wieland Director, Cyclotron
OTHER SENIOR STAFF: NAME/POSITION
Dr. Michael Zalutsky, Professor
[3] TYPE OF CYCLOTRON: Isochronous fixed field, positive ion
YEAR OF: (I) INSTALLATION 1985
MANUFACTURER: The Cyclotron Corporation
(II) UPGRADE:
MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 27.6 14 28.3 Yes No Maximum beam available (µA) 120 120 100 Typical beam employed (µA) 70 70 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
32 32 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
380
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.1 4/week Yes No Yes No 201Tl Yes No Yes No 211At 1 1/week Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
381
COUNTRY: UNITED STATES OF AMERICA USA-12 [1] INSTITUTE: Emory University, Division of Nuclear Medicine
1364 Clifton Road NE Atlanta, GA 30322
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 404 712 7930
[2] PERSON IN CHARGE: POSITION:
Mark Goodman
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Ronald Crowe
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30 ~ 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
382
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
383
COUNTRY: UNITED STATES OF AMERICA USA-13 [1] INSTITUTE: Gershenson Radiation Oncology Center
Harper University Hospital and Wayne State University 3990 John R Detroit, MI 48201
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 313 745 2487 [email protected] +1 313 745 2314
[2] PERSON IN CHARGE: POSITION:
Dr. Richard L. Maughan
OTHER SENIOR STAFF: NAME/POSITION
Mark Yudelev, PhD., Senior Clinical Medical Physicist
[3] TYPE OF CYCLOTRON: 50 MeV deuteron superconducting cyclotron
YEAR OF: (I) INSTALLATION 1990
MANUFACTURER: Michigan State University
(II) UPGRADE:
MODEL: K100-Harper [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 48.5 Yes No Maximum beam available (µA) ~ 20 Typical beam employed (µA) ~ 12 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
71 6 15 50 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 1 Radiography: Materials science: Proton therapy: Physics: (medical) 5 Neutron therapy: 50 Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No En = 19MeV,
55 [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): None [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
384
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α)18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
385
COUNTRY: UNITED STATES OF AMERICA USA-14 [1] INSTITUTE: Good Samaritan Medical Center
PET Net Pharmaceutical Services 1111 E. McDowell Road, West Tower, Lower Level 1
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 602 239 4100/4747 +1 602 239 2810
[2] PERSON IN CHARGE: POSITION:
Dr. Tricia Giurlani PDC Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Michael Lawson Mr. David Stith Mr. Jay Stivers
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40-100 Typical beam employed (µA) 20-100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
15-30 5-10 5-10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-FDG, daily; 13N-ammonia, 1/month.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
386
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
387
COUNTRY: UNITED STATES OF AMERICA USA-15 [1] INSTITUTE: Indiana University Cyclotron Facility
2401 Milo B. Sampson Lane Bloomington, IN 47408
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 812 8559 365 @iucf.indiana.edu +1 812 8556 645
[2] PERSON IN CHARGE: POSITION:
Dr. John M. Cameron Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
D. Friesel J. Collins G. East
[3] TYPE OF CYCLOTRON: Separated sector YEAR OF: (I) INSTALLATION 1975 MANUFACTURER: In-house (II) UPGRADE: MODEL: K200 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 205 Yes No Maximum beam available (µA) 5 Typical beam employed (µA) 5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
125 10 20 95 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 5 Radiography: Materials science: 50 Proton therapy: 90 Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): None [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
388
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α)18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
389
COUNTRY: UNITED STATES OF AMERICA USA-16 [1] INSTITUTE: Indiana University Cyclotron Facility
2401 Milo B. Sampson Lane Bloomington, IN 47408
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 812 8559 365 @iucf.indiana.edu +1 812 8556 645
[2] PERSON IN CHARGE: POSITION:
Dr. John M. Cameron Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
D. Friesel J. Collins G. East
[3] TYPE OF CYCLOTRON: Separated sector YEAR OF: (I) INSTALLATION 1972 MANUFACTURER: In-house (II) UPGRADE: MODEL: K16 [4] CYCLOTRON CHARACTERISTICS: (Used as injector to K2000). 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 Yes No Maximum beam available (µA) 20 Typical beam employed (µA) 5 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
125 10 20 95 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 5 Radiography: Materials science: 50 Proton therapy: 90 Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
390
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No 20Ne (d, α)18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
391
COUNTRY: UNITED STATES OF AMERICA USA-17 [1] INSTITUTE: John Hopkins University School of Medicine
Division of Nuclear Medicine PET Center 600 North Wolfe Street Nelson B1-150 Baltimore, MD 21287
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 410 955 2916 rfd @jhu.edu +1 410 955 0691
[2] PERSON IN CHARGE: POSITION:
Robert F. Dannais, PhD. Professor, Radiology/Director, PET Center
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Hayden T. Ravert, PhD. John L. Musachio, PhD. William B. Mathews, PhD.
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: GE (II) UPGRADE: The installation of the PETtrace MODEL: PET Trace represents an upgrace from our previous Scandinotrix MC-16F which
is still on-site, but no longer used. [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (µA) 75 40 Typical beam employed (µA) 60 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 39 20 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): Radiotracer chemistry [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
392
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F ~ 90 > 90 1.5 800 Yes
No 20Ne (d, α)18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG > 55 2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Many 11C ligands
~ 3.7 4/daily Yes No Yes No
Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water On-line, ~ 3 GBq daily 14N(d,n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
393
COUNTRY: UNITED STATES OF AMERICA USA-18 [1] INSTITUTE: Karmanos Cancer Institute
Gershenson Radiation Oncology Center Wayne State University 3990 John R Detroit, MI 48201
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 313 745 2076 [email protected] +1 313 745 2314
[2] PERSON IN CHARGE: POSITION:
Mark Yudelev, PhD. Medical Physicist
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
J.D. Forman, MD, Chairman, Rad. Oncology E. Blosser, Service Engineer, Medcyc Corporation C.G. Orton, PhD., Head - Medical Physics
[3] TYPE OF CYCLOTRON: Superconducting YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: NSCL (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 100K 1H 2H 3He 4He Dual Beams Beam energies (MeV) 48.5 Yes No Maximum beam available (µA) 15 Typical beam employed (µA) 10-12 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
80 n/a 10 20 50 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 5 Radiography: Materials science: Proton therapy: Physics: 5 Neutron therapy: 50 Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) 25 MeV Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
394
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
395
COUNTRY: UNITED STATES OF AMERICA USA-19 [1] INSTITUTE: Kettering Memorial Hospital
Department of Nuclear Medicine and PET 3535 Southern Boulevard Kettering, OH 45429
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 937 296 7211 +1 937 296 4265
[2] PERSON IN CHARGE: POSITION:
Dr. Joseph Mantil
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Martin Satter
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 25-43 Typical beam employed (µA) 20-35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
12 12 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
396
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
397
COUNTRY: UNITED STATES OF AMERICA USA-20 [1] INSTITUTE: LA Tech Center
UCLA School of Medicine Department of Molecular and Medical Pharmacology and PETNet Pharmaceuticals, Inc.
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 310 670 1010 [email protected] +1 310 670 2521
[2] PERSON IN CHARGE: POSITION:
Henry C. Padgett, PhD. Managing Director
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Deep Valley YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS-111 (2) [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20-30 20-30 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 124I [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
398
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 95+ ~ 1 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 5 days/week Yes No Yes No F-dopa (in progress) Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
[11C] CO2 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
399
COUNTRY: UNITED STATES OF AMERICA USA-21 [1] INSTITUTE: Lawrence Berkeley Laboratory
Department of Functional Imaging 1 Cyclotron Road, 55-121 Berkeley, CA 94720
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 510 486 5276 [email protected] +1 510 486 6208
[2] PERSON IN CHARGE: POSITION:
James P. O’Neil Supervisor, Biomedical Isotope Facility
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Dr. Thomas F. Budinger Dr. Henry VanBrocklin
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: Prototype(1st built), H+ only, dual beam, 1 fixed 112–style target, 1 8 position turret
assembly 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 50 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: <10 Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 55Co, 124I, 94mTc, 76Br [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) KLEON Positron emission tomography (PET) ECAT 531
(1)
– Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
400
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 9
37 33
> 95 0.3 1
10 Yes No
20Ne (d, α)18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Various 1/week Yes No Yes No 18FMT 1.9 - 3.7 24/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Choline Various 1 week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 1.1 3/month 16O(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
401
COUNTRY: UNITED STATES OF AMERICA USA-22 [1] INSTITUTE: Mallinckrodt Institute of Radiology
Washington University 510 Kingshighway St. Louis, MO
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 314 362 8435
[2] PERSON IN CHARGE: POSITION:
Professor M.J. Welch Division Head of Radiological Sciences
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Cyclone 30; 4 beam lines
YEAR OF: (I) INSTALLATION 1977 and 1991
MANUFACTURER: IBA, s.a., The Cyclotron Corp., and Japan Steel Works
(II) UPGRADE:
MODEL: CS-15 (3); JSW 168 (1)
[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8 Yes No Maximum beam available (µA) 80 80 Typical beam employed (µA) 40-50 30-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
35 35 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): PET 35 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 5 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
402
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37-111 95 1.7
1.2 Yes
No 20Ne (d, α)18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 29-60 daily Yes No Yes No Captopi1 Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 10 3/week Yes No Yes No Palmitate 8 3/week Yes No Yes No Glucose 1.5 3/week Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 4 16O(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 4-8 Varies 14N(d,n)15O Oxygen 4-8 Varies 14N(d,n)15O CO 4-8 Varies 14N(d,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu 15 2/week Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 76Br, 66Ga
403
COUNTRY: UNITED STATES OF AMERICA USA-23 [1] INSTITUTE: Massachusetts General Hospital
Department of Radiology Boston, MA 02114
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 617 726 8336 [email protected] +1 617 726 5123
[2] PERSON IN CHARGE: POSITION:
John A. Correia, PhD. Director, Cyclotron Laboratory
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Eli Livni, PhD., Radiochemist David Elmaleh, PhD., Radiochemist Alan Fischman, MD, PhD., Physician William Bucekwicz, Cyclotron Engineer
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 [4] CYCLOTRON CHARACTERISTICS: Fixed energy, 18 MeV protons, 8.5 MeV deuterons 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 8.5 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 35 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
55 20 6 4 25 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18FDG daily, ten local institutions/hospitals.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 2 Gamma camera 15 Single photon tomography (SPET) 6 Positron emission tomography (PET) – Clinical 3 – Small animal 3 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
404
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 80 97+ 1 500 Yes
No 20Ne (d, α)18F 1.2 250 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 40 daily Yes No Yes No DOPA 0.05 weekly Yes No Yes No Setopirine 0.1-0.5 weekly Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C-CFT, Raclopride
Yes No Yes No
Altopene, SCH 50 mCi 10/week Yes No Yes No 11CO 100 mCi 2/week Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13N2 100 mCi 10/week 12C(d,n) Yes No 13N2H3 300 mCi 5/week 16O(p, α) Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
C15O2 300 mCi 10/week 14N(d,n) 15O 15O2 300 mCi 2/week 14N(d,n) 15O H21
5O 300 mCi 5/week 14N(d,n) 15O OTHER ISOTOPES PRODUCED
Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 0.037 Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
405
COUNTRY: UNITED STATES OF AMERICA USA-24 [1] INSTITUTE: Medi-Physics, Inc.
Amersham Healthcare 900 Durham Avenue South Plainfield, NJ 07080
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 908 757 0500
[2] PERSON IN CHARGE: POSITION:
Gordon Glass Site Administration Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
William McClain
[3] TYPE OF CYCLOTRON: Negative ion, fixed field, fixed freq., var. energy
YEAR OF: (I) INSTALLATION 1989
MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
Proprietary info [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Proprietary info Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
406
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
407
COUNTRY: UNITED STATES OF AMERICA USA-25 [1] INSTITUTE: Medi-Physics, Inc.
Amersham Healthcare 3350 Ridge Avenue Arlington Heights, IL 60004
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 847 3988 400
[2] PERSON IN CHARGE: POSITION:
Thomas Springer Director of Operations
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Brian Carus
[3] TYPE OF CYCLOTRON: Positive ion, variable energy
YEAR OF: (I) INSTALLATION 1986
MANUFACTURER: Sumitomo & CGR (II) UPGRADE: MODEL: PV-750 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
Proprietary info [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Proprietary info Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
408
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
409
COUNTRY: UNITED STATES OF AMERICA USA-26 [1] INSTITUTE: Medi-Physics, Inc.
Amersham Healthcare 3350 Ridge Avenue Arlington Heights, IL 60004
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 847 3988 400
[2] PERSON IN CHARGE: POSITION:
Thomas Springer Director of Operations
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Brian Carus
[3] TYPE OF CYCLOTRON: Positive ion, variable energy
YEAR OF: (I) INSTALLATION 1979
MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
Proprietary info [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Proprietary info Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
410
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
411
COUNTRY: UNITED STATES OF AMERICA USA-27 [1] INSTITUTE: Medi-Physics, Inc.
Amersham Healthcare 900 Durham Avenue South Plainfield, NJ 07080
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 847 3988 400
[2] PERSON IN CHARGE: POSITION:
Gordon Glass Site Administration Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
William McClain
[3] TYPE OF CYCLOTRON: Positive ion, Azimuthally varying field, isochronous
YEAR OF: (I) INSTALLATION 1973
MANUFACTURER: The Cyclotron Corporation
(II) UPGRADE:
MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
Proprietary info [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Proprietary info Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
412
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
413
COUNTRY: UNITED STATES OF AMERICA USA-28 [1] INSTITUTE: Mount Sinai Medical Center
4300 Alton Road Miami Beach, FL 33140
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 305 674 2465 +1 305 674 2428
[2] PERSON IN CHARGE: POSITION:
Dr. Thomas E. Boothe Director, Cyclotron/Radiochemistry
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mike Plitnikes Patricia Smith Manny Tavana
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1972 MANUFACTURER: The Cyclotron
Corporation (II) UPGRADE:
MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Proprietary Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
Proprietary Proprietary Proprietary [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 67Ga-chloride; 111In-chloride; 201Tl-chloride – world wide
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
414
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced):
415
COUNTRY: UNITED STATES OF AMERICA USA-29 [1] INSTITUTE: National Institute of Drug Abuse
NIDA/IRP, NIH 5500 Nathan Shock Drive, Room 405 Baltimore, MD 21224
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 410 550 1440 (general)/ +1 410 550 2916 (cyclotron) [email protected] +1 410 550 2724
[2] PERSON IN CHARGE: POSITION:
Alane Kimes, PhD. Acting Branch Chief
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Andrew Horti, PhD., Chief Radiochemist Carlo Contoreggi, MD, Authorized Radiation User/ Nuclear Medicine Physician
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1997 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 25-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 0 8 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 0 Radiography: 0 Materials science: 0 Proton therapy: 0 Physics: 0 Neutron therapy: 0 Activation analysis: 0 Other (specify): 20: PET [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
416
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 12-15 95 1.1 200 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 4-8 1-2/week Yes No Yes No 18F – 2-Fa 1 0-2/week Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Raclopride 4-8 0-6/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
n/a Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 0.7-1 0-30/week 15N(p,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Many research tracers labeled with 11C and 18F.
417
COUNTRY: UNITED STATES OF AMERICA USA-30 [1] INSTITUTE: National Institute of Health
Building 10, Room 1C401, MSC 1180 Bethesda, MD 20892
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 301 496 0345 [email protected] +1 301 402 3521
[2] PERSON IN CHARGE: POSITION:
Dr. William Eckelman Chief, PET Department
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Paul S. Plascjak
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes No Maximum beam available (µA) 50 50 Typical beam employed (µA) 35 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 5 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 40 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? ORNL - monthly; NIST - yearly.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 1 Single photon tomography (SPET) 3 Positron emission tomography (PET) – Clinical 3 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
418
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 40 95 1.5 600 Yes
No 20Ne (d, α) 18F 10 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 20 1/day Yes No Yes No Dopamine 0.3 1/week Yes No Yes No DOPA 0.3 1/week Yes No Yes No FPTZTP 0.2 1/week Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Raclopride 1 1/week Yes No Yes No Palmitic acid 1 2/week Yes No Yes No Aracidonic 0.5 4/week Yes No Yes No CO 2 2/week Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 1.5 10/week 16O(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water Continuous daily 14N(d, n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 0.75 1/week Yes No Yes No 94mTc 1.0 1/week Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I 1.5 1/month Yes No Yes No 201Tl Yes No Yes No 211At 1.5 1/month Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
419
COUNTRY: UNITED STATES OF AMERICA USA-31 [1] INSTITUTE: National Institute of Health
Building 10, Room 1C401, MSC 1180 Bethesda, MD 20892
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 301 496 0345 +1 301 402 3521
[2] PERSON IN CHARGE: POSITION:
Dr. William Eckelman Chief, PET Department
OTHER SENIOR STAFF: NAME/POSITION
Paul S. Plascjak
[3] TYPE OF CYCLOTRON: Fixed energy compact
YEAR OF: (I) INSTALLATION 1985
MANUFACTURER: Japan Steel Works, Ltd.
(II) UPGRADE:
MODEL: JSW-1710 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17.5 9.8 Yes No
Maximum beam available (µA) 150 150 Typical beam employed (µA) 50 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
72 (6 days/ week) ~ 35 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F FDG provided to one centre 1/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 3 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
420
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Dopa Yes No Yes No Dopamine Yes No Yes No F Pr TZPZ Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 6 -18F – Cylofoxy.
421
COUNTRY: UNITED STATES OF AMERICA USA-32 [1] INSTITUTE: National Institute of Health
Building 10, Room 1C401, MSC 1180 Bethesda, MD 20892
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 301 496 0345 [email protected] +1 301 402 3521
[2] PERSON IN CHARGE: POSITION:
Dr. William Eckelman Chief, PET Department
OTHER SENIOR STAFF: NAME/POSITION
Paul S. Plascjak
[3] TYPE OF CYCLOTRON: Fixed energy compact
YEAR OF: (I) INSTALLATION 1985
MANUFACTURER: The Cyclotron Corporation
(II) UPGRADE:
MODEL: CS 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 26.5 14.8 38.1 29.6 Yes No Maximum beam available (µA) 200 300 135 90 Typical beam employed (µA) 60 100 60 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
72 (6 days/week) ~ 35 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18FDG provided to one centre, 1/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Research/diagnosis on site.
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 3 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
422
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Dopa Yes No Yes No Dopamine Yes No Yes No F Pr TZPZ Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 6 -18F – Cylofoxy.
423
COUNTRY: UNITED STATES OF AMERICA USA-33 [1] INSTITUTE: National Superconducting Cyclotron Laboratory
South Shaw Lane East Lansing, MI 48824-1321
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 517 355 9671 +1 517 353 5967
[2] PERSON IN CHARGE: POSITION:
Dr. C.-K. Gelbke Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Peter S. Miller
[3] TYPE OF CYCLOTRON: Superconducting magnet cyclotron
YEAR OF: (I) INSTALLATION 1980-1987
MANUFACTURER: In-house (II) UPGRADE: 1996-1998 MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
156 12 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? We supply beams of radionuclides to users, many from other institutions.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
424
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
425
COUNTRY: UNITED STATES OF AMERICA USA-34 [1] INSTITUTE: National Superconducting Cyclotron Laboratory
Michigan State University South Shaw Lane East Lansing, MI 48824-1321
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 517 355 9671 +1 517 353 5967
[2] PERSON IN CHARGE: POSITION:
Dr. C.-K. Gelbke Director4
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Peter S. Miller
[3] TYPE OF CYCLOTRON: Superconducting magnet cyclotron
YEAR OF: (I) INSTALLATION 1977-1981
MANUFACTURER: In-house (II) UPGRADE: 1996-1998 MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
426
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
427
COUNTRY: UNITED STATES OF AMERICA USA-35 [1] INSTITUTE: North Shore University Hospital
Research Department - Cyclotron/ PET Facility 350 Community Drive Manhasett, NY 11021
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 516 562 1055 [email protected] +1 516 562 1120
[2] PERSON IN CHARGE: POSITION:
Dr. J. Robert Dahl
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Thomas Chaly
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17.5 8.75 17.5 Yes No Maximum beam available (µA) 180 180 Typical beam employed (µA) 30-40 30-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 20 4, plus 2 weeks/year for periodic maintenance
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Only to research collaborators with continuing joint projects.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
428
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
429
COUNTRY: UNITED STATES OF AMERICA USA-36 [1] INSTITUTE: Northern California PET Imaging Center
3195 Folsom Boulevard Sacramento, CA 95816
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 916 737 3200
[2] PERSON IN CHARGE: POSITION:
Dr. Peter Valk
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Mason Jones
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 10 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-FDG, 1/month Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
430
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18F-FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13N-ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
15O-water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
431
COUNTRY: UNITED STATES OF AMERICA USA-37 [1] INSTITUTE: Oak Ridge National Laboratory
Bldg. 6000, MS 6368 Oak Ridge, TN 37831-6368
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 423 574 4111 +1 423 574 1268
[2] PERSON IN CHARGE: POSITION:
B.A. Tatum Engineering Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
S.W. Mosko
[3] TYPE OF CYCLOTRON: K=100 Isochronous YEAR OF: (I) INSTALLATION 1960 MANUFACTURER: ORNL (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) < 60 < 40 Yes No Maximum beam available (µA) < 100 < 200 Typical beam employed (µA) < 50 < 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 40 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
432
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
433
COUNTRY: UNITED STATES OF AMERICA USA-38 [1] INSTITUTE: PET Net - Chicago
200 E. Howard Street No. 240 Des Plaines, IL 60018
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 847 297 1322
[2] PERSON IN CHARGE: POSITION:
Mr. Russ Greenberg Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Clyde Cole
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1995 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 10 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-FDG, 5 × per week Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
434
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18F-FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
435
COUNTRY: UNITED STATES OF AMERICA USA-39 [1] INSTITUTE: PETNet Pharmaceutical Services
1350 Manufacturing Drive, Suite 105 Dallas, TX 75207
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 214 741 2075 [email protected] +1 214 741 9323
[2] PERSON IN CHARGE: POSITION:
Mr. Steve Torres
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 2001 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 33 18 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
436
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 133 96 1.3 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 59 3 /day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
437
COUNTRY: UNITED STATES OF AMERICA USA-40 [1] INSTITUTE: PETNet Pharmaceutical Services
1350 Manufacturing Drive, Suite 105 Dallas, TX 75207
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 214 741 2075 [email protected] +1 214 741 9323
[2] PERSON IN CHARGE: POSITION:
Mr. Steve Torres
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 1999 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 33 18 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
438
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 133 96 1.3 Yes
No 20Ne (d, α) 18F 16O (α, d) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 59 3 /day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
439
COUNTRY: UNITED STATES OF AMERICA USA-41 [1] INSTITUTE: PET Net/VAMC Palo Alto
Nuclear Medicine Service (115) 3801 Miranda Avenue
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 415 493 5000 [email protected]
[2] PERSON IN CHARGE: POSITION:
Dr. Henry C. Padgett Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dave Wilson
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 25-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
5-15 5-15 ~ 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 15O [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 2-3/ week Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) 3 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
440
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
441
COUNTRY: UNITED STATES OF AMERICA USA-42 [1] INSTITUTE: Positron Emission Tomography Facility
Room 0402 Yellow Zone, Box 3808 Department of Radiology Duke University Medical Center Durham, NC 27710
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 919 684 7836 [email protected] +1 919 684 7130
[2] PERSON IN CHARGE: POSITION:
Bruce W. Wieland, PhD. Cyclotron Director, Associate Research Professor
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Caludio Illan, MSEE Michael Dailey, Operator Shawn Murphy, BSNE, Operator
[3] TYPE OF CYCLOTRON: AVF YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: The Cyclotron
Corporation (II) UPGRADE: 2001 — vacuum lock ion source
system by Cyclotron, Inc. MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: Switching magnet into seven external target beam lines, internal 211At target system MIT-1
by Cyclotron, Inc. 1H 2H 3He 4He Dual Beams Beam energies (MeV) 27 15 39 30 Yes No Maximum beam available (µA) 40 external 20 external 20 external 100 internal Typical beam employed (µA) 20 15 20 60 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
32 28 4 8 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
442
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 40 97 0.4 300 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 12 3/day Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 1 3/week 13C(p, n) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
H2 O 1 2/week 14N(d, n) 15O O2 8 2/week 14N(d, n) 15O CO 8 2/week 14N(d, n) 15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At 4 1/week Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
443
COUNTRY: UNITED STATES OF AMERICA USA-43 [1] INSTITUTE: Regional Nuclear Pharmaceutical, LLC
1224 3rd Avenue South University Park Birmingham, Alabama 35233
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 205 322 4252 [email protected] +1 205 322 4859
[2] PERSON IN CHARGE: POSITION:
Mr. John Haynes Director of Operations
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION 2000 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 80 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30 25 0 2 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify):
18F production
25/week [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? New Orleans, Regional PET; Memphis Regional PET; Jeff Anderson Regional Medical Centre.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
444
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 37 >95 1 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 55 2/day Yes No Yes No $750/dose Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
445
COUNTRY: UNITED STATES OF AMERICA USA-44 [1] INSTITUTE: Saint Louis University
Health Sciences Center, School of Medicine Division of Nuclear Medicine 3635 Vista Avenue at Grand Blvd. P.O. Box 15250 St. Louis, MO 63110-0250
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 314 577 8801 +1 314 268 5486
[2] PERSON IN CHARGE: POSITION:
Dr. Ranajit K. Bera Assistant Professor
OTHER SENIOR STAFF: NAME/POSITION
Dr. James W. Fletcher, Director
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify):
Radiopharmaceuticals
20 h/week [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) Advanced – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
446
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 40 95 0.38 140 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 15-20 everyday Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13NH3 0.8 13C(p,n)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
H215O 15 15N(p,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 18F - Cyclofoxy
447
COUNTRY: UNITED STATES OF AMERICA USA-45 [1] INSTITUTE: Saint Joseph's Positron Center
3003 W. Dr. Martin Luther King, Jr. Boulevard Tampa, FL 33607-4227
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 813 876 5620
[2] PERSON IN CHARGE: POSITION:
John Mather
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Kathie Krista Mike Mosley John O'Connen
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 10 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-FDG, 5 days/week Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
448
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
449
COUNTRY: UNITED STATES OF AMERICA USA-46 [1] INSTITUTE: State University of New York at Buffalo
Department of Nuclear Medicine 105 Parker Hall, 3435 Main Street Buffalo, NY 14214-3007
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 716 838 5889 [email protected] +1 716 838 4918
[2] PERSON IN CHARGE: POSITION:
Prof. R. E. Ackerhalt Director of the Cyclotron Facility
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Michael S. Haka
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15-30 Yes No Maximum beam available (µA) 0-450 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
164 8 ~ 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 103 Pd [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-FDG VA, daily; 13N-ammonia, weekly; -18F-FDG, MFH 3-4 x/week/Roswell 1/week/Biomedical Research, 1-2/week
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 15 Single photon tomography (SPET) 22 Positron emission tomography (PET) 3 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
450
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 1/week Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water CO
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 62Cu, 62Zn
451
COUNTRY: UNITED STATES OF AMERICA USA-47 [1] INSTITUTE: Texas A & M Cyclotron Institute
Texas A & M University College Station, TX 77843-3366
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 409 845 1411 [email protected] +1 409 845 1899
[2] PERSON IN CHARGE: POSITION:
J.B. Natowitz Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
D. May F. Abegglen
[3] TYPE OF CYCLOTRON: Superconducting with ECR source
YEAR OF: (I) INSTALLATION 1989
MANUFACTURER: TAMU (II) UPGRADE: MODEL: K500 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 60 120 130 240 Yes No Maximum beam available (µA) Typical beam employed (µA) 0.2 0.1 0.2 0.1 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
160 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
452
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 7.5 - 15 96 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
453
COUNTRY: UNITED STATES OF AMERICA USA-48 [1] INSTITUTE: The Christ Hospital
2139 Auburn Avenue Cincinnati, OH 45219
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 513 585 0836 [email protected] +1 513 585 0835
[2] PERSON IN CHARGE: POSITION:
Mr. Thomas G. Kemme Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Ms. Carla C. Pemberton, RPh. Mr. George H. Day, RPh.
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
12 12 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F- FDG, 13NH3 [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? University of Cincinnati – 2/week; Fort Hamilton Hughes Hostpital – 1/month; Proctor & Gamble – 1/month
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
454
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 32 > 95 0.33 100 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 10 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 30 1-2/yr Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 1.2 1/week Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
455
COUNTRY: UNITED STATES OF AMERICA USA-49 [1] INSTITUTE: The Queen's Medical Center
1301 Punchbowl Street Honolulu, HI 96813
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 808 537 7077 [email protected] +1 808 585 5095
[2] PERSON IN CHARGE: POSITION:
Pat McGuigan Manager
OTHER SENIOR STAFF: NAME/POSITION
Marc Coel, MD
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1998 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) (yes) Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
5 1 5 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [F-18] Choline [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Tripler Hospital and Kuakini Hospital
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
456
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F > 95 1.1 200 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 9 1/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) [F-18] Choline
457
COUNTRY: UNITED STATES OF AMERICA USA-50 [1] INSTITUTE: Theragenics Corporation
5325 Oakbrook Parkway Norcross, GA 30093
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 770 381 8447
[2] PERSON IN CHARGE: POSITION:
Tony Longo Cyclotron Facility Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Tom West; Ty Tobin Mr. Joe Rodgers; J. Hwung
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1996 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18+ [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 Yes No Maximum beam available (µA) various Typical beam employed (µA) N/A [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
144-168 Typical 0-36 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Medical; Typical 1 to 10 / month/ client
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
458
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd 10 - 60 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Brachytherapy
459
COUNTRY: UNITED STATES OF AMERICA USA-51 [1] INSTITUTE: Theragenics Corporation
5325 Oakbrook Parkway Norcross, GA 30093
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 770 3818 447
[2] PERSON IN CHARGE: POSITION:
Tony Longo Cyclotron Facility Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Tom West; Ty Tobin Mr. Joe Rodgers; J. Hwung
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18+ [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 Yes No Maximum beam available (µA) various Typical beam employed (µA) N/A [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
144-168 Typical 0-36 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Medical; Typical 1 to 10 / month/ client
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
460
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd 10 - 60 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Brachytherapy
461
COUNTRY: UNITED STATES OF AMERICA USA-52 [1] INSTITUTE: Theragenics Corporation
5325 Oakbrook Parkway Norcross, GA 30093
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 770 381 8447
[2] PERSON IN CHARGE: POSITION:
Tony Longo Cyclotron Facility Manager
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Tom West; Ty Robin Joe Rodgers; J. Hwung
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1992 MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 18+ [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 Yes No Maximum beam available (µA) various Typical beam employed (µA) N/A [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
144-168 Typical 0-36 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Medical; Typical 1 to 10 / month/ client
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
462
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd 10 - 60 1/week Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Brachytherapy
463
COUNTRY: UNITED STATES OF AMERICA USA-53 [1] INSTITUTE: University of California at Los Angeles
Biomedical Cyclotron 10833 Le Conte Avenue Los Angeles, CA 90095
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 310 825 6231 +1 310 825 4517
[2] PERSON IN CHARGE: POSITION:
N. Satyamurthy
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1994 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 100 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
40 20 10 2-3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Several 18F and 11C labeled radiopharmaceuticals [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 3 – Small animal 3 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
464
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 40 95 0.8 15 750 5 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 20 10/week Yes No Yes No Variety of 18F-labeled prods.
10/week Yes No Yes No
Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
11C-Acetate 10 2/week Yes No Yes No Variety of 11C-labeled prods.
4/week Yes No Yes No
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 3 20/week 16O(p, α) 13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
H2O 4 10/week 15N(p, n) 15O O2 4 3/week CO 4 3/week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
465
COUNTRY: UNITED STATES OF AMERICA USA-54 [1] INSTITUTE: University of California-Irvine
Brain Imaging Centre Irvine, CA 92697
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 714 824 2018 [email protected] +1 714 824 2230
[2] PERSON IN CHARGE: POSITION:
Dr. Ahmod A. Najafi
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1988 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC 17 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 8-10 Yes No Maximum beam available (µA) 20 Typical beam employed (µA) 2-3 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
12 12 2 -3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) (yes) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
466
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Dopa Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
467
COUNTRY: UNITED STATES OF AMERICA USA-55 [1] INSTITUTE: University of Iowa
PET Imaging Centre Iowa City, IA 52242
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 319 356 4100 [email protected] +1 319 353 6512
[2] PERSON IN CHARGE: POSITION:
Professor Richard D. Hichwa Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
G. Leonard Watkins Laura Boles Ponto Mark T. Madsen
[3] TYPE OF CYCLOTRON: Positive ion, sector-focused, resistive magnet
YEAR OF: (I) INSTALLATION 1990
MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17 F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 7.3 (fixed energy) Yes No Maximum beam available (µA) 1-70 1-70 Typical beam employed (µA) 25-50
100 max 10-15
100 max
[5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
> 40 20-30 < 1 target maintenance 1/year
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Medical research/diagnosis
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
468
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Mehionine Yes No Yes No Acetate Yes No Yes No CO, CO2 Yes No Yes No Receptor ligands
Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water CO, CO2 O2
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 48V
469
COUNTRY: UNITED STATES OF AMERICA USA-56 [1] INSTITUTE: University of Michigan
3480 Kresge III Ann Arbor, MI 48109-0552
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 313 763 9244 +1 313 764 0288
[2] PERSON IN CHARGE: POSITION:
Professor Michael R. Kilbourn Director, PET Chemistry
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Dr. Robert Koeppe Mr. James Moskwa
[3] TYPE OF CYCLOTRON: Medical YEAR OF: (I) INSTALLATION 1982 MANUFACTURER: The Cyclotron
Corporation (II) UPGRADE:
MODEL: CS-30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 26.0 15.0 38.0 30.0 Yes No Maximum beam available (µA) 200 300 100 90 Typical beam employed (µA) 30 30 50 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
15 12 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 3 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
470
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Epinephrine Yes No Yes No Pseuolophedrine Yes No Yes No Diahydiotetabenazine
Yes No Yes No
Acetate Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED
Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 62Zn
471
COUNTRY: UNITED STATES OF AMERICA USA-57 [1] INSTITUTE: University of Pennsylvania
Department of Radiology 1 Silverstein Philadelphia, PA 19104
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 215 662 7552 [email protected] +1 215 662 7551
[2] PERSON IN CHARGE: POSITION:
Dr. Carlos Gonzalez Lepera Facility Manager
OTHER SENIOR STAFF: NAME/POSITION
Harry White
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1986 MANUFACTURER: Japan Steel Works,
Ltd. (II) UPGRADE:
MODEL: BC 3015 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 13/22/30 11/15 17/23/40 13/22/30 Yes No Maximum beam available (µA) Typical beam employed (µA) 25 25 20 25 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
15 12 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 55Co; 89Zr [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 7 Positron emission tomography (PET) 2 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
472
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Flumazenil Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
473
COUNTRY: UNITED STATES OF AMERICA USA-58 [1] INSTITUTE: University of Southern California
1510 San Pablo, #350 Los Angeles, CA 90033
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 213 342 5884 [email protected] +1 213 342 5778
[2] PERSON IN CHARGE: POSITION:
Dr. Peter S. Conti Director, PET Imaging & Radiological Resources
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
James R. Bading; Miar Alauddin Mr. John Fissikis; Mr. Keith Higa
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1990 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 111 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 150 Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
20 15 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-FDG daily Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Both on and off site
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
474
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water O CO, CO2
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
475
COUNTRY: UNITED STATES OF AMERICA USA-59 [1] INSTITUTE: University of Tennesse Medical Centre
Biomedical Imaging Center 1924 Alcoa Highway, Knoxville, TN 37920
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 865 544 9818 or 865 544 9697 [email protected] OR [email protected] +1 865 544 8395
[2] PERSON IN CHARGE: POSITION:
C.P.D. Longford Manager
OTHER SENIOR STAFF: NAME/POSITION
K.F. Hubner
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1987 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 2000 - two (2) high pressure target; APS power supply upgraded
2001 - new main magnet power supply - solid state; new automated chemistry equipment
[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11.2 Yes No Maximum beam available (µA) Typical beam employed (µA) 32/target [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30-40 30-40 1-2 4-8 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Daily deliveries of 18FDG to hospitals within 4-5 km radius. Currently have 20 customers, shipping up to 20 doses/day with planned expansion to ship 60 doses/day.
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
476
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 65 > 94 0.90 5 1200 None Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 30-60 2-3/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
ACBC 3.0 5-10/year Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Planned: 18F -BPA and DOPA – not yet available.
477
COUNTRY: UNITED STATES OF AMERICA USA-60 [1] INSTITUTE: University of Texas Houston
6431 Fannin Street, Houston, TX 77030
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 713 500 7755 [email protected] +1 713 500 7771
[2] PERSON IN CHARGE: POSITION:
Carlos Gonzalez Lepera Associate Professor and Executive Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Nancy Haberman, Chemist Kevin Grilley, Radiopharmacist Russell Hildebrandt, Radiopharmacist Isidoro Vaquila, Cyclotron Engineer David Andews, Cyclotron Operator
[3] TYPE OF CYCLOTRON: Variable energy isochronous
YEAR OF: (I) INSTALLATION 1983
MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 20 40 Yes No Maximum beam available (µA) 150 40 30 Typical beam employed (µA) 40 15 15 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
50 25 10 4 5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 1 Radiography: Materials science: 1 Proton therapy: Physics: 1 Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No 22Na, 0.037 GBq Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 124I , 211At [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Hospitals and PET Centres throughout Southeast Texas
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
478
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 100 95 1.4 300 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 50 2/day Yes No Yes No NaF 50 1/day Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 4 6/day 160(p, α)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 4 1/day 14N(d, n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga 555 Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In 370 Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
479
COUNTRY: UNITED STATES OF AMERICA USA-61 [1] INSTITUTE: University of Texas Research Imaging Center
Health Science Center, San Antonia 7703 Floyd Curl Drive San Antonio, TX 78284
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 210 567 8190 [email protected] +1 210 567 8152
[2] PERSON IN CHARGE: POSITION:
Dr. Peter Fox Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Paul Jerabbk
[3] TYPE OF CYCLOTRON: Fixed energy, isochronous, positive ion
YEAR OF: (I) INSTALLATION 1991
MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-17F [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 17.2 8.6 Yes No Maximum beam available (µA) < 10 < 10 Typical beam employed (µA) 10-50 10-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
3-5 3-5 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
480
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate Yes No Yes No Methionine Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
481
COUNTRY: UNITED STATES OF AMERICA USA-62 [1] INSTITUTE: University of Washington Medical Centre
Department of Radiation Oncology Box 356043, Room NN-136, 1959 NE Pacific Street Seattle, WA 98195-6043
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 206 548 4136 [email protected] +1 206 548 6218
[2] PERSON IN CHARGE: POSITION:
Dr. Ruedi Risler Senior Cyclotron Engineer
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Professor Kenneth A. Krohn Professor Jeanne A. Link
[3] TYPE OF CYCLOTRON: Compact room temperature cyclotron
YEAR OF: (I) INSTALLATION 1983
MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 50.5 Yes No Maximum beam available (µA) 60 Typical beam employed (µA) 60 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
10 3 6 30 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: 1 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: 30 Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No 35 [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F, 11C, 15O, 13N, 86Y, 99Tc, 124I, 19Ne [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 0 Gamma camera 6 Single photon tomography (SPET) 2 Positron emission tomography (PET) 1 – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
482
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 15-20 95 3 No 60 None Yes
No Ne (d, α) 18F No 16O (α, x) 18F No
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 5 2/day Yes No Yes No FES 1 3/month Yes No Yes No FM180 1 3/month Yes No Yes No FLT 1 3/month Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Glucose 1 1/month Yes No Yes No Thyamidine 1 3/momth Yes No Yes No MHED 1 4/month Yes No Yes No CGP12177 2 8/month Yes No Yes No Flumazenile 1 1/month Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
H2O O2
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 2/yr Yes No Yes No 94mTc 2/yr Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I planned Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
483
COUNTRY: UNITED STATES OF AMERICA USA-63 [1] INSTITUTE: University of Wisconsin
Medical Physics Department, 1530 Med. Serv. Center 1300 University Avenue Madison, WI 53706
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 608 262 2170 +1 608 263 3910
[2] PERSON IN CHARGE: POSITION:
Professor R.J. Nickels
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Andrew Roberts Onofre de Jesus
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1986 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) Typical beam employed (µA) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
8 8 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera 3 Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
484
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
485
COUNTRY: UNITED STATES OF AMERICA USA-64 [1] INSTITUTE: VA Medical Centre (11P)
1 Veterans Drive Minneapolis, MN 55417
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 612 725 2230 [email protected] +1 612 725 2068
[2] PERSON IN CHARGE: POSITION:
Dr. David Rotenberg
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION NAME/POSITION
Mr. Rashid Syed Ms. Carroll Arnett E. Akguen Munawwar Sajjad
[3] TYPE OF CYCLOTRON: Positive ion YEAR OF: (I) INSTALLATION 1985 MANUFACTURER: Scandinotrix (II) UPGRADE: MODEL: MC-40 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 40 20 Yes No Maximum beam available (µA) 40 50 Typical beam employed (µA) 25 30 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30 15 2 6 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other
institutions? If yes and available, name of institution/s & how often?
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
486
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 15 > 95 1.2 100
Yes No
Ne (d, α) 18F 11 99.999 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 6.5 3/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Acetate 1.8 on demand Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia 2.2 5/week 16O(p,a)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
15O Water 6.0 36/week 14N(d,n)15O 14O Water 3.5 on demand 14N(p,n)14O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
487
COUNTRY: UNITED STATES OF AMERICA USA-65 [1] INSTITUTE: VAMC & University of Pittsburgh Medical Facility
PET Center -9B 200 Lothrop Street Pittsburg, PA 15213
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 412 647 0736 [email protected] +1 412 647 0700
[2] PERSON IN CHARGE: POSITION:
Professor Chet Mathis Co-Director, PET Facility
OTHER SENIOR STAFF: NAME/POSITION
Professor David Townsend, Co-Dir., PET Facility
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) 40 [5] CYCLOTRON OPERATION:
Total hours (h)/ week h/week for radionuclide production
h/week for research
h/week for maintenance
h/week for applications
35 20 15 <5 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): Many, various – 11C-CFT, 11C-acetate and choline [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 3 Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 + 2 – Small animal 1 – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
488
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 22 > 95 0.3 200 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 7 5/week Yes No Yes No 18F-Altanarin 2 2/week Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Flumezenil 4 1/week Yes No Yes No McN 5652 4 2/week Yes No Yes No Way 100635 1 4/week Yes No Yes No PMD 4 4/week Yes No Yes No Raclopride 3 10/week Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
NH3 3 4/week 16O(p,a)13N Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
H2O 4-20 20/week O2 4-10 5/week 15N(p,n)15O
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
489
COUNTRY: UNITED STATES OF AMERICA USA-66 [1] INSTITUTE: Vanderbilt University Medical Center
Radiology Department 100 Medical Center South Nashville, TN 3723206315
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 615 3220508 [email protected]
[2] PERSON IN CHARGE: POSITION:
Dr. Ronald G. Manning
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Jeff Clanton Jeff Clauton,; Dominique Delbeke Robert Kessler
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1989 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 80 Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
25 25 20 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? PETNet Site; Several Customers >15
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site? Both on & off sites.
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera Single photon tomography (SPET) 4 Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
490
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
491
COUNTRY: UNITES STATES OF AMERICA USA-67 [1] INSTITUTE: Weill Medical College at Cornell University and
Memorial Sloan Kettering Cancer Center Consortium 1300 York Avenue New York, NY 10021
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 212 639 2458 [email protected] +1 212 717 3821
[2] PERSON IN CHARGE: POSITION:
Dr. Ron Finn Head, Cyclotron Division
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
Yiauchung Sheh, MS, Senior Cyclotron Engineer
[3] TYPE OF CYCLOTRON: Negative Ion YEAR OF: (I) INSTALLATION Ongoing and in progress (2001) MANUFACTURER: EBCO Industries (II) UPGRADE: Incorporation of external beam MODEL: TR 19/9 line with target changer [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: 10% anticipated Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): Radionuclide
preparation 90% anticipated
[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? On scientific collaborative basis
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
492
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F >95 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 69Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) Imaging Center building completion scheduled for October 2001. Cyclotron already in vault, awaiting building service availability for start of the assembly.
493
COUNTRY: UNITED STATES OF AMERICA USA-68 [1] INSTITUTE: West Virginia University Hospital PET Centre
P.O. Box 9236 Morgantown, WV 26506-9236
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 304 293 7798 [email protected] +1 304 293 7142
[2] PERSON IN CHARGE: POSITION:
Dr. Naresh C. Gupta Director
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION
Mr. Samuel M. Mazza Mr. Raymond R. Raylman
[3] TYPE OF CYCLOTRON: Negative ion, dual beam
YEAR OF: (I) INSTALLATION 1995
MANUFACTURER: General Electric (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.5 Yes No Maximum beam available (µA) Typical beam employed (µA) 20 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
5 5 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? 18F-Fluoride – irregularly; 18F-FDG - planned
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
494
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
495
COUNTRY: UNITED STATES OF AMERICA USA-69 [1] INSTITUTE: William Beaumont Hospital
Department of Nuclear Medicine 3601 West Thirteen Mile Road Royal Oak, MI 48083-6769
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 313 551 831
[2] PERSON IN CHARGE: POSITION:
Dr. Ram B. Sharma Radiochemist
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20-35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
13 13 2 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Nucl. Med. 40 Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 11C and 15O [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
496
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F 30 95-98 0.3 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 16/batch 5/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
13NH3 1.9 2/month Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)
497
COUNTRY: UNITED STATES OF AMERICA USA-70 [1] INSTITUTE: Yale University/VAMC West Haven
PET Imaging Center (115A) 950 Campbell Avenue West Haven, CT 06516
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
+1 203 937 4884 [email protected]
[2] PERSON IN CHARGE: POSITION:
Dr. Pradeep Garg Director, Radiopharmaceutical Chemistry
OTHER SENIOR STAFF: NAME/POSITION
[3] TYPE OF CYCLOTRON: Negative ion YEAR OF: (I) INSTALLATION 1991 MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (µA) 40 Typical beam employed (µA) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
30-40 ~ 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F- labeled androgens, 18F- labeled prostate probes [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yale University and VA Nuclear Medicine: 0-2 times/month
Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical 1 – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
498
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F ~16 >98 0.32 Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG 5 - 6 4 - 10/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Ammonia ~1 1-10/month 16O(p,a)13N Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
Water 3-4 0-40/week
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced) 11C - NNC 112, Dolipram, Tropanes; 18F Deutero-Altanserine, para fluoro benzylguanidine, Fallypride.
499
SAMPLE QUESTIONNAIRE COUNTRY: [1] INSTITUTE:
TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:
[2] PERSON IN CHARGE: POSITION:
OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION NAME/POSITION
[3] TYPE OF CYCLOTRON: YEAR OF: (I) INSTALLATION MANUFACTURER: (II) UPGRADE: MODEL: [4] CYCLOTRON CHARACTERISTICS:
1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (µA) Typical beam employed (µA) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide
production h/week for research
h/week for maintenance
h/week for applications
[6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify): [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mössbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): [9] Do you supply radionuclides to other institutions?
If yes and available, name of institution/s & how often? Yes No
[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?
Yes No
[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) – Clinical – Small animal – Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for
agricultural applications such as plant biochemistry/research? Yes No
[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No
500
18F RADIONUCLIDE PRODUCTION
Production Typical production yield (GBq)
% Isotopic enrichment
18O used
Target Volume Usage/year Do you recycle 18OH2?
18OH2 (ml) 18O2 (ml) 18OH2 (g)
18O2 (l) 18O (p, n) 18F Yes
No Ne (d, α) 18F 16O (α, x) 18F
18F RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
11C RADIOPHARMACEUTICALS PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No
13N RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production
Nuclear reaction used Distribution/ sales
Price/GBq if available
Yes No Yes No Yes No
15O RADIOPHARMACEUTICALS PRODUCED Name (list)
Typical yield on batch (GBq)
Frequency of production Nuclear reaction used
Price/GBq if available
OTHER ISOTOPES PRODUCED Name (list)
Yield on batch (GBq)
Frequency of production
Used on site Distribution/ sales
Price/GBq if available
64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No
COMMENTS: (e.g. you may add names of additional labelled compounds/radiopharmaceuticals being produced)